TGFBR2_knockout_296_GSE22989 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22989
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Genes

600 genes differentially expressed following the TGFBR2_knockout_296_GSE22989 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
ADD3 adducin 3 (gamma) 3.39251
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 3.20723
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 3.16476
RPL23 ribosomal protein L23 3.12185
COG7 component of oligomeric golgi complex 7 3.00608
FOXD2 forkhead box D2 2.95815
TPI1 triosephosphate isomerase 1 2.95392
TMIE transmembrane inner ear 2.74839
RPS28 ribosomal protein S28 2.74803
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.74332
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.73954
APP amyloid beta (A4) precursor protein 2.7273
ANKRD13D ankyrin repeat domain 13 family, member D 2.65951
KREMEN1 kringle containing transmembrane protein 1 2.65721
KRT34 keratin 34, type I 2.58016
DMWD dystrophia myotonica, WD repeat containing 2.55725
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.51733
IL17RA interleukin 17 receptor A 2.48293
NDRG2 NDRG family member 2 2.46331
DNTT DNA nucleotidylexotransferase 2.42832
GLIS3 GLIS family zinc finger 3 2.4217
ADGRV1 adhesion G protein-coupled receptor V1 2.41495
ODF3B outer dense fiber of sperm tails 3B 2.39576
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 2.38338
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.32294
KCTD1 potassium channel tetramerization domain containing 1 2.31544
ARHGAP6 Rho GTPase activating protein 6 2.30389
AUH AU RNA binding protein/enoyl-CoA hydratase 2.2904
SORCS1 sortilin-related VPS10 domain containing receptor 1 2.27662
SHISA5 shisa family member 5 2.26165
FTH1 ferritin, heavy polypeptide 1 2.24789
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.2272
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.21123
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.20895
ABHD4 abhydrolase domain containing 4 2.14353
CD40 CD40 molecule, TNF receptor superfamily member 5 2.13147
TRIM7 tripartite motif containing 7 2.12855
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.10986
PNMA1 paraneoplastic Ma antigen 1 2.1011
DYX1C1 dyslexia susceptibility 1 candidate 1 2.09172
HLF hepatic leukemia factor 2.08697
SYNGR4 synaptogyrin 4 2.08456
RIMS2 regulating synaptic membrane exocytosis 2 2.083
SHARPIN SHANK-associated RH domain interactor 2.06354
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.05911
TOX thymocyte selection-associated high mobility group box 2.05749
TRIM14 tripartite motif containing 14 2.0451
KIAA0556 KIAA0556 2.03709
ACE angiotensin I converting enzyme 2.02866
TSC22D4 TSC22 domain family, member 4 2.02715
C4ORF29 chromosome 4 open reading frame 29 2.02386
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.00709
TMEM176B transmembrane protein 176B 1.97866
FAM204A family with sequence similarity 204, member A 1.97708
ANKDD1B ankyrin repeat and death domain containing 1B 1.96372
ABHD2 abhydrolase domain containing 2 1.96352
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.96151
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.92331
MXI1 MAX interactor 1, dimerization protein 1.90787
TRIOBP TRIO and F-actin binding protein 1.90325
PYCR1 pyrroline-5-carboxylate reductase 1 1.9027
ATXN10 ataxin 10 1.90031
ATXN7L1 ataxin 7-like 1 1.89174
LTBP4 latent transforming growth factor beta binding protein 4 1.88757
POSTN periostin, osteoblast specific factor 1.88347
PLAC8L1 PLAC8-like 1 1.88278
SYCN syncollin 1.88142
CTSD cathepsin D 1.88057
LAPTM5 lysosomal protein transmembrane 5 1.87398
GSC2 goosecoid homeobox 2 1.86543
ACVR1C activin A receptor, type IC 1.84963
GOLGB1 golgin B1 1.847
LGALS12 lectin, galactoside-binding, soluble, 12 1.83862
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 1.82628
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 1.8261
DDR1 discoidin domain receptor tyrosine kinase 1 1.8255
TCN2 transcobalamin II 1.81876
SLITRK3 SLIT and NTRK-like family, member 3 1.81312
IGSF5 immunoglobulin superfamily, member 5 1.8063
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.7962
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 1.79606
PARD3B par-3 family cell polarity regulator beta 1.79419
