THP1 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
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Genes

705 gene knockdowns changing fitness of THP1 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
CLIC2 chloride intracellular channel 2 3.19303
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.19303
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 3.18884
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 3.18147
ATG4B autophagy related 4B, cysteine peptidase 3.15598
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 3.13505
MMP23B matrix metallopeptidase 23B 3.12556
WSB2 WD repeat and SOCS box containing 2 3.12129
SBK1 SH3 domain binding kinase 1 2.97538
ATG4C autophagy related 4C, cysteine peptidase 2.68997
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.61784
INPP5K inositol polyphosphate-5-phosphatase K 2.61233
ATN1 atrophin 1 2.59993
SERHL serine hydrolase-like (pseudogene) 2.57401
C11ORF24 chromosome 11 open reading frame 24 2.56799
NKX2-5 NK2 homeobox 5 2.55371
CSF3 colony stimulating factor 3 (granulocyte) 2.54774
NONO non-POU domain containing, octamer-binding 2.54653
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.52779
TTC23 tetratricopeptide repeat domain 23 2.52376
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.47786
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.453
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.43534
TXN thioredoxin 2.43237
TLR5 toll-like receptor 5 2.41574
ERCC1 excision repair cross-complementation group 1 2.3953
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.3923
IFI30 interferon, gamma-inducible protein 30 2.38498
SPRED2 sprouty-related, EVH1 domain containing 2 2.38115
ZNF747 zinc finger protein 747 2.35799
SYT3 synaptotagmin III 2.3233
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.31477
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.28306
PCDHGB1 protocadherin gamma subfamily B, 1 2.27425
PLIN3 perilipin 3 2.27385
BLOC1S1-RDH5 BLOC1S1-RDH5 readthrough 2.25892
LONP1 lon peptidase 1, mitochondrial 2.24705
NME7 NME/NM23 family member 7 2.22297
CCNT1 cyclin T1 2.22057
PCDHGC3 protocadherin gamma subfamily C, 3 2.20718
ACHE acetylcholinesterase (Yt blood group) 2.18638
OR2T12 olfactory receptor, family 2, subfamily T, member 12 2.177
TASP1 taspase, threonine aspartase, 1 2.13661
IFI16 interferon, gamma-inducible protein 16 2.12786
EMD emerin 2.11479
CCL19 chemokine (C-C motif) ligand 19 2.10774
ZFP62 ZFP62 zinc finger protein 2.10697
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.10322
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.10241
TULP4 tubby like protein 4 2.08551
IQGAP2 IQ motif containing GTPase activating protein 2 2.07543
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 2.07484
SERHL2 serine hydrolase-like 2 2.07299
EMP2 epithelial membrane protein 2 2.07001
USF2 upstream transcription factor 2, c-fos interacting 2.02525
MRPL12 mitochondrial ribosomal protein L12 2.01757
CD47 CD47 molecule 2.01704
SLC39A5 solute carrier family 39 (zinc transporter), member 5 1.95674
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 1.94785
RORA RAR-related orphan receptor A 1.9366
ZNF324 zinc finger protein 324 1.93059
BCL9L B-cell CLL/lymphoma 9-like 1.92949
MMP23A matrix metallopeptidase 23A (pseudogene) 1.91962
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.91623
HSD3BP4 hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4 1.89615
KCNK4 potassium channel, two pore domain subfamily K, member 4 1.89276
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 1.88554
IGFBP6 insulin-like growth factor binding protein 6 1.87835
COX7B2 cytochrome c oxidase subunit VIIb2 1.87179
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.8648
OR52W1 olfactory receptor, family 52, subfamily W, member 1 1.85541
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.84663
PIGR polymeric immunoglobulin receptor 1.84285
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.83864
TWIST1 twist family bHLH transcription factor 1 1.8055
ZNF8 zinc finger protein 8 1.80436
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 1.80143
EGR1 early growth response 1 1.79623
CRYAA crystallin, alpha A 1.79449
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 1.79101
ZNF688 zinc finger protein 688 1.78705
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 1.78092
