TGIF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description TGFB-induced factor homeobox 2|The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 60436)
Similar Terms
Downloads & Tools

Genes

348 genes differentially expressed following the TGIF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.10113
LOC105378220 macrophage receptor MARCO-like 3.10113
CCDC92 coiled-coil domain containing 92 3.10113
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.10113
FCRLB Fc receptor-like B 3.10113
TCF23 transcription factor 23 3.10113
RGPD1 RANBP2-like and GRIP domain containing 1 3.10113
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.10113
POTEI POTE ankyrin domain family, member I 3.10113
HLA-DOB major histocompatibility complex, class II, DO beta 3.10113
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.10113
PFN4 profilin family, member 4 3.10113
MBLAC1 metallo-beta-lactamase domain containing 1 3.10113
ISL1 ISL LIM homeobox 1 3.10113
COMP cartilage oligomeric matrix protein 3.10113
ANXA2R annexin A2 receptor 3.10113
CCDC194 coiled-coil domain containing 194 3.10113
GPR149 G protein-coupled receptor 149 3.10113
ARL5C ADP-ribosylation factor-like 5C 3.10113
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.10113
MRC1 mannose receptor, C type 1 3.10113
AMIGO1 adhesion molecule with Ig-like domain 1 3.10113
OSGIN1 oxidative stress induced growth inhibitor 1 3.0519
CELA3A chymotrypsin-like elastase family, member 3A 3.0519
MGAM2 maltase-glucoamylase 2 (putative) 3.0519
EPPIN epididymal peptidase inhibitor 3.0519
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.0519
NXPH4 neurexophilin 4 3.0519
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.0519
TBX22 T-box 22 3.0519
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.0519
CD274 CD274 molecule 3.0519
MYO7B myosin VIIB 3.0519
WDR87 WD repeat domain 87 3.0519
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.0519
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.0519
SPINK4 serine peptidase inhibitor, Kazal type 4 3.0519
GRXCR2 glutaredoxin, cysteine rich 2 3.0519
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.0519
CRH corticotropin releasing hormone 3.0519
OC90 otoconin 90 3.0519
OR1D2 olfactory receptor, family 1, subfamily D, member 2 3.0519
LOC124900192 uncharacterized LOC124900192 3.0519
BMP3 bone morphogenetic protein 3 3.0519
CLEC14A C-type lectin domain family 14, member A 3.0519
CPLX4 complexin 4 3.0519
C2ORF78 chromosome 2 open reading frame 78 3.0519
CRYAA crystallin, alpha A 3.0519
CELA1 chymotrypsin-like elastase family, member 1 3.0519
PAEP progestagen-associated endometrial protein 3.0519
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.0519
PCDHGB3 protocadherin gamma subfamily B, 3 3.0519
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.0519
FETUB fetuin B 3.0519
FOLR3 folate receptor 3 (gamma) 3.0519
MUSK muscle, skeletal, receptor tyrosine kinase 3.0519
MYOM2 myomesin 2 3.0519
TRIM73 tripartite motif containing 73 3.0519
C9ORF152 chromosome 9 open reading frame 152 3.0519
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.0519
SH2D6 SH2 domain containing 6 3.0519
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.0519
YIPF7 Yip1 domain family, member 7 3.0519
TYROBP TYRO protein tyrosine kinase binding protein 3.0519
CCER2 coiled-coil glutamate-rich protein 2 3.0519
AMY1A amylase, alpha 1A (salivary) 3.0519
FMOD fibromodulin 3.0519
ANO3 anoctamin 3 3.0519
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.0519
SRPK3 SRSF protein kinase 3 3.0519
MYEOV myeloma overexpressed 3.0519
MIOX myo-inositol oxygenase 3.0519
GBP4 guanylate binding protein 4 3.0519
MT4 metallothionein 4 3.0519
C1ORF232 chromosome 1 open reading frame 230 3.0519
CIMAP1B ciliary microtubule associated protein 1B 3.0519
SPAAR small regulatory polypeptide of amino acid response 3.0519
CIBAR2 CBY1 interacting BAR domain containing 2 3.0519
PLPP4 phospholipid phosphatase 4 3.0519
CRACDL CRACD like 3.0519
PLAAT2 phospholipase A and acyltransferase 2 3.0519
TMEM271 transmembrane protein 271 3.0519
FYB1 FYN binding protein 1 3.0519
VSIR V-set immunoregulatory receptor 3.0519
