| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-like receptor 2|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7097) |
| External Link | https://ncbi.nlm.nih.gov/gene/7097 |
| Similar Terms | |
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499 genes differentially expressed following the TLR2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0274898 |
| LCN2 | lipocalin 2 | 0.0144511 |
| S100A7 | S100 calcium binding protein A7 | 0.0140819 |
| DSP | desmoplakin | 0.013663 |
| KRT14 | keratin 14, type I | 0.0124788 |
| KRT16 | keratin 16, type I | 0.012286 |
| S100A9 | S100 calcium binding protein A9 | 0.0122162 |
| KRT6A | keratin 6A, type II | 0.0120762 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0115926 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0114135 |
| KLK11 | kallikrein-related peptidase 11 | 0.0113033 |
| KRT17 | keratin 17, type I | 0.0112485 |
| PERP | PERP, TP53 apoptosis effector | 0.0112037 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.0111686 |
| TARP | TCR gamma alternate reading frame protein | 0.0105494 |
| SPRR2B | small proline-rich protein 2B | 0.010445 |
| KRT6B | keratin 6B, type II | 0.0101343 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00971855 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00968951 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00964124 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00963572 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00956594 |
| KRT15 | keratin 15, type I | 0.00927049 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00922732 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00920754 |
| GLOD4 | glyoxalase domain containing 4 | 0.00920659 |
| EPHB2 | EPH receptor B2 | 0.00912475 |
| SFN | stratifin | 0.00910579 |
| CA12 | carbonic anhydrase XII | 0.00900724 |
| KLK6 | kallikrein-related peptidase 6 | 0.00897558 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00896162 |
| CSTA | cystatin A (stefin A) | 0.00886036 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.00874545 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00870238 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.00863166 |
| CLCA2 | chloride channel accessory 2 | 0.00854762 |
| SPRR1A | small proline-rich protein 1A | 0.00850054 |
| S100A8 | S100 calcium binding protein A8 | 0.00844415 |
| SYNGR3 | synaptogyrin 3 | 0.00843767 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00831639 |
| RHCG | Rh family, C glycoprotein | 0.00831288 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00814937 |
| TRIM29 | tripartite motif containing 29 | 0.0081368 |
| TGM2 | transglutaminase 2 | 0.00808011 |
| S100A2 | S100 calcium binding protein A2 | 0.00803942 |
| TRIM16 | tripartite motif containing 16 | 0.0080106 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 0.00792977 |
| OPN3 | opsin 3 | 0.00782939 |
| KLK8 | kallikrein-related peptidase 8 | 0.00775493 |
| CTSH | cathepsin H | 0.0077435 |
| PKP1 | plakophilin 1 | 0.00770847 |
| VSNL1 | visinin-like 1 | 0.00770043 |
| MZB1 | marginal zone B and B1 cell-specific protein | 0.00764325 |
| SPRR1B | small proline-rich protein 1B | 0.00763975 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00763252 |
| KRT1 | keratin 1, type II | 0.00751613 |
| KLK7 | kallikrein-related peptidase 7 | 0.00750385 |
| GPX2 | glutathione peroxidase 2 | 0.00750162 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00741943 |
| CST7 | cystatin F (leukocystatin) | 0.00740888 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00738309 |
| CALML5 | calmodulin-like 5 | 0.00730668 |
| YBX3 | Y box binding protein 3 | 0.00729341 |
| KLK10 | kallikrein-related peptidase 10 | 0.00729311 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.00728648 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00720677 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00719742 |
| FOXD1 | forkhead box D1 | 0.00693814 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00687408 |
| ADI1 | acireductone dioxygenase 1 | 0.00686159 |
| IPO13 | importin 13 | 0.00681869 |
| CD38 | CD38 molecule | 0.0067743 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00674008 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00668808 |
| LOR | loricrin | 0.00667921 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00666941 |
| EPHB6 | EPH receptor B6 | 0.00659343 |
| SFTPA2 | surfactant protein A2 | 0.00648559 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00646437 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00644754 |
| DSG1 | desmoglein 1 | 0.00643434 |
| CALML3 | calmodulin-like 3 | 0.00640789 |
| TGFA | transforming growth factor, alpha | 0.00639835 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.00639678 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00637009 |
| KRT5 | keratin 5, type II | 0.00634852 |
| KLK2 | kallikrein-related peptidase 2 | 0.00633373 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00630365 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00628385 |
| CTSV | cathepsin V | 0.00625404 |
| SERINC5 | serine incorporator 5 | 0.00625091 |
| SATB2 | SATB homeobox 2 | 0.00623351 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00619527 |
| NPY | neuropeptide Y | 0.00618956 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00617338 |
| SFTPB | surfactant protein B | 0.00613243 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.00608741 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00603617 |
