TIMELESS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description timeless circadian clock|The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 8914)
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Genes

671 genes differentially expressed following the TIMELESS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CENPL centromere protein L 2.46577
RIOX1 ribosomal oxygenase 1 2.46577
CAPN12 calpain 12 2.46577
ZDHHC16 zinc finger, DHHC-type containing 16 2.46577
PRTFDC1 phosphoribosyl transferase domain containing 1 2.46577
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.46577
ZNF681 zinc finger protein 681 2.46577
IQCJ IQ motif containing J 2.46577
RABL2B RAB, member of RAS oncogene family-like 2B 2.46577
ZNF449 zinc finger protein 449 2.45189
PROS1 protein S (alpha) 2.45189
RBBP9 retinoblastoma binding protein 9 2.45189
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.45189
LRRC45 leucine rich repeat containing 45 2.45189
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.45189
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.45189
YAF2 YY1 associated factor 2 2.45189
MED18 mediator complex subunit 18 2.45189
DMWD dystrophia myotonica, WD repeat containing 2.45189
UNC5CL unc-5 homolog C (C. elegans)-like 2.45189
TEK TEK tyrosine kinase, endothelial 2.45189
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.45189
PARVG parvin, gamma 2.45189
NRL neural retina leucine zipper 2.45189
VEGFA vascular endothelial growth factor A 2.45189
SWSAP1 SWIM-type zinc finger 7 associated protein 1 2.45189
ARHGAP9 Rho GTPase activating protein 9 2.45189
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.45189
TMEM240 transmembrane protein 240 2.45189
TOR1B torsin family 1, member B (torsin B) 2.45189
C5ORF63 chromosome 5 open reading frame 63 2.45189
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.45189
MTUS2 microtubule associated tumor suppressor candidate 2 2.45189
ZNF599 zinc finger protein 599 2.45189
MYO18B myosin XVIIIB 2.45189
MYO15B myosin XVB 2.45189
DPF1 D4, zinc and double PHD fingers family 1 2.45189
FBF1 Fas (TNFRSF6) binding factor 1 2.45189
TMSB15B thymosin beta 15B 2.45189
PCNX3 pecanex 3 2.45189
SLC26A5 solute carrier family 26 (anion exchanger), member 5 2.45189
ASAH2B N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B 2.45189
BTN1A1 butyrophilin, subfamily 1, member A1 2.45189
RIN2 Ras and Rab interactor 2 2.45189
SPATA12 spermatogenesis associated 12 2.45189
ARV1 ARV1 homolog (S. cerevisiae) 2.45189
MAPRE3 microtubule-associated protein, RP/EB family, member 3 2.45189
ASNSD1 asparagine synthetase domain containing 1 2.45189
ZNF740 zinc finger protein 740 2.45189
CTXND1 cortexin domain containing 1 2.45189
MSH4 mutS homolog 4 2.45189
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.45189
CISD3 CDGSH iron sulfur domain 3 2.45189
IL32 interleukin 32 2.45189
LYPD1 LY6/PLAUR domain containing 1 2.45189
HRAS Harvey rat sarcoma viral oncogene homolog 2.45189
RAG2 recombination activating gene 2 2.45189
ALAD aminolevulinate dehydratase 2.45189
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.45189
ZNF671 zinc finger protein 671 2.45189
RBKS ribokinase 2.44492
SCFD1 sec1 family domain containing 1 2.42443
FBXL14 F-box and leucine-rich repeat protein 14 2.40918
GPR157 G protein-coupled receptor 157 2.40859
LMLN leishmanolysin-like (metallopeptidase M8 family) 2.40859
SMAP2 small ArfGAP2 2.40859
STRADA STE20-related kinase adaptor alpha 2.40859
RANBP2 RAN binding protein 2 2.31211
NELFE negative elongation factor complex member E 2.25177
EXD2 exonuclease 3'-5' domain containing 2 2.24119
STEEP1 STING1 ER exit protein 1 2.24119
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 2.23633
NT5C2 5'-nucleotidase, cytosolic II 2.23633
IFI27L1 interferon, alpha-inducible protein 27-like 1 2.20912
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.18408
ZNF638 zinc finger protein 638 2.18408
NXNL2 nucleoredoxin-like 2 2.18408
ASMTL acetylserotonin O-methyltransferase-like 2.18408
NFE2L1 nuclear factor, erythroid 2-like 1 2.18408
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.18408
BBX bobby sox homolog (Drosophila) 2.18408
N4BP2L2 NEDD4 binding protein 2-like 2 2.18408
