| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9907093 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in TGX-221 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRD5A3 | steroid 5 alpha-reductase 3 | 2.69 |
| C7 | complement component 7 | 0.8 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.78 |
| MT2A | metallothionein 2A | 0.72 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.67 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | 0.67 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.66 |
| DUOX1 | dual oxidase 1 | 0.52 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.51 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.51 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.5 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | 0.5 |
| PIP | prolactin-induced protein | 0.5 |
| NCOR1 | nuclear receptor corepressor 1 | 0.49 |
| RIBC2 | RIB43A domain with coiled-coils 2 | 0.49 |
| TNS2 | tensin 2 | 0.46 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.46 |
| TMC6 | transmembrane channel-like 6 | 0.44 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.44 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.43 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.43 |
| DUSP4 | dual specificity phosphatase 4 | 0.42 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.42 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.42 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.42 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | 0.41 |
| LRRK1 | leucine-rich repeat kinase 1 | 0.41 |
| MT1E | metallothionein 1E | 0.4 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.4 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.4 |
| FAM122B | family with sequence similarity 122B | 0.39 |
| ODC1 | ornithine decarboxylase 1 | 0.38 |
| SQSTM1 | sequestosome 1 | 0.38 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.37 |
| ELK1 | ELK1, member of ETS oncogene family | 0.37 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.37 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.36 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.36 |
| MZT2B | mitotic spindle organizing protein 2B | 0.36 |
| DYSF | dysferlin | 0.35 |
| FAM161A | family with sequence similarity 161, member A | 0.35 |
| METTL6 | methyltransferase like 6 | 0.34 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 0.34 |
| SERINC5 | serine incorporator 5 | 0.34 |
| NOP10 | NOP10 ribonucleoprotein | 0.34 |
| EGR1 | early growth response 1 | 0.33 |
| CNTNAP3 | contactin associated protein-like 3 | 0.33 |
| FAS | Fas cell surface death receptor | 0.33 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.33 |
| SVIP | small VCP/p97-interacting protein | 0.33 |
| FOSL1 | FOS-like antigen 1 | 0.32 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.32 |
| TSPAN5 | tetraspanin 5 | 0.32 |
| STX1A | syntaxin 1A (brain) | 0.32 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.32 |
| ACY1 | aminoacylase 1 | 0.31 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | 0.31 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.31 |
| MUTYH | mutY homolog | 0.31 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.31 |
| MCL1 | myeloid cell leukemia 1 | 0.31 |
| ZADH2 | zinc binding alcohol dehydrogenase domain containing 2 | 0.31 |
| DHFR | dihydrofolate reductase | 0.31 |
| GLI2 | GLI family zinc finger 2 | 0.3 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.3 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.3 |
| ARMC7 | armadillo repeat containing 7 | 0.3 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.3 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.3 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.3 |
| AFG1L | AFG1 like ATPase | 0.3 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.29 |
| OTUD5 | OTU deubiquitinase 5 | 0.29 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.29 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.29 |
| C14ORF93 | chromosome 14 open reading frame 93 | 0.29 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | 0.29 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.29 |
| IRS2 | insulin receptor substrate 2 | 0.29 |
| KIFC3 | kinesin family member C3 | 0.29 |
| ZNF445 | zinc finger protein 445 | 0.29 |
| OBSL1 | obscurin-like 1 | 0.29 |
| PDZD11 | PDZ domain containing 11 | 0.28 |
| WRB | tryptophan rich basic protein | 0.28 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 0.28 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.28 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.28 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.28 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | 0.28 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.28 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.28 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.28 |
| EAPP | E2F-associated phosphoprotein | 0.28 |
| COQ4 | coenzyme Q4 | 0.28 |
