TIE1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tyrosine kinase with immunoglobulin-like and EGF-like domains 1|This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 7075)
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Genes

357 genes differentially expressed following the TIE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GRXCR1 glutaredoxin, cysteine rich 1 3.26126
CD19 CD19 molecule 3.26126
IL22RA1 interleukin 22 receptor, alpha 1 3.26126
CAMP cathelicidin antimicrobial peptide 3.26126
TRIM15 tripartite motif containing 15 3.26126
TSGA13 testis specific, 13 3.26126
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.26126
CAPNS2 calpain, small subunit 2 3.26126
PNMA5 paraneoplastic Ma antigen family member 5 3.26126
HYAL4 hyaluronoglucosaminidase 4 3.26126
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.26126
FGD2 FYVE, RhoGEF and PH domain containing 2 3.26126
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.26126
FPR2 formyl peptide receptor 2 3.26126
PRB1 proline-rich protein BstNI subfamily 1 3.26126
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.26126
FABP9 fatty acid binding protein 9, testis 3.26126
GJA3 gap junction protein, alpha 3, 46kDa 3.26126
FOXQ1 forkhead box Q1 3.26126
CD274 CD274 molecule 3.26126
CD96 CD96 molecule 3.26126
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.26126
GRXCR2 glutaredoxin, cysteine rich 2 3.26126
RIMBP3 RIMS binding protein 3 3.26126
TBX18 T-box 18 3.26126
ANKK1 ankyrin repeat and kinase domain containing 1 3.26126
S100A2 S100 calcium binding protein A2 3.26126
NPIPA3 nuclear pore complex interacting protein family, member A3 3.26126
RFX6 regulatory factor X, 6 3.26126
BFSP2 beaded filament structural protein 2, phakinin 3.26126
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 3.26126
GALR2 galanin receptor 2 3.26126
SERTM1 serine-rich and transmembrane domain containing 1 3.26126
KIAA1755 KIAA1755 3.26126
CLEC5A C-type lectin domain family 5, member A 3.26126
TMEM72 transmembrane protein 72 3.26126
ADGB androglobin 3.26126
CRISP2 cysteine-rich secretory protein 2 3.26126
SLC25A47 solute carrier family 25, member 47 3.26126
OSR2 odd-skipped related transciption factor 2 3.26126
PAX7 paired box 7 3.26126
SIGLEC9 sialic acid binding Ig-like lectin 9 3.26126
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.26126
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.26126
PBOV1 prostate and breast cancer overexpressed 1 3.26126
CA6 carbonic anhydrase VI 3.26126
SLC10A5 solute carrier family 10, member 5 3.26126
KLHL33 kelch-like family member 33 3.26126
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.26126
P3R3URF PIK3R3 upstream open reading frame 3.26126
STING1 stimulator of interferon response cGAMP interactor 1 3.26126
SEPTIN14 septin 14 3.26126
ERVW-1 endogenous retrovirus group W, member 1 3.26126
GIPC3 GIPC PDZ domain containing family, member 3 3.26126
GBP3 guanylate binding protein 3 3.26126
AVPR1A arginine vasopressin receptor 1A 3.26126
CLDN16 claudin 16 3.26126
FOXC1 forkhead box C1 3.26126
AJM1 apical junction component 1 homolog 3.26126
WDR97 WD repeat domain 97 3.26126
H2BC3 H2B clustered histone 3 3.26126
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.26126
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.26126
SPMAP2 sperm microtubule associated protein 2 3.26126
H4C15 H4 clustered histone 15 3.26126
SPAAR small regulatory polypeptide of amino acid response 3.26126
AKAIN1 A-kinase anchor inhibitor 1 3.26126
LY6L lymphocyte antigen 6 family member L 3.26126
CLEC20A C-type lectin domain containing 20A 3.26126
GARIN1A golgi associated RAB2 interactor 1A 3.26126
DYNLRB2 dynein, light chain, roadblock-type 2 3.26126
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.26126
GATA6 GATA binding protein 6 3.26126
C6ORF118 chromosome 6 open reading frame 118 3.26126
LEF1 lymphoid enhancer-binding factor 1 3.26126
BHLHA9 basic helix-loop-helix family, member a9 3.26126
TLR6 toll-like receptor 6 3.26126
GOLGA7B golgin A7 family, member B 3.26126
IL31RA interleukin 31 receptor A 3.26126
CLDN9 claudin 9 3.26126
WDR38 WD repeat domain 38 3.26126
PTPRH protein tyrosine phosphatase, receptor type, H 3.26126
RASAL3 RAS protein activator like 3 3.26126
UTS2 urotensin 2 3.26126
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.26126
PARVG parvin, gamma 3.26126
