TIA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description TIA1 cytotoxic granule-associated RNA binding protein|The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7072)
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Genes

326 genes differentially expressed following the TIA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HKDC1 hexokinase domain containing 1 2.49694
SIGLEC10 sialic acid binding Ig-like lectin 10 2.49694
MLN motilin 2.49694
ANGPTL6 angiopoietin-like 6 2.49694
CDH5 cadherin 5, type 2 (vascular endothelium) 2.49694
FAM86B2 family with sequence similarity 86, member B2 2.49694
SVOP SV2 related protein homolog (rat) 2.49694
SCN10A sodium channel, voltage gated, type X alpha subunit 2.49694
SH2D6 SH2 domain containing 6 2.49694
MAGIX MAGI family member, X-linked 2.49694
TMEM139 transmembrane protein 139 2.49694
ASB15 ankyrin repeat and SOCS box containing 15 2.49694
MYADM myeloid-associated differentiation marker 2.49694
ERICH6B glutamate-rich 6B 2.49694
CNTNAP4 contactin associated protein-like 4 2.49694
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 2.49694
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.49694
C11ORF87 chromosome 11 open reading frame 87 2.49694
CPZ carboxypeptidase Z 2.49694
TLCD3B TLC domain containing 3B 2.49694
IGFBP7 insulin-like growth factor binding protein 7 2.49694
CCN4 cellular communication network factor 4 2.49694
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.49694
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.49694
SPATS1 spermatogenesis associated, serine-rich 1 2.49694
MYL10 myosin, light chain 10, regulatory 2.49694
WNK4 WNK lysine deficient protein kinase 4 2.49694
RPL3L ribosomal protein L3-like 2.49694
MSC musculin 2.49694
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.49694
SLC46A3 solute carrier family 46, member 3 2.42744
SIX2 SIX homeobox 2 2.42744
SIGLECL1 SIGLEC family like 1 2.42744
HRH1 histamine receptor H1 2.42744
FOXQ1 forkhead box Q1 2.42744
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.42744
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.42744
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.42744
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.42744
ADGRE3 adhesion G protein-coupled receptor E3 2.42744
ZNF503 zinc finger protein 503 2.42744
GLUD2 glutamate dehydrogenase 2 2.42744
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.42744
AVP arginine vasopressin 2.42744
FBXW9 F-box and WD repeat domain containing 9 2.42744
ERLIN1 ER lipid raft associated 1 2.42744
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.42744
RHOXF2 Rhox homeobox family, member 2 2.42744
S100A5 S100 calcium binding protein A5 2.42744
NPIPA8 nuclear pore complex interacting protein family, member A8 2.42744
GNRHR gonadotropin-releasing hormone receptor 2.42744
LRRC61 leucine rich repeat containing 61 2.42744
OTUD6A OTU deubiquitinase 6A 2.42744
SERF1A small EDRK-rich factor 1A (telomeric) 2.42744
PRSS41 protease, serine, 41 2.42744
HES4 hes family bHLH transcription factor 4 2.42744
MAP7D2 MAP7 domain containing 2 2.42744
TM4SF20 transmembrane 4 L six family member 20 2.42744
CCNB3 cyclin B3 2.42744
NOD2 nucleotide-binding oligomerization domain containing 2 2.42744
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.42744
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.42744
MYOM2 myomesin 2 2.42744
BHMT2 betaine--homocysteine S-methyltransferase 2 2.42744
ACKR5 atypical chemokine receptor 5 2.42744
SCEL sciellin 2.42744
RD3 retinal degeneration 3 2.42744
FRG2C FSHD region gene 2 family, member C 2.42744
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.42744
SMPX small muscle protein, X-linked 2.42744
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.42744
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.42744
FCMR Fc fragment of IgM receptor 2.42744
GRAP GRB2-related adaptor protein 2.42744
CLDN16 claudin 16 2.42744
YIPF7 Yip1 domain family, member 7 2.42744