CD96 CD96 molecule 1.79161
FOSL2 FOS-like antigen 2 1.78918
ING4 inhibitor of growth family, member 4 1.78366
FOXH1 forkhead box H1 1.77351
C16ORF72 chromosome 16 open reading frame 72 1.77296
CLEC3B C-type lectin domain family 3, member B 1.76918
PGK2 phosphoglycerate kinase 2 1.76888
FMO5 flavin containing monooxygenase 5 1.76783
PHF19 PHD finger protein 19 1.7669
PLEKHA5 pleckstrin homology domain containing, family A member 5 1.76528
MAPK3 mitogen-activated protein kinase 3 1.75997
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 1.75279
QSOX1 quiescin Q6 sulfhydryl oxidase 1 1.7503
MPEG1 macrophage expressed 1 1.74866
TMEM132E transmembrane protein 132E 1.74761
SLC38A10 solute carrier family 38, member 10 1.73948
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.73551
PLIN2 perilipin 2 1.73456
PGRMC1 progesterone receptor membrane component 1 1.73456
PGK1 phosphoglycerate kinase 1 1.73257
HOXA4 homeobox A4 1.72815
UBXN11 UBX domain protein 11 1.72583
TRNP1 TMF1-regulated nuclear protein 1 1.71665
COL20A1 collagen, type XX, alpha 1 1.71474
MYBPC3 myosin binding protein C, cardiac 1.70971
FAM63B family with sequence similarity 63, member B 1.7091
TAS1R2 taste receptor, type 1, member 2 1.69919
MFSD6L major facilitator superfamily domain containing 6-like 1.69681
CPTP ceramide-1-phosphate transfer protein 1.69431
TPP1 tripeptidyl peptidase I 1.69317
CDX2 caudal type homeobox 2 1.69113
TTC21A tetratricopeptide repeat domain 21A 1.6893
GDI1 GDP dissociation inhibitor 1 1.68774
DOCK9 dedicator of cytokinesis 9 1.68251
RGS3 regulator of G-protein signaling 3 1.68079
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 1.67708
ESRRB estrogen-related receptor beta 1.67351
NOTUM notum pectinacetylesterase homolog (Drosophila) 1.67248
KLF13 Kruppel-like factor 13 1.66882
RCAN2 regulator of calcineurin 2 1.66843
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.66796
BATF2 basic leucine zipper transcription factor, ATF-like 2 1.66732
KRT83 keratin 83, type II 1.66424
TMLHE trimethyllysine hydroxylase, epsilon 1.66405
SNAI2 snail family zinc finger 2 1.66389
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 1.65861
ACOT11 acyl-CoA thioesterase 11 1.65552
C16ORF89 chromosome 16 open reading frame 89 1.65454
INHBB inhibin, beta B 1.64966
TRAF1 TNF receptor-associated factor 1 1.64964
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1.64691
PLIN5 perilipin 5 1.64602
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 1.64579
UBXN10 UBX domain protein 10 1.64569
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 1.64335
KIAA0930 KIAA0930 1.64292
KPNA6 karyopherin alpha 6 (importin alpha 7) 1.63988
WDR38 WD repeat domain 38 1.6382
AGXT alanine-glyoxylate aminotransferase 1.6377
SARAF store-operated calcium entry-associated regulatory factor 1.63623
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.62978
ZBTB16 zinc finger and BTB domain containing 16 1.62775
PGAM1 phosphoglycerate mutase 1 (brain) 1.61477
CTSF cathepsin F 1.61335
TNIP1 TNFAIP3 interacting protein 1 1.61328
SARDH sarcosine dehydrogenase 1.61306
ACSM2A acyl-CoA synthetase medium-chain family member 2A 1.61186
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.61104
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.60453
EML3 echinoderm microtubule associated protein like 3 1.60397
FGFR3 fibroblast growth factor receptor 3 1.60378
TGFA transforming growth factor, alpha 1.60305
ADCY5 adenylate cyclase 5 1.60281
EGFR epidermal growth factor receptor 1.60224
EPDR1 ependymin related 1 1.60136
GPR108 G protein-coupled receptor 108 1.59739
DMTF1 cyclin D binding myb-like transcription factor 1 1.59
SCNN1B sodium channel, non voltage gated 1 beta subunit 1.58152
SOX30 SRY (sex determining region Y)-box 30 1.57409
CXCL12 chemokine (C-X-C motif) ligand 12 1.57098
TMEM89 transmembrane protein 89 1.57031
CCDC13 coiled-coil domain containing 13 1.56911
AHR aryl hydrocarbon receptor 1.56904
TNS4 tensin 4 1.56807
PAQR7 progestin and adipoQ receptor family member VII 1.56753
RASA4 RAS p21 protein activator 4 1.56745
NDFIP1 Nedd4 family interacting protein 1 1.56683
C17ORF99 chromosome 17 open reading frame 99 1.56551
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 1.56441
NRXN2 neurexin 2 1.56028