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.18408
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.18408
MACF1 microtubule-actin crosslinking factor 1 2.18408
RASA2 RAS p21 protein activator 2 2.18408
ZNF512 zinc finger protein 512 2.18408
PLCH1 phospholipase C, eta 1 2.18408
WNK2 WNK lysine deficient protein kinase 2 2.17837
ETNK2 ethanolamine kinase 2 2.13982
DUSP22 dual specificity phosphatase 22 2.13982
RASA1 RAS p21 protein activator (GTPase activating protein) 1 2.12635
GUCA1A guanylate cyclase activator 1A (retina) 2.12589
ZNF184 zinc finger protein 184 2.12313
RFPL2 ret finger protein-like 2 2.12313
TGFB3 transforming growth factor, beta 3 2.12313
MYCT1 myc target 1 2.12313
NAGS N-acetylglutamate synthase 2.12313
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.12313
SFXN3 sideroflexin 3 2.12313
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.12313
RGS7BP regulator of G-protein signaling 7 binding protein 2.12313
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.12313
ZNF747 zinc finger protein 747 2.12313
ZNF554 zinc finger protein 554 2.12313
ENAH enabled homolog (Drosophila) 2.12313
ADAMTSL2 ADAMTS-like 2 2.12313
CA7 carbonic anhydrase VII 2.12313
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.12313
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 2.12313
GPR162 G protein-coupled receptor 162 2.12313
SACK1G scaffolding CK1 anchoring protein G 2.12313
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.12313
CD19 CD19 molecule 2.12313
CABP4 calcium binding protein 4 2.12313
DDIT4L DNA-damage-inducible transcript 4-like 2.12313
VSTM2B V-set and transmembrane domain containing 2B 2.12313
ZNF469 zinc finger protein 469 2.12313
PDLIM2 PDZ and LIM domain 2 (mystique) 2.12313
PTAFR platelet-activating factor receptor 2.12313
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.12313
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.12313
TBX15 T-box 15 2.12313
GSTM3 glutathione S-transferase mu 3 (brain) 2.12313
SIRPB2 signal-regulatory protein beta 2 2.12313
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.12313
ZBTB42 zinc finger and BTB domain containing 42 2.12313
WDTC1 WD and tetratricopeptide repeats 1 2.12313
DDR2 discoidin domain receptor tyrosine kinase 2 2.12313
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 2.12313
LBP lipopolysaccharide binding protein 2.12313
CROCC ciliary rootlet coiled-coil, rootletin 2.12313
SPOCD1 SPOC domain containing 1 2.12313
ASB14 ankyrin repeat and SOCS box containing 14 2.12313
KHNYN KH and NYN domain containing 2.12313
C1ORF116 chromosome 1 open reading frame 116 2.12313
CRLS1 cardiolipin synthase 1 2.12313
CHGB chromogranin B 2.12313
SSMEM1 serine-rich single-pass membrane protein 1 2.12313
TCL1A T-cell leukemia/lymphoma 1A 2.12313
TRIL TLR4 interactor with leucine-rich repeats 2.12313
BMP8B bone morphogenetic protein 8b 2.12313
PPP1R10 protein phosphatase 1, regulatory subunit 10 2.12313
LIPT2-AS1 LIPT2 antisense RNA 1 2.12313
ASPNAT aspartate N-acetyltransferase 2.12313
TRIM39 tripartite motif containing 39 2.12313
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.12313
NBPF10 neuroblastoma breakpoint family, member 10 2.12313
ZNF600 zinc finger protein 600 2.12313
TMEM260 transmembrane protein 260 2.12313
F8 coagulation factor VIII, procoagulant component 2.12313
LAMA3 laminin, alpha 3 2.12313
PXDC1 PX domain containing 1 2.12313
ASIC4 acid sensing (proton gated) ion channel family member 4 2.12313
GPR139 G protein-coupled receptor 139 2.12313
ADPRH ADP-ribosylarginine hydrolase 2.12313
CCR5AS CCR5 antisense RNA 2.12313
BARX1 BARX homeobox 1 2.12313
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.12313
RASAL1 RAS protein activator like 1 (GAP1 like) 2.12313
TOM1 target of myb1 (chicken) 2.12313
SPRR2F small proline-rich protein 2F 2.12313
BCAN brevican 2.12313
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.12313
ZNG1C Zn regulated GTPase metalloprotein activator 1C 2.12313
CRIPTO3 cripto, EGF-CFC family member 3 2.12313
HNRNPA1L3 heterogeneous nuclear ribonucleoprotein A1 like 3 2.12313
H4C9 H4 clustered histone 9 2.12313
SCAND3 SCAN domain containing 3 2.12313