YPEL4 yippee-like 4 (Drosophila) 2.42744
LY6S lymphocyte antigen 6 family member S 2.42744
H2BK1 H2B.K variant histone 1 2.42744
C20ORF204 chromosome 20 open reading frame 204 2.42744
SERTM2 serine rich and transmembrane domain containing 2 2.42744
CPHXL cytoplasmic polyadenylated homeobox like 2.42744
GARIN6 golgi associated RAB2 interactor family member 6 2.42744
AJM1 apical junction component 1 homolog 2.42744
PACC1 proton activated chloride channel 1 2.42744
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.42744
LY6H lymphocyte antigen 6 complex, locus H 2.42744
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.42744
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.42744
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.42744
CCR6 chemokine (C-C motif) receptor 6 2.42744
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.42744
MAGEB1 melanoma antigen family B1 2.42744
TUBA3E tubulin, alpha 3e 2.42744
PCDHA7 protocadherin alpha 7 2.42744
RAET1E retinoic acid early transcript 1E 2.42744
SCARA5 scavenger receptor class A, member 5 2.42744
NCBP2L nuclear cap binding protein subunit 2-like 2.42744
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.42744
DNASE2B deoxyribonuclease II beta 2.42744
OVOL3 ovo-like zinc finger 3 2.42744
CNTN6 contactin 6 2.42744
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.42744
LTK leukocyte receptor tyrosine kinase 2.42744
IL16 interleukin 16 2.42744
OOSP2 oocyte secreted protein 2 2.42744
S100G S100 calcium binding protein G 2.42744
CCR4 chemokine (C-C motif) receptor 4 2.42744
PRR4 proline rich 4 (lacrimal) 2.42744
PLCB4 phospholipase C, beta 4 2.42744
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.42744
PLA2G4E phospholipase A2, group IVE 2.42744
NANOGNB NANOG neighbor homeobox 2.42744
CDHR5 cadherin-related family member 5 2.42744
FAM20C family with sequence similarity 20, member C 2.42744
SPATA4 spermatogenesis associated 4 2.42744
CDH10 cadherin 10, type 2 (T2-cadherin) 2.42744
PAGE4 P antigen family, member 4 (prostate associated) 2.42744
MAB21L1 mab-21-like 1 (C. elegans) 2.42744
TRIM55 tripartite motif containing 55 2.42744
LMOD3 leiomodin 3 (fetal) 2.42744
VWA3B von Willebrand factor A domain containing 3B 2.42744
CXCR2 chemokine (C-X-C motif) receptor 2 2.42744
AQP3 aquaporin 3 (Gill blood group) 2.42744
BTNL9 butyrophilin-like 9 2.42744
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.42744
TMEM132D transmembrane protein 132D 2.42744
ZSCAN4 zinc finger and SCAN domain containing 4 2.42744
MR1 major histocompatibility complex, class I-related 2.42744
PKDREJ polycystin (PKD) family receptor for egg jelly 2.42744
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.42744
UBQLNL ubiquilin-like 2.42744
DQX1 DEAQ box RNA-dependent ATPase 1 2.42744
OTC ornithine carbamoyltransferase 2.42744
PIH1D2 PIH1 domain containing 2 2.42744
CHI3L2 chitinase 3-like 2 2.42744
EMILIN1 elastin microfibril interfacer 1 2.42744
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.42744
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.42744
OTP orthopedia homeobox 2.42744
C10ORF105 chromosome 10 open reading frame 105 2.42744
SYT5 synaptotagmin V 2.42744
GOLGA8T golgin A8 family, member T 2.42744
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.42744
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.42744
MZB1 marginal zone B and B1 cell-specific protein 2.42744
CFH complement factor H 2.42744
NYX nyctalopin 2.42744
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.42744
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.42744
KLK15 kallikrein-related peptidase 15 2.42744
CFAP47 cilia and flagella associated protein 47 2.42744
DMRTA2 DMRT-like family A2 2.42744
C8B complement component 8, beta polypeptide 2.42744
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.42744
CTXN2 cortexin 2 2.42744
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.42744
AMN amnion associated transmembrane protein 2.42744
ANKRD55 ankyrin repeat domain 55 2.42744