CLEC6A C-type lectin domain family 6, member A 3.26126
CNGA3 cyclic nucleotide gated channel alpha 3 3.26126
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.26126
PNPLA1 patatin-like phospholipase domain containing 1 3.26126
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.26126
TAS1R2 taste receptor, type 1, member 2 3.26126
FGFBP2 fibroblast growth factor binding protein 2 3.26126
GTSF1 gametocyte specific factor 1 3.26126
PTPRC protein tyrosine phosphatase, receptor type, C 3.26126
PRPH peripherin 3.26126
LCNL1 lipocalin-like 1 3.26126
ESAM endothelial cell adhesion molecule 3.26126
LRRC32 leucine rich repeat containing 32 3.26126
A3GALT2 alpha 1,3-galactosyltransferase 2 3.26126
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.26126
DNAH12 dynein, axonemal, heavy chain 12 3.26126
C18ORF63 chromosome 18 open reading frame 63 3.26126
SLC38A3 solute carrier family 38, member 3 3.26126
RORC RAR-related orphan receptor C 3.26126
FAIM2 Fas apoptotic inhibitory molecule 2 3.26126
PSG3 pregnancy specific beta-1-glycoprotein 3 3.26126
PCDHAC2 protocadherin alpha subfamily C, 2 3.26126
PPY pancreatic polypeptide 3.26126
NPAS4 neuronal PAS domain protein 4 3.26126
CARNS1 carnosine synthase 1 3.26126
NUTM2D NUT family member 2D 3.26126
LPAR5 lysophosphatidic acid receptor 5 3.26126
TBC1D21 TBC1 domain family, member 21 3.26126
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.26126
DQX1 DEAQ box RNA-dependent ATPase 1 3.26126
ISL1 ISL LIM homeobox 1 3.26126
TP63 tumor protein p63 3.26126
KLK3 kallikrein-related peptidase 3 3.26126
STX11 syntaxin 11 3.26126
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.26126
UTS2R urotensin 2 receptor 3.26126
GSTA5 glutathione S-transferase alpha 5 3.26126
LY96 lymphocyte antigen 96 3.26126
BCO1 beta-carotene oxygenase 1 3.26126
APOC2 apolipoprotein C-II 3.26126
SLC38A8 solute carrier family 38, member 8 3.26126
ARR3 arrestin 3, retinal (X-arrestin) 3.26126
HHLA2 HERV-H LTR-associating 2 3.26126
SOSTDC1 sclerostin domain containing 1 3.26126
PRM1 protamine 1 3.26126
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.26126
PKDREJ polycystin (PKD) family receptor for egg jelly 3.26126
GPR61 G protein-coupled receptor 61 3.26126
C10ORF105 chromosome 10 open reading frame 105 3.26126
NLRP8 NLR family, pyrin domain containing 8 3.26126
SSX3 synovial sarcoma, X breakpoint 3 3.26126
MEIG1 meiosis/spermiogenesis associated 1 3.26126
ICAM2 intercellular adhesion molecule 2 3.26126
ZBBX zinc finger, B-box domain containing 3.26126
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.26126
ZNF831 zinc finger protein 831 3.26126
C5ORF46 chromosome 5 open reading frame 46 3.26126
ST18 suppression of tumorigenicity 18, zinc finger 3.26126
KRTAP8-1 keratin associated protein 8-1 3.26126
DISP2 dispatched homolog 2 (Drosophila) 3.26126
TWIST1 twist family bHLH transcription factor 1 3.26126
NPY2R neuropeptide Y receptor Y2 3.26126
PRSS22 protease, serine, 22 3.26126
CLEC18A C-type lectin domain family 18, member A 3.26126
TEX29 testis expressed 29 3.26126
FGF8 fibroblast growth factor 8 (androgen-induced) 3.26126
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 3.25288
DUSP28 dual specificity phosphatase 28 3.18838
CCDC158 coiled-coil domain containing 158 3.18838
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.18838
GLCE glucuronic acid epimerase 3.17042
FSD1 fibronectin type III and SPRY domain containing 1 3.05362
PYGB phosphorylase, glycogen; brain 2.8761
KANTR KDM5C adjacent non-coding transcript 2.83938
CAPN14 calpain 14 2.83872
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.82823
SDHAF4 succinate dehydrogenase complex assembly factor 4 2.77712
ZMIZ2 zinc finger, MIZ-type containing 2 2.76384
C21ORF58 chromosome 21 open reading frame 58 2.67993
OSBPL5 oxysterol binding protein-like 5 2.66715
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.66182
ZC3H7B zinc finger CCCH-type containing 7B 2.59088
NRBF2 nuclear receptor binding factor 2 2.58377
ANKRD12 ankyrin repeat domain 12 2.52455
ZIM3 zinc finger, imprinted 3 2.52455
SERGEF secretion regulating guanine nucleotide exchange factor 2.52455
PRTN3 proteinase 3 2.48135
GDNF glial cell derived neurotrophic factor 2.48135
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 2.47315
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.46686
CWC15 CWC15 spliceosome-associated protein 2.46337