| CD177 | CD177 molecule | 0.00602583 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 0.00601501 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | 0.00598809 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00598046 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.0059358 |
| NKX3-1 | NK3 homeobox 1 | 0.00588493 |
| COL7A1 | collagen, type VII, alpha 1 | 0.00585656 |
| PGD | phosphogluconate dehydrogenase | 0.00585602 |
| SLAMF7 | SLAM family member 7 | 0.00582367 |
| MAP7 | microtubule-associated protein 7 | 0.00581974 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00581741 |
| MPC2 | mitochondrial pyruvate carrier 2 | 0.00580441 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00578052 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00577309 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00577297 |
| LAMB3 | laminin, beta 3 | 0.00577219 |
| SULT2B1 | sulfotransferase family, cytosolic, 2B, member 1 | 0.0057601 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.00575908 |
| S100A12 | S100 calcium binding protein A12 | 0.00575024 |
| MORN1 | MORN repeat containing 1 | 0.00573629 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.0057153 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00570213 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 0.00569182 |
| TGM1 | transglutaminase 1 | 0.0056854 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 0.00567815 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 0.00563923 |
| PKP3 | plakophilin 3 | 0.00563595 |
| RNF167 | ring finger protein 167 | 0.00562753 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00561647 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.00559242 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00557736 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | 0.00554107 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.00553424 |
| PRKCZ | protein kinase C, zeta | 0.00549636 |
| NPC2 | Niemann-Pick disease, type C2 | 0.0054807 |
| SERPINB7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 0.00545267 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.0054487 |
| CRLF1 | cytokine receptor-like factor 1 | 0.00543554 |
| DEFB1 | defensin, beta 1 | 0.0054283 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0054092 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.00539003 |
| TMEM45A | transmembrane protein 45A | 0.00538306 |
| KLK3 | kallikrein-related peptidase 3 | 0.00534573 |
| SMOX | spermine oxidase | 0.00530443 |
| MSMB | microseminoprotein, beta- | 0.00528789 |
| PPL | periplakin | 0.00525677 |
| TLK1 | tousled-like kinase 1 | 0.00523975 |
| IVL | involucrin | 0.00523795 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00523063 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00521459 |
| GP1BB | glycoprotein Ib (platelet), beta polypeptide | 0.00520624 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.00519665 |
| CPTP | ceramide-1-phosphate transfer protein | 0.00515522 |
| ITM2C | integral membrane protein 2C | 0.00515503 |
| TUBA4A | tubulin, alpha 4a | 0.00514411 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.00513802 |
| DEFB4A | defensin, beta 4A | 0.00513261 |
| NVL | nuclear VCP-like | 0.00512661 |
| TBC1D2 | TBC1 domain family, member 2 | 0.00510684 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.00508968 |
| CD8A | CD8a molecule | 0.00505462 |
| CLIP3 | CAP-GLY domain containing linker protein 3 | 0.00502825 |
| SFTPD | surfactant protein D | 0.0050169 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00501671 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00501403 |
| SQLE | squalene epoxidase | 0.00500691 |
| CRNN | cornulin | 0.00499828 |
| BRD8 | bromodomain containing 8 | 0.00499198 |
| QPCT | glutaminyl-peptide cyclotransferase | 0.00498694 |
| MALL | mal, T-cell differentiation protein-like | 0.0049819 |
| CKAP5 | cytoskeleton associated protein 5 | 0.004981 |
| TYMS | thymidylate synthetase | 0.00497594 |
| PTGES | prostaglandin E synthase | 0.00497262 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00496543 |
| MMP12 | matrix metallopeptidase 12 | 0.00495455 |
| CDSN | corneodesmosin | 0.00495247 |
| MAP2K2 | mitogen-activated protein kinase kinase 2 | 0.00493698 |
| PILRB | paired immunoglobin-like type 2 receptor beta | 0.00493198 |
| TMEM131 | transmembrane protein 131 | 0.00493145 |
| LIF | leukemia inhibitory factor | 0.00491732 |
| HIST3H2A | histone cluster 3, H2a | 0.00489043 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00488861 |
| EXOSC7 | exosome component 7 | 0.00488016 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00487145 |
| RTN3 | reticulon 3 | 0.00486883 |
| PRSS22 | protease, serine, 22 | 0.00486178 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.00484898 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.00483834 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00483498 |
| GPC1 | glypican 1 | 0.00481831 |
| TEX264 | testis expressed 264 | 0.00481143 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.00479902 |
| KLK5 | kallikrein-related peptidase 5 | 0.00479075 |
| S100P | S100 calcium binding protein P | 0.00478445 |
| KYNU | kynureninase | 0.00478006 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0047747 |
| R3HDM1 | R3H domain containing 1 | 0.00477431 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00477162 |
| LTF | lactotransferrin | 0.00476087 |
| GIPC1 | GIPC PDZ domain containing family, member 1 | 0.00476067 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | 0.00474973 |
