| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-interleukin 1 receptor (TIR) domain containing adaptor protein|The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 114609) |
| External Link | https://ncbi.nlm.nih.gov/gene/114609 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the TIRAP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SIRT3 | sirtuin 3 | 0.0184521 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0162371 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0156686 |
| CHKB | choline kinase beta | 0.0130411 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0122683 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0120692 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0119103 |
| EPHB2 | EPH receptor B2 | 0.0116922 |
| FASN | fatty acid synthase | 0.0114385 |
| MAGEA3 | melanoma antigen family A3 | 0.0106812 |
| AURKB | aurora kinase B | 0.0103874 |
| NELL2 | NEL-like 2 (chicken) | 0.0103492 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00985099 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00946588 |
| SYNGR3 | synaptogyrin 3 | 0.00921616 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.00910638 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00909122 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00901337 |
| ADI1 | acireductone dioxygenase 1 | 0.00898368 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00880299 |
| INSIG1 | insulin induced gene 1 | 0.00873805 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00868533 |
| CCNA2 | cyclin A2 | 0.00853769 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00838816 |
| PRDX2 | peroxiredoxin 2 | 0.0083573 |
| PGD | phosphogluconate dehydrogenase | 0.00831594 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00802521 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.00801731 |
| CCNB1 | cyclin B1 | 0.00792378 |
| ELN | elastin | 0.00777973 |
| MXRA7 | matrix-remodelling associated 7 | 0.00773879 |
| OLFM4 | olfactomedin 4 | 0.00768824 |
| RPS5 | ribosomal protein S5 | 0.00759664 |
| HAMP | hepcidin antimicrobial peptide | 0.00749336 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00749245 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.00746938 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00745507 |
| FBLN1 | fibulin 1 | 0.00742842 |
| THYN1 | thymocyte nuclear protein 1 | 0.00739449 |
| PRKCA | protein kinase C, alpha | 0.00731506 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 0.00730593 |
| GLUL | glutamate-ammonia ligase | 0.00724734 |
| RANBP1 | RAN binding protein 1 | 0.00724674 |
| NMU | neuromedin U | 0.00724102 |
| ANXA6 | annexin A6 | 0.00723834 |
| CDCA4 | cell division cycle associated 4 | 0.00721756 |
| CCNF | cyclin F | 0.00718374 |
| SORD | sorbitol dehydrogenase | 0.0071305 |
| TMEM50B | transmembrane protein 50B | 0.00708616 |
| ACOT7 | acyl-CoA thioesterase 7 | 0.00707814 |
| RPA3 | replication protein A3, 14kDa | 0.00703394 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.00702936 |
| CD9 | CD9 molecule | 0.00698512 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00691464 |
| HMGB1 | high mobility group box 1 | 0.00690259 |
| FLOT2 | flotillin 2 | 0.00687686 |
| KIF20A | kinesin family member 20A | 0.00686161 |
| MMP12 | matrix metallopeptidase 12 | 0.00683409 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00680499 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00679213 |
| CBS | cystathionine-beta-synthase | 0.00672593 |
| HMBS | hydroxymethylbilane synthase | 0.0067216 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00671438 |
| HMGB3 | high mobility group box 3 | 0.00669912 |
| TRMT5 | tRNA methyltransferase 5 | 0.00665889 |
| PCP4 | Purkinje cell protein 4 | 0.00664492 |
| CNN2 | calponin 2 | 0.00662038 |
| TBCD | tubulin folding cofactor D | 0.00660638 |
| NDRG3 | NDRG family member 3 | 0.00660582 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | 0.00660137 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00659912 |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 0.00659542 |
| ADK | adenosine kinase | 0.00658451 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.00658417 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00658397 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.00658348 |
| RXRA | retinoid X receptor, alpha | 0.00655477 |
| BGN | biglycan | 0.00654684 |
| FABP1 | fatty acid binding protein 1, liver | 0.00653131 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00652599 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 0.00652486 |
| RTL8C | retrotransposon Gag like 8C | 0.00647587 |
| LMNB1 | lamin B1 | 0.0064717 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00646591 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.00645075 |
| HYOU1 | hypoxia up-regulated 1 | 0.0064465 |
| SNX7 | sorting nexin 7 | 0.00644162 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.0064409 |
| TPX2 | TPX2, microtubule-associated | 0.00640573 |
| SPAG5 | sperm associated antigen 5 | 0.00637621 |
| TPI1 | triosephosphate isomerase 1 | 0.00633347 |
| ACACA | acetyl-CoA carboxylase alpha | 0.00632899 |
| ACO1 | aconitase 1, soluble | 0.0063287 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.00632751 |
| SNRNP40 | small nuclear ribonucleoprotein 40kDa (U5) | 0.00631352 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00628399 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00627897 |
| CDC45 | cell division cycle 45 | 0.00625506 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00624401 |
| CCDC85B | coiled-coil domain containing 85B | 0.00623448 |
