TLE2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transducin-like enhancer of split 2| (NCBI Entrez Gene Database, 7089)
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Genes

356 genes differentially expressed following the TLE2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LIPJ lipase, family member J 3.33306
CABP4 calcium binding protein 4 3.33306
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.33306
MAGEA2 melanoma antigen family A2 3.33306
DNASE1L2 deoxyribonuclease I-like 2 3.33306
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.33306
SIGLEC7 sialic acid binding Ig-like lectin 7 3.33306
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.33306
SFXN3 sideroflexin 3 3.33306
GYPB glycophorin B (MNS blood group) 3.33306
KCNRG potassium channel regulator 3.33306
PRICKLE4 prickle homolog 4 (Drosophila) 3.33306
IGFL3 IGF-like family member 3 3.33306
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.33306
FPR2 formyl peptide receptor 2 3.33306
RNF151 ring finger protein 151 3.33306
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.33306
COL7A1 collagen, type VII, alpha 1 3.33306
RNF17 ring finger protein 17 3.33306
SOX7 SRY (sex determining region Y)-box 7 3.33306
TXLNB taxilin beta 3.33306
LRRD1 leucine-rich repeats and death domain containing 1 3.33306
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.33306
GCKR glucokinase (hexokinase 4) regulator 3.33306
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.33306
C1ORF146 chromosome 1 open reading frame 146 3.33306
FGF7 fibroblast growth factor 7 3.33306
KRTAP4-1 keratin associated protein 4-1 3.33306
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 3.33306
GRM6 glutamate receptor, metabotropic 6 3.33306
NRSN1 neurensin 1 3.33306
NPR3 natriuretic peptide receptor 3 3.33306
CD33 CD33 molecule 3.33306
ABRA actin binding Rho activating protein 3.33306
GHRH growth hormone releasing hormone 3.33306
DCST1 DC-STAMP domain containing 1 3.33306
PMCH pro-melanin-concentrating hormone 3.33306
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.33306
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.33306
LCN15 lipocalin 15 3.33306
UVRAG UV radiation resistance associated 3.33306
GMNC geminin coiled-coil domain containing 3.33306
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.33306
TBATA thymus, brain and testes associated 3.33306
KRT77 keratin 77, type II 3.33306
OXT oxytocin/neurophysin I prepropeptide 3.33306
LDHC lactate dehydrogenase C 3.33306
SERTM1 serine-rich and transmembrane domain containing 1 3.33306
ASCL2 achaete-scute family bHLH transcription factor 2 3.33306
SAXO5 stabilizer of axonemal microtubules 5 3.33306
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.33306
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.33306
ALDOB aldolase B, fructose-bisphosphate 3.33306
OTOF otoferlin 3.33306
GBP4 guanylate binding protein 4 3.33306
UNC93A unc-93 homolog A (C. elegans) 3.33306
GPR35 G protein-coupled receptor 35 3.33306
SPRR2A small proline-rich protein 2A 3.33306
PDF peptide deformylase (mitochondrial) 3.33306
SMPX small muscle protein, X-linked 3.33306
PNMA8B PNMA family member 8B 3.33306
ALPG alkaline phosphatase, germ cell 3.33306
CIMIP1 ciliary microtubule inner protein 1 3.33306
C1ORF232 chromosome 1 open reading frame 230 3.33306
H4C12 H4 clustered histone 12 3.33306
SERTM2 serine rich and transmembrane domain containing 2 3.33306
MEIOSIN meiosis initiator 3.33306
GARIN6 golgi associated RAB2 interactor family member 6 3.33306
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.33306
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.33306
ERFE erythroferrone 3.33306
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.33306
FOXC1 forkhead box C1 3.33306
GC group-specific component (vitamin D binding protein) 3.33306
RAB36 RAB36, member RAS oncogene family 3.33306
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.33306
S100B S100 calcium binding protein B 3.33306
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.33306
DMBX1 diencephalon/mesencephalon homeobox 1 3.33306
SIM2 single-minded family bHLH transcription factor 2 3.33306
LOC124901449 uncharacterized LOC124901449 3.33306
MAL mal, T-cell differentiation protein 3.33306
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.33306
CLDN2 claudin 2 3.33306
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.33306
