| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-like receptor 1|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7096) |
| External Link | https://ncbi.nlm.nih.gov/gene/7096 |
| Similar Terms | |
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499 genes differentially expressed following the TLR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LTF | lactotransferrin | 0.0187923 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.015574 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.0151514 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0147013 |
| S100A8 | S100 calcium binding protein A8 | 0.0143492 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.0136743 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.0135623 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.0134495 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.0134296 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.0132007 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0129291 |
| PRF1 | perforin 1 (pore forming protein) | 0.0129107 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.0126416 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0124463 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0123024 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.0121406 |
| CST7 | cystatin F (leukocystatin) | 0.0115654 |
| LYZ | lysozyme | 0.0112025 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0108053 |
| TARP | TCR gamma alternate reading frame protein | 0.0107216 |
| MEIS2 | Meis homeobox 2 | 0.0106542 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.0106227 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0106015 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.0105787 |
| TRIB2 | tribbles pseudokinase 2 | 0.0104435 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.0104397 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0103393 |
| TLE4 | transducin-like enhancer of split 4 | 0.0103024 |
| SYNGR3 | synaptogyrin 3 | 0.0102066 |
| HBB | hemoglobin, beta | 0.0101465 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0100783 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00999811 |
| MT1X | metallothionein 1X | 0.0099821 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00971791 |
| NIPSNAP2 | nipsnap homolog 2 | 0.00971018 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00967819 |
| H1-0 | H1.0 linker histone | 0.00964191 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00957687 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00943383 |
| AK4 | adenylate kinase 4 | 0.00942398 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.00940872 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.0091897 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00915629 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00915135 |
| KIF20A | kinesin family member 20A | 0.00913104 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00909518 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00908724 |
| NRIP3 | nuclear receptor interacting protein 3 | 0.00908106 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 0.00902556 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00897634 |
| NPY | neuropeptide Y | 0.00896964 |
| RNF167 | ring finger protein 167 | 0.00894603 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.00885492 |
| NKG7 | natural killer cell granule protein 7 | 0.00885119 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.00877681 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00876684 |
| GNLY | granulysin | 0.0087248 |
| HBD | hemoglobin, delta | 0.00871402 |
| CD2 | CD2 molecule | 0.00869055 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00865671 |
| CFI | complement factor I | 0.00861176 |
| IL2RG | interleukin 2 receptor, gamma | 0.00853015 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.00852347 |
| LST1 | leukocyte specific transcript 1 | 0.00850346 |
| LCN2 | lipocalin 2 | 0.00846745 |
| CD247 | CD247 molecule | 0.0084435 |
| S100A9 | S100 calcium binding protein A9 | 0.00842816 |
| KLK8 | kallikrein-related peptidase 8 | 0.00839064 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.00838243 |
| DMD | dystrophin | 0.00832923 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00832292 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00831857 |
| SCARA3 | scavenger receptor class A, member 3 | 0.00831394 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00830889 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.00830738 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00830529 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.00828469 |
| CCNB2 | cyclin B2 | 0.00827945 |
| CCNF | cyclin F | 0.00827051 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00820973 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00820172 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.00819583 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00817235 |
| SRGN | serglycin | 0.00812736 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00812116 |
| KAZN | kazrin, periplakin interacting protein | 0.00810514 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0080876 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00806308 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00800383 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00797501 |
| KRT1 | keratin 1, type II | 0.00797418 |
| IL7R | interleukin 7 receptor | 0.00796198 |
| PTCH1 | patched 1 | 0.00794979 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.00791782 |
| LAPTM5 | lysosomal protein transmembrane 5 | 0.00791371 |
| CHI3L2 | chitinase 3-like 2 | 0.00790044 |