TAFA3 TAFA chemokine like family member 3 2.12313
CFAP77 cilia and flagella associated protein 77 2.12313
PHETA1 PH domain containing endocytic trafficking adaptor 1 2.12313
TSPOAP1 TSPO associated protein 1 2.12313
GPAT3 glycerol-3-phosphate acyltransferase 3 2.12313
MINDY1 MINDY lysine 48 deubiquitinase 1 2.12313
RIPOR1 RHO family interacting cell polarization regulator 1 2.12313
NHLH2 nescient helix loop helix 2 2.12313
HPS6 Hermansky-Pudlak syndrome 6 2.12313
FKBP2 FK506 binding protein 2, 13kDa 2.12313
RIPK4 receptor-interacting serine-threonine kinase 4 2.12313
PNLIPRP1 pancreatic lipase-related protein 1 2.12313
TMEM183A transmembrane protein 183A 2.12313
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.12313
SMIM10L2A small integral membrane protein 10 like 2A 2.12313
C1ORF216 chromosome 1 open reading frame 216 2.12313
FAM3B family with sequence similarity 3, member B 2.12313
GUCA1B guanylate cyclase activator 1B (retina) 2.12313
KLHL34 kelch-like family member 34 2.12313
CRYZ crystallin, zeta (quinone reductase) 2.12313
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.12313
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.12313
TMEM145 transmembrane protein 145 2.12313
FLT3 fms-related tyrosine kinase 3 2.12313
IPO13 importin 13 2.12313
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.12313
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 2.12313
ELF4 E74-like factor 4 (ets domain transcription factor) 2.12313
GTF2IRD2B GTF2I repeat domain containing 2B 2.12313
MALL mal, T-cell differentiation protein-like 2.12313
ZC3H11A zinc finger CCCH-type containing 11A 2.12313
ACP5 acid phosphatase 5, tartrate resistant 2.12313
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.12313
E2F2 E2F transcription factor 2 2.12313
CTBS chitobiase, di-N-acetyl- 2.12313
IAPP islet amyloid polypeptide 2.12313
RPH3AL rabphilin 3A-like (without C2 domains) 2.12313
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 2.12313
HAP1 huntingtin-associated protein 1 2.12313
TMEM234 transmembrane protein 234 2.12313
FAM78A family with sequence similarity 78, member A 2.12313
ZSWIM3 zinc finger, SWIM-type containing 3 2.12313
TRIM68 tripartite motif containing 68 2.12313
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 2.12313
CCDC13 coiled-coil domain containing 13 2.12313
TLE6 transducin-like enhancer of split 6 2.12313
ZFP28 ZFP28 zinc finger protein 2.12313
PTPRH protein tyrosine phosphatase, receptor type, H 2.12313
CCDC81 coiled-coil domain containing 81 2.12313
SLC35D3 solute carrier family 35, member D3 2.12313
ZNF432 zinc finger protein 432 2.12313
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.12313
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 2.12313
SHISA7 shisa family member 7 2.12313
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.12313
EVA1A eva-1 homolog A (C. elegans) 2.12313
AQP4 aquaporin 4 2.12313
AQP5 aquaporin 5 2.12313
AQP3 aquaporin 3 (Gill blood group) 2.12313
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.12313
LYG2 lysozyme G-like 2 2.12313
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 2.12313
RAD51AP2 RAD51 associated protein 2 2.12313
AUTS2 autism susceptibility candidate 2 2.12313
SMIM24 small integral membrane protein 24 2.12313
RNFT1 ring finger protein, transmembrane 1 2.12313
TBXA2R thromboxane A2 receptor 2.12313
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.12313
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.12313
SH2D4A SH2 domain containing 4A 2.12313
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.12313
WFDC3 WAP four-disulfide core domain 3 2.12313
RTBDN retbindin 2.12313
FHDC1 FH2 domain containing 1 2.12313
CST6 cystatin E/M 2.12313
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.12313
MRPL49 mitochondrial ribosomal protein L49 2.12313
NGF nerve growth factor (beta polypeptide) 2.12313
KEL Kell blood group, metallo-endopeptidase 2.12313
STAB2 stabilin 2 2.12313
CCDC88B coiled-coil domain containing 88B 2.12313
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.12313
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.12313
PKLR pyruvate kinase, liver and RBC 2.12313
APOB apolipoprotein B 2.12313