FAM163B family with sequence similarity 163, member B 1.55738
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 1.55636
C1ORF198 chromosome 1 open reading frame 198 1.549
ALDOA aldolase A, fructose-bisphosphate 1.54638
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.54378
RS1 retinoschisin 1 1.54053
HSPA2 heat shock 70kDa protein 2 1.53963
TMEM159 transmembrane protein 159 1.53468
RAB11FIP2 RAB11 family interacting protein 2 (class I) 1.53186
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 1.52993
PSCA prostate stem cell antigen 1.52892
GPR146 G protein-coupled receptor 146 1.52596
BSN bassoon presynaptic cytomatrix protein 1.52248
ACAD10 acyl-CoA dehydrogenase family, member 10 1.52186
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 1.52177
ARMCX2 armadillo repeat containing, X-linked 2 1.52151
IGIP IgA-inducing protein 1.5168
F10 coagulation factor X 1.51424
ACSS1 acyl-CoA synthetase short-chain family member 1 1.51293
CNTD1 cyclin N-terminal domain containing 1 1.51205
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 1.51137
NXPH3 neurexophilin 3 1.50624
KLHL6 kelch-like family member 6 1.50459
SPTBN4 spectrin, beta, non-erythrocytic 4 1.50283
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.50106
STK36 serine/threonine kinase 36 1.50053
NIPAL3 NIPA-like domain containing 3 1.49861
PRSS23 protease, serine, 23 1.4943
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 1.48956
LRRC18 leucine rich repeat containing 18 1.48844
FTCD formimidoyltransferase cyclodeaminase 1.48403
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.48121
TMEM230 transmembrane protein 230 1.48028
C2ORF50 chromosome 2 open reading frame 50 1.4768
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 1.47587
CTSB cathepsin B 1.47013
MYCBPAP MYCBP associated protein 1.46805
SH3KBP1 SH3-domain kinase binding protein 1 1.46758
MOK MOK protein kinase 1.46484
IFNA4 interferon, alpha 4 1.46481
CHRM1 cholinergic receptor, muscarinic 1 1.46389
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.46306
WDFY1 WD repeat and FYVE domain containing 1 1.45894
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.4589
IL22RA2 interleukin 22 receptor, alpha 2 1.4569
RHOBTB1 Rho-related BTB domain containing 1 1.45679
NPHP4 nephronophthisis 4 1.45653
TAGLN2 transgelin 2 1.45625
DCAF12 DDB1 and CUL4 associated factor 12 1.45079
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 1.45065
KIF1C kinesin family member 1C 1.44859
S100A6 S100 calcium binding protein A6 1.44809
MXD1 MAX dimerization protein 1 1.44312
KIAA1045 KIAA1045 1.43593
FBXL20 F-box and leucine-rich repeat protein 20 1.43582
RHO rhodopsin 1.43444
CCDC61 coiled-coil domain containing 61 1.43247
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 1.43185
CCDC80 coiled-coil domain containing 80 1.43014
SLC22A18 solute carrier family 22, member 18 1.42991
AK4 adenylate kinase 4 1.42883
C19ORF12 chromosome 19 open reading frame 12 1.42595
UBE2D2 ubiquitin-conjugating enzyme E2D 2 1.42317
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 1.4205
MMP16 matrix metallopeptidase 16 (membrane-inserted) 1.41399
COL5A3 collagen, type V, alpha 3 1.41201
TAS2R4 taste receptor, type 2, member 4 1.40896
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 1.40636
AVPR1A arginine vasopressin receptor 1A 1.40452
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 1.40283
C17ORF62 chromosome 17 open reading frame 62 1.40062
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 1.39766
FAM134A family with sequence similarity 134, member A 1.39677
FAAH fatty acid amide hydrolase 1.39144
BOC BOC cell adhesion associated, oncogene regulated 1.38911
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.38564
PCDHAC1 protocadherin alpha subfamily C, 1 1.38271
ERO1L ERO1-like (S. cerevisiae) 1.3822
FBXO41 F-box protein 41 1.38205
TGFB2 transforming growth factor, beta 2 1.38179
SYN3 synapsin III 1.38159
ITPKA inositol-trisphosphate 3-kinase A 1.38119
ARRDC1 arrestin domain containing 1 1.37975
CD82 CD82 molecule 1.3753
GPNMB glycoprotein (transmembrane) nmb 1.37488
FAM131C family with sequence similarity 131, member C 1.37452
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 1.37382
TTLL3 tubulin tyrosine ligase-like family member 3 1.3722
MIP major intrinsic protein of lens fiber 1.37124