| FBXO11 | F-box protein 11 | 0.00789333 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00786577 |
| CNTN1 | contactin 1 | 0.00784861 |
| HOPX | HOP homeobox | 0.00781872 |
| HAUS4 | HAUS augmin-like complex, subunit 4 | 0.00781847 |
| KLK6 | kallikrein-related peptidase 6 | 0.00777065 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.0077551 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0077519 |
| PRPF4 | pre-mRNA processing factor 4 | 0.00772632 |
| CTSW | cathepsin W | 0.00771839 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00769896 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00769333 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00767176 |
| C7 | complement component 7 | 0.00765384 |
| IL2RB | interleukin 2 receptor, beta | 0.00764702 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00763637 |
| ACSF2 | acyl-CoA synthetase family member 2 | 0.00762779 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0076237 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00761182 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00761093 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00759686 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 0.00758681 |
| GPR65 | G protein-coupled receptor 65 | 0.00758363 |
| XK | X-linked Kx blood group | 0.00750431 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00750273 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00748751 |
| TEAD4 | TEA domain family member 4 | 0.00744509 |
| MSLN | mesothelin | 0.00743904 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00742301 |
| FOXM1 | forkhead box M1 | 0.00741548 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00741135 |
| NES | nestin | 0.00740328 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00737627 |
| CDK14 | cyclin-dependent kinase 14 | 0.00737501 |
| NMT2 | N-myristoyltransferase 2 | 0.00736082 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00736031 |
| IL18RAP | interleukin 18 receptor accessory protein | 0.00735431 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00735053 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.00733335 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.00732333 |
| GAS1 | growth arrest-specific 1 | 0.00729058 |
| LMNB1 | lamin B1 | 0.00727054 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00726652 |
| MAOB | monoamine oxidase B | 0.007253 |
| ACP3 | acid phosphatase 3 | 0.00718263 |
| TPM4 | tropomyosin 4 | 0.0071591 |
| SLA | Src-like-adaptor | 0.00715463 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00714019 |
| PSPH | phosphoserine phosphatase | 0.00713649 |
| RNF130 | ring finger protein 130 | 0.00712428 |
| MT1M | metallothionein 1M | 0.00706942 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00706922 |
| MT1H | metallothionein 1H | 0.00706438 |
| GMPR | guanosine monophosphate reductase | 0.00705838 |
| GPX1 | glutathione peroxidase 1 | 0.00703858 |
| RTN1 | reticulon 1 | 0.00703568 |
| S100A12 | S100 calcium binding protein A12 | 0.00703104 |
| SELL | selectin L | 0.0070283 |
| THYN1 | thymocyte nuclear protein 1 | 0.00697326 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00696438 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00695146 |
| AMACR | alpha-methylacyl-CoA racemase | 0.00690484 |
| PDZD2 | PDZ domain containing 2 | 0.00689889 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00689461 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00688371 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00687242 |
| ITK | IL2-inducible T-cell kinase | 0.00686789 |
| TRIM68 | tripartite motif containing 68 | 0.00686641 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00686417 |
| CHRDL1 | chordin-like 1 | 0.00685843 |
| KLK10 | kallikrein-related peptidase 10 | 0.00684553 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00684094 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00683834 |
| MIA3 | melanoma inhibitory activity family, member 3 | 0.0068299 |
| ZNF274 | zinc finger protein 274 | 0.00682854 |
| DENND2B | DENN domain containing 2B | 0.00679316 |
| NKX3-1 | NK3 homeobox 1 | 0.00679303 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00679205 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00678135 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00677314 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | 0.0067719 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00675481 |
| VIPR1 | vasoactive intestinal peptide receptor 1 | 0.00675022 |
| CRIP2 | cysteine-rich protein 2 | 0.00674753 |
| RNF187 | ring finger protein 187 | 0.00672555 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | 0.00671783 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | 0.0066734 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.00665867 |
| IRF2 | interferon regulatory factor 2 | 0.00665843 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.00662147 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00661712 |
| C1R | complement component 1, r subcomponent | 0.0066129 |
| ELANE | elastase, neutrophil expressed | 0.0066006 |
| SRPRA | SRP receptor subunit alpha | 0.00657098 |
| CORO1A | coronin, actin binding protein, 1A | 0.00656632 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00656433 |
| TSNAX | translin-associated factor X | 0.00654661 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.00654641 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00653575 |
| NEK2 | NIMA-related kinase 2 | 0.00653506 |
| NEO1 | neogenin 1 | 0.00652458 |
| CENPU | centromere protein U | 0.00652045 |
| BIN1 | bridging integrator 1 | 0.0065047 |