REC8 REC8 meiotic recombination protein 2.12313
ACOX2 acyl-CoA oxidase 2, branched chain 2.12313
GP5 glycoprotein V (platelet) 2.12313
EXTL2 exostosin-like glycosyltransferase 2 2.12313
AP4B1 adaptor-related protein complex 4, beta 1 subunit 2.12313
ZC3H10 zinc finger CCCH-type containing 10 2.12313
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.12313
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.12313
IGFBP7 insulin-like growth factor binding protein 7 2.12313
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.12313
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.12313
SYPL2 synaptophysin-like 2 2.12313
KCTD16 potassium channel tetramerization domain containing 16 2.12313
KCTD19 potassium channel tetramerization domain containing 19 2.12313
NYX nyctalopin 2.12313
CFAP126 cilia and flagella associated protein 126 2.12313
PAH phenylalanine hydroxylase 2.12313
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.12313
GNMT glycine N-methyltransferase 2.12313
ZNF497 zinc finger protein 497 2.12313
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.12313
BCL3 B-cell CLL/lymphoma 3 2.12313
GLT8D2 glycosyltransferase 8 domain containing 2 2.12313
CCDC170 coiled-coil domain containing 170 2.12313
CCDC172 coiled-coil domain containing 172 2.12313
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.12313
PLA2G5 phospholipase A2, group V 2.12313
DENND2D DENN/MADD domain containing 2D 2.12313
C2ORF81 chromosome 2 open reading frame 81 2.12313
ARHGAP40 Rho GTPase activating protein 40 2.12313
MEIS1 Meis homeobox 1 2.12313
PEX11G peroxisomal biogenesis factor 11 gamma 2.12313
GATAD1 GATA zinc finger domain containing 1 2.12313
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.12313
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.12313
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.12313
PVR poliovirus receptor 2.12313
VWA1 von Willebrand factor A domain containing 1 2.12313
RUMY3 RUMY family member 3 2.12313
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.12313
C2CD4B C2 calcium-dependent domain containing 4B 2.12313
VSTM4 V-set and transmembrane domain containing 4 2.12313
IGSF6 immunoglobulin superfamily, member 6 2.12313
AMN amnion associated transmembrane protein 2.12313
PYGO1 pygopus family PHD finger 1 2.12313
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.12313
KLHDC8A kelch domain containing 8A 2.12313
USP12 ubiquitin specific peptidase 12 2.12313
USP18 ubiquitin specific peptidase 18 2.12313
IFFO1 intermediate filament family orphan 1 2.12313
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.12313
ANKRD50 ankyrin repeat domain 50 2.12313
KIF3B kinesin family member 3B 2.12313
LCN10 lipocalin 10 2.12313
PLXNA3 plexin A3 2.12313
PODNL1 podocan-like 1 2.12313
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.12313
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.12313
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.12313
ZNF804B zinc finger protein 804B 2.12313
FIBCD1 fibrinogen C domain containing 1 2.12313
ANKRD42 ankyrin repeat domain 42 2.12313
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 2.12313
EXOC8 exocyst complex component 8 2.12313
TSHR thyroid stimulating hormone receptor 2.12313
HRC histidine rich calcium binding protein 2.12313
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.12313
FAT4 FAT atypical cadherin 4 2.12313
PLCE1 phospholipase C, epsilon 1 2.12313
KAT2B K(lysine) acetyltransferase 2B 2.12313
LDHC lactate dehydrogenase C 2.12313
EYA2 EYA transcriptional coactivator and phosphatase 2 2.12313
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.12313
LEFTY2 left-right determination factor 2 2.12313
GLRA3 glycine receptor, alpha 3 2.12313
OXCT2 3-oxoacid CoA transferase 2 2.12313
FAM89A family with sequence similarity 89, member A 2.12313
MEIKIN meiotic kinetochore factor 2.12313
SMC1B structural maintenance of chromosomes 1B 2.12313
ATP8B4 ATPase, class I, type 8B, member 4 2.12313
PCGF1 polycomb group ring finger 1 2.12313
ZNF343 zinc finger protein 343 2.12313
AHSG alpha-2-HS-glycoprotein 2.12313
IDUA iduronidase, alpha-L- 2.12313
SLC44A4 solute carrier family 44, member 4 2.12313