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.75282
AAK1 AP2 associated kinase 1 1.74854
ADRB2 adrenoceptor beta 2, surface 1.74636
CD79A CD79a molecule, immunoglobulin-associated alpha 1.73393
SYNJ2 synaptojanin 2 1.72854
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 1.72836
LIPE lipase, hormone-sensitive 1.72808
CLEC3B C-type lectin domain family 3, member B 1.71047
ZNF461 zinc finger protein 461 1.69814
ING2 inhibitor of growth family, member 2 1.69115
LSR lipolysis stimulated lipoprotein receptor 1.68938
ZNF655 zinc finger protein 655 1.68444
PRKCZ protein kinase C, zeta 1.67619
CABP4 calcium binding protein 4 1.66144
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 1.64361
ZNF665 zinc finger protein 665 1.63965
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.63757
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 1.63751
PDIA6 protein disulfide isomerase family A, member 6 1.628
RPP25 ribonuclease P/MRP 25kDa subunit 1.6206
GCKR glucokinase (hexokinase 4) regulator 1.62013
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.61928
SMAD5 SMAD family member 5 1.61839
ZNF563 zinc finger protein 563 1.61805
ZNFX1 zinc finger, NFX1-type containing 1 1.61389
ZNF57 zinc finger protein 57 1.60453
ZNF41 zinc finger protein 41 1.60427
HAUS1 HAUS augmin-like complex, subunit 1 1.59876
BTNL3 butyrophilin-like 3 1.5984
PRSS48 protease, serine, 48 1.59837
ZNF626 zinc finger protein 626 1.59525
GPR142 G protein-coupled receptor 142 1.59052
FCGBP Fc fragment of IgG binding protein 1.59005
UMODL1 uromodulin-like 1 1.58757
PDE1A phosphodiesterase 1A, calmodulin-dependent 1.58376
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.58177
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 1.57954
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.57405
KLK4 kallikrein-related peptidase 4 1.56754
TUFT1 tuftelin 1 1.56628
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.56586
CHD2 chromodomain helicase DNA binding protein 2 1.5602
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.55838
FANCD2 Fanconi anemia, complementation group D2 1.5447
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 1.54038
NRD1 nardilysin (N-arginine dibasic convertase) 1.53722
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 1.53525
KRT79 keratin 79, type II 1.53432
EPHB1 EPH receptor B1 1.52608
ELF1 E74-like factor 1 (ets domain transcription factor) 1.51585
JMJD6 jumonji domain containing 6 1.51448
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 1.51251
SLAMF7 SLAM family member 7 1.51193
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 1.51155
MCM4 minichromosome maintenance complex component 4 1.50558
E2F3 E2F transcription factor 3 1.50388
GABPB1 GA binding protein transcription factor, beta subunit 1 1.49975
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 1.49666
SCO2 SCO2 cytochrome c oxidase assembly protein 1.49571
DCLRE1C DNA cross-link repair 1C 1.49261
TAS2R42 taste receptor, type 2, member 42 1.49118
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.49006
ARL13B ADP-ribosylation factor-like 13B 1.48383
NECAB2 N-terminal EF-hand calcium binding protein 2 1.47788
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1.47604
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 1.47374
UNKL unkempt family zinc finger-like 1.47136
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.46452
NELL1 NEL-like 1 (chicken) 1.46381
TCF7 transcription factor 7 (T-cell specific, HMG-box) 1.45879
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 1.45513
AEBP1 AE binding protein 1 1.45306
GSK3B glycogen synthase kinase 3 beta 1.45202
ETNK1 ethanolamine kinase 1 1.448
KIF13B kinesin family member 13B 1.44776
CSAD cysteine sulfinic acid decarboxylase 1.44583
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1.43826
IFNA21 interferon, alpha 21 1.43191
R3HDM2 R3H domain containing 2 1.42911
FXN frataxin 1.4276
TMEM241 transmembrane protein 241 1.4252
PPME1 protein phosphatase methylesterase 1 1.41676
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 1.41593
NME1-NME2 NME1-NME2 readthrough 1.4155
BRCA1 breast cancer 1, early onset 1.41318
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1.41233
GFPT1 glutamine--fructose-6-phosphate transaminase 1 1.40587
LRP12 low density lipoprotein receptor-related protein 12 1.4051
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 1.40495