GPR61 G protein-coupled receptor 61 2.42744
LCT lactase 2.42744
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.42744
GYS2 glycogen synthase 2 (liver) 2.42744
TAS2R40 taste receptor, type 2, member 40 2.42744
TGM3 transglutaminase 3 2.42744
SAP25 Sin3A-associated protein, 25kDa 2.42744
DLL4 delta-like 4 (Drosophila) 2.42744
SYTL4 synaptotagmin-like 4 2.42744
LAMP5 lysosomal-associated membrane protein family, member 5 2.42744
WFDC10A WAP four-disulfide core domain 10A 2.42744
UBAP2L ubiquitin associated protein 2-like 2.42744
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.42744
CD28 CD28 molecule 2.42744
IL17B interleukin 17B 2.42744
OR56A5 olfactory receptor, family 56, subfamily A, member 5 2.42744
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.42744
BOLA2 bolA family member 2 2.42744
LEP leptin 2.42744
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.42744
RHOJ ras homolog family member J 2.42744
NPC1L1 NPC1-like 1 2.42744
POPDC2 popeye domain containing 2 2.42744
CHRM4 cholinergic receptor, muscarinic 4 2.42744
USP17L2 ubiquitin specific peptidase 17-like family member 2 2.42744
MME membrane metallo-endopeptidase 2.42744
NUTM2B NUT family member 2B 2.42744
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2.42744
ECM1 extracellular matrix protein 1 2.42744
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.42744
PRSS57 protease, serine, 57 2.42744
IL12A interleukin 12A 2.42744
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.42744
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.42744
AMER2 APC membrane recruitment protein 2 2.42744
AMDHD1 amidohydrolase domain containing 1 2.4108
TPST1 tyrosylprotein sulfotransferase 1 2.40645
GNG2 guanine nucleotide binding protein (G protein), gamma 2 2.40645
FAM114A2 family with sequence similarity 114, member A2 2.38672
WDR93 WD repeat domain 93 2.36511
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.36128
RAB40C RAB40C, member RAS oncogene family 2.3444
PKDCC protein kinase domain containing, cytoplasmic 2.3444
PRH2 proline-rich protein HaeIII subfamily 2 2.31619
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.31619
NTNG2 netrin G2 2.29847
C17ORF58 chromosome 17 open reading frame 58 2.29579
TMC3 transmembrane channel-like 3 2.27499
TECR trans-2,3-enoyl-CoA reductase 2.24272
TCHP trichoplein, keratin filament binding 2.23209
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2.23084
CEP20 centrosomal protein 20 2.2263
ZNF669 zinc finger protein 669 2.21888
USP47 ubiquitin specific peptidase 47 2.21076
SPNS1 spinster homolog 1 (Drosophila) 2.19802
LEFTY2 left-right determination factor 2 2.17365
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.17077
ART5 ADP-ribosyltransferase 5 2.16479
PLAGL1 pleiomorphic adenoma gene-like 1 2.16177
LMNB2 lamin B2 2.13602
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.12418
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.11532
PARP8 poly (ADP-ribose) polymerase family, member 8 2.08854
ZNF236 zinc finger protein 236 2.08437
NUB1 negative regulator of ubiquitin-like proteins 1 2.05829
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 2.05084
MTMR8 myotubularin related protein 8 2.04441
TMEM63B transmembrane protein 63B 2.02901
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.02473
NANS N-acetylneuraminic acid synthase 2.02473
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.02473
AHNAK AHNAK nucleoprotein 2.02447
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.01526
METTL23 methyltransferase like 23 2.0092
SETDB2 SET domain, bifurcated 2 2.00102

decreased expression

Symbol Name Standardized Value
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.49694
CCDC68 coiled-coil domain containing 68 -2.49694
ALX3 ALX homeobox 3 -2.49694
RUBCNL rubicon like autophagy enhancer -2.42744
MGARP mitochondria-localized glutamic acid-rich protein -2.42744
PNKD paroxysmal nonkinesigenic dyskinesia -2.42744
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.42744
POLQ polymerase (DNA directed), theta -2.42744