ULK4 unc-51 like kinase 4 1.37064
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 1.36997
ERLIN2 ER lipid raft associated 2 1.36797
TYR tyrosinase 1.3676
LAT2 linker for activation of T cells family, member 2 1.36538
TTC16 tetratricopeptide repeat domain 16 1.36517
PTGES prostaglandin E synthase 1.36515
FAM3A family with sequence similarity 3, member A 1.35985
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1.35971
C14ORF180 chromosome 14 open reading frame 180 1.35585
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 1.35497
KLF3 Kruppel-like factor 3 (basic) 1.35364
RUSC1 RUN and SH3 domain containing 1 1.35322
C1ORF43 chromosome 1 open reading frame 43 1.35278
C1ORF105 chromosome 1 open reading frame 105 1.35268
PRLR prolactin receptor 1.35142
NDRG1 N-myc downstream regulated 1 1.34875
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.34771
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.34653
PCDH10 protocadherin 10 1.34541
UBE2H ubiquitin-conjugating enzyme E2H 1.34452
NEIL1 nei endonuclease VIII-like 1 (E. coli) 1.3435
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 1.34238
TCTEX1D1 Tctex1 domain containing 1 1.3406
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.33911
FAM189A2 family with sequence similarity 189, member A2 1.33891
RTN4 reticulon 4 1.33784
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.33718
KCNK15 potassium channel, two pore domain subfamily K, member 15 1.33555
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.33415
STYK1 serine/threonine/tyrosine kinase 1 1.33313
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 1.33292
RTBDN retbindin 1.33246
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.33201
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.33139
HRH1 histamine receptor H1 1.33048
RPS26 ribosomal protein S26 1.33
SCLT1 sodium channel and clathrin linker 1 1.32887
GPR88 G protein-coupled receptor 88 1.3253

decreased expression

Symbol Name Standardized Value
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -3.59407
API5 apoptosis inhibitor 5 -3.42554
HAUS4 HAUS augmin-like complex, subunit 4 -3.36458
POLD2 polymerase (DNA directed), delta 2, accessory subunit -3.24978
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.22876
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -3.1606
UMPS uridine monophosphate synthetase -3.14516
KRAS Kirsten rat sarcoma viral oncogene homolog -3.13908
NCAPH non-SMC condensin I complex, subunit H -3.13166
WDHD1 WD repeat and HMG-box DNA binding protein 1 -3.11403
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -3.00658
CDK4 cyclin-dependent kinase 4 -2.96441
WDR55 WD repeat domain 55 -2.9508
XRCC6BP1 XRCC6 binding protein 1 -2.88861
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -2.83588
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.81622
NADK NAD kinase -2.81218
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.76587
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -2.76377
DHODH dihydroorotate dehydrogenase (quinone) -2.74302
CDC5L cell division cycle 5-like -2.7297
RASL11B RAS-like, family 11, member B -2.72775
PRDM4 PR domain containing 4 -2.71895
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 -2.71895
STAG1 stromal antigen 1 -2.69156
SERTAD4 SERTA domain containing 4 -2.68401
ACTL6A actin-like 6A -2.68332
CS citrate synthase -2.67443
PHB2 prohibitin 2 -2.61021
RBM14 RNA binding motif protein 14 -2.58645
MVK mevalonate kinase -2.58192
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.57673
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.56752
MRPS2 mitochondrial ribosomal protein S2 -2.56354
TSN translin -2.562
EPS15 epidermal growth factor receptor pathway substrate 15 -2.55474
TGS1 trimethylguanosine synthase 1 -2.54905
RPA2 replication protein A2, 32kDa -2.5463
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.53764
APIP APAF1 interacting protein -2.53506
GEN1 GEN1 Holliday junction 5' flap endonuclease -2.52896
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) -2.52404
GTSE1 G-2 and S-phase expressed 1 -2.51672
REPS1 RALBP1 associated Eps domain containing 1 -2.49285
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.4839
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -2.47629