ANAPC16 anaphase promoting complex subunit 16 1.40372
KRTAP10-5 keratin associated protein 10-5 1.39815
IFT27 intraflagellar transport 27 1.39694
FZD8 frizzled class receptor 8 1.39418
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.39298
FOSL2 FOS-like antigen 2 1.3758
CALML4 calmodulin-like 4 1.3711
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 1.36836
BOK BCL2-related ovarian killer 1.36586
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 1.36202
TP73 tumor protein p73 1.35871
CNGA3 cyclic nucleotide gated channel alpha 3 1.35867
SLC16A12 solute carrier family 16, member 12 1.35832
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 1.35726
AKR1E2 aldo-keto reductase family 1, member E2 1.35677
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 1.35659
WDR54 WD repeat domain 54 1.35654
USP17L5 ubiquitin specific peptidase 17-like family member 5 1.35342
IL27RA interleukin 27 receptor, alpha 1.35229
ELP3 elongator acetyltransferase complex subunit 3 1.34693
DMBT1 deleted in malignant brain tumors 1 1.34491
HPCAL1 hippocalcin-like 1 1.34457
GPX6 glutathione peroxidase 6 1.3416
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.33679
SOX5 SRY (sex determining region Y)-box 5 1.33393
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.32809
GRB2 growth factor receptor-bound protein 2 1.32524
NF1 neurofibromin 1 1.32259
MAP2 microtubule-associated protein 2 1.31979
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1.31344
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 1.31286
ZNF546 zinc finger protein 546 1.30984
BAG1 BCL2-associated athanogene 1.30858
BATF2 basic leucine zipper transcription factor, ATF-like 2 1.30654
LAMA3 laminin, alpha 3 1.30019
CHST10 carbohydrate sulfotransferase 10 1.29837
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.29807
PRDM5 PR domain containing 5 1.2969
LOXL4 lysyl oxidase-like 4 1.29625
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.29501
ABHD11 abhydrolase domain containing 11 1.29442
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough 1.29102
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 1.28744
ERF Ets2 repressor factor 1.28571
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 1.27523
BST1 bone marrow stromal cell antigen 1 1.27398
PPID peptidylprolyl isomerase D 1.27306
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 1.27237
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 1.26334
ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough 1.25867
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.25465
PTAFR platelet-activating factor receptor 1.24698
TRPV3 transient receptor potential cation channel, subfamily V, member 3 1.2442
AMDHD1 amidohydrolase domain containing 1 1.24031
AANAT aralkylamine N-acetyltransferase 1.23964
SOX7 SRY (sex determining region Y)-box 7 1.23868
TRIM7 tripartite motif containing 7 1.23652
HMOX2 heme oxygenase 2 1.23469
FPGS folylpolyglutamate synthase 1.23197
ADGRE1 adhesion G protein-coupled receptor E1 1.22954
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 1.22559
CBX7 chromobox homolog 7 1.22485
AGTRAP angiotensin II receptor-associated protein 1.21971
FASN fatty acid synthase 1.21652
POLN polymerase (DNA directed) nu 1.21298
RBBP6 retinoblastoma binding protein 6 1.20721
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.20628
ZNF84 zinc finger protein 84 1.20615
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 1.20564
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 1.19067
WNT7B wingless-type MMTV integration site family, member 7B 1.18682
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.18643
METAP1 methionyl aminopeptidase 1 1.18155
ZNF407 zinc finger protein 407 1.18098
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 1.17988
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.17974
IFT57 intraflagellar transport 57 1.17761
DRP2 dystrophin related protein 2 1.17484
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 1.17155
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.17121
TRAF4 TNF receptor-associated factor 4 1.16578
PLS3 plastin 3 1.16391
MBD2 methyl-CpG binding domain protein 2 1.1635
HAS1 hyaluronan synthase 1 1.15929
ZNF620 zinc finger protein 620 1.15889
GRM6 glutamate receptor, metabotropic 6 1.15681
CRX cone-rod homeobox 1.15563