HMGA1 high mobility group AT-hook 1 2.44293
CCDC175 coiled-coil domain containing 175 2.42311
METTL9 methyltransferase like 9 2.41455
UNC13A unc-13 homolog A (C. elegans) 2.33269
GPR26 G protein-coupled receptor 26 2.33269
DPRX divergent-paired related homeobox 2.33269
OTUD6A OTU deubiquitinase 6A 2.33269
RNF6 ring finger protein (C3H2C3 type) 6 2.30304
TMIE transmembrane inner ear 2.27398
TDRD1 tudor domain containing 1 2.26894
KDM5C lysine (K)-specific demethylase 5C 2.25268
FLRT1 fibronectin leucine rich transmembrane protein 1 2.23184
PFN4 profilin family, member 4 2.23079
FGF18 fibroblast growth factor 18 2.23079
TEX46 testis expressed 46 2.23079
CLUL1 clusterin-like 1 (retinal) 2.23079
TBC1D19 TBC1 domain family, member 19 2.23079
VEGFD vascular endothelial growth factor D 2.23079
ANKRD61 ankyrin repeat domain 61 2.23079
LOXL4 lysyl oxidase-like 4 2.23079
MGARP mitochondria-localized glutamic acid-rich protein 2.23079
FSCN3 fascin actin-bundling protein 3, testicular 2.23079
CRIP1 cysteine-rich protein 1 (intestinal) 2.23079
QTGAL queuosine-tRNA galactosyltransferase 2.21151
ARL6 ADP-ribosylation factor-like 6 2.21019
RHOA ras homolog family member A 2.21019
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.1947
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4 2.1944
JAK3 Janus kinase 3 2.1903
NLRP3 NLR family, pyrin domain containing 3 2.17278
CISH cytokine inducible SH2-containing protein 2.17278
AP1M1 adaptor-related protein complex 1, mu 1 subunit 2.16547
MALRD1 MAM and LDL receptor class A domain containing 1 2.15728
S100A10 S100 calcium binding protein A10 2.15662
FAM219B family with sequence similarity 219, member B 2.15653
GRB2 growth factor receptor-bound protein 2 2.15062
CD2AP CD2-associated protein 2.11113
HLTF helicase-like transcription factor 2.11039
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.10458
CLK4 CDC-like kinase 4 2.10318
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 2.10176
NME1 NME/NM23 nucleoside diphosphate kinase 1 2.09837
LRP2 low density lipoprotein receptor-related protein 2 2.09837
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.08627
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 2.06007
KIF9 kinesin family member 9 2.05436
FRS2 fibroblast growth factor receptor substrate 2 2.05339
IGSF9 immunoglobulin superfamily, member 9 2.05024
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.04234
ORC6 origin recognition complex, subunit 6 2.04137
GNPDA1 glucosamine-6-phosphate deaminase 1 2.04137
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.04137
FBXL15 F-box and leucine-rich repeat protein 15 2.02277
MUC12 mucin 12, cell surface associated 2.02017
DENND11 DENN domain containing 11 2.01682
CRELD1 cysteine-rich with EGF-like domains 1 2.01339
TTLL6 tubulin tyrosine ligase-like family member 6 2.01152
SOWAHC sosondowah ankyrin repeat domain family member C 2.00718
STX19 syntaxin 19 2.0058
FAM227B family with sequence similarity 227, member B 2.00347

decreased expression

Symbol Name Standardized Value
NFAM1 NFAT activating protein with ITAM motif 1 -3.26126
TMPRSS13 transmembrane protease, serine 13 -3.26126
ALLC allantoicase -3.26126
LAMP3 lysosomal-associated membrane protein 3 -3.26126
TAS2R5 taste receptor, type 2, member 5 -3.26126
ROM1 retinal outer segment membrane protein 1 -3.26126
PVRIG poliovirus receptor related immunoglobulin domain containing -3.26126
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.26126
NPIPB8 nuclear pore complex interacting protein family, member B8 -3.26126
NGB neuroglobin -3.26126
CCDC154 coiled-coil domain containing 154 -3.26126
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -3.26126
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -3.26126
FBLN5 fibulin 5 -3.26126
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -3.26126
SUSD2 sushi domain containing 2 -3.26126
SH2D7 SH2 domain containing 7 -3.26126
CCNB3 cyclin B3 -3.26126
PCDHGB3 protocadherin gamma subfamily B, 3 -3.26126
SHE Src homology 2 domain containing E -3.26126
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -3.26126
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -3.26126
PCDHGA11 protocadherin gamma subfamily A, 11 -3.26126
RNF112 ring finger protein 112 -3.26126
SPI1 Spi-1 proto-oncogene -3.26126
GOLGA8H golgin A8 family, member H -3.26126
PCDHA11 protocadherin alpha 11 -3.26126