| MXRA7 | matrix-remodelling associated 7 | 0.00650053 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00648906 |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 0.00648387 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00648022 |
| FECH | ferrochelatase | 0.00646328 |
| PRKCQ | protein kinase C, theta | 0.00645792 |
| STOM | stomatin | 0.00645028 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00644922 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00643036 |
| ANXA3 | annexin A3 | 0.00641272 |
| RBM38 | RNA binding motif protein 38 | 0.0064093 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00640872 |
| SMC2 | structural maintenance of chromosomes 2 | 0.00639819 |
| TMEM100 | transmembrane protein 100 | 0.00639605 |
| KIFAP3 | kinesin-associated protein 3 | 0.00639349 |
| DMTN | dematin actin binding protein | 0.00638469 |
| PEX6 | peroxisomal biogenesis factor 6 | 0.00637027 |
| KIF4A | kinesin family member 4A | 0.00634236 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.00634021 |
| METTL7A | methyltransferase like 7A | 0.00631516 |
| PITPNA | phosphatidylinositol transfer protein, alpha | 0.00630986 |
| CD53 | CD53 molecule | 0.00630712 |
| TSPAN7 | tetraspanin 7 | 0.00629609 |
| CEP55 | centrosomal protein 55kDa | 0.00626995 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.00624748 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.00624332 |
| RRM1 | ribonucleotide reductase M1 | 0.00623881 |
| NEFH | neurofilament, heavy polypeptide | 0.00622108 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | 0.00621369 |
| GPM6B | glycoprotein M6B | 0.00621066 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.00620797 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00619202 |
| NTAQ1 | N-terminal glutamine amidase 1 | 0.00618821 |
| RAB20 | RAB20, member RAS oncogene family | 0.00617673 |
| RGS1 | regulator of G-protein signaling 1 | 0.00617655 |
| TCF21 | transcription factor 21 | 0.00617006 |
| CLEC5A | C-type lectin domain family 5, member A | 0.00615972 |
| RCAN1 | regulator of calcineurin 1 | 0.00612581 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.00612552 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00610872 |
| MYBPC1 | myosin binding protein C, slow type | 0.00610792 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00610649 |
| CCNA2 | cyclin A2 | 0.0060964 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00609056 |
| EPB42 | erythrocyte membrane protein band 4.2 | 0.00608972 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00608427 |
| TRMT5 | tRNA methyltransferase 5 | 0.00607958 |
| GLOD4 | glyoxalase domain containing 4 | 0.00607906 |
| PRKCA | protein kinase C, alpha | 0.00606379 |
| RLN1 | relaxin 1 | 0.00604907 |
| ASRGL1 | asparaginase like 1 | 0.00604664 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0289338 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -0.0212548 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0197293 |
| MAP7 | microtubule-associated protein 7 | -0.0195841 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0162941 |
| XIC | X chromosome inactivation center | -0.015889 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0158618 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0157302 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.0147427 |
| STC1 | stanniocalcin 1 | -0.0136913 |
| MX1 | MX dynamin-like GTPase 1 | -0.0136334 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0134594 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0127273 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0125911 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0123537 |
| TOX3 | TOX high mobility group box family member 3 | -0.0123106 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.012153 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0120238 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0118931 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0117768 |
| IFI44L | interferon-induced protein 44-like | -0.01134 |
| MIR22HG | MIR22 host gene | -0.0113203 |
| PON3 | paraoxonase 3 | -0.0112577 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0111354 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0109329 |
| CTSK | cathepsin K | -0.0109199 |
| AGR2 | anterior gradient 2 | -0.0108939 |
| BEX4 | brain expressed, X-linked 4 | -0.0108639 |
| COL15A1 | collagen, type XV, alpha 1 | -0.0107435 |
| COMP | cartilage oligomeric matrix protein | -0.0106873 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0106632 |
| PNN | pinin, desmosome associated protein | -0.0104484 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.010401 |
| MVP | major vault protein | -0.0103726 |
| CHGB | chromogranin B | -0.010285 |
| MYO1B | myosin IB | -0.0101936 |
| FGB | fibrinogen beta chain | -0.0101552 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.0101184 |
| HEBP2 | heme binding protein 2 | -0.0100591 |
| MX2 | MX dynamin-like GTPase 2 | -0.01003 |
| CCNG2 | cyclin G2 | -0.00998107 |
| IFI44 | interferon-induced protein 44 | -0.0099658 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00976295 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00967084 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0096498 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00963169 |
| GOLGA8A | golgin A8 family, member A | -0.00963067 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00957216 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.00951102 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00948078 |
| CPE | carboxypeptidase E | -0.00940544 |
| H1-2 | H1.2 linker histone, cluster member | -0.00935134 |
