TIRAP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description toll-interleukin 1 receptor (TIR) domain containing adaptor protein|The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 114609)
External Link http://www.ncbi.nlm.nih.gov/gene/114609
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Genes

62 interacting proteins for TIRAP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC47 coiled-coil domain containing 47
CD14 CD14 molecule
CD247 CD247 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHUK conserved helix-loop-helix ubiquitous kinase
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL33R interleukin 33 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
JAK1 Janus kinase 1
KAT2A K(lysine) acetyltransferase 2A
LRRK1 leucine-rich repeat kinase 1
LTN1 listerin E3 ubiquitin protein ligase 1
LY96 lymphocyte antigen 96
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYD88 myeloid differentiation primary response 88
NF1 neurofibromin 1
PCNA proliferating cell nuclear antigen
PDS5A PDS5 cohesin associated factor A
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PTEN phosphatase and tensin homolog
RNF216 ring finger protein 216
RPTOR regulatory associated protein of MTOR, complex 1
SAMHD1 SAM domain and HD domain 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SOCS1 suppressor of cytokine signaling 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAM1 translocation associated membrane protein 1
UBC ubiquitin C
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2