TIMP2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description TIMP metallopeptidase inhibitor 2|This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7077)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_TIMP2
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Genes

45 co-expressed genes for TIMP2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
ALPP alkaline phosphatase, placental
CAPN6 calpain 6
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CRH corticotropin releasing hormone
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EBI3 Epstein-Barr virus induced 3
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
ENDOU endonuclease, polyU-specific
FBN2 fibrillin 2
GCM1 glial cells missing homolog 1 (Drosophila)
GDF15 growth differentiation factor 15
GH2 growth hormone 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IGFBP1 insulin-like growth factor binding protein 1
INSL4 insulin-like 4 (placenta)
KISS1 KiSS-1 metastasis-suppressor
LEP leptin
LGALS14 lectin, galactoside-binding, soluble, 14
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP11 matrix metallopeptidase 11
PAGE4 P antigen family, member 4 (prostate associated)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PLAC1 placenta-specific 1
PSG1 pregnancy specific beta-1-glycoprotein 1
PSG2 pregnancy specific beta-1-glycoprotein 2
PSG3 pregnancy specific beta-1-glycoprotein 3
PSG4 pregnancy specific beta-1-glycoprotein 4
PSG5 pregnancy specific beta-1-glycoprotein 5
PSG6 pregnancy specific beta-1-glycoprotein 6
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PSG9 pregnancy specific beta-1-glycoprotein 9
RHOBTB1 Rho-related BTB domain containing 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP2 TIMP metallopeptidase inhibitor 2
VGLL1 vestigial-like family member 1