TLR3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description toll-like receptor 3|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7098)
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Genes

325 genes differentially expressed following the TLR3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SMIM38 small integral membrane protein 38 2.43092
HIC1 hypermethylated in cancer 1 2.43092
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.43092
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.43092
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.43092
CLCF1 cardiotrophin-like cytokine factor 1 2.43092
FGF4 fibroblast growth factor 4 2.43092
TTC16 tetratricopeptide repeat domain 16 2.43092
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.43092
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.43092
PGLYRP2 peptidoglycan recognition protein 2 2.43092
MEIG1 meiosis/spermiogenesis associated 1 2.43092
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.43092
HCST hematopoietic cell signal transducer 2.43092
C17ORF107 chromosome 17 open reading frame 107 2.43092
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.43092
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.43092
SIX3 SIX homeobox 3 2.43092
RNF39 ring finger protein 39 2.43092
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.43092
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.43092
GOLGA8R golgin A8 family, member R 2.43092
CHRD chordin 2.43092
CFAP299 cilia and flagella associated protein 299 2.43092
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.43092
PGAM2 phosphoglycerate mutase 2 (muscle) 2.43092
CFAP65 cilia and flagella associated protein 65 2.43092
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.43092
LBHD1 LBH domain containing 1 2.30346
FOXL2 forkhead box L2 2.30346
ADGRE3 adhesion G protein-coupled receptor E3 2.30346
CD6 CD6 molecule 2.30346
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.30346
LAPTM5 lysosomal protein transmembrane 5 2.30346
TMPRSS11F transmembrane protease, serine 11F 2.30346
SLC35D3 solute carrier family 35, member D3 2.30346
NKX2-6 NK2 homeobox 6 2.30346
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.30346
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.30346
RS1 retinoschisin 1 2.30346
IL22RA1 interleukin 22 receptor, alpha 1 2.30346
DNASE1L2 deoxyribonuclease I-like 2 2.30346
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.30346
CA7 carbonic anhydrase VII 2.30346
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.30346
C1ORF141 chromosome 1 open reading frame 141 2.30346
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.30346
TDRD1 tudor domain containing 1 2.30346
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.30346
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.30346
MYOM3 myomesin 3 2.30346
GPR26 G protein-coupled receptor 26 2.30346
HGD homogentisate 1,2-dioxygenase 2.30346
GPR151 G protein-coupled receptor 151 2.30346
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.30346
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.30346
DSG2 desmoglein 2 2.30346
PAX5 paired box 5 2.30346
SLC15A5 solute carrier family 15, member 5 2.30346
LRG1 leucine-rich alpha-2-glycoprotein 1 2.30346
GAGE12F G antigen 12F 2.30346
KLHL33 kelch-like family member 33 2.30346
PEDS1 plasmanylethanolamine desaturase 1 2.30346
CES4A carboxylesterase 4A 2.30346
GIPC3 GIPC PDZ domain containing family, member 3 2.30346
GPX5 glutathione peroxidase 5 2.30346
VGLL1 vestigial-like family member 1 2.30346
VN1R1 vomeronasal 1 receptor 1 2.30346
BZW2 basic leucine zipper and W2 domains 2 2.30346
PLN phospholamban 2.30346
DUSP8 dual specificity phosphatase 8 2.30346
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 2.30346
LPIN3 lipin 3 2.30346
ITPRID2 ITPR interacting domain containing 2 2.30346
SQOR sulfide quinone oxidoreductase 2.30346
SMIM35 small integral membrane protein 35 2.30346
H3C11 H3 clustered histone 11 2.30346
TEX13D TEX13 family member D 2.30346
SPATA46 spermatogenesis associated 46 2.30346
CALHM5 calcium homeostasis modulator family member 5 2.30346
HJV hemojuvelin BMP co-receptor 2.30346