AP3D1 adaptor-related protein complex 3, delta 1 subunit 1.15549
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.15268
CHDH choline dehydrogenase 1.15105
KIF1C kinesin family member 1C 1.14893
BCL2L10 BCL2-like 10 (apoptosis facilitator) 1.14632
PDCL3 phosducin-like 3 1.14129
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 1.13695
PPARD peroxisome proliferator-activated receptor delta 1.13443
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 1.12987
NAE1 NEDD8 activating enzyme E1 subunit 1 1.12786
TRIP13 thyroid hormone receptor interactor 13 1.12742
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 1.12676
TRPC7 transient receptor potential cation channel, subfamily C, member 7 1.12482
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 1.12399
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 1.12387
PPA1 pyrophosphatase (inorganic) 1 1.12141
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.12118
FBXL5 F-box and leucine-rich repeat protein 5 1.12073
PHAX phosphorylated adaptor for RNA export 1.11954
CLASRP CLK4-associating serine/arginine rich protein 1.11856
PCLO piccolo presynaptic cytomatrix protein 1.11806
ACAT2 acetyl-CoA acetyltransferase 2 1.11409
ERCC8 excision repair cross-complementation group 8 1.11245
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 1.11138
CCND2 cyclin D2 1.11063
IFNA4 interferon, alpha 4 1.1096
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.1089
LBR lamin B receptor 1.10782
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 1.1076
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 1.10513
CHERP calcium homeostasis endoplasmic reticulum protein 1.10301
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 1.09961
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.09486
ABLIM3 actin binding LIM protein family, member 3 1.09466
SORBS1 sorbin and SH3 domain containing 1 1.09396
OR12D3 olfactory receptor, family 12, subfamily D, member 3 1.0911
AKAP3 A kinase (PRKA) anchor protein 3 1.09053
EDF1 endothelial differentiation-related factor 1 1.08986
CASP8AP2 caspase 8 associated protein 2 1.08916
PREPL prolyl endopeptidase-like 1.08688
FDX1 ferredoxin 1 1.08344
SSX1 synovial sarcoma, X breakpoint 1 1.08259
ITGB4 integrin, beta 4 1.08135
MMP21 matrix metallopeptidase 21 1.0813
ULK2 unc-51 like autophagy activating kinase 2 1.08097
HIST1H2AE histone cluster 1, H2ae 1.0799
UBAP2 ubiquitin associated protein 2 1.0785
ZNF25 zinc finger protein 25 1.07814
APOC3 apolipoprotein C-III 1.07633
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.07304
PDE7A phosphodiesterase 7A 1.07103
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 1.06995
LOC286297 uncharacterized LOC286297 1.0696
POC1A POC1 centriolar protein A 1.06813
GCLM glutamate-cysteine ligase, modifier subunit 1.06509
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.06495
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.06325
NKIRAS2 NFKB inhibitor interacting Ras-like 2 1.05822
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 1.05573
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 1.05474
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 1.05434
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 1.05367
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 1.05151
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 1.04968
S1PR5 sphingosine-1-phosphate receptor 5 1.0476
FGFR1 fibroblast growth factor receptor 1 1.047
RASL11B RAS-like, family 11, member B 1.04683
RPS6KL1 ribosomal protein S6 kinase-like 1 1.04609
USP17L1 ubiquitin specific peptidase 17-like family member 1 1.046
CBX6 chromobox homolog 6 1.04542
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.04482
IFNA2 interferon, alpha 2 1.04229
MAPRE2 microtubule-associated protein, RP/EB family, member 2 1.0419
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.04187
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 1.04104
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 1.04082
GSK3A glycogen synthase kinase 3 alpha 1.03647
ELP4 elongator acetyltransferase complex subunit 4 1.03618
PDLIM5 PDZ and LIM domain 5 1.03609
GCH1 GTP cyclohydrolase 1 1.0341
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.03036
PPP4R1L protein phosphatase 4, regulatory subunit 1-like (pseudogene) 1.02987
SPRYD7 SPRY domain containing 7 1.02606
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.02399