| CRYM | crystallin, mu | 0.00472571 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.0047177 |
| TPD52L1 | tumor protein D52-like 1 | 0.00471744 |
| ACP3 | acid phosphatase 3 | 0.00470553 |
| S100A4 | S100 calcium binding protein A4 | 0.00470336 |
| DSC2 | desmocollin 2 | 0.00469887 |
| EREG | epiregulin | 0.00469765 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.00469678 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00469316 |
| RUFY1 | RUN and FYVE domain containing 1 | 0.00469137 |
| CFB | complement factor B | 0.00468809 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00468259 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00467399 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 0.00466292 |
| DSG3 | desmoglein 3 | 0.00466153 |
| GPATCH8 | G patch domain containing 8 | 0.00465837 |
| APOC1 | apolipoprotein C-I | 0.00465613 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.0046542 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.00464287 |
| NEFH | neurofilament, heavy polypeptide | 0.00462355 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 0.00462308 |
| PINK1 | PTEN induced putative kinase 1 | 0.00461825 |
| MMP1 | matrix metallopeptidase 1 | 0.00460379 |
| PLPP2 | phospholipid phosphatase 2 | 0.00459678 |
| TCTN2 | tectonic family member 2 | 0.00459521 |
| CD82 | CD82 molecule | 0.00459413 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00458271 |
| KIAA0513 | KIAA0513 | 0.00458154 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00457484 |
| FBLN1 | fibulin 1 | 0.00457366 |
| DGS2 | DiGeorge syndrome/velocardiofacial syndrome complex 2 | 0.00456912 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00456154 |
| TMEM132A | transmembrane protein 132A | 0.00453596 |
| EVPL | envoplakin | 0.00453317 |
| STX1A | syntaxin 1A (brain) | 0.00452712 |
| HOPX | HOP homeobox | 0.00452132 |
| NISCH | nischarin | 0.00451752 |
| EMP1 | epithelial membrane protein 1 | 0.00449843 |
| PYGL | phosphorylase, glycogen, liver | 0.00449046 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00448545 |
| SAMD14 | sterile alpha motif domain containing 14 | 0.00448384 |
| COL16A1 | collagen, type XVI, alpha 1 | 0.00447781 |
| PRSS8 | protease, serine, 8 | 0.00446977 |
| COMT | catechol-O-methyltransferase | 0.00446203 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 0.00446116 |
| CD151 | CD151 molecule (Raph blood group) | 0.004461 |
| FOXC1 | forkhead box C1 | 0.00445666 |
| PCBP4 | poly(rC) binding protein 4 | 0.00444653 |
| ZNF282 | zinc finger protein 282 | 0.00444455 |
| SCEL | sciellin | 0.00444379 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PROM1 | prominin 1 | -0.0137111 |
| CHEK2 | checkpoint kinase 2 | -0.0133326 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0129428 |
| IFI44L | interferon-induced protein 44-like | -0.0129327 |
| XIC | X chromosome inactivation center | -0.0126186 |
| FHL1 | four and a half LIM domains 1 | -0.0120386 |
| PLIN2 | perilipin 2 | -0.0118836 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0108721 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.010414 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.0102325 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0102187 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0101337 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.0101328 |
| MX1 | MX dynamin-like GTPase 1 | -0.00994955 |
| GPM6B | glycoprotein M6B | -0.00994915 |
| AOX1 | aldehyde oxidase 1 | -0.00986731 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00975637 |
| IFI44 | interferon-induced protein 44 | -0.00954837 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00952042 |
| TPBG | trophoblast glycoprotein | -0.00945446 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00917052 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00910332 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0090666 |
| ASPN | asporin | -0.00905851 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.0090052 |
| ACKR3 | atypical chemokine receptor 3 | -0.00896525 |
| FRY | furry homolog (Drosophila) | -0.00885398 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00850526 |
| NRCAM | neuronal cell adhesion molecule | -0.00849629 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00847762 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.00847073 |
| PTK2 | protein tyrosine kinase 2 | -0.00837323 |
| KRT19 | keratin 19, type I | -0.00831932 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00827106 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -0.0082169 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00821029 |
| SGCE | sarcoglycan, epsilon | -0.00815598 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00813863 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.00809065 |
| DIO1 | deiodinase, iodothyronine, type I | -0.00803959 |
| XAF1 | XIAP associated factor 1 | -0.00797123 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00791223 |
| MT1E | metallothionein 1E | -0.00788621 |
| SNX11 | sorting nexin 11 | -0.00787753 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -0.00780173 |
| PDGFD | platelet derived growth factor D | -0.00774477 |
| ADGRL4 | adhesion G protein-coupled receptor L4 | -0.00768372 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00766121 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00762418 |
| MMD | monocyte to macrophage differentiation-associated | -0.00759934 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00759539 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00759274 |