| COL6A2 | collagen, type VI, alpha 2 | 0.00620449 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00619681 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 0.00619263 |
| CDCA3 | cell division cycle associated 3 | 0.00617443 |
| TRIP13 | thyroid hormone receptor interactor 13 | 0.00614279 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.00614037 |
| PLTP | phospholipid transfer protein | 0.00613952 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.00612791 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00610841 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 0.00609987 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00608114 |
| OIP5 | Opa interacting protein 5 | 0.00605854 |
| HK1 | hexokinase 1 | 0.00604698 |
| ESD | esterase D | 0.00602202 |
| SPRR1A | small proline-rich protein 1A | 0.0060174 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00601186 |
| HPF1 | histone PARylation factor 1 | 0.00600321 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.005984 |
| HAL | histidine ammonia-lyase | 0.00597553 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.00596125 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.00595144 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00593424 |
| DCK | deoxycytidine kinase | 0.00591795 |
| KIF1B | kinesin family member 1B | 0.00591356 |
| GCHFR | GTP cyclohydrolase I feedback regulator | 0.00591096 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00588819 |
| DONSON | downstream neighbor of SON | 0.0058815 |
| CRLF1 | cytokine receptor-like factor 1 | 0.0058657 |
| ENO1 | enolase 1, (alpha) | 0.00586497 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.00584873 |
| LBR | lamin B receptor | 0.00584178 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00580292 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | 0.00579823 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.00578647 |
| CPOX | coproporphyrinogen oxidase | 0.00578542 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.00577354 |
| RHOB | ras homolog family member B | 0.00576174 |
| PLBD1 | phospholipase B domain containing 1 | 0.00575984 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00574576 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 0.00573106 |
| KIF18B | kinesin family member 18B | 0.00572301 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.0057195 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 0.00570525 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 0.0056946 |
| MEX3D | mex-3 RNA binding family member D | 0.00568985 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00568791 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00568328 |
| DBF4 | DBF4 zinc finger | 0.00567818 |
| CTSB | cathepsin B | 0.00567167 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00565693 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | 0.00565615 |
| CLCA1 | chloride channel accessory 1 | 0.00565025 |
| COL5A1 | collagen, type V, alpha 1 | 0.00564895 |
| DDHD2 | DDHD domain containing 2 | 0.00564517 |
| MFAP4 | microfibrillar-associated protein 4 | 0.00563927 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00563586 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.00562213 |
| PKM | pyruvate kinase, muscle | 0.00561444 |
| GPSM2 | G-protein signaling modulator 2 | 0.00561145 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.00559176 |
| MAGEA12 | melanoma antigen family A12 | 0.00557055 |
| XPO7 | exportin 7 | 0.00557052 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00556865 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.00555675 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.00555167 |
| MXRA8 | matrix-remodelling associated 8 | 0.00555156 |
| ACTL6A | actin-like 6A | 0.0055474 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.00552566 |
| CENPX | centromere protein X | 0.00551737 |
| CD99 | CD99 molecule | 0.00550801 |
| COL6A1 | collagen, type VI, alpha 1 | 0.00550077 |
| TTR | transthyretin | 0.00548944 |
| PIMREG | PICALM interacting mitotic regulator | 0.00548032 |
| GSTT1 | glutathione S-transferase theta 1 | 0.00547915 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.00544244 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 0.00542068 |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.00540002 |
| CHMP6 | charged multivesicular body protein 6 | 0.00538744 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00537698 |
| MMP9 | matrix metallopeptidase 9 | 0.00535305 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00535268 |
| PENK | proenkephalin | 0.00535218 |
| PLK1 | polo-like kinase 1 | 0.00534424 |
| MAPK1 | mitogen-activated protein kinase 1 | 0.00534345 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.00530978 |
| SPRR2B | small proline-rich protein 2B | 0.00530623 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | 0.00529796 |
| FXYD1 | FXYD domain containing ion transport regulator 1 | 0.00528533 |
| HPR | haptoglobin-related protein | 0.00527212 |
| TCF4 | transcription factor 4 | 0.00526123 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.00525082 |
| GANAB | glucosidase, alpha; neutral AB | 0.00524784 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00524223 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | 0.0052303 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00522694 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00522558 |
| TMPO | thymopoietin | 0.00522437 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.00521882 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00521083 |
| PFKL | phosphofructokinase, liver | 0.00521072 |
| BORA | bora, aurora kinase A activator | 0.0052056 |
| WASF2 | WAS protein family, member 2 | 0.00520556 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.00519464 |
| CST3 | cystatin C | 0.00519062 |
| FST | follistatin | 0.00518942 |
| KRT16 | keratin 16, type I | 0.00518629 |
| KIF18A | kinesin family member 18A | 0.00517905 |
| NEK2 | NIMA-related kinase 2 | 0.00517451 |
| SLC2A4RG | SLC2A4 regulator | 0.00517335 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0051549 |
| CENPF | centromere protein F, 350/400kDa | 0.00515109 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.00514824 |
| NAGA | N-acetylgalactosaminidase, alpha- | 0.005144 |
| FZD2 | frizzled class receptor 2 | 0.00514057 |
| PER3 | period circadian clock 3 | 0.00513032 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 0.00511843 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00511407 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | 0.00511197 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00510064 |
| FAM162A | family with sequence similarity 162, member A | 0.00509237 |
| RAPSN | receptor-associated protein of the synapse | 0.0050886 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.0050885 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00508464 |
| THAP7 | THAP domain containing 7 | 0.0050823 |
| TARDBP | TAR DNA binding protein | 0.00507779 |
| ILK | integrin-linked kinase | 0.00507187 |
| DEK | DEK proto-oncogene | 0.00506303 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.00503472 |
| RIOX2 | ribosomal oxygenase 2 | 0.00503042 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 0.00502542 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.00501723 |
| TMEM41B | transmembrane protein 41B | 0.00500535 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00499974 |
| EXOSC4 | exosome component 4 | 0.00499789 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00499456 |
| ORM1 | orosomucoid 1 | 0.00498878 |
| AURKA | aurora kinase A | 0.004984 |
| SV2A | synaptic vesicle glycoprotein 2A | 0.00497586 |
| TK1 | thymidine kinase 1, soluble | 0.00497476 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00496901 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.00495963 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00495733 |
| DBP | D site of albumin promoter (albumin D-box) binding protein | 0.00495687 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 0.00495508 |
| PRODH | proline dehydrogenase (oxidase) 1 | 0.00495335 |
| ZBTB5 | zinc finger and BTB domain containing 5 | 0.00495157 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.00494597 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0049451 |
| CIT | citron rho-interacting serine/threonine kinase | 0.00492918 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | -0.0195455 |
| MAP7 | microtubule-associated protein 7 | -0.0168472 |
| CRYAB | crystallin, alpha B | -0.015567 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.014422 |
| PROM1 | prominin 1 | -0.0137691 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0137684 |
| MX1 | MX dynamin-like GTPase 1 | -0.0131111 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.0129147 |
| KRT7 | keratin 7, type II | -0.0128364 |
| ATF3 | activating transcription factor 3 | -0.0125858 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0119815 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.0119144 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0119114 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.0118927 |
| CPM | carboxypeptidase M | -0.0118062 |
| IFI44L | interferon-induced protein 44-like | -0.0117009 |
| APOD | apolipoprotein D | -0.0115797 |
| CLIC5 | chloride intracellular channel 5 | -0.011304 |
| DUSP5 | dual specificity phosphatase 5 | -0.0112711 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.011201 |
| HSPB8 | heat shock 22kDa protein 8 | -0.0111407 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.0109856 |
| MFAP5 | microfibrillar associated protein 5 | -0.0109189 |
| IER5 | immediate early response 5 | -0.01081 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.0107965 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0106703 |
| RND3 | Rho family GTPase 3 | -0.0104264 |
| CTSD | cathepsin D | -0.0104153 |
| TSPYL5 | TSPY-like 5 | -0.0103835 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0103669 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0101731 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | -0.0101393 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0101201 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0100622 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0100195 |
| MGLL | monoglyceride lipase | -0.010001 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00992658 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00988808 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.0098201 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00980568 |
| AHR | aryl hydrocarbon receptor | -0.00980357 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00978918 |
| INAVA | innate immunity activator | -0.00971416 |
| MVP | major vault protein | -0.00969835 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.009677 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00957635 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00954171 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00952878 |
| NRCAM | neuronal cell adhesion molecule | -0.0094756 |