C10ORF53 chromosome 10 open reading frame 53 3.0519
TSPAN8 tetraspanin 8 3.0519
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.0519
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.0519
EID1 EP300 interacting inhibitor of differentiation 1 3.0519
BHLHA9 basic helix-loop-helix family, member a9 3.0519
HAPLN2 hyaluronan and proteoglycan link protein 2 3.0519
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.0519
SLC22A25 solute carrier family 22, member 25 3.0519
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.0519
PCDHB12 protocadherin beta 12 3.0519
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.0519
C1QL2 complement component 1, q subcomponent-like 2 3.0519
GLP2R glucagon-like peptide 2 receptor 3.0519
GATA4 GATA binding protein 4 3.0519
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.0519
PRG4 proteoglycan 4 3.0519
BEST3 bestrophin 3 3.0519
PLEK2 pleckstrin 2 3.0519
FGFBP1 fibroblast growth factor binding protein 1 3.0519
STARD6 StAR-related lipid transfer (START) domain containing 6 3.0519
VCX3A variable charge, X-linked 3A 3.0519
SAA4 serum amyloid A4, constitutive 3.0519
SBSN suprabasin 3.0519
GRXCR1 glutaredoxin, cysteine rich 1 3.0519
EVPL envoplakin 3.0519
TREH trehalase (brush-border membrane glycoprotein) 3.0519
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 3.0519
CCDC177 coiled-coil domain containing 177 3.0519
CCL24 chemokine (C-C motif) ligand 24 3.0519
UTS2R urotensin 2 receptor 3.0519
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.0519
NGB neuroglobin 3.0519
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.0519
HEMGN hemogen 3.0519
SHOX short stature homeobox 3.0519
MC5R melanocortin 5 receptor 3.0519
PLGLB2 plasminogen-like B2 3.0519
AKNAD1 AKNA domain containing 1 3.0519
SYNGR4 synaptogyrin 4 3.0519
NUTM2A NUT family member 2A 3.0519
CLIC3 chloride intracellular channel 3 3.0519
MRLN myoregulin 3.0519
ZCCHC12 zinc finger, CCHC domain containing 12 3.0519
NIPAL4 NIPA-like domain containing 4 3.0519
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.0519
TAS2R50 taste receptor, type 2, member 50 3.0519
RANBP3L RAN binding protein 3-like 3.0519
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 3.0519
DUOX2 dual oxidase 2 3.0519
PCDHGA4 protocadherin gamma subfamily A, 4 3.0519
PCDHGA7 protocadherin gamma subfamily A, 7 3.0519
CSTA cystatin A (stefin A) 3.0519
BAHCC1 BAH domain and coiled-coil containing 1 3.0519
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 3.0519
TEKT2 tektin 2 (testicular) 3.0519
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 3.0519
DHH desert hedgehog 3.0519
TMEM31 transmembrane protein 31 3.0519
KIAA1755 KIAA1755 3.0519
C19ORF18 chromosome 19 open reading frame 18 3.0519
GPR150 G protein-coupled receptor 150 3.0519
TMEM156 transmembrane protein 156 3.0519
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.0519
PADI6 peptidyl arginine deiminase, type VI 3.0519
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.0519
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.0519
ANGPTL6 angiopoietin-like 6 3.0519
TMEM215 transmembrane protein 215 3.0519
ZNF648 zinc finger protein 648 3.0519
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.0519
NLRP3 NLR family, pyrin domain containing 3 3.0519
ASCL3 achaete-scute family bHLH transcription factor 3 3.0519
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.0519
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.0519
NCR3 natural cytotoxicity triggering receptor 3 3.0519
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 3.0519
CLPSL1 colipase-like 1 3.0519
CFAP126 cilia and flagella associated protein 126 3.0519
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.0519
RBBP8NL RBBP8 N-terminal like 3.0519
CLEC1A C-type lectin domain family 1, member A 3.0519
KIAA1958 KIAA1958 3.03218
LSMEM1 leucine-rich single-pass membrane protein 1 3.00978
PRSS50 protease, serine, 50 2.95133
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.95133
NUTM2G NUT family member 2G 2.93382
TOP1 topoisomerase (DNA) I 2.88857
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.88857
LMAN2L lectin, mannose-binding 2-like 2.84973
ADPRHL1 ADP-ribosylhydrolase like 1 2.83977