| SLIT1 | slit homolog 1 (Drosophila) | -0.00918224 |
| JMJD1C | jumonji domain containing 1C | -0.00912589 |
| POSTN | periostin, osteoblast specific factor | -0.00912043 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00907142 |
| MRPL18 | mitochondrial ribosomal protein L18 | -0.00905149 |
| FN1 | fibronectin 1 | -0.00902421 |
| GNAS | GNAS complex locus | -0.00891856 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | -0.00883577 |
| MXRA5 | matrix-remodelling associated 5 | -0.00876882 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | -0.00876102 |
| MFAP5 | microfibrillar associated protein 5 | -0.00867633 |
| CBX1 | chromobox homolog 1 | -0.0086677 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -0.0086459 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0086003 |
| CSTB | cystatin B (stefin B) | -0.00857608 |
| IL1B | interleukin 1, beta | -0.00857409 |
| KLF6 | Kruppel-like factor 6 | -0.00856097 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00852462 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00848989 |
| BRD2 | bromodomain containing 2 | -0.0084279 |
| PERP | PERP, TP53 apoptosis effector | -0.00841958 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.00840757 |
| CEL | carboxyl ester lipase | -0.00839954 |
| HMOX1 | heme oxygenase 1 | -0.00836139 |
| ODC1 | ornithine decarboxylase 1 | -0.00834797 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0083073 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00828125 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00819717 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00817899 |
| ACKR3 | atypical chemokine receptor 3 | -0.00817809 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00817536 |
| MAGEA3 | melanoma antigen family A3 | -0.00816662 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00813268 |
| PRSS23 | protease, serine, 23 | -0.00813262 |
| TCP1 | t-complex 1 | -0.00813255 |
| FAM13A | family with sequence similarity 13, member A | -0.00811203 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00807114 |
| PEG10 | paternally expressed 10 | -0.0080495 |
| FHL2 | four and a half LIM domains 2 | -0.00803622 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00801394 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00798239 |
| SPAG9 | sperm associated antigen 9 | -0.00798088 |
| ADIRF | adipogenesis regulatory factor | -0.00794329 |
| RSRP1 | arginine/serine-rich protein 1 | -0.00792538 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | -0.0078976 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00789166 |
| RGS5 | regulator of G-protein signaling 5 | -0.00787848 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00783492 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00781319 |
| ECM1 | extracellular matrix protein 1 | -0.00781315 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00780088 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00779519 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0077937 |
| GSN | gelsolin | -0.00778847 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00778358 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00776268 |
| HIST1H2BK | histone cluster 1, H2bk | -0.0077322 |
| PSMB1 | proteasome (prosome, macropain) subunit, beta type, 1 | -0.0077096 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00770648 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00769215 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00765064 |
| DUSP1 | dual specificity phosphatase 1 | -0.00763742 |
| STK26 | serine/threonine protein kinase 26 | -0.00763463 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.00762508 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00755285 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00754289 |
| CES3 | carboxylesterase 3 | -0.00751945 |
| PSCA | prostate stem cell antigen | -0.00748436 |
| APOD | apolipoprotein D | -0.00747034 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00743751 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00743079 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00741678 |
| TPD52 | tumor protein D52 | -0.0073933 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00735883 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.00735697 |
| CLEC2B | C-type lectin domain family 2, member B | -0.00733571 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00729326 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.0072808 |
| SERF2 | small EDRK-rich factor 2 | -0.00723931 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00723499 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.00722911 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00721061 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00719819 |
| SNX11 | sorting nexin 11 | -0.0071957 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00719214 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | -0.00717479 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00716607 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00715852 |
| ZNF638 | zinc finger protein 638 | -0.00714013 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00713225 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.00712371 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.0071198 |
| CHMP2A | charged multivesicular body protein 2A | -0.0070883 |
| SRSF10 | serine/arginine-rich splicing factor 10 | -0.00708347 |
| TM4SF20 | transmembrane 4 L six family member 20 | -0.00708068 |
| JAM3 | junctional adhesion molecule 3 | -0.00706608 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.00705439 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00701253 |