CFI complement factor I -3.26126
HAO2 hydroxyacid oxidase 2 (long chain) -3.26126
FSHR follicle stimulating hormone receptor -3.26126
CTXND1 cortexin domain containing 1 -3.26126
VWA3A von Willebrand factor A domain containing 3A -3.26126
CFP complement factor properdin -3.26126
H4C14 H4 clustered histone 14 -3.26126
HDDC2 HD domain containing 2 -3.26126
IQCN IQ motif containing N -3.26126
CXCR4 chemokine (C-X-C motif) receptor 4 -3.26126
ARRDC2 arrestin domain containing 2 -3.19226
MRPS25 mitochondrial ribosomal protein S25 -3.18368
APOOL apolipoprotein O-like -3.17042
FAM171B family with sequence similarity 171, member B -3.13994
CA12 carbonic anhydrase XII -3.09268
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.99106
GPSM1 G-protein signaling modulator 1 -2.90708
STK40 serine/threonine kinase 40 -2.83938
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.80675
FSD2 fibronectin type III and SPRY domain containing 2 -2.76602
KIF18B kinesin family member 18B -2.76384
COMMD5 COMM domain containing 5 -2.69657
MRE11 MRE11 homolog, double strand break repair nuclease -2.62005
TADA1 transcriptional adaptor 1 -2.61345
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -2.6059
NCOA6 nuclear receptor coactivator 6 -2.59088
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.58681
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.57964
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -2.56146
RPAIN RPA interacting protein -2.4807
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.46686
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.4666
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) -2.46337
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.46337
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.44293
OTX2 orthodenticle homeobox 2 -2.44293
IFT172 intraflagellar transport 172 -2.44293
LAMA4 laminin, alpha 4 -2.41174
CYGB cytoglobin -2.41174
GPR137 G protein-coupled receptor 137 -2.39178
SSR1 signal sequence receptor, alpha -2.37184
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -2.36993
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.36738
CKS1B CDC28 protein kinase regulatory subunit 1B -2.35235
CHN2 chimerin 2 -2.34278
SFT2D3 SFT2 domain containing 3 -2.33443
SLITRK5 SLIT and NTRK-like family, member 5 -2.28095
EGFL7 EGF-like-domain, multiple 7 -2.24962
ZNF547 zinc finger protein 547 -2.24283
ZNF621 zinc finger protein 621 -2.23168
SMC1A structural maintenance of chromosomes 1A -2.23168
RGPD6 RANBP2-like and GRIP domain containing 6 -2.23079
NHLH1 nescient helix loop helix 1 -2.23079
CDO1 cysteine dioxygenase type 1 -2.23079
PCDHB14 protocadherin beta 14 -2.23079
WAS Wiskott-Aldrich syndrome -2.23079
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.23079
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.23079
SUMO3 small ubiquitin-like modifier 3 -2.22
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.20954
ACTMAP actin maturation protease -2.20153
BCAN brevican -2.19829
CD58 CD58 molecule -2.16547
NUDCD2 NudC domain containing 2 -2.15458
GIGYF1 GRB10 interacting GYF protein 1 -2.12464
HAVCR2 hepatitis A virus cellular receptor 2 -2.11113
CUL4A cullin 4A -2.10956
LAMA5 laminin, alpha 5 -2.10937
TMPO thymopoietin -2.10458
ACTRT3 actin-related protein T3 -2.10318
TKFC triokinase/FMN cyclase -2.10318
TENM1 teneurin transmembrane protein 1 -2.09837
AKT3 v-akt murine thymoma viral oncogene homolog 3 -2.09824
SYT17 synaptotagmin XVII -2.09164
MCPH1 microcephalin 1 -2.08649
ZSCAN12 zinc finger and SCAN domain containing 12 -2.07547
SCYL1 SCY1-like 1 (S. cerevisiae) -2.07356
NUP98 nucleoporin 98kDa -2.07356
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) -2.07342
MYO9A myosin IXA -2.07342
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.06068
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase -2.05339
LHFPL2 lipoma HMGIC fusion partner-like 2 -2.05339
PTPRE protein tyrosine phosphatase, receptor type, E -2.0481
GREB1L growth regulation by estrogen in breast cancer-like -2.04208
N4BP2 NEDD4 binding protein 2 -2.04137
BCL3 B-cell CLL/lymphoma 3 -2.03888
STPG4 sperm-tail PG-rich repeat containing 4 -2.02975
FKBP7 FK506 binding protein 7 -2.01682
KLHL9 kelch-like family member 9 -2.01682
MYO1D myosin ID -2.01495
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -2.00806
AURKC aurora kinase C -2.00184