| ADD3 | adducin 3 (gamma) | -0.00758059 |
| ZNF160 | zinc finger protein 160 | -0.00757843 |
| ADIRF | adipogenesis regulatory factor | -0.00755381 |
| EDNRB | endothelin receptor type B | -0.00754153 |
| CDC20 | cell division cycle 20 | -0.00748514 |
| PRR11 | proline rich 11 | -0.0074531 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00744137 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00743576 |
| CD83 | CD83 molecule | -0.00723431 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00719463 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.00717245 |
| PLN | phospholamban | -0.00710747 |
| QKI | QKI, KH domain containing, RNA binding | -0.00708344 |
| OCRL | oculocerebrorenal syndrome of Lowe | -0.00706504 |
| KLF9 | Kruppel-like factor 9 | -0.00705035 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -0.00704661 |
| PNMA2 | paraneoplastic Ma antigen 2 | -0.00704144 |
| LXN | latexin | -0.00703947 |
| THBS2 | thrombospondin 2 | -0.00703043 |
| MX2 | MX dynamin-like GTPase 2 | -0.00700182 |
| CD302 | CD302 molecule | -0.00698412 |
| TMEM47 | transmembrane protein 47 | -0.0069457 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00693916 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00690875 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00689644 |
| BEX4 | brain expressed, X-linked 4 | -0.00689344 |
| NFIB | nuclear factor I/B | -0.00685756 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0068364 |
| TMSB15A | thymosin beta 15a | -0.00681125 |
| JAM2 | junctional adhesion molecule 2 | -0.00680565 |
| BBX | bobby sox homolog (Drosophila) | -0.00679726 |
| ANXA10 | annexin A10 | -0.00678454 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00676461 |
| SNX7 | sorting nexin 7 | -0.00675149 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00672473 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00672359 |
| NANOG | Nanog homeobox | -0.00671117 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00669867 |
| NES | nestin | -0.0066885 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00665968 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00661739 |
| MXRA5 | matrix-remodelling associated 5 | -0.00660581 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.006594 |
| ZNF721 | zinc finger protein 721 | -0.00656249 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.00656119 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00649395 |
| MSR1 | macrophage scavenger receptor 1 | -0.00649007 |
| PUDP | pseudouridine 5'-phosphatase | -0.00648958 |
| F2R | coagulation factor II (thrombin) receptor | -0.00647583 |
| GAS1 | growth arrest-specific 1 | -0.00645793 |
| PDE8B | phosphodiesterase 8B | -0.00644628 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00644536 |
| TEK | TEK tyrosine kinase, endothelial | -0.00642684 |
| DACH1 | dachshund family transcription factor 1 | -0.00641149 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00640482 |
| GNAS | GNAS complex locus | -0.00639737 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00636581 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00632371 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00630576 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00629852 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00629669 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00625585 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.00625169 |
| IL17RB | interleukin 17 receptor B | -0.00624641 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00624259 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00622506 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00620627 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.0062024 |
| PAH | phenylalanine hydroxylase | -0.00619543 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00618434 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00618422 |
| RGS5 | regulator of G-protein signaling 5 | -0.00616448 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00613933 |
| RET | ret proto-oncogene | -0.00612749 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -0.00609216 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00608777 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.00607628 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00607514 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0060709 |
| TFEC | transcription factor EC | -0.00605971 |
| FBLN5 | fibulin 5 | -0.00604122 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00603299 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.00603295 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00603243 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00602294 |
| ZNF91 | zinc finger protein 91 | -0.00601609 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00599916 |
| CD93 | CD93 molecule | -0.00599226 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00598616 |
| PLAT | plasminogen activator, tissue | -0.00597491 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00596104 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00595521 |
| LRRC17 | leucine rich repeat containing 17 | -0.00595039 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.00593822 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00592964 |
| FCGBP | Fc fragment of IgG binding protein | -0.00590568 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00588557 |
| ZNF83 | zinc finger protein 83 | -0.00587382 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00587083 |