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.33306
CNTFR ciliary neurotrophic factor receptor 3.33306
PCP4L1 Purkinje cell protein 4 like 1 3.33306
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 3.33306
FAM228A family with sequence similarity 228, member A 3.33306
SMCP sperm mitochondria-associated cysteine-rich protein 3.33306
ASIC4 acid sensing (proton gated) ion channel family member 4 3.33306
FGFBP1 fibroblast growth factor binding protein 1 3.33306
STARD6 StAR-related lipid transfer (START) domain containing 6 3.33306
OPN5 opsin 5 3.33306
IL1RN interleukin 1 receptor antagonist 3.33306
RGS22 regulator of G-protein signaling 22 3.33306
PCDHA3 protocadherin alpha 3 3.33306
BRDT bromodomain, testis-specific 3.33306
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.33306
TRIM55 tripartite motif containing 55 3.33306
WNT7A wingless-type MMTV integration site family, member 7A 3.33306
LMOD2 leiomodin 2 (cardiac) 3.33306
VWA3A von Willebrand factor A domain containing 3A 3.33306
IL19 interleukin 19 3.33306
CNGB3 cyclic nucleotide gated channel beta 3 3.33306
PLA1A phospholipase A1 member A 3.33306
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.33306
PSKH2 protein serine kinase H2 3.33306
ADAM7 ADAM metallopeptidase domain 7 3.33306
GOLGA6B golgin A6 family, member B 3.33306
MRLN myoregulin 3.33306
C18ORF63 chromosome 18 open reading frame 63 3.33306
OTC ornithine carbamoyltransferase 3.33306
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.33306
BTNL3 butyrophilin-like 3 3.33306
C11ORF97 chromosome 11 open reading frame 97 3.33306
CXCR2 chemokine (C-X-C motif) receptor 2 3.33306
GLOD5 glyoxalase domain containing 5 3.33306
F11 coagulation factor XI 3.33306
EGR4 early growth response 4 3.33306
EPHA10 EPH receptor A10 3.33306
CHIT1 chitinase 1 (chitotriosidase) 3.33306
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.33306
SH2D1A SH2 domain containing 1A 3.33306
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.33306
C11ORF42 chromosome 11 open reading frame 42 3.33306
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.33306
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.33306
GOLGA8M golgin A8 family, member M 3.33306
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.33306
ART1 ADP-ribosyltransferase 1 3.33306
RGS8 regulator of G-protein signaling 8 3.33306
SOSTDC1 sclerostin domain containing 1 3.33306
CA5A carbonic anhydrase VA, mitochondrial 3.33306
C8G complement component 8, gamma polypeptide 3.33306
ITGA11 integrin, alpha 11 3.33306
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.33306
TG thyroglobulin 3.33306
PLA2G12B phospholipase A2, group XIIB 3.33306
GSTA5 glutathione S-transferase alpha 5 3.33306
TP63 tumor protein p63 3.33306
PENK proenkephalin 3.33306
CTSW cathepsin W 3.33306
TNR tenascin R 3.33306
EREG epiregulin 3.33306
PRSS50 protease, serine, 50 3.33306
CASS4 Cas scaffolding protein family member 4 3.33306
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.33306
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.33306
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.33306
MMP3 matrix metallopeptidase 3 3.33306
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.33306
LST1 leukocyte specific transcript 1 3.33306
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.33306
CARD6 caspase recruitment domain family, member 6 3.33306
STMND1 stathmin domain containing 1 3.33306
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.33306
ECM1 extracellular matrix protein 1 3.33306
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.33306
GRAPL GRB2-related adaptor protein-like 3.33306
EPO erythropoietin 3.33306
NNMT nicotinamide N-methyltransferase 3.33306
MSLN mesothelin 3.33306
POPDC2 popeye domain containing 2 3.33306
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.33306
GPRC5A G protein-coupled receptor, class C, group 5, member A 3.33306
KIF4B kinesin family member 4B 3.33306
CASR calcium-sensing receptor 3.33306
APOF apolipoprotein F 3.33306
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.33306
PMP2 peripheral myelin protein 2 3.33306
SBDS Shwachman-Bodian-Diamond syndrome 3.27938
PHAF1 phagosome assembly factor 1 3.2746
CCDC183 coiled-coil domain containing 183 3.17115
CDHR2 cadherin-related family member 2 3.17115
EDN1 endothelin 1 3.17115
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 3.17115