CCDC198 coiled-coil domain containing 198 2.30346
DEPP1 DEPP autophagy regulator 1 2.30346
NOTCH2NLB notch 2 N-terminal like B 2.30346
H1-4 H1.4 linker histone, cluster member 2.30346
MYZAP myocardial zonula adherens protein 2.30346
TMEM40 transmembrane protein 40 2.30346
SAG S-antigen; retina and pineal gland (arrestin) 2.30346
TARM1 T cell-interacting, activating receptor on myeloid cells 1 2.30346
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.30346
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.30346
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.30346
MIP major intrinsic protein of lens fiber 2.30346
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.30346
FAM240C family with sequence similarity 240 member C 2.30346
CBLN3 cerebellin 3 precursor 2.30346
MEOX1 mesenchyme homeobox 1 2.30346
CLDN2 claudin 2 2.30346
ARHGAP15 Rho GTPase activating protein 15 2.30346
LRRC71 leucine rich repeat containing 71 2.30346
FOXC2 forkhead box C2 2.30346
GC group-specific component (vitamin D binding protein) 2.30346
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.30346
ZNF441 zinc finger protein 441 2.30346
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.30346
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.30346
TBX10 T-box 10 2.30346
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.30346
CNGA4 cyclic nucleotide gated channel alpha 4 2.30346
ZNF683 zinc finger protein 683 2.30346
C5ORF52 chromosome 5 open reading frame 52 2.30346
NEUROG3 neurogenin 3 2.30346
IBSP integrin-binding sialoprotein 2.30346
MRLN myoregulin 2.30346
LCT lactase 2.30346
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.30346
EFCAB9 EF-hand calcium binding domain 9 2.30346
TNR tenascin R 2.30346
DDB2 damage-specific DNA binding protein 2, 48kDa 2.30346
FGB fibrinogen beta chain 2.30346
AQP6 aquaporin 6, kidney specific 2.30346
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.30346
HAMP hepcidin antimicrobial peptide 2.30346
DLX3 distal-less homeobox 3 2.30346
GMDS GDP-mannose 4,6-dehydratase 2.30346
ANKRD62 ankyrin repeat domain 62 2.30346
DLX5 distal-less homeobox 5 2.30346
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.30346
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.30346
MORC1 MORC family CW-type zinc finger 1 2.30346
PCDHGB4 protocadherin gamma subfamily B, 4 2.30346
PCDHGB1 protocadherin gamma subfamily B, 1 2.30346
GLOD5 glyoxalase domain containing 5 2.30346
MTFR1 mitochondrial fission regulator 1 2.30346
IFITM5 interferon induced transmembrane protein 5 2.30346
KCNT2 potassium channel, sodium activated subfamily T, member 2 2.30346
VWA3A von Willebrand factor A domain containing 3A 2.30346
IL19 interleukin 19 2.30346
KISS1 KiSS-1 metastasis-suppressor 2.30346
EGR3 early growth response 3 2.30346
ZNF337 zinc finger protein 337 2.30346
MUC7 mucin 7, secreted 2.30346
SHISA8 shisa family member 8 2.30346
LIMCH1 LIM and calponin homology domains 1 2.30346
MAB21L3 mab-21-like 3 (C. elegans) 2.30346
SCML4 sex comb on midleg-like 4 (Drosophila) 2.30346
KLHL41 kelch-like family member 41 2.30346
IL21R interleukin 21 receptor 2.30346
VSTM1 V-set and transmembrane domain containing 1 2.30346
TRADD TNFRSF1A-associated via death domain 2.30346
NPFFR1 neuropeptide FF receptor 1 2.30346
SPATA4 spermatogenesis associated 4 2.30346
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.30346
FSHR follicle stimulating hormone receptor 2.30346
RUFY4 RUN and FYVE domain containing 4 2.30346
TCP11 t-complex 11, testis-specific 2.30346
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.30346
STAP1 signal transducing adaptor family member 1 2.30346
GOLGA8Q golgin A8 family, member Q 2.30346
TMEM184A transmembrane protein 184A 2.30346
CD22 CD22 molecule 2.30346
NKPD1 NTPase, KAP family P-loop domain containing 1 2.30346
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.30346
MMP10 matrix metallopeptidase 10 2.30346
TRAF3IP3 TRAF3 interacting protein 3 2.30346
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.30346
LOC105378220 macrophage receptor MARCO-like 2.30346
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.30346
S100A2 S100 calcium binding protein A2 2.30346