| STON1 | stonin 1 | -0.00586996 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00586436 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -0.00586295 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.00584808 |
| GPM6A | glycoprotein M6A | -0.00583498 |
| HNMT | histamine N-methyltransferase | -0.00582764 |
| RPL10 | ribosomal protein L10 | -0.00581932 |
| KLHL41 | kelch-like family member 41 | -0.00580984 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 | -0.00580177 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00579095 |
| VNN1 | vanin 1 | -0.00578288 |
| CNR1 | cannabinoid receptor 1 (brain) | -0.00578235 |
| MXI1 | MAX interactor 1, dimerization protein | -0.00578214 |
| THBS1 | thrombospondin 1 | -0.00577201 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00576067 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00575818 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | -0.00574569 |
| CSAD | cysteine sulfinic acid decarboxylase | -0.00573934 |
| RHOBTB1 | Rho-related BTB domain containing 1 | -0.00572798 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | -0.00570901 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.00570578 |
| PITX3 | paired-like homeodomain 3 | -0.00570544 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | -0.00569734 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0056943 |
| NOX4 | NADPH oxidase 4 | -0.00567973 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00565303 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.00565075 |
| BCHE | butyrylcholinesterase | -0.00564651 |
| LYZ | lysozyme | -0.0056462 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00564552 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00559578 |
| ZNF44 | zinc finger protein 44 | -0.00559247 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.0055864 |
| ZNF652 | zinc finger protein 652 | -0.00556718 |
| CDO1 | cysteine dioxygenase type 1 | -0.00556148 |
| TOX | thymocyte selection-associated high mobility group box | -0.00554797 |
| ZNF573 | zinc finger protein 573 | -0.00554663 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.00554221 |
| CTSS | cathepsin S | -0.00552927 |
| VDAC1 | voltage-dependent anion channel 1 | -0.00552665 |
| PLSCR4 | phospholipid scramblase 4 | -0.00550971 |
| COL10A1 | collagen, type X, alpha 1 | -0.00550474 |
| RAB29 | RAB29, member RAS oncogene family | -0.00550172 |
| MCL1 | myeloid cell leukemia 1 | -0.00549242 |
| PDZK1 | PDZ domain containing 1 | -0.00548976 |
| BST2 | bone marrow stromal cell antigen 2 | -0.00547484 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.0054718 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -0.00546685 |
| RTN2 | reticulon 2 | -0.0054633 |
| ANK2 | ankyrin 2, neuronal | -0.00546014 |
| HHEX | hematopoietically expressed homeobox | -0.00545633 |
| MT1F | metallothionein 1F | -0.00543262 |
| FMO1 | flavin containing monooxygenase 1 | -0.00542771 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00540781 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.00540703 |
| VCL | vinculin | -0.00539924 |
| LRRC37A3 | leucine rich repeat containing 37, member A3 | -0.00538803 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00538215 |
| HBB | hemoglobin, beta | -0.00536788 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | -0.00536053 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00535379 |
| MFAP5 | microfibrillar associated protein 5 | -0.00535179 |
| SSPN | sarcospan | -0.00535108 |
| MARK1 | MAP/microtubule affinity-regulating kinase 1 | -0.00535006 |
| KLF11 | Kruppel-like factor 11 | -0.00533837 |
| GAP43 | growth associated protein 43 | -0.00532647 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00532182 |
| SDCBP | syndecan binding protein (syntenin) | -0.00531391 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.00529099 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00528632 |
| ADRA2A | adrenoceptor alpha 2A | -0.00527952 |
| MPPED2 | metallophosphoesterase domain containing 2 | -0.00525866 |
| MYBPC1 | myosin binding protein C, slow type | -0.00525428 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.00525219 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0052509 |
| FBN1 | fibrillin 1 | -0.00524279 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | -0.00524156 |
| CPQ | carboxypeptidase Q | -0.00523093 |
| SALL2 | spalt-like transcription factor 2 | -0.00522595 |
| PODXL | podocalyxin-like | -0.0052255 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00522333 |
| DENND1B | DENN/MADD domain containing 1B | -0.00522173 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.00521871 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.00519769 |
| GPC3 | glypican 3 | -0.00519125 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | -0.00517697 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00517387 |
| OGN | osteoglycin | -0.00517164 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00517154 |
| GATA3 | GATA binding protein 3 | -0.0051707 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.0051634 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00515664 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00514331 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.00513662 |
| CPM | carboxypeptidase M | -0.00512844 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.00512415 |
| ZNF107 | zinc finger protein 107 | -0.00512161 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.0051166 |
| MEOX2 | mesenchyme homeobox 2 | -0.00510773 |