HIPK3 homeodomain interacting protein kinase 3 -2.42744
HEPHL1 hephaestin-like 1 -2.42744
TMC1 transmembrane channel-like 1 -2.42744
TBC1D30 TBC1 domain family, member 30 -2.42744
PSD2 pleckstrin and Sec7 domain containing 2 -2.42744
REEP2 receptor accessory protein 2 -2.42744
FSTL5 follistatin-like 5 -2.42744
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -2.42744
SPON2 spondin 2, extracellular matrix protein -2.42744
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.42744
SNX8 sorting nexin 8 -2.42744
TMEM106B transmembrane protein 106B -2.42744
ADD3 adducin 3 (gamma) -2.42744
COX8C cytochrome c oxidase subunit VIIIC -2.42744
ZNF25 zinc finger protein 25 -2.42744
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -2.42744
SLC22A25 solute carrier family 22, member 25 -2.42744
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.42744
GJA5 gap junction protein, alpha 5, 40kDa -2.42744
INHBC inhibin, beta C -2.42744
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.42744
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.42744
RTN3 reticulon 3 -2.42744
ZFTRAF1 zinc finger TRAF-type containing 1 -2.42744
DUSP13B dual specificity phosphatase 13B -2.42744
TMEM52 transmembrane protein 52 -2.42744
TTC22 tetratricopeptide repeat domain 22 -2.42744
EXTL1 exostosin-like glycosyltransferase 1 -2.42744
PLET1 placenta expressed transcript 1 -2.42744
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.42744
TSLP thymic stromal lymphopoietin -2.42744
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.42744
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.42744
ADAM12 ADAM metallopeptidase domain 12 -2.42744
CNR1 cannabinoid receptor 1 (brain) -2.42744
MAP1A microtubule-associated protein 1A -2.42744
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -2.42744
NPPA natriuretic peptide A -2.42744
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -2.42744
CPO carboxypeptidase O -2.42744
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.42744
RWDD2B RWD domain containing 2B -2.42353
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.36613
UPK2 uroplakin 2 -2.36286
CCDC74B coiled-coil domain containing 74B -2.36034
SYAP1 synapse associated protein 1 -2.29618
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.29579
KIF15 kinesin family member 15 -2.27928
TMEM79 transmembrane protein 79 -2.26537
TUBA8 tubulin, alpha 8 -2.26537
LAS1L LAS1-like (S. cerevisiae) -2.26491
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 -2.23646
TRAIP TRAF interacting protein -2.23539
NUP98 nucleoporin 98kDa -2.2263
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -2.22129
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.21891
HIST1H2BI histone cluster 1, H2bi -2.21891
TENT5A terminal nucleotidyltransferase 5A -2.2172
COIL coilin -2.18219
MLPH melanophilin -2.16743
ZWINT ZW10 interacting kinetochore protein -2.15902
ZNF155 zinc finger protein 155 -2.15773
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit -2.15429
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.14296
USP33 ubiquitin specific peptidase 33 -2.12867
RLIM ring finger protein, LIM domain interacting -2.12418
UNC5D unc-5 homolog D (C. elegans) -2.11532
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.09652
BROX BRO1 domain and CAAX motif containing -2.08625
SRSF10 serine/arginine-rich splicing factor 10 -2.08259
TRIM22 tripartite motif containing 22 -2.07564
ZMAT3 zinc finger, matrin-type 3 -2.07564
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.06274
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.04594
CATSPER4 cation channel, sperm associated 4 -2.04441
AQP11 aquaporin 11 -2.04441
MRPL55 mitochondrial ribosomal protein L55 -2.03513
SNX1 sorting nexin 1 -2.02901
SLC38A10 solute carrier family 38, member 10 -2.0273
CADM2 cell adhesion molecule 2 -2.02632
PLAC9 placenta-specific 9 -2.02473
SLC16A14 solute carrier family 16, member 14 -2.02432
TSPAN6 tetraspanin 6 -2.00384
SNX13 sorting nexin 13 -2.00169