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.12313
LGALS8 lectin, galactoside-binding, soluble, 8 2.12313
BEGAIN brain-enriched guanylate kinase-associated 2.12313
OVCH1 ovochymase 1 2.12313
RDH16 retinol dehydrogenase 16 (all-trans) 2.12313
PITX3 paired-like homeodomain 3 2.12313
OR2H2 olfactory receptor, family 2, subfamily H, member 2 2.12313
POU3F3 POU class 3 homeobox 3 2.12313
NATD1 N-acetyltransferase domain containing 1 2.12313
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.12313
COL12A1 collagen, type XII, alpha 1 2.12313
KCTD11 potassium channel tetramerization domain containing 11 2.12313
TBXAS1 thromboxane A synthase 1 (platelet) 2.12313
METTL24 methyltransferase like 24 2.12313
TLCD2 TLC domain containing 2 2.12313
SAP25 Sin3A-associated protein, 25kDa 2.12313
ZNF311 zinc finger protein 311 2.12313
COMTD1 catechol-O-methyltransferase domain containing 1 2.12313
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.12313
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 2.12313
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.12313
PAQR7 progestin and adipoQ receptor family member VII 2.12313
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 2.12313
C16ORF54 chromosome 16 open reading frame 54 2.12313
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.12313
CORIN corin, serine peptidase 2.12313
ADAM20 ADAM metallopeptidase domain 20 2.12313
MAPK15 mitogen-activated protein kinase 15 2.12313
WDFY3 WD repeat and FYVE domain containing 3 2.12313
ENDOD1 endonuclease domain containing 1 2.12313
CCDC160 coiled-coil domain containing 160 2.12313
FBLL1 fibrillarin-like 1 2.12313
EPPK1 epiplakin 1 2.12313
GPC5 glypican 5 2.09956
POGK pogo transposable element with KRAB domain 2.0985
MARCHF8 membrane associated ring-CH-type finger 8 2.0985
DTNA dystrobrevin, alpha 2.0985
TEAD3 TEA domain family member 3 2.08954
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 2.08954
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.08062
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.07858
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 2.07858
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.07858
EMC8 ER membrane protein complex subunit 8 2.07858
POLM polymerase (DNA directed), mu 2.07858
KIF24 kinesin family member 24 2.07858
KLHL9 kelch-like family member 9 2.07858
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 2.07498
DZIP1L DAZ interacting zinc finger protein 1-like 2.07264
SNAP91 synaptosomal-associated protein, 91kDa 2.07264
BICC1 BicC family RNA binding protein 1 2.07264
PLCB2 phospholipase C, beta 2 2.07264
NEMP2 nuclear envelope integral membrane protein 2 2.07264
CHRM2 cholinergic receptor, muscarinic 2 2.07264
DTX4 deltex 4, E3 ubiquitin ligase 2.07264
SYS1 Sys1 golgi trafficking protein 2.07264
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2.07264
BMPR1B bone morphogenetic protein receptor, type IB 2.07264
C10ORF95 chromosome 10 open reading frame 95 2.07264
CC2D1B coiled-coil and C2 domain containing 1B 2.07264
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.07264
MSS51 MSS51 mitochondrial translational activator 2.07264
SHB Src homology 2 domain containing adaptor protein B 2.07264
CPNE9 copine family member IX 2.07264
FAM131A family with sequence similarity 131, member A 2.06881
ZFP30 ZFP30 zinc finger protein 2.04736
ETV1 ets variant 1 2.01885
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.01284
DZIP1 DAZ interacting zinc finger protein 1 2.0107
COP1 COP1 E3 ubiquitin ligase 2.0107
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.00594
ATF7IP2 activating transcription factor 7 interacting protein 2 2.00368

decreased expression

Symbol Name Standardized Value
IKZF4 IKAROS family zinc finger 4 (Eos) -2.46577
NAP1L2 nucleosome assembly protein 1-like 2 -2.46577
MRPL35 mitochondrial ribosomal protein L35 -2.46577
SERAC1 serine active site containing 1 -2.46577
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha -2.46577
FAM76B family with sequence similarity 76, member B -2.46577
PDCD2L programmed cell death 2-like -2.46577
SAP30BP SAP30 binding protein -2.46577
SCYL1 SCY1-like 1 (S. cerevisiae) -2.46577