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 2.99199
BDNF brain-derived neurotrophic factor 2.83456
FBXO33 F-box protein 33 2.81141
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.79222
DENND2A DENN/MADD domain containing 2A 2.78603
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.72195
SHISA2 shisa family member 2 2.67158
LATS2 large tumor suppressor kinase 2 2.65256
FCF1 FCF1 rRNA-processing protein 2.61731
RAB3D RAB3D, member RAS oncogene family 2.60754
TUBA8 tubulin, alpha 8 2.6036
MRPL18 mitochondrial ribosomal protein L18 2.5955
FRYL FRY-like 2.58044
METTL13 methyltransferase like 13 2.50286
IL10RA interleukin 10 receptor, alpha 2.49955
CXCR4 chemokine (C-X-C motif) receptor 4 2.49955
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.4692
PRADC1 protease-associated domain containing 1 2.44046
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.41296
TPRG1 tumor protein p63 regulated 1 2.4017
RANBP1 RAN binding protein 1 2.39551
FSD1L fibronectin type III and SPRY domain containing 1-like 2.38915
GAPVD1 GTPase activating protein and VPS9 domains 1 2.37555
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.36839
WDR89 WD repeat domain 89 2.34471
SDC2 syndecan 2 2.33162
GOLM2 golgi membrane protein 2 2.32437
KLHDC7A kelch domain containing 7A 2.32094
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 2.30119
STX2 syntaxin 2 2.2689
HSBP1L1 heat shock factor binding protein 1-like 1 2.26122
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.25277
CPNE4 copine IV 2.23138
PRRC2A proline-rich coiled-coil 2A 2.229
STAB2 stabilin 2 2.21482
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.19579
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.1716
MPLKIP M-phase specific PLK1 interacting protein 2.16743
WDR6 WD repeat domain 6 2.13029
PCDHB12 protocadherin beta 12 2.10084
DNAI2 dynein, axonemal, intermediate chain 2 2.10084
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.09058
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 2.06045
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.0552
USP46 ubiquitin specific peptidase 46 2.035
SMCO2 single-pass membrane protein with coiled-coil domains 2 2.03101
DGKE diacylglycerol kinase, epsilon 64kDa 2.03101
CARF calcium responsive transcription factor 2.03025
TMEM214 transmembrane protein 214 2.025
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.02173
TWSG1 twisted gastrulation BMP signaling modulator 1 2.01859
UNG uracil-DNA glycosylase 2.01606
GON4L gon-4-like (C. elegans) 2.00357

decreased expression

Symbol Name Standardized Value
SPNS2 spinster homolog 2 (Drosophila) -3.33306
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -3.33306
SMOC1 SPARC related modular calcium binding 1 -3.33306
TBX22 T-box 22 -3.33306
ISM2 isthmin 2 -3.33306
C17ORF100 chromosome 17 open reading frame 100 -3.33306
MT1M metallothionein 1M -3.33306
TBC1D28 TBC1 domain family, member 28 -3.33306
ARL5C ADP-ribosylation factor-like 5C -3.33306
ZBTB16 zinc finger and BTB domain containing 16 -3.33306
ZMYND15 zinc finger, MYND-type containing 15 -3.33306
ARF3 ADP-ribosylation factor 3 -3.33306
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.33306
DUSP26 dual specificity phosphatase 26 (putative) -3.33306
CYSRT1 cysteine-rich tail protein 1 -3.33306
GTF2IRD2B GTF2I repeat domain containing 2B -3.33306
RGPD1 RANBP2-like and GRIP domain containing 1 -3.33306
TTLL9 tubulin tyrosine ligase-like family member 9 -3.33306
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -3.33306
ABI3BP ABI family, member 3 (NESH) binding protein -3.33306
C1R complement component 1, r subcomponent -3.33306
GDNF glial cell derived neurotrophic factor -3.33306
DEGS2 delta(4)-desaturase, sphingolipid 2 -3.33306
TMEM151A transmembrane protein 151A -3.33306
REM2 RAS (RAD and GEM)-like GTP binding 2 -3.33306
PCDHB2 protocadherin beta 2 -3.33306
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -3.33306
SLC16A11 solute carrier family 16, member 11 -3.33306
SPINK6 serine peptidase inhibitor, Kazal type 6 -3.33306
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -3.33306
UCMA upper zone of growth plate and cartilage matrix associated -3.33306
HPD 4-hydroxyphenylpyruvate dioxygenase -3.33306
RNF207 ring finger protein 207 -3.33306
LRRC3 leucine rich repeat containing 3 -3.33306
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.33306