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.47114
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.46056
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.45543
ZMYND19 zinc finger, MYND-type containing 19 -2.4463
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.43029
PROM1 prominin 1 -2.4235
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.42251
SRSF2 serine/arginine-rich splicing factor 2 -2.41901
COQ6 coenzyme Q6 monooxygenase -2.41534
PLRG1 pleiotropic regulator 1 -2.4134
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.39059
RBM28 RNA binding motif protein 28 -2.37981
NEK6 NIMA-related kinase 6 -2.37239
C1QBP complement component 1, q subcomponent binding protein -2.36254
USP3 ubiquitin specific peptidase 3 -2.36252
XPO5 exportin 5 -2.33258
KARS lysyl-tRNA synthetase -2.32923
NDE1 nudE neurodevelopment protein 1 -2.32259
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.31689
CDC45 cell division cycle 45 -2.31591
CTNNBL1 catenin, beta like 1 -2.31212
SMNDC1 survival motor neuron domain containing 1 -2.31149
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.30942
MARCH5 membrane-associated ring finger (C3HC4) 5 -2.3089
FAM73B family with sequence similarity 73, member B -2.29347
PIGC phosphatidylinositol glycan anchor biosynthesis, class C -2.28479
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.28231
ACO2 aconitase 2, mitochondrial -2.27939
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.27873
TMEM183A transmembrane protein 183A -2.26467
TTL tubulin tyrosine ligase -2.26444
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -2.26378
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.25654
SET SET nuclear proto-oncogene -2.24264
BEX1 brain expressed, X-linked 1 -2.23535
NMRAL1 NmrA-like family domain containing 1 -2.23423
GFER growth factor, augmenter of liver regeneration -2.23358
MMS22L MMS22-like, DNA repair protein -2.20934
BTNL9 butyrophilin-like 9 -2.19434
MED4 mediator complex subunit 4 -2.19178
BIRC5 baculoviral IAP repeat containing 5 -2.18411
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.17928
LRPPRC leucine-rich pentatricopeptide repeat containing -2.17803
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.17705
CENPU centromere protein U -2.16304
INTS3 integrator complex subunit 3 -2.15917
WBSCR22 Williams Beuren syndrome chromosome region 22 -2.15849
FDPS farnesyl diphosphate synthase -2.15606
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.15382
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.15379
LIMD1 LIM domains containing 1 -2.13949
BLM Bloom syndrome, RecQ helicase-like -2.13909
GEMIN5 gem (nuclear organelle) associated protein 5 -2.1352
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.13482
MTFR2 mitochondrial fission regulator 2 -2.13204
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.12069
CKAP2 cytoskeleton associated protein 2 -2.12045
COPS7B COP9 signalosome subunit 7B -2.11892
EIF3G eukaryotic translation initiation factor 3, subunit G -2.11618
TUBB tubulin, beta class I -2.11383
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.11157
SEPHS1 selenophosphate synthetase 1 -2.10769
MFSD2A major facilitator superfamily domain containing 2A -2.10223
XPO1 exportin 1 -2.09109
HAUS6 HAUS augmin-like complex, subunit 6 -2.09061
DERL2 derlin 2 -2.08257
FUK fucokinase -2.08245
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.07897
AMZ2 archaelysin family metallopeptidase 2 -2.07689
EXOSC4 exosome component 4 -2.07632
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.07489
EMC8 ER membrane protein complex subunit 8 -2.07435
KIAA0040 KIAA0040 -2.07304
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.06897
GLRX5 glutaredoxin 5 -2.06796
CTPS1 CTP synthase 1 -2.06669
PRPF3 pre-mRNA processing factor 3 -2.064
HN1 hematological and neurological expressed 1 -2.05679
FEN1 flap structure-specific endonuclease 1 -2.05533
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.05312
TARS threonyl-tRNA synthetase -2.04413
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.04278
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.03901
HDAC3 histone deacetylase 3 -2.03373
OLA1 Obg-like ATPase 1 -2.0334
ANAPC4 anaphase promoting complex subunit 4 -2.03096
TRIP13 thyroid hormone receptor interactor 13 -2.03079