| CDA | cytidine deaminase | -0.00700778 |
| EFHD1 | EF-hand domain family, member D1 | -0.00697236 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00696252 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | -0.00695716 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00693937 |
| PCDH9 | protocadherin 9 | -0.00692964 |
| RGS16 | regulator of G-protein signaling 16 | -0.00690385 |
| DSP | desmoplakin | -0.00690116 |
| ANGPT2 | angiopoietin 2 | -0.00688589 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00688098 |
| MYO1E | myosin IE | -0.00685079 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00684643 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.00683855 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00682147 |
| MECOM | MDS1 and EVI1 complex locus | -0.006815 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00679331 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0067873 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00677807 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.00677601 |
| INHBA | inhibin, beta A | -0.00677036 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.00674409 |
| C9ORF3 | chromosome 9 open reading frame 3 | -0.00673533 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00673297 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00673265 |
| EIF4E2 | eukaryotic translation initiation factor 4E family member 2 | -0.00670534 |
| C4BPB | complement component 4 binding protein, beta | -0.00669365 |
| PMP22 | peripheral myelin protein 22 | -0.00667731 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00667442 |
| SETD5 | SET domain containing 5 | -0.00667275 |
| ZBED5 | zinc finger, BED-type containing 5 | -0.00666858 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00666441 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00666237 |
| ZNF331 | zinc finger protein 331 | -0.00665755 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00665298 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00664948 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00664902 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0066461 |
| SIX1 | SIX homeobox 1 | -0.00664138 |
| ZNF165 | zinc finger protein 165 | -0.00663048 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | -0.00662847 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.00659988 |
| HSBP1 | heat shock factor binding protein 1 | -0.00659915 |
| ZC3H7A | zinc finger CCCH-type containing 7A | -0.00656926 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00656571 |
| THBS2 | thrombospondin 2 | -0.00654199 |
| FGA | fibrinogen alpha chain | -0.00654071 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00653491 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00650979 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00650149 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00648877 |
| TPP2 | tripeptidyl peptidase II | -0.00648522 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00648361 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00642528 |
| BEX1 | brain expressed, X-linked 1 | -0.00641392 |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) | -0.00638806 |
| TXN | thioredoxin | -0.00637533 |
| PELO | pelota homolog (Drosophila) | -0.00635962 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.00633354 |
| RRAGC | Ras-related GTP binding C | -0.00631943 |
| TMEM243 | transmembrane protein 243, mitochondrial | -0.00629744 |
| EMP1 | epithelial membrane protein 1 | -0.00629621 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0062804 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.00626559 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00625997 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00625699 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00625004 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00624866 |
| KLHL24 | kelch-like family member 24 | -0.00623871 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.00623859 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00622972 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00622621 |
| LUM | lumican | -0.00622279 |
| IER5 | immediate early response 5 | -0.00620684 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | -0.00620181 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00620123 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.00619667 |
| CALCA | calcitonin-related polypeptide alpha | -0.006192 |
| HOXC6 | homeobox C6 | -0.00618058 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0061787 |
| DUSP10 | dual specificity phosphatase 10 | -0.00617247 |
| SNAI2 | snail family zinc finger 2 | -0.00617224 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -0.00616811 |
| KCTD5 | potassium channel tetramerization domain containing 5 | -0.0061564 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.0061286 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.00612274 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.00611737 |
| MYO6 | myosin VI | -0.00611365 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00610731 |
| ASPN | asporin | -0.00610354 |
| MGP | matrix Gla protein | -0.00609756 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.00609363 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00609278 |
| GCH1 | GTP cyclohydrolase 1 | -0.00607498 |
| SQSTM1 | sequestosome 1 | -0.00607105 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.00606985 |
| MAGEA4 | melanoma antigen family A4 | -0.00606595 |
| LPIN1 | lipin 1 | -0.00605959 |
| HSPE1 | heat shock 10kDa protein 1 | -0.00605435 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00605291 |