PSRC1 proline/serine-rich coiled-coil 1 -2.46577
KIAA2013 KIAA2013 -2.46577
EVC Ellis van Creveld protein -2.46577
NBN nibrin -2.46577
SIRT3 sirtuin 3 -2.45189
NFIL3 nuclear factor, interleukin 3 regulated -2.45189
H4C8 H4 clustered histone 8 -2.45189
MKS1 Meckel syndrome, type 1 -2.45189
COG2 component of oligomeric golgi complex 2 -2.45189
SLC16A4 solute carrier family 16, member 4 -2.45189
ZMAT5 zinc finger, matrin-type 5 -2.45189
SYNC syncoilin, intermediate filament protein -2.45189
TMEM150A transmembrane protein 150A -2.45189
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -2.45189
PISD phosphatidylserine decarboxylase -2.45189
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.45189
RGS5 regulator of G-protein signaling 5 -2.45189
SLC66A2 solute carrier family 66 member 2 -2.45189
RANBP6 RAN binding protein 6 -2.45189
ORAI1 ORAI calcium release-activated calcium modulator 1 -2.45189
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.45189
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -2.45189
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.42016
TSFM Ts translation elongation factor, mitochondrial -2.42016
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.40972
MRPS22 mitochondrial ribosomal protein S22 -2.40859
GPX8 glutathione peroxidase 8 (putative) -2.40859
RPS4X ribosomal protein S4, X-linked -2.40836
TMEM60 transmembrane protein 60 -2.39908
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.39908
SMNDC1 survival motor neuron domain containing 1 -2.37876
PYCR1 pyrroline-5-carboxylate reductase 1 -2.36761
KMT2E lysine (K)-specific methyltransferase 2E -2.34801
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.32765
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.30759
RPL39 ribosomal protein L39 -2.27166
CYLD cylindromatosis (turban tumor syndrome) -2.23633
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.23633
LGALSL lectin, galactoside-binding-like -2.23633
CCDC136 coiled-coil domain containing 136 -2.23633
METTL22 methyltransferase like 22 -2.23633
TCTN3 tectonic family member 3 -2.23633
UBE2M ubiquitin-conjugating enzyme E2M -2.21774
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.20912
H2AC20 H2A clustered histone 20 -2.20912
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -2.20912
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -2.20912
PHKB phosphorylase kinase, beta -2.20912
TRAM1 translocation associated membrane protein 1 -2.20912
ZSWIM4 zinc finger, SWIM-type containing 4 -2.20912
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -2.20912
C9ORF72 chromosome 9 open reading frame 72 -2.20912
ARMCX4 armadillo repeat containing, X-linked 4 -2.19647
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.18408
RTN4R reticulon 4 receptor -2.18408
RPL30 ribosomal protein L30 -2.18408
RNF6 ring finger protein (C3H2C3 type) 6 -2.18408
RNF31 ring finger protein 31 -2.18408
ZBTB24 zinc finger and BTB domain containing 24 -2.18408
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 -2.18408
ZNF692 zinc finger protein 692 -2.18408
GUCY2C guanylate cyclase 2C -2.18408
SPPL2B signal peptide peptidase like 2B -2.18408
SNAP29 synaptosomal-associated protein, 29kDa -2.18408
LEMD1 LEM domain containing 1 -2.18408
ZNF157 zinc finger protein 157 -2.18408
LRRC37A leucine rich repeat containing 37A -2.18408
PER2 period circadian clock 2 -2.18408
PLAAT5 phospholipase A and acyltransferase 5 -2.18408
ERLEC1 endoplasmic reticulum lectin 1 -2.18408
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -2.18408
BAK1 BCL2-antagonist/killer 1 -2.18408
PSMC3IP PSMC3 interacting protein -2.18408
ZNF250 zinc finger protein 250 -2.18408
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -2.18408
FAM162B family with sequence similarity 162, member B -2.18408
MMGT1 membrane magnesium transporter 1 -2.18408
CUL9 cullin 9 -2.18408
HSPA8 heat shock 70kDa protein 8 -2.18408
TMEM196 transmembrane protein 196 -2.18408
RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 -2.18408
PTGR3 prostaglandin reductase 3 -2.18408
CAVIN4 caveolae associated protein 4 -2.18408
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.18408
ABITRAM actin binding transcription modulator -2.18408