MRPL2 mitochondrial ribosomal protein L2 -2.02539
CNST consortin, connexin sorting protein -2.01662
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.01326
NMT1 N-myristoyltransferase 1 -2.01147
GPN3 GPN-loop GTPase 3 -2.00872
DYNLL1 dynein, light chain, LC8-type 1 -2.00286
BRMS1L breast cancer metastasis-suppressor 1-like -2.00262
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.00125
USP39 ubiquitin specific peptidase 39 -2.00052
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -1.99874
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.99403
LRRC57 leucine rich repeat containing 57 -1.9925
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -1.99127
CDH4 cadherin 4, type 1, R-cadherin (retinal) -1.9884
GPSM2 G-protein signaling modulator 2 -1.9805
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.97879
RPP14 ribonuclease P/MRP 14kDa subunit -1.9752
LPCAT1 lysophosphatidylcholine acyltransferase 1 -1.96088
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -1.95853
CHD1L chromodomain helicase DNA binding protein 1-like -1.95376
EIF4A3 eukaryotic translation initiation factor 4A3 -1.9502
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -1.94643
RBL1 retinoblastoma-like 1 -1.93951
CTGF connective tissue growth factor -1.93591
NDOR1 NADPH dependent diflavin oxidoreductase 1 -1.93575
ZDHHC6 zinc finger, DHHC-type containing 6 -1.93247
CCDC12 coiled-coil domain containing 12 -1.92978
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) -1.92949
EMD emerin -1.9266
MRPL14 mitochondrial ribosomal protein L14 -1.92433
TIPIN TIMELESS interacting protein -1.92377
DAND5 DAN domain family member 5, BMP antagonist -1.9216
DSN1 DSN1, MIS12 kinetochore complex component -1.9188
ARMC10 armadillo repeat containing 10 -1.91835
C9ORF40 chromosome 9 open reading frame 40 -1.91242
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -1.91058
PARD6G par-6 family cell polarity regulator gamma -1.90775
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) -1.90772
C8ORF33 chromosome 8 open reading frame 33 -1.90676
TMEM135 transmembrane protein 135 -1.90514
VASH2 vasohibin 2 -1.90216
CDCA8 cell division cycle associated 8 -1.90014
TK1 thymidine kinase 1, soluble -1.89728
SHMT1 serine hydroxymethyltransferase 1 (soluble) -1.89587
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -1.89363
EME1 essential meiotic structure-specific endonuclease 1 -1.89275
CKS1B CDC28 protein kinase regulatory subunit 1B -1.89165
RPA1 replication protein A1, 70kDa -1.89066
NDNL2 necdin-like 2 -1.88903
EBI3 Epstein-Barr virus induced 3 -1.88847
TICRR TOPBP1-interacting checkpoint and replication regulator -1.88232
MRAP melanocortin 2 receptor accessory protein -1.88214
CCNB2 cyclin B2 -1.88045
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -1.87965
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -1.87885
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -1.87626
CDC25B cell division cycle 25B -1.87604
CLNS1A chloride channel, nucleotide-sensitive, 1A -1.87486
FER fer (fps/fes related) tyrosine kinase -1.86331
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 -1.86263
PCDH11X protocadherin 11 X-linked -1.8606
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -1.85911
TACC3 transforming, acidic coiled-coil containing protein 3 -1.85733
RFC5 replication factor C (activator 1) 5, 36.5kDa -1.85357
ZDHHC7 zinc finger, DHHC-type containing 7 -1.85267
GREM2 gremlin 2, DAN family BMP antagonist -1.85014
FNTA farnesyltransferase, CAAX box, alpha -1.84949
MIS12 MIS12 kinetochore complex component -1.84901
RDM1 RAD52 motif containing 1 -1.84716
RNASEH1 ribonuclease H1 -1.84716
IKZF5 IKAROS family zinc finger 5 (Pegasus) -1.83669
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -1.83618
TOR1B torsin family 1, member B (torsin B) -1.83212
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -1.83026
PPP4R1 protein phosphatase 4, regulatory subunit 1 -1.82785
CDKN2AIPNL CDKN2A interacting protein N-terminal like -1.82448
GRK6 G protein-coupled receptor kinase 6 -1.82178
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -1.82121
ENSA endosulfine alpha -1.8195
MAF1 MAF1 homolog (S. cerevisiae) -1.81602
TMED1 transmembrane emp24 protein transport domain containing 1 -1.81538