NPIPA7 nuclear pore complex interacting protein family, member A7 2.30346
GPR101 G protein-coupled receptor 101 2.30346
KRT72 keratin 72, type II 2.30346
OXT oxytocin/neurophysin I prepropeptide 2.30346
KRTAP5-11 keratin associated protein 5-11 2.30346
ASGR2 asialoglycoprotein receptor 2 2.30346
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.30346
SPACA5 sperm acrosome associated 5 2.30346
IFITM10 interferon induced transmembrane protein 10 2.30346
LHB luteinizing hormone beta polypeptide 2.30346
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.30346
FADS6 fatty acid desaturase 6 2.30346
CARNS1 carnosine synthase 1 2.30346
POTEI POTE ankyrin domain family, member I 2.30346
GHR growth hormone receptor 2.30346
MOBP myelin-associated oligodendrocyte basic protein 2.30346
RGS4 regulator of G-protein signaling 4 2.30346
EOMES eomesodermin 2.30346
TTC28 tetratricopeptide repeat domain 28 2.30346
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.30346
CLCNKA chloride channel, voltage-sensitive Ka 2.30346
MMP3 matrix metallopeptidase 3 2.30346
GRAPL GRB2-related adaptor protein-like 2.30346
ELF4 E74-like factor 4 (ets domain transcription factor) 2.28993
STAB1 stabilin 1 2.28993
HLA-DRA major histocompatibility complex, class II, DR alpha 2.28835
SMIM15 small integral membrane protein 15 2.28835
TMEM150A transmembrane protein 150A 2.28835
GCLC glutamate-cysteine ligase, catalytic subunit 2.28835
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.28619
ZIC5 Zic family member 5 2.2642
TENT5C terminal nucleotidyltransferase 5C 2.2446
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 2.2446
COL14A1 collagen, type XIV, alpha 1 2.23889
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.23889
SH3PXD2B SH3 and PX domains 2B 2.23844
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.22824
NLGN2 neuroligin 2 2.21095
COL19A1 collagen, type XIX, alpha 1 2.20412
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.20412
APOOL apolipoprotein O-like 2.11686
TMEM144 transmembrane protein 144 2.11066
TERT telomerase reverse transcriptase 2.10575
MED17 mediator complex subunit 17 2.10575
USP54 ubiquitin specific peptidase 54 2.09417
QPRT quinolinate phosphoribosyltransferase 2.07247
H4C3 H4 clustered histone 3 2.06897
FBXL4 F-box and leucine-rich repeat protein 4 2.06443
BTBD9 BTB (POZ) domain containing 9 2.06231
YIPF2 Yip1 domain family, member 2 2.05562
ITFG2 integrin alpha FG-GAP repeat containing 2 2.05408
ADPGK ADP-dependent glucokinase 2.05203
MAEA macrophage erythroblast attacher 2.04961
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 2.04961
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.04961
PLSCR2 phospholipid scramblase 2 2.04892
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.03462
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.02839
BOD1L1 biorientation of chromosomes in cell division 1-like 1 2.02543
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 2.02459
MEF2C myocyte enhancer factor 2C 2.02459
SLC35E2B solute carrier family 35, member E2B 2.01438
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 2.00108

decreased expression

Symbol Name Standardized Value
COX6C cytochrome c oxidase subunit VIc -2.43092
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) -2.43092
SWSAP1 SWIM-type zinc finger 7 associated protein 1 -2.43092
GHRHR growth hormone releasing hormone receptor -2.43092
ZNF445 zinc finger protein 445 -2.43092
GRK2 G protein-coupled receptor kinase 2 -2.40856
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -2.35492
SLC30A10 solute carrier family 30, member 10 -2.35492
BTN3A1 butyrophilin, subfamily 3, member A1 -2.30346
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.30346
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.30346
PRIMPOL primase and polymerase (DNA-directed) -2.30346
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -2.30346
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.30346
IKZF1 IKAROS family zinc finger 1 (Ikaros) -2.30346
TTC1 tetratricopeptide repeat domain 1 -2.30346
GTPBP3 GTP binding protein 3 (mitochondrial) -2.30346
RAB13 RAB13, member RAS oncogene family -2.30346
IPO13 importin 13 -2.30346
TMEM221 transmembrane protein 221 -