TMEM94 transmembrane protein 94 -2.18408
MMUT methylmalonyl-CoA mutase -2.18408
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.18408
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.18408
CLIP3 CAP-GLY domain containing linker protein 3 -2.18408
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.18408
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -2.18408
DEDD death effector domain containing -2.18408
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 -2.18408
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -2.18408
LMAN2L lectin, mannose-binding 2-like -2.18408
PZP pregnancy-zone protein -2.18408
KPTN kaptin (actin binding protein) -2.18408
FAM3A family with sequence similarity 3, member A -2.18408
ARHGAP33 Rho GTPase activating protein 33 -2.18408
SH2D2A SH2 domain containing 2A -2.18408
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.18408
PUSL1 pseudouridylate synthase-like 1 -2.18408
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.18408
PLAUR plasminogen activator, urokinase receptor -2.18408
SOX3 SRY (sex determining region Y)-box 3 -2.18408
AKT1S1 AKT1 substrate 1 (proline-rich) -2.18408
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.18408
MED25 mediator complex subunit 25 -2.18408
CARD10 caspase recruitment domain family, member 10 -2.18408
SMN1 survival of motor neuron 1, telomeric -2.18408
DNALI1 dynein, axonemal, light intermediate chain 1 -2.18408
SHARPIN SHANK-associated RH domain interactor -2.18408
TSLIG3C tRNA splicing ligase complex subunit 3C -2.18408
ANKAR ankyrin and armadillo repeat containing -2.18408
ZC3H14 zinc finger CCCH-type containing 14 -2.18408
GAL3ST3 galactose-3-O-sulfotransferase 3 -2.18408
TMEM109 transmembrane protein 109 -2.18408
TMCC2 transmembrane and coiled-coil domain family 2 -2.18408
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.18408
HYLS1 hydrolethalus syndrome 1 -2.18408
ACADVL acyl-CoA dehydrogenase, very long chain -2.18408
USP19 ubiquitin specific peptidase 19 -2.18408
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 -2.18408
CNRIP1 cannabinoid receptor interacting protein 1 -2.18408
ZNF674 zinc finger protein 674 -2.18408
ERCC6 excision repair cross-complementation group 6 -2.18408
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -2.18408
COL9A3 collagen, type IX, alpha 3 -2.18408
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.18408
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -2.18408
TIPE1 TNF alpha induced protein 8 like 1 -2.18408
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.18408
ZNF142 zinc finger protein 142 -2.18408
DDRGK1 DDRGK domain containing 1 -2.18408
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.18408
CDH13 cadherin 13 -2.18408
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -2.18408
SCRN2 secernin 2 -2.18408
ERMAP erythroblast membrane-associated protein (Scianna blood group) -2.18408
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.18408
DNASE1L1 deoxyribonuclease I-like 1 -2.18408
RCE1 Ras converting CAAX endopeptidase 1 -2.18408
IGSF9 immunoglobulin superfamily, member 9 -2.18408
GPC4 glypican 4 -2.18408
DNAH9 dynein, axonemal, heavy chain 9 -2.18408
ZNF114 zinc finger protein 114 -2.18408
ACSS2 acyl-CoA synthetase short-chain family member 2 -2.18408
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.18408
TP53I3 tumor protein p53 inducible protein 3 -2.18408
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 -2.18408
TBL3 transducin (beta)-like 3 -2.18408
KAT2A K(lysine) acetyltransferase 2A -2.18408
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.18408
UPK1A uroplakin 1A -2.18408
FBRS fibrosin -2.18408
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.18408
ART5 ADP-ribosyltransferase 5 -2.18408
LXN latexin -2.18408
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.18408
EPHB6 EPH receptor B6 -2.18408
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.18408
ANGEL1 angel homolog 1 (Drosophila) -2.18408
INMT indolethylamine N-methyltransferase -2.18408
MAN2B1 mannosidase, alpha, class 2B, member 1 -2.18408
TTPAL tocopherol (alpha) transfer protein-like -2.18408
SPATA18 spermatogenesis associated 18 -2.18408