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -1.81468
TBCB tubulin folding cofactor B -1.81374
ICAM2 intercellular adhesion molecule 2 -1.81294
RRM2 ribonucleotide reductase M2 -1.81061
ANGPTL1 angiopoietin-like 1 -1.80903
PSRC1 proline/serine-rich coiled-coil 1 -1.80209
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -1.801
IPO5 importin 5 -1.80017
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -1.79979
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -1.79886
RCL1 RNA terminal phosphate cyclase-like 1 -1.7975
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.78913
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -1.78861
REV1 REV1, polymerase (DNA directed) -1.78798
LAP3 leucine aminopeptidase 3 -1.78733
TTK TTK protein kinase -1.7852
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -1.77941
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -1.77882
TNFAIP8L1 tumor necrosis factor, alpha-induced protein 8-like 1 -1.77804
RNF121 ring finger protein 121 -1.77595
LYAR Ly1 antibody reactive -1.77428
TTC23 tetratricopeptide repeat domain 23 -1.77032
CDCA5 cell division cycle associated 5 -1.7702
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -1.76992
ELAC2 elaC ribonuclease Z 2 -1.76985
RARS arginyl-tRNA synthetase -1.76975
DGCR14 DiGeorge syndrome critical region gene 14 -1.76268
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -1.75724
TSEN15 TSEN15 tRNA splicing endonuclease subunit -1.75668
NCBP1 nuclear cap binding protein subunit 1, 80kDa -1.7564
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -1.75584
COPS6 COP9 signalosome subunit 6 -1.7548
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -1.75401
NUBP1 nucleotide binding protein 1 -1.7525
DEPDC1B DEP domain containing 1B -1.75049
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -1.74924
ZNF410 zinc finger protein 410 -1.74872
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -1.74839
NSFL1C NSFL1 (p97) cofactor (p47) -1.74713
TMEM242 transmembrane protein 242 -1.7449
NCAPD3 non-SMC condensin II complex, subunit D3 -1.74217
ING5 inhibitor of growth family, member 5 -1.74202
RIMKLB ribosomal modification protein rimK-like family member B -1.74049
CCNA2 cyclin A2 -1.73867
IPO9 importin 9 -1.73678
MYH11 myosin, heavy chain 11, smooth muscle -1.73642
UBAC1 UBA domain containing 1 -1.73598
BAG2 BCL2-associated athanogene 2 -1.73508
CRELD2 cysteine-rich with EGF-like domains 2 -1.73002
ZSCAN22 zinc finger and SCAN domain containing 22 -1.7292
PHF5A PHD finger protein 5A -1.72876
FMNL2 formin-like 2 -1.7286
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -1.72781
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -1.72497
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -1.72425
NME2 NME/NM23 nucleoside diphosphate kinase 2 -1.72315
MMRN1 multimerin 1 -1.71993
BUB3 BUB3 mitotic checkpoint protein -1.71988
C7ORF26 chromosome 7 open reading frame 26 -1.71972
TCF19 transcription factor 19 -1.71936
CIPC CLOCK-interacting pacemaker -1.71493
MXD3 MAX dimerization protein 3 -1.71363
LIG1 ligase I, DNA, ATP-dependent -1.70915
APOA1BP apolipoprotein A-I binding protein -1.70908
CRYZ crystallin, zeta (quinone reductase) -1.70863
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) -1.70857
NDC1 NDC1 transmembrane nucleoporin -1.70118
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -1.7
RACGAP1 Rac GTPase activating protein 1 -1.69922
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) -1.69804
RIPK3 receptor-interacting serine-threonine kinase 3 -1.69577
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -1.69512
HNRNPF heterogeneous nuclear ribonucleoprotein F -1.69454
JAGN1 jagunal homolog 1 (Drosophila) -1.69435
HAX1 HCLS1 associated protein X-1 -1.69387
ZNF319 zinc finger protein 319 -1.68988
IPO8 importin 8 -1.68849
CSK c-src tyrosine kinase -1.68736
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -1.68536
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -1.68193
METAP1 methionyl aminopeptidase 1 -1.67836
NSUN4 NOP2/Sun domain family, member 4 -1.67263
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -1.67223
DHRS4 dehydrogenase/reductase (SDR family) member 4 -1.6709
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -1.67045
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.66989
Funding