THRA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description thyroid hormone receptor, alpha|The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7067)
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Genes

282 genes differentially expressed following the THRA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TBX21 T-box 21 2.83834
COLEC10 collectin sub-family member 10 (C-type lectin) 2.83834
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.83834
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.83834
SLC46A2 solute carrier family 46, member 2 2.83834
MTDH metadherin 2.83834
DNASE1L3 deoxyribonuclease I-like 3 2.83834
MGAM2 maltase-glucoamylase 2 (putative) 2.83834
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.83834
FGF23 fibroblast growth factor 23 2.83834
NKAPL NFKB activating protein-like 2.83834
RAET1E retinoic acid early transcript 1E 2.83834
CETN1 centrin, EF-hand protein, 1 2.83834
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.83834
CFHR3 complement factor H-related 3 2.83834
TMPRSS11F transmembrane protease, serine 11F 2.83834
CD274 CD274 molecule 2.83834
TSHB thyroid stimulating hormone, beta 2.83834
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.83834
TM4SF20 transmembrane 4 L six family member 20 2.83834
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.83834
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.83834
LRRC66 leucine rich repeat containing 66 2.83834
TREML2 triggering receptor expressed on myeloid cells-like 2 2.83834
FAM216B family with sequence similarity 216, member B 2.83834
MYO1A myosin IA 2.83834
SPACA5 sperm acrosome associated 5 2.83834
SPACA4 sperm acrosome associated 4 2.83834
RNF39 ring finger protein 39 2.83834
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.83834
PNOC prepronociceptin 2.83834
MLNR motilin receptor 2.83834
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.83834
CD300A CD300a molecule 2.83834
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.83834
RSPO1 R-spondin 1 2.83834
GPR22 G protein-coupled receptor 22 2.83834
ADAD2 adenosine deaminase domain containing 2 2.83834
C1ORF141 chromosome 1 open reading frame 141 2.83834
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.83834
PRR29 proline rich 29 2.83834
GRXCR1 glutaredoxin, cysteine rich 1 2.83834
LNC-LBCS lncRNA bladder and prostate cancer suppressor, hnRNPK interacting 2.83834
ADGRG3 adhesion G protein-coupled receptor G3 2.83834
KRT80 keratin 80, type II 2.83834
SMLR1 small leucine-rich protein 1 2.83834
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.83834
RAB36 RAB36, member RAS oncogene family 2.83834
ZNF441 zinc finger protein 441 2.83834
VSIG2 V-set and immunoglobulin domain containing 2 2.83834
VSIG8 V-set and immunoglobulin domain containing 8 2.83834
ARX aristaless related homeobox 2.83834
HAO2 hydroxyacid oxidase 2 (long chain) 2.83834
C1ORF232 chromosome 1 open reading frame 230 2.83834
ARMH2 armadillo like helical domain containing 2 2.83834
ODAPH odontogenesis associated phosphoprotein 2.83834
CBY2 chibby family member 2 2.83834
H2AP H2A.P histone 2.83834
CALHM5 calcium homeostasis modulator family member 5 2.83834
GMCL2 germ cell-less 2, spermatogenesis associated 2.83834
ACP3 acid phosphatase 3 2.83834
GATA2 GATA binding protein 2 2.83834
HNF1A HNF1 homeobox A 2.83834
LTF lactotransferrin 2.83834
CCDC92 coiled-coil domain containing 92 2.83834
ZIC4 Zic family member 4 2.83834
MRPL2 mitochondrial ribosomal protein L2 2.83834
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.83834
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.83834
TRIM67 tripartite motif containing 67 2.83834
ZBTB16 zinc finger and BTB domain containing 16 2.83834
ZBTB12 zinc finger and BTB domain containing 12 2.83834
ADGRG1 adhesion G protein-coupled receptor G1 2.83834
GDF10 growth differentiation factor 10 2.83834
ASIC4 acid sensing (proton gated) ion channel family member 4 2.83834
NPIPB8 nuclear pore complex interacting protein family, member B8 2.83834
GSC goosecoid homeobox 2.83834
EXOC3L1 exocyst complex component 3-like 1 2.83834
SPDYC speedy/RINGO cell cycle regulator family member C 2.83834
PRR18 proline rich 18 2.83834
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.83834
SLC45A2 solute carrier family 45, member 2 2.83834
PCDHA7 protocadherin alpha 7 2.83834
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.83834
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.83834
EDN3 endothelin 3 2.83834
IGF2 insulin-like growth factor 2 2.83834
ASTL astacin-like metallo-endopeptidase (M12 family) 2.83834
PRPH peripherin 2.83834