| MYT1 | myelin transcription factor 1 | 0.28 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.27 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.27 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.27 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.27 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANGPTL4 | angiopoietin-like 4 | -1.27 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.86 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.76 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.74 |
| DAP | death-associated protein | -0.72 |
| MEX3C | mex-3 RNA binding family member C | -0.62 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -0.62 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.58 |
| PRSS8 | protease, serine, 8 | -0.58 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -0.57 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.56 |
| CCDC158 | coiled-coil domain containing 158 | -0.56 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.55 |
| SGMS2 | sphingomyelin synthase 2 | -0.52 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.51 |
| ECE1 | endothelin converting enzyme 1 | -0.48 |
| MYO7B | myosin VIIB | -0.47 |
| SPOPL | speckle-type POZ protein-like | -0.47 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.47 |
| IL10RB | interleukin 10 receptor, beta | -0.46 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.46 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -0.45 |
| SLC41A3 | solute carrier family 41, member 3 | -0.43 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.43 |
| CETN1 | centrin, EF-hand protein, 1 | -0.42 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.42 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | -0.42 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.41 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.41 |
| ZIC2 | Zic family member 2 | -0.41 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.41 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.41 |
| VSIR | V-set immunoregulatory receptor | -0.4 |
| SARS | seryl-tRNA synthetase | -0.39 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.39 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.39 |
| ANKRD22 | ankyrin repeat domain 22 | -0.39 |
| RAET1G | retinoic acid early transcript 1G | -0.39 |
| MLXIPL | MLX interacting protein-like | -0.38 |
| CDK10 | cyclin-dependent kinase 10 | -0.38 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.38 |
| E2F3 | E2F transcription factor 3 | -0.37 |
| TREX1 | three prime repair exonuclease 1 | -0.37 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.37 |
| RAB24 | RAB24, member RAS oncogene family | -0.37 |
| ZNF286B | zinc finger protein 286B | -0.37 |
| PPP1R2B | PPP1R2 family member B | -0.36 |
| LIX1L | Lix1 homolog (chicken) like | -0.36 |
| FAM241B | family with sequence similarity 241 member B | -0.36 |
| JOSD1 | Josephin domain containing 1 | -0.36 |
| SYN1 | synapsin I | -0.35 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.35 |
| TPPP | tubulin polymerization promoting protein | -0.35 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.35 |
| AGFG2 | ArfGAP with FG repeats 2 | -0.35 |
| RNF181 | ring finger protein 181 | -0.34 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.34 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | -0.34 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.34 |
| ZFAND2A | zinc finger, AN1-type domain 2A | -0.34 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.32 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.32 |
| RTN4RL2 | reticulon 4 receptor-like 2 | -0.31 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.31 |
| TMSB10 | thymosin beta 10 | -0.31 |
| SESN1 | sestrin 1 | -0.31 |
| CADPS | Ca++-dependent secretion activator | -0.31 |
| FKTN | fukutin | -0.3 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.3 |
| PRIMPOL | primase and polymerase (DNA-directed) | -0.3 |
| NOP16 | NOP16 nucleolar protein | -0.3 |
| UBTD1 | ubiquitin domain containing 1 | -0.3 |
| TRIM14 | tripartite motif containing 14 | -0.3 |
| SESN2 | sestrin 2 | -0.3 |
| FAM126B | family with sequence similarity 126, member B | -0.3 |
| C1ORF226 | chromosome 1 open reading frame 226 | -0.29 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.29 |
| HK3 | hexokinase 3 (white cell) | -0.29 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.29 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.29 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.29 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.29 |
| SGCE | sarcoglycan, epsilon | -0.29 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.28 |
| DOP1A | DOP1 leucine zipper like protein A | -0.28 |
| ASB6 | ankyrin repeat and SOCS box containing 6 | -0.28 |
| SP100 | SP100 nuclear antigen | -0.28 |
| HOXB9 | homeobox B9 | -0.28 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.28 |
| METTL8 | methyltransferase like 8 | -0.28 |
| HPCAL4 | hippocalcin like 4 | -0.28 |
| PACC1 | proton activated chloride channel 1 | -0.28 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -0.28 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.27 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.27 |
| METAP2 | methionyl aminopeptidase 2 | -0.27 |
| COX18 | COX18 cytochrome c oxidase assembly factor | -0.27 |
| SUSD2 | sushi domain containing 2 | -0.27 |