RNF2 ring finger protein 2 2.78729
SRSF1 serine/arginine-rich splicing factor 1 2.77182
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.74704
CDYL chromodomain protein, Y-like 2.68946
BEX5 brain expressed, X-linked 5 2.60535
BRAP BRCA1 associated protein 2.59711
SNX5 sorting nexin 5 2.57447
CLCNKA chloride channel, voltage-sensitive Ka 2.48885
RHBDD1 rhomboid domain containing 1 2.47151
ZNF841 zinc finger protein 841 2.47118
FBXO17 F-box protein 17 2.41676
ZNF714 zinc finger protein 714 2.3875
DES desmin 2.35218
STAU1 staufen double-stranded RNA binding protein 1 2.34941
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.34734
SYTL4 synaptotagmin-like 4 2.32399
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.32399
EBLN2 endogenous Bornavirus-like nucleoprotein 2 2.32399
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.32399
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.32399
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 2.3115
RAB40B RAB40B, member RAS oncogene family 2.30813
ZNF736 zinc finger protein 736 2.28164
HMCN1 hemicentin 1 2.27248
RBM27 RNA binding motif protein 27 2.23192
PDF peptide deformylase (mitochondrial) 2.21206
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 2.19622
ZNF813 zinc finger protein 813 2.18895
PDLIM2 PDZ and LIM domain 2 (mystique) 2.17665
ETFDH electron-transferring-flavoprotein dehydrogenase 2.17092
PHRF1 PHD and ring finger domains 1 2.16854
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.14792
MGME1 mitochondrial genome maintenance exonuclease 1 2.13043
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.12318
SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.11953
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 2.11845
FAM32A family with sequence similarity 32, member A 2.11405
MGST1 microsomal glutathione S-transferase 1 2.11405
MCMDC2 minichromosome maintenance domain containing 2 2.11051
UBE3C ubiquitin protein ligase E3C 2.10524
ZNF138 zinc finger protein 138 2.0909
EIF4H eukaryotic translation initiation factor 4H 2.0854
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.06575
SYNJ1 synaptojanin 1 2.06009
RABGAP1 RAB GTPase activating protein 1 2.05615
FBXW2 F-box and WD repeat domain containing 2 2.04553
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2.0445
TARDBP TAR DNA binding protein 2.04216
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2.03918
ABHD3 abhydrolase domain containing 3 2.0255
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 2.0255
LZTS2 leucine zipper, putative tumor suppressor 2 2.01394
XRRA1 X-ray radiation resistance associated 1 2.00508
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 2.00328
LEF1 lymphoid enhancer-binding factor 1 2.00293
SGSH N-sulfoglucosamine sulfohydrolase 2.00293
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.00293
CNGB3 cyclic nucleotide gated channel beta 3 2.00293
HLA-G major histocompatibility complex, class I, G 2.00293

decreased expression

Symbol Name Standardized Value
ZNF324B zinc finger protein 324B -3.10113
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -3.10113
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -3.10113
LHX1 LIM homeobox 1 -3.10113
DRC3 dynein regulatory complex subunit 3 -3.10113
TNC tenascin C -3.10113
CHGB chromogranin B -3.10113
PTCH2 patched 2 -3.09665
ASB12 ankyrin repeat and SOCS box containing 12 -3.0519
LBP lipopolysaccharide binding protein -3.0519
HAS1 hyaluronan synthase 1 -3.0519
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -3.0519
AVP arginine vasopressin -3.0519
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -3.0519
TWIST1 twist family bHLH transcription factor 1 -3.0519
CDC14A cell division cycle 14A -3.0519
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -3.0519
WNT3A wingless-type MMTV integration site family, member 3A -3.0519
DNAAF19 dynein axonemal assembly factor 19 -3.0519
MAP3K4-AS1 MAP3K4 antisense RNA 1 -3.0519
CFAP299 cilia and flagella associated protein 299 -3.0519
CAPN9 calpain 9 -3.0519
ALX4 ALX homeobox 4 -3.0519
LTB lymphotoxin beta (TNF superfamily, member 3) -3.0519
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -3.0519