SAMD7 sterile alpha motif domain containing 7 2.83834
ITGA10 integrin, alpha 10 2.83834
ALAS2 5'-aminolevulinate synthase 2 2.83834
HSF4 heat shock transcription factor 4 2.83834
AMN amnion associated transmembrane protein 2.83834
TPPP2 tubulin polymerization-promoting protein family member 2 2.83834
DMTN dematin actin binding protein 2.83834
ANKRD13C ankyrin repeat domain 13C 2.83834
ARR3 arrestin 3, retinal (X-arrestin) 2.83834
RUFY4 RUN and FYVE domain containing 4 2.83834
LCT lactase 2.83834
FBXO40 F-box protein 40 2.83834
ZNF541 zinc finger protein 541 2.83834
MAMLD1 mastermind-like domain containing 1 2.83834
C22ORF42 chromosome 22 open reading frame 42 2.83834
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.83834
NOX1 NADPH oxidase 1 2.83834
C2CD4D C2 calcium-dependent domain containing 4D 2.83834
CTAGE9 CTAGE family, member 9 2.83834
CXCR6 chemokine (C-X-C motif) receptor 6 2.83834
CCL15 chemokine (C-C motif) ligand 15 2.83834
AQP9 aquaporin 9 2.83834
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.83834
IL1A interleukin 1, alpha 2.83834
CERKL ceramide kinase-like 2.83834
CST1 cystatin SN 2.83834
SLC22A24 solute carrier family 22, member 24 2.83834
AGR2 anterior gradient 2 2.83834
WDFY4 WDFY family member 4 2.83834
SUN1 Sad1 and UNC84 domain containing 1 2.83834
CGN cingulin 2.83834
TSPAN16 tetraspanin 16 2.83834
CASQ2 calsequestrin 2 (cardiac muscle) 2.83834
PSG11 pregnancy specific beta-1-glycoprotein 11 2.83834
GJB6 gap junction protein, beta 6, 30kDa 2.83834
GBX2 gastrulation brain homeobox 2 2.83834
PHACTR3 phosphatase and actin regulator 3 2.83834
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.83834
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.83834
CFI complement factor I 2.83834
AKR1B15 aldo-keto reductase family 1, member B15 2.83834
MRGPRX3 MAS-related GPR, member X3 2.83834
PITX2 paired-like homeodomain 2 2.83834
PITX1 paired-like homeodomain 1 2.83834
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.83834
FOXF2 forkhead box F2 2.83834
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.83834
MT1A metallothionein 1A 2.83834
PENK proenkephalin 2.83834
GPR65 G protein-coupled receptor 65 2.83834
SYNGR4 synaptogyrin 4 2.83834
ADGRF5 adhesion G protein-coupled receptor F5 2.83834
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.83834
NKX6-2 NK6 homeobox 2 2.83834
ITPKA inositol-trisphosphate 3-kinase A 2.83834
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.83834
TH tyrosine hydroxylase 2.83834
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 2.79922
DUSP9 dual specificity phosphatase 9 2.78587
TMPRSS5 transmembrane protease, serine 5 2.78587
CYGB cytoglobin 2.78587
SCG5 secretogranin V 2.60144
CRTC2 CREB regulated transcription coactivator 2 2.59324
IFFO2 intermediate filament family orphan 2 2.56827
ZNF491 zinc finger protein 491 2.50222
FECH ferrochelatase 2.4882
FMO2 flavin containing monooxygenase 2 (non-functional) 2.47936
MAGEB17 melanoma antigen family B17 2.47936
LIPH lipase, member H 2.47936
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.47936
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2.4692
MCRS1 microspherule protein 1 2.4692
TCEAL4 transcription elongation factor A (SII)-like 4 2.45095
SFXN4 sideroflexin 4 2.43238
PABPC4L poly(A) binding protein, cytoplasmic 4-like 2.3826
PODXL2 podocalyxin-like 2 2.35296
FAM161B family with sequence similarity 161, member B 2.33925
SLC22A14 solute carrier family 22, member 14 2.33925
GOLGA6L4 golgin A6 family-like 4 2.31677
KIAA0408 KIAA0408 2.31578
ZFPM1 zinc finger protein, FOG family member 1 2.31578
SLC7A14 solute carrier family 7, member 14 2.30206
C1ORF202 chromosome 1 open reading frame 202 2.30206
CCDC125 coiled-coil domain containing 125 2.26852
ANGPTL7 angiopoietin-like 7 2.25113
ERCC2 excision repair cross-complementation group 2 2.23961
DNASE1 deoxyribonuclease I 2.23213
ARGLU1 arginine and glutamate rich 1 2.22241
KTN1 kinectin 1 (kinesin receptor) 2.21906
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.203
KCTD9 potassium channel tetramerization domain containing 9 2.16773
RPL41 ribosomal protein L41 2.16305
GARRE1 granule associated Rac and RHOG effector 1 2.15636
TANK TRAF family member-associated NFKB activator 2.14977
RECQL RecQ helicase-like 2.13714
MAN2B2 mannosidase, alpha, class 2B, member 2 2.13357
SLC30A8 solute carrier family 30 (zinc transporter), member 8 2.12696
STK33 serine/threonine kinase 33 2.12616
FER1L6 fer-1-like family member 6 2.12362
TRIM11 tripartite motif containing 11 2.10569
ARHGAP11B Rho GTPase activating protein 11B 2.10356
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.09452