NPIPB7 nuclear pore complex interacting protein family, member B7 -3.33306
CARHSP1 calcium regulated heat stable protein 1, 24kDa -3.33306
LTB lymphotoxin beta (TNF superfamily, member 3) -3.33306
ADPRHL1 ADP-ribosylhydrolase like 1 -3.33306
DUSP8 dual specificity phosphatase 8 -3.33306
AMOTL2 angiomotin like 2 -3.33306
DUSP29 dual specificity phosphatase 29 -3.33306
FAIM2 Fas apoptotic inhibitory molecule 2 -3.33306
EXD1 exonuclease 3'-5' domain containing 1 -3.33306
VILL villin-like -3.33306
CFAP97D2 CFAP97 domain containing 2 -3.33306
TCEA3 transcription elongation factor A (SII), 3 -3.33306
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -3.33306
RBM44 RNA binding motif protein 44 -3.33306
BTNL8 butyrophilin-like 8 -3.33306
CCDC85A coiled-coil domain containing 85A -3.15269
IGFBP3 insulin-like growth factor binding protein 3 -3.15269
HUNK hormonally up-regulated Neu-associated kinase -3.07008
LRRN3 leucine rich repeat neuronal 3 -3.03751
CHP2 calcineurin-like EF-hand protein 2 -2.91936
WSB2 WD repeat and SOCS box containing 2 -2.91057
GPA33 glycoprotein A33 (transmembrane) -2.89531
ABHD12B abhydrolase domain containing 12B -2.85174
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.79824
CCL26 chemokine (C-C motif) ligand 26 -2.77718
YARS1 tyrosyl-tRNA synthetase 1 -2.77634
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.76254
ATP5MJ ATP synthase membrane subunit j -2.74341
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.71086
ZNHIT1 zinc finger, HIT-type containing 1 -2.67717
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -2.67323
PYY peptide YY -2.64422
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.6036
TRIM58 tripartite motif containing 58 -2.58476
TLR3 toll-like receptor 3 -2.58476
TRIM28 tripartite motif containing 28 -2.58283
SNX16 sorting nexin 16 -2.56859
MPZL3 myelin protein zero-like 3 -2.567
PRR19 proline rich 19 -2.52816
PRSS3 protease, serine, 3 -2.52816
SCTR secretin receptor -2.52816
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.52816
SLC71A2 solute carrier family 71 member 2 -2.41296
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.4017
LYPLAL1 lysophospholipase-like 1 -2.39903
CYSTM1 cysteine-rich transmembrane module containing 1 -2.36975
NT5DC1 5'-nucleotidase domain containing 1 -2.36839
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -2.36839
IFI6 interferon, alpha-inducible protein 6 -2.36839
ZNF641 zinc finger protein 641 -2.35424
ATAD2B ATPase family, AAA domain containing 2B -2.34973
NAGS N-acetylglutamate synthase -2.32237
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.32237
CNTN3 contactin 3 (plasmacytoma associated) -2.32237
CIRBP cold inducible RNA binding protein -2.28164
TSPAN15 tetraspanin 15 -2.27262
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.27221
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.2607
ZNF680 zinc finger protein 680 -2.2527
HAUS3 HAUS augmin-like complex, subunit 3 -2.2373
POU6F2 POU class 6 homeobox 2 -2.22531
CPLX2 complexin 2 -2.20598
PDS5A PDS5 cohesin associated factor A -2.18538
TMEM97 transmembrane protein 97 -2.18029
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.17883
WRAP53 WD repeat containing, antisense to TP53 -2.17453
BAG2 BCL2-associated athanogene 2 -2.17144
GPR3 G protein-coupled receptor 3 -2.16627
SP2 Sp2 transcription factor -2.16335
KRABD2 KRAB domain containing 2 -2.15961
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.15961
RORA RAR-related orphan receptor A -2.14516
ASB1 ankyrin repeat and SOCS box containing 1 -2.11853
SOD1 superoxide dismutase 1, soluble -2.09415
KLHL29 kelch-like family member 29 -2.09325
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -2.08881
CUX1 cut-like homeobox 1 -2.08605
MED23 mediator complex subunit 23 -2.0839
DOCK9 dedicator of cytokinesis 9 -2.07905
PAIP2B poly(A) binding protein interacting protein 2B -2.07028
ZNF569 zinc finger protein 569 -2.06953
TBC1D2 TBC1 domain family, member 2 -2.06657
DSP desmoplakin -2.06611
SCN5A sodium channel, voltage gated, type V alpha subunit -2.06332
MPV17L MPV17 mitochondrial membrane protein-like -2.05977
RAB3IP RAB3A interacting protein -2.04211
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.03025
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.025
SRP72 signal recognition particle 72kDa -2.025
TRAK1 trafficking protein, kinesin binding 1 -2.00357