GPX3 glutathione peroxidase 3 1.02358
ACBD3 acyl-CoA binding domain containing 3 1.02015
HARS histidyl-tRNA synthetase 1.01954
USP30 ubiquitin specific peptidase 30 1.01804
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.017
CD151 CD151 molecule (Raph blood group) 1.01583
ADCK5 aarF domain containing kinase 5 1.01512
MIB1 mindbomb E3 ubiquitin protein ligase 1 1.01409
TRAFD1 TRAF-type zinc finger domain containing 1 1.01344
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 1.01303
TTLL4 tubulin tyrosine ligase-like family member 4 1.01202
IGF2R insulin-like growth factor 2 receptor 1.01017
ANOS1 anosmin 1 1.00932
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.00919
ITGA7 integrin, alpha 7 1.00897
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 1.00544
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.00275
ETFDH electron-transferring-flavoprotein dehydrogenase 1.00058

decreased fitness

Symbol Name Standardized Value
TP53RK TP53 regulating kinase -3.53599
SARDH sarcosine dehydrogenase -3.45146
MLKL mixed lineage kinase domain-like -3.3329
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -3.32647
LAMP1 lysosomal-associated membrane protein 1 -3.21233
MYBPH myosin binding protein H -3.12619
ZNF213 zinc finger protein 213 -3.0952
MAP2K6 mitogen-activated protein kinase kinase 6 -2.89626
PNLIPRP1 pancreatic lipase-related protein 1 -2.82477
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -2.70242
ZBTB40 zinc finger and BTB domain containing 40 -2.57913
MAPK14 mitogen-activated protein kinase 14 -2.52623
GTF2IRD1 GTF2I repeat domain containing 1 -2.52384
TRIM24 tripartite motif containing 24 -2.50875
MOCS2 molybdenum cofactor synthesis 2 -2.4741
DHH desert hedgehog -2.45541
STK19 serine/threonine kinase 19 -2.43606
ANKRD29 ankyrin repeat domain 29 -2.42246
NME5 NME/NM23 family member 5 -2.39232
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -2.39151
ACRBP acrosin binding protein -2.38877
MAPK4 mitogen-activated protein kinase 4 -2.38468
A2ML1 alpha-2-macroglobulin-like 1 -2.36235
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.35343
KIF5A kinesin family member 5A -2.31701
RASA2 RAS p21 protein activator 2 -2.29874
HBE1 hemoglobin, epsilon 1 -2.26746
LPA lipoprotein, Lp(a) -2.25322
GPR78 G protein-coupled receptor 78 -2.24424
CLNK cytokine-dependent hematopoietic cell linker -2.23395
TRIM45 tripartite motif containing 45 -2.21579
IRF8 interferon regulatory factor 8 -2.1829
METTL14 methyltransferase like 14 -2.18017
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.16876
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) -2.15192
EPS15 epidermal growth factor receptor pathway substrate 15 -2.12886
ACTC1 actin, alpha, cardiac muscle 1 -2.11053
CDK6 cyclin-dependent kinase 6 -2.08969
NLK nemo-like kinase -2.0806
RNF144A ring finger protein 144A -2.07226
MAPKBP1 mitogen-activated protein kinase binding protein 1 -2.0643
RNF145 ring finger protein 145 -2.06405
EAF2 ELL associated factor 2 -2.06109
ZCCHC13 zinc finger, CCHC domain containing 13 -2.06025
CBX2 chromobox homolog 2 -2.05467
ZNF43 zinc finger protein 43 -2.03924
PLSCR1 phospholipid scramblase 1 -2.03888
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.0345
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.03127
ADPRHL1 ADP-ribosylhydrolase like 1 -2.02968
SOAT2 sterol O-acyltransferase 2 -2.01015
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -2.00432
NOX4 NADPH oxidase 4 -1.97408
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -1.96635
ADRA2A adrenoceptor alpha 2A -1.95797
IL26 interleukin 26 -1.95094
COL7A1 collagen, type VII, alpha 1 -1.93619
MGAT4C MGAT4 family, member C -1.93188
FOSB FBJ murine osteosarcoma viral oncogene homolog B -1.91634
F9 coagulation factor IX -1.90787
BCOR BCL6 corepressor -1.90045
AOC3 amine oxidase, copper containing 3 -1.89936
UGDH UDP-glucose 6-dehydrogenase -1.88458
LDHB lactate dehydrogenase B -1.88241
SNX15 sorting nexin 15 -1.88238
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -1.86933
TRIM6 tripartite motif containing 6 -1.82834
MNX1 motor neuron and pancreas homeobox 1 -1.82377
CST3 cystatin C -1.81755
BCAT1 branched chain amino-acid transaminase 1, cytosolic -1.81201
SENP8 SUMO/sentrin specific peptidase family member 8 -1.81064
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -1.80471
ULBP1 UL16 binding protein 1 -1.79695