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.18408
SHANK3 SH3 and multiple ankyrin repeat domains 3 -2.18408
SZT2 seizure threshold 2 homolog (mouse) -2.18408
SPHK2 sphingosine kinase 2 -2.17837
NPY1R neuropeptide Y receptor Y1 -2.17837
MOCS1 molybdenum cofactor synthesis 1 -2.17837
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.17837
TMEM9B TMEM9 domain family, member B -2.17837
TMEM53 transmembrane protein 53 -2.17837
EIF4A1 eukaryotic translation initiation factor 4A1 -2.16972
SNRPA small nuclear ribonucleoprotein polypeptide A -2.15521
NT5DC1 5'-nucleotidase domain containing 1 -2.12313
RPL29 ribosomal protein L29 -2.12313
RPL27 ribosomal protein L27 -2.12313
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -2.12313
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.12313
UGDH UDP-glucose 6-dehydrogenase -2.12313
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.12313
EEF1AKMT1 EEF1A lysine methyltransferase 1 -2.12313
ELP6 elongator acetyltransferase complex subunit 6 -2.12313
IQGAP2 IQ motif containing GTPase activating protein 2 -2.12313
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.12313
TGS1 trimethylguanosine synthase 1 -2.12313
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -2.12313
POU5F1B POU class 5 homeobox 1B -2.12313
USP10 ubiquitin specific peptidase 10 -2.12313
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) -2.12313
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -2.12313
PNKP polynucleotide kinase 3'-phosphatase -2.12313
RCC2 regulator of chromosome condensation 2 -2.12313
JUND jun D proto-oncogene -2.12313
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.12313
PCDH1 protocadherin 1 -2.12313
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.12313
CLCN5 chloride channel, voltage-sensitive 5 -2.12313
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.12313
LCOR ligand dependent nuclear receptor corepressor -2.12313
FZD7 frizzled class receptor 7 -2.12313
TMX2 thioredoxin-related transmembrane protein 2 -2.12313
SEC11A SEC11 homolog A (S. cerevisiae) -2.12313
BOD1 biorientation of chromosomes in cell division 1 -2.12313
PFDN1 prefoldin subunit 1 -2.12313
TUBD1 tubulin, delta 1 -2.12313
RAD21 RAD21 homolog (S. pombe) -2.12313
SRSF5 serine/arginine-rich splicing factor 5 -2.12313
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.12313
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.12313
CFL1 cofilin 1 (non-muscle) -2.12313
ESD esterase D -2.12313
TIGD5 tigger transposable element derived 5 -2.12313
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.12313
UBQLN4 ubiquilin 4 -2.12313
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.12313
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.12313
CEP78 centrosomal protein 78kDa -2.12194
MRPL27 mitochondrial ribosomal protein L27 -2.11922
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.11143
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.09956
EDF1 endothelial differentiation-related factor 1 -2.09875
FAM133B family with sequence similarity 133, member B -2.08791
ZNF732 zinc finger protein 732 -2.0804
CCNG2 cyclin G2 -2.07858
KYAT3 kynurenine aminotransferase 3 -2.07858
SNRPG small nuclear ribonucleoprotein polypeptide G -2.07753
HCFC1 host cell factor C1 -2.06561
SMIM19 small integral membrane protein 19 -2.04809
CWC22 CWC22 spliceosome-associated protein -2.0336
TMEM39A transmembrane protein 39A -2.0336
HDAC7 histone deacetylase 7 -2.03251
ZIC3 Zic family member 3 -2.02858
SFT2D3 SFT2 domain containing 3 -2.02671
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.02428
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) -2.02428
LZIC leucine zipper and CTNNBIP1 domain containing -2.02407
RPSA2 ribosomal protein SA 2 -2.02062
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.01774
RAB4B RAB4B, member RAS oncogene family -2.01284
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -2.01284
PCYOX1 prenylcysteine oxidase 1 -2.01284
MORN4 MORN repeat containing 4 -2.01284
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.009
PHB1 prohibitin 1 -2.00513
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.00485
MT1G metallothionein 1G -2.00141