AKAP13 A kinase (PRKA) anchor protein 13 2.08832
APOO apolipoprotein O 2.07965
TBC1D16 TBC1 domain family, member 16 2.06993
MEGF10-DT MEGF10 divergent transcript 2.06185
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase 2.04957
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.04473
ATXN7 ataxin 7 2.03902
CCDC112 coiled-coil domain containing 112 2.02738
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.02295
DYNC2I1 dynein 2 intermediate chain 1 2.02259
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.02259
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.01515

decreased expression

Symbol Name Standardized Value
EVI2B ecotropic viral integration site 2B -2.83834
VIM vimentin -2.83834
FGF4 fibroblast growth factor 4 -2.83834
XKRX XK, Kell blood group complex subunit-related, X-linked -2.83834
TMEM70 transmembrane protein 70 -2.83834
LHFPL6 LHFPL tetraspan subfamily member 6 -2.83834
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.83834
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.83834
EEF1AKMT1 EEF1A lysine methyltransferase 1 -2.83735
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.83086
ORC2 origin recognition complex, subunit 2 -2.78746
ZAN zonadhesin (gene/pseudogene) -2.78587
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 -2.78587
TGM1 transglutaminase 1 -2.78587
MMP10 matrix metallopeptidase 10 -2.78587
NRGN neurogranin (protein kinase C substrate, RC3) -2.78587
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.78587
TMEM184A transmembrane protein 184A -2.78587
ANKRD18A ankyrin repeat domain 18A -2.78587
SLC35G5 solute carrier family 35, member G5 -2.78587
GALR3 galanin receptor 3 -2.78587
PSCA prostate stem cell antigen -2.78587
ADGRE3 adhesion G protein-coupled receptor E3 -2.78587
COL20A1 collagen, type XX, alpha 1 -2.78587
YY2 YY2 transcription factor -2.78587
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.78587
OR56A4 olfactory receptor, family 56, subfamily A, member 4 -2.78587
WFDC1 WAP four-disulfide core domain 1 -2.78587
IL21R interleukin 21 receptor -2.78587
NPBWR1 neuropeptides B/W receptor 1 -2.78587
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.78587
FGR FGR proto-oncogene, Src family tyrosine kinase -2.78587
TBC1D3L TBC1 domain family, member 3L -2.78587
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.78587
ERICH6 glutamate-rich 6 -2.78587
CFAP52 cilia and flagella associated protein 52 -2.78587
IHO1 interactor of HORMAD1 1 -2.78587
FAM133A family with sequence similarity 133, member A -2.78587
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.5829
TCP1 t-complex 1 -2.52025
MTRF1 mitochondrial translational release factor 1 -2.50527
SPOUT1 SPOUT domain containing methyltransferase 1 -2.47781
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.44122
TACC1 transforming, acidic coiled-coil containing protein 1 -2.43217
PDCD5 programmed cell death 5 -2.39703
STPG1 sperm-tail PG-rich repeat containing 1 -2.38699
SURF1 surfeit 1 -2.37349
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.37349
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.36345
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -2.34465
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -2.34465
IL17RD interleukin 17 receptor D -2.24506
HYDIN HYDIN, axonemal central pair apparatus protein -2.24174
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.24067
C17ORF113 chromosome 17 open reading frame 113 -2.24005
NCAN neurocan -2.24005
NOX3 NADPH oxidase 3 -2.24005
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.19271
ZNF284 zinc finger protein 284 -2.18939
SNAP29 synaptosomal-associated protein, 29kDa -2.18939
RAB22A RAB22A, member RAS oncogene family -2.18939
GPX2 glutathione peroxidase 2 -2.13714
FAM120B family with sequence similarity 120B -2.10569
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.1047
ASB7 ankyrin repeat and SOCS box containing 7 -2.10356
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.09655
TUSC3 tumor suppressor candidate 3 -2.06989
ANGEL2 angel homolog 2 (Drosophila) -2.06491
MT1H metallothionein 1H -2.06224
ZBTB9 zinc finger and BTB domain containing 9 -2.06185
TPO thyroid peroxidase -2.04957
C1ORF116 chromosome 1 open reading frame 116 -2.04473
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.04473
STOX1 storkhead box 1 -2.02873
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.02668
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -2.01689
RAB11A RAB11A, member RAS oncogene family -2.01515
SCP2 sterol carrier protein 2 -2.01515
LCLAT1 lysocardiolipin acyltransferase 1 -2.00966