ULBP3 UL16 binding protein 3 -3.0519
CBLN3 cerebellin 3 precursor -3.0519
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -3.0519
COL19A1 collagen, type XIX, alpha 1 -3.0519
HLF hepatic leukemia factor -3.0519
SCG2 secretogranin II -3.0519
RERGL RERG/RAS-like -3.0519
OAZ1 ornithine decarboxylase antizyme 1 -3.0519
PCDH20 protocadherin 20 -3.0519
TEX11 testis expressed 11 -3.0519
S100A14 S100 calcium binding protein A14 -3.0519
ADCY4 adenylate cyclase 4 -3.0519
KLK5 kallikrein-related peptidase 5 -3.0519
TTC16 tetratricopeptide repeat domain 16 -3.0519
MZB1 marginal zone B and B1 cell-specific protein -3.0519
MAPK11 mitogen-activated protein kinase 11 -3.0519
FLRT3 fibronectin leucine rich transmembrane protein 3 -3.0519
OPRK1 opioid receptor, kappa 1 -3.0519
QRICH2 glutamine rich 2 -2.98294
SPRED1 sprouty-related, EVH1 domain containing 1 -2.95735
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -2.88857
PSEN2 presenilin 2 -2.78538
LPIN3 lipin 3 -2.7668
H3C6 H3 clustered histone 6 -2.76405
LOC102723564 uncharacterized LOC102723564 -2.66819
TGFBR3 transforming growth factor, beta receptor III -2.663
INA internexin neuronal intermediate filament protein, alpha -2.5464
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.51709
EXT1 exostosin glycosyltransferase 1 -2.48697
ASS1 argininosuccinate synthase 1 -2.45424
ATAD3B ATPase family, AAA domain containing 3B -2.45424
TCF12 transcription factor 12 -2.43309
BET1 Bet1 golgi vesicular membrane trafficking protein -2.4237
EVA1C eva-1 homolog C (C. elegans) -2.41285
EMC8 ER membrane protein complex subunit 8 -2.40771
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.38374
ZRANB1 zinc finger, RAN-binding domain containing 1 -2.36839
KLHL9 kelch-like family member 9 -2.36707
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.35218
FA2H fatty acid 2-hydroxylase -2.35218
EIF1B eukaryotic translation initiation factor 1B -2.3512
UFL1 UFM1-specific ligase 1 -2.34574
RFK riboflavin kinase -2.3412
LRRC8D leucine rich repeat containing 8 family, member D -2.32915
LGALS7B lectin, galactoside-binding, soluble, 7B -2.32399
RSPO4 R-spondin 4 -2.32399
UTP4 UTP4 small subunit processome component -2.32399
TGIF2 TGFB-induced factor homeobox 2 -2.31819
STAG3 stromal antigen 3 -2.3115
SORBS1 sorbin and SH3 domain containing 1 -2.27767
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -2.27248
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.27248
EIF3M eukaryotic translation initiation factor 3, subunit M -2.25271
TBC1D22B TBC1 domain family, member 22B -2.25271
COL6A3 collagen, type VI, alpha 3 -2.25162
ADAM9 ADAM metallopeptidase domain 9 -2.2513
LIF leukemia inhibitory factor -2.23192
TMEM242 transmembrane protein 242 -2.21418
ATF1 activating transcription factor 1 -2.20627
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.19249
ZBTB26 zinc finger and BTB domain containing 26 -2.19249
INO80 INO80 complex subunit -2.19112
IL34 interleukin 34 -2.1865
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.17533
TSLP thymic stromal lymphopoietin -2.16643
PLXNB2 plexin B2 -2.16506
P3H2 prolyl 3-hydroxylase 2 -2.16443
TTC26 tetratricopeptide repeat domain 26 -2.14792
ENOX2 ecto-NOX disulfide-thiol exchanger 2 -2.14186
RBM7 RNA binding motif protein 7 -2.12099
TMEM221 transmembrane protein 221 -2.11408
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.11405
SCN4B sodium channel, voltage gated, type IV beta subunit -2.11051
C11ORF71 chromosome 11 open reading frame 71 -2.10868
TRIM9 tripartite motif containing 9 -2.10838
EID2B EP300 interacting inhibitor of differentiation 2B -2.0991
ZNF652 zinc finger protein 652 -2.09106
ARHGAP33 Rho GTPase activating protein 33 -2.0854
SH2D3A SH2 domain containing 3A -2.08203
PLCL1 phospholipase C-like 1 -2.05989
RPS21-DT RPS21 divergent transcript -2.05989
TLE6 transducin-like enhancer of split 6 -2.05989
EFNA2 ephrin-A2 -2.05615
ZNF202 zinc finger protein 202 -2.05615
H2AC14 H2A clustered histone 14 -2.04801
LIN37 lin-37 DREAM MuvB core complex component -2.04597
ADGRB2 adhesion G protein-coupled receptor B2 -2.00539
GSS glutathione synthetase -2.00301
TYW5 tRNA-yW synthesizing protein 5 -2.00031