| PEG10 | paternally expressed 10 | -0.00935746 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00933665 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00932836 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00931294 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00930631 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00921085 |
| LXN | latexin | -0.00917381 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00901477 |
| ZNF91 | zinc finger protein 91 | -0.0088234 |
| CCN3 | cellular communication network factor 3 | -0.00881598 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00880994 |
| KLF6 | Kruppel-like factor 6 | -0.008777 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | -0.00875694 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00871709 |
| PERP | PERP, TP53 apoptosis effector | -0.00867078 |
| TGFA | transforming growth factor, alpha | -0.00863185 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00859686 |
| PUF60 | poly-U binding splicing factor 60KDa | -0.00855703 |
| MYO6 | myosin VI | -0.00855417 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00853048 |
| JMJD1C | jumonji domain containing 1C | -0.00852546 |
| PRSS23 | protease, serine, 23 | -0.00847704 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00845671 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00842988 |
| PLXNC1 | plexin C1 | -0.00838722 |
| MAMLD1 | mastermind-like domain containing 1 | -0.00837325 |
| PLIN2 | perilipin 2 | -0.00836261 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00835951 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00825214 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00820928 |
| DST | dystonin | -0.00817627 |
| GAS1 | growth arrest-specific 1 | -0.00817122 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00815893 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00814012 |
| KRT23 | keratin 23, type I | -0.00812547 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00811035 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00807326 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00805866 |
| IFI44 | interferon-induced protein 44 | -0.00805037 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00801202 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00800321 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00798174 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.00792398 |
| PLK2 | polo-like kinase 2 | -0.00791877 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00785348 |
| IL1R1 | interleukin 1 receptor, type I | -0.00782305 |
| BTG2 | BTG family, member 2 | -0.00780717 |
| PDZK1 | PDZ domain containing 1 | -0.00779311 |
| EMX2 | empty spiracles homeobox 2 | -0.00776443 |
| RRAGD | Ras-related GTP binding D | -0.00761438 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0076037 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00759348 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00754628 |
| MX2 | MX dynamin-like GTPase 2 | -0.00754473 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00752329 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00750148 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00750035 |
| DPP4 | dipeptidyl-peptidase 4 | -0.00748183 |
| HMOX1 | heme oxygenase 1 | -0.00746726 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00745608 |
| IPO13 | importin 13 | -0.00741958 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00740392 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.00738248 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00737058 |
| LRRC1 | leucine rich repeat containing 1 | -0.00736408 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0073549 |
| VLDLR | very low density lipoprotein receptor | -0.00734921 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.00733928 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -0.00733095 |
| WT1 | Wilms tumor 1 | -0.00732263 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00730115 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0072895 |
| TUFT1 | tuftelin 1 | -0.00728869 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00728829 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.0072684 |
| HOMER3 | homer scaffolding protein 3 | -0.00724553 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.00723563 |
| AREG | amphiregulin | -0.00722952 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00718183 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.00717969 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00715544 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.0071548 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.00711773 |
| RNF103 | ring finger protein 103 | -0.00711102 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00709129 |
| FHL2 | four and a half LIM domains 2 | -0.00707449 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00707273 |
| LAT2 | linker for activation of T cells family, member 2 | -0.00706796 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -0.00704747 |
| GPX3 | glutathione peroxidase 3 | -0.00701841 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00700692 |
| TFEC | transcription factor EC | -0.00699039 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00699018 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00698198 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00693683 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.00693638 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0069145 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.00690456 |
| CA2 | carbonic anhydrase II | -0.00685826 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0068582 |
| ABLIM1 | actin binding LIM protein 1 | -0.00685741 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0068207 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00680743 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.00679036 |
| OXTR | oxytocin receptor | -0.00676632 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00676416 |
| CHRDL1 | chordin-like 1 | -0.00674109 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00674034 |
| STK26 | serine/threonine protein kinase 26 | -0.00672509 |
| HNMT | histamine N-methyltransferase | -0.00670653 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.00669869 |
| IRS2 | insulin receptor substrate 2 | -0.00669849 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00669612 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00669517 |
| THBS1 | thrombospondin 1 | -0.00669475 |
| STK10 | serine/threonine kinase 10 | -0.00669109 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00667448 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00666873 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00665967 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00662018 |
| RET | ret proto-oncogene | -0.00660194 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00659862 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | -0.00659783 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00659634 |
| AOX1 | aldehyde oxidase 1 | -0.00658938 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00657373 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00656352 |
| PITX3 | paired-like homeodomain 3 | -0.00656295 |
| CLDN8 | claudin 8 | -0.00656212 |
| CCN2 | cellular communication network factor 2 | -0.00655367 |
| PTEN | phosphatase and tensin homolog | -0.00654911 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.00654192 |
| DUSP4 | dual specificity phosphatase 4 | -0.00654127 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00654116 |
| IQCK | IQ motif containing K | -0.00649932 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0064939 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.0064863 |
| OPN3 | opsin 3 | -0.00648199 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00647813 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.00645462 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00644928 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00644752 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00644564 |
| INSR | insulin receptor | -0.00644346 |
| KRT8 | keratin 8, type II | -0.00643876 |
| NVL | nuclear VCP-like | -0.00642029 |
| HIST1H2AE | histone cluster 1, H2ae | -0.00638057 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00634831 |
| RRAD | Ras-related associated with diabetes | -0.00634655 |
| ANXA1 | annexin A1 | -0.00632955 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00632344 |
| BEX4 | brain expressed, X-linked 4 | -0.00630281 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00629669 |
| RUNX3 | runt-related transcription factor 3 | -0.00629236 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -0.00629182 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.00628008 |
| IL6R | interleukin 6 receptor | -0.00627674 |
| COBL | cordon-bleu WH2 repeat protein | -0.00627253 |
| PIP | prolactin-induced protein | -0.00626871 |
| PKP2 | plakophilin 2 | -0.00626152 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00625997 |
| BICC1 | BicC family RNA binding protein 1 | -0.00625857 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00625656 |
| CST1 | cystatin SN | -0.00625531 |
| HECA | headcase homolog (Drosophila) | -0.00624563 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00624532 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00624403 |
| RRAGC | Ras-related GTP binding C | -0.00624318 |
| EPCAM | epithelial cell adhesion molecule | -0.00623847 |
| C3 | complement component 3 | -0.0062318 |
| TPD52L1 | tumor protein D52-like 1 | -0.00622418 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00621821 |
| CCNG2 | cyclin G2 | -0.0062005 |
| IL15 | interleukin 15 | -0.00619632 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00617077 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00615754 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00612734 |
| NOTCH2NL | notch 2 N-terminal like | -0.00611521 |
| JAK1 | Janus kinase 1 | -0.00610796 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00610584 |
| KRT81 | keratin 81, type II | -0.00610192 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | -0.0061015 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00608681 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00608245 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00607986 |
| CSTA | cystatin A (stefin A) | -0.00607358 |
| S100A14 | S100 calcium binding protein A14 | -0.00607234 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.00607221 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00607188 |
| TDRD7 | tudor domain containing 7 | -0.006064 |
| NME5 | NME/NM23 family member 5 | -0.00606272 |
| PYCARD | PYD and CARD domain containing | -0.00605562 |
| NPR3 | natriuretic peptide receptor 3 | -0.00603914 |
| KLK5 | kallikrein-related peptidase 5 | -0.00603028 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00602906 |
| OLFML2A | olfactomedin-like 2A | -0.00601825 |
| FGF13 | fibroblast growth factor 13 | -0.00601027 |
| YBX3 | Y box binding protein 3 | -0.00600071 |
| MCAM | melanoma cell adhesion molecule | -0.00599977 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00599832 |