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -1.79621
MAP7D1 MAP7 domain containing 1 -1.78841
TATDN2 TatD DNase domain containing 2 -1.78549
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 -1.78427
DYNLL1 dynein, light chain, LC8-type 1 -1.77957
FLCN folliculin -1.77894
ZNF676 zinc finger protein 676 -1.7737
RHPN1 rhophilin, Rho GTPase binding protein 1 -1.76866
STX5 syntaxin 5 -1.76862
ACSL6 acyl-CoA synthetase long-chain family member 6 -1.76399
CTSC cathepsin C -1.75915
DCHS2 dachsous cadherin-related 2 -1.74222
EOMES eomesodermin -1.74111
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -1.73729
ARL2-SNX15 ARL2-SNX15 readthrough (NMD candidate) -1.73201
COL4A2 collagen, type IV, alpha 2 -1.72804
TFCP2L1 transcription factor CP2-like 1 -1.72551
FBXO15 F-box protein 15 -1.7044
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -1.69621
TRIM62 tripartite motif containing 62 -1.68818
HAL histidine ammonia-lyase -1.67724
STX1B syntaxin 1B -1.66675
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -1.66149
TPK1 thiamin pyrophosphokinase 1 -1.66104
PIAS4 protein inhibitor of activated STAT, 4 -1.65971
MBIP MAP3K12 binding inhibitory protein 1 -1.65952
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 -1.6578
OSGEP O-sialoglycoprotein endopeptidase -1.6577
NGB neuroglobin -1.65708
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -1.65619
DCT dopachrome tautomerase -1.65086
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -1.65025
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -1.62836
ZNF281 zinc finger protein 281 -1.62559
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -1.624
RAP2C RAP2C, member of RAS oncogene family -1.62111
FAM13A family with sequence similarity 13, member A -1.61513
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -1.61503
ZBTB25 zinc finger and BTB domain containing 25 -1.60786
ZNF497 zinc finger protein 497 -1.6069
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -1.6047
TMLHE trimethyllysine hydroxylase, epsilon -1.60395
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -1.60183
KRT23 keratin 23, type I -1.58968
AIRE autoimmune regulator -1.58674
TSHZ2 teashirt zinc finger homeobox 2 -1.58558
ADAM9 ADAM metallopeptidase domain 9 -1.58404
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d -1.584
IRF2BP2 interferon regulatory factor 2 binding protein 2 -1.57651
METTL4 methyltransferase like 4 -1.57129
LUC7L LUC7-like (S. cerevisiae) -1.56888
ZNF708 zinc finger protein 708 -1.56884
TRIM27 tripartite motif containing 27 -1.56849
FZD9 frizzled class receptor 9 -1.56811
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -1.5609
MADD MAP-kinase activating death domain -1.55577
TBX21 T-box 21 -1.54416
CDC34 cell division cycle 34 -1.5424
DMAP1 DNA methyltransferase 1 associated protein 1 -1.54209
UBE4B ubiquitination factor E4B -1.54025
AKR7A2P1 aldo-keto reductase family 7, member A2 pseudogene 1 -1.53745
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -1.53731
HILS1 histone linker H1 domain, spermatid-specific 1, pseudogene -1.53056
MEX3D mex-3 RNA binding family member D -1.52023
HIST1H4E histone cluster 1, H4e -1.50999
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -1.49986
HIST1H2AC histone cluster 1, H2ac -1.49434
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -1.49274
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -1.48227
ACOT4 acyl-CoA thioesterase 4 -1.47756
RANBP1 RAN binding protein 1 -1.47399
MED9 mediator complex subunit 9 -1.47377
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -1.47021
STK17A serine/threonine kinase 17a -1.46925
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -1.4538
NAMPT nicotinamide phosphoribosyltransferase -1.45039
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -1.44552
FXYD7 FXYD domain containing ion transport regulator 7 -1.44551
HHAT hedgehog acyltransferase -1.4424
GPR155 G protein-coupled receptor 155 -1.44133
ACADL acyl-CoA dehydrogenase, long chain -1.43658
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -1.43627
SP1 Sp1 transcription factor -1.43374
SLC35A4 solute carrier family 35, member A4 -1.43101
KIF5B kinesin family member 5B -1.42753
ZNF227 zinc finger protein 227 -1.41851
ACSL4 acyl-CoA synthetase long-chain family member 4 -1.4182
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -1.41343
