TLR2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description toll-like receptor 2|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7097)
External Link http://www.ncbi.nlm.nih.gov/gene/7097
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Genes

35 interacting proteins for TLR2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
CD14 CD14 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CLEC4M C-type lectin domain family 4, member M
CLEC7A C-type lectin domain family 7, member A
CREBBP CREB binding protein
CXCR4 chemokine (C-X-C motif) receptor 4
EGFR epidermal growth factor receptor
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
LY96 lymphocyte antigen 96
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MYD88 myeloid differentiation primary response 88
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RIPK2 receptor-interacting serine-threonine kinase 2
SFTPA1 surfactant protein A1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SOCS1 suppressor of cytokine signaling 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR6 toll-like receptor 6
TOLLIP toll interacting protein
TRIP6 thyroid hormone receptor interactor 6