THPO Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description thrombopoietin|Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 7066)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_THPO
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Genes

129 co-expressed genes for THPO from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAMTSL3 ADAMTS-like 3
ADGRL2 adhesion G protein-coupled receptor L2
AOC4P amine oxidase, copper containing 4, pseudogene
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ATF2 activating transcription factor 2
ATP10B ATPase, class V, type 10B
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATXN3 ataxin 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CADM4 cell adhesion molecule 4
CALN1 calneuron 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMTA1 calmodulin binding transcription activator 1
CDC73 cell division cycle 73
CDH8 cadherin 8, type 2
CDR1 cerebellar degeneration-related protein 1, 34kDa
CEP162 centrosomal protein 162kDa
CLCN4 chloride channel, voltage-sensitive 4
COL14A1 collagen, type XIV, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL8A1 collagen, type VIII, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CRHR1 corticotropin releasing hormone receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DMD dystrophin
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DOCK3 dedicator of cytokinesis 3
DRD1 dopamine receptor D1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EXOC4 exocyst complex component 4
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM110B family with sequence similarity 110, member B
FAM153B family with sequence similarity 153, member B
FBXL4 F-box and leucine-rich repeat protein 4
FLRT2 fibronectin leucine rich transmembrane protein 2
FSHR follicle stimulating hormone receptor
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD5 frizzled class receptor 5
GCA grancalcin, EF-hand calcium binding protein
GCM1 glial cells missing homolog 1 (Drosophila)
GLRA3 glycine receptor, alpha 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR171 G protein-coupled receptor 171
GPR18 G protein-coupled receptor 18
GUCY2C guanylate cyclase 2C
GUCY2F guanylate cyclase 2F, retinal
GYPA glycophorin A (MNS blood group)
HCG8 HLA complex group 8
HCRTR2 hypocretin (orexin) receptor 2
HIST1H3E histone cluster 1, H3e
HNF1A HNF1 homeobox A
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNW1 interferon, omega 1
IL4 interleukin 4
IL7 interleukin 7
IPO9 importin 9
ISL1 ISL LIM homeobox 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
JADE3 jade family PHD finger 3
JRKL JRK-like
KLHL23 kelch-like family member 23
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KRT2 keratin 2, type II
KRT34 keratin 34, type I
LDB3 LIM domain binding 3
LGI1 leucine-rich, glioma inactivated 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAGEA8 melanoma antigen family A8
MAGEA9 melanoma antigen family A9
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MON2 MON2 homolog (S. cerevisiae)
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NHEJ1 nonhomologous end-joining factor 1
NPFF neuropeptide FF-amide peptide precursor
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG2 netrin G2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCDHB17P protocadherin beta 17 pseudogene
PCM1 pericentriolar material 1
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PGM3 phosphoglucomutase 3
PHOX2B paired-like homeobox 2b
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRKCA protein kinase C, alpha
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRB protein tyrosine phosphatase, receptor type, B
RAD51D RAD51 paralog D
RB1CC1 RB1-inducible coiled-coil 1
RORB RAR-related orphan receptor B
RREB1 ras responsive element binding protein 1
RYR3 ryanodine receptor 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIX6 SIX homeobox 6
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMYD3 SET and MYND domain containing 3
SOAT2 sterol O-acyltransferase 2
SPA17 sperm autoantigenic protein 17
SPAG11B sperm associated antigen 11B
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TBX19 T-box 19
THPO thrombopoietin
TLL1 tolloid-like 1
TNK1 tyrosine kinase, non-receptor, 1
TPD52L1 tumor protein D52-like 1
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
ZBTB14 zinc finger and BTB domain containing 14
ZNF132 zinc finger protein 132
ZNF141 zinc finger protein 141
ZNF157 zinc finger protein 157
ZSCAN26 zinc finger and SCAN domain containing 26