HK3 hexokinase 3 (white cell) -1.41115
PCGF6 polycomb group ring finger 6 -1.4094
PITRM1 pitrilysin metallopeptidase 1 -1.40349
HACL1 2-hydroxyacyl-CoA lyase 1 -1.40157
HIST3H3 histone cluster 3, H3 -1.40098
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -1.39828
RSG1 REM2 and RAB-like small GTPase 1 -1.39416
FGF17 fibroblast growth factor 17 -1.39091
HOXD13 homeobox D13 -1.38975
TUBB4B tubulin, beta 4B class IVb -1.38948
TAS2R9 taste receptor, type 2, member 9 -1.38687
LPAR2 lysophosphatidic acid receptor 2 -1.38361
AKAP8 A kinase (PRKA) anchor protein 8 -1.38005
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 -1.3762
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2 -1.37569
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -1.37391
EP300 E1A binding protein p300 -1.37211
SPATA8 spermatogenesis associated 8 -1.36999
CD207 CD207 molecule, langerin -1.36699
DSG4 desmoglein 4 -1.35656
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -1.35201
CELF3 CUGBP, Elav-like family member 3 -1.33829
NAAA N-acylethanolamine acid amidase -1.33547
KDM4A lysine (K)-specific demethylase 4A -1.3335
HDAC8 histone deacetylase 8 -1.33016
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -1.32886
NR5A1 nuclear receptor subfamily 5, group A, member 1 -1.32742
NRIP3 nuclear receptor interacting protein 3 -1.31127
MAN2A1 mannosidase, alpha, class 2A, member 1 -1.30929
HCAR1 hydroxycarboxylic acid receptor 1 -1.30689
CASP5 caspase 5, apoptosis-related cysteine peptidase -1.30123
CALN1 calneuron 1 -1.29656
TOM1 target of myb1 (chicken) -1.29556
MNAT1 MNAT CDK-activating kinase assembly factor 1 -1.29507
OR7C2 olfactory receptor, family 7, subfamily C, member 2 -1.29397
KRT3 keratin 3, type II -1.29235
CBFB core-binding factor, beta subunit -1.28419
ZNF138 zinc finger protein 138 -1.27969
CHRNG cholinergic receptor, nicotinic, gamma (muscle) -1.27373
PURA purine-rich element binding protein A -1.27282
KRT24 keratin 24, type I -1.27015
MSMO1 methylsterol monooxygenase 1 -1.26651
DPYS dihydropyrimidinase -1.26466
ERI1 exoribonuclease 1 -1.26373
EIF2D eukaryotic translation initiation factor 2D -1.26366
RABL3 RAB, member of RAS oncogene family-like 3 -1.26011
FBXW2 F-box and WD repeat domain containing 2 -1.25705
CLCA1 chloride channel accessory 1 -1.25523
HIPK1 homeodomain interacting protein kinase 1 -1.25456
GLRX2 glutaredoxin 2 -1.24828
ACLY ATP citrate lyase -1.2452
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -1.24181
CD109 CD109 molecule -1.23672
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -1.23361
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -1.23215
ZNF728 zinc finger protein 728 -1.23011
P3H1 prolyl 3-hydroxylase 1 -1.2292
PDCL phosducin-like -1.22635
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -1.22632
CIB4 calcium and integrin binding family member 4 -1.21321
TUSC1 tumor suppressor candidate 1 -1.21199
LOC100506859 -1.20796
MVD mevalonate (diphospho) decarboxylase -1.20488
RRAGA Ras-related GTP binding A -1.20387
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -1.19333
DLG2 discs, large homolog 2 (Drosophila) -1.19205
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -1.18985
GAK cyclin G associated kinase -1.18959
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -1.18922
ABHD14A abhydrolase domain containing 14A -1.18777
GAMT guanidinoacetate N-methyltransferase -1.1866
NUP155 nucleoporin 155kDa -1.18638
SPI1 Spi-1 proto-oncogene -1.18614
PCDHGA11 protocadherin gamma subfamily A, 11 -1.18551
MKRN1 makorin ring finger protein 1 -1.1838
MYB v-myb avian myeloblastosis viral oncogene homolog -1.17757
ADCK1 aarF domain containing kinase 1 -1.17625
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.17436
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A -1.1737
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -1.17323
RCOR3 REST corepressor 3 -1.17231
PC pyruvate carboxylase -1.17146
RNF152 ring finger protein 152 -1.17073
MYLK3 myosin light chain kinase 3 -1.17051
MATR3 matrin 3 -1.17044
ADH6 alcohol dehydrogenase 6 (class V) -1.1701
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -1.16977
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 -1.16917
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -1.16578
CXORF23 chromosome X open reading frame 23 -1.16469
PADI3 peptidyl arginine deiminase, type III -1.16432
CNGA1 cyclic nucleotide gated channel alpha 1 -1.16347
CARM1 coactivator-associated arginine methyltransferase 1 -1.16294
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -1.16274
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -1.16262
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -1.15323
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -1.15285
OR1E1 olfactory receptor, family 1, subfamily E, member 1 -1.15222
CUTC cutC copper transporter -1.15207
BAG4 BCL2-associated athanogene 4 -1.15131
INSM1 insulinoma-associated 1 -1.15031
TMEM234 transmembrane protein 234 -1.1391
CETP cholesteryl ester transfer protein, plasma -1.13821
OR2L13 olfactory receptor, family 2, subfamily L, member 13 -1.13119
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -1.12841
WBP11 WW domain binding protein 11 -1.12537
PDIK1L PDLIM1 interacting kinase 1 like -1.12451
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -1.11953
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 -1.11627
GAP43 growth associated protein 43 -1.11421
MBD1 methyl-CpG binding domain protein 1 -1.11351
MMP28 matrix metallopeptidase 28 -1.11084
CCND3 cyclin D3 -1.10801
MYBBP1A MYB binding protein (P160) 1a -1.10795
ZNF208 zinc finger protein 208 -1.10675
PAQR3 progestin and adipoQ receptor family member III -1.10631
PTCH1 patched 1 -1.10541
LMO7 LIM domain 7 -1.10464
GMIP GEM interacting protein -1.10384
DDR2 discoidin domain receptor tyrosine kinase 2 -1.10153
KIAA0195 KIAA0195 -1.10044
TMPRSS4 transmembrane protease, serine 4 -1.09782
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -1.0977
EBF2 early B-cell factor 2 -1.09656
LEP leptin -1.09317
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -1.09285
GBX1 gastrulation brain homeobox 1 -1.08979
NELL2 NEL-like 2 (chicken) -1.08418
CBX4 chromobox homolog 4 -1.0819
HSPE1-MOB4 HSPE1-MOB4 readthrough -1.0797
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene -1.07783
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -1.07656
F2RL1 coagulation factor II (thrombin) receptor-like 1 -1.0657
CCNA2 cyclin A2 -1.05985
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -1.05882
OR1S2 olfactory receptor, family 1, subfamily S, member 2 -1.05769
MASTL microtubule associated serine/threonine kinase-like -1.05524
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 -1.05483
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -1.05276
NEB nebulin -1.05113
UBL3 ubiquitin-like 3 -1.04946
POU1F1 POU class 1 homeobox 1 -1.04808
DNM1P46 dynamin 1 pseudogene 46 -1.04694
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -1.04627
HK2 hexokinase 2 -1.04415
ZNF81 zinc finger protein 81 -1.0429
ZBTB3 zinc finger and BTB domain containing 3 -1.04282
ANPEP alanyl (membrane) aminopeptidase -1.0423
KIF17 kinesin family member 17 -1.0411
ZNF560 zinc finger protein 560 -1.03955
DCST1 DC-STAMP domain containing 1 -1.03917
ZNF426 zinc finger protein 426 -1.03902
RAPSN receptor-associated protein of the synapse -1.03459
AFG3L1P AFG3-like AAA ATPase 1, pseudogene -1.03321
RNPEP arginyl aminopeptidase (aminopeptidase B) -1.0323
D2HGDH D-2-hydroxyglutarate dehydrogenase -1.03131
CCDC12 coiled-coil domain containing 12 -1.03096
BIRC8 baculoviral IAP repeat containing 8 -1.03071
MED19 mediator complex subunit 19 -1.02751
LIMK2 LIM domain kinase 2 -1.02504
GYS1 glycogen synthase 1 (muscle) -1.02274
RPL31 ribosomal protein L31 -1.02254
PLSCR3 phospholipid scramblase 3 -1.02222
KISS1R KISS1 receptor -1.02074
FOXL2 forkhead box L2 -1.02006
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -1.01779
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.01613
NFIB nuclear factor I/B -1.01557
RNASET2 ribonuclease T2 -1.01532
MED16 mediator complex subunit 16 -1.01468
CASP14 caspase 14, apoptosis-related cysteine peptidase -1.01427
FBXO18 F-box protein, helicase, 18 -1.01382
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -1.01217
MED26 mediator complex subunit 26 -1.00922
PSKH1 protein serine kinase H1 -1.008
ADGRF5 adhesion G protein-coupled receptor F5 -1.00662
PKN1 protein kinase N1 -1.00625
MSC musculin -1.00483
GYLTL1B glycosyltransferase-like 1B -1.00482
ZMIZ1 zinc finger, MIZ-type containing 1 -1.00411
EGLN1 egl-9 family hypoxia-inducible factor 1 -1.00393
TAS2R1 taste receptor, type 2, member 1 -1.00386
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -1.0034
CCNL1 cyclin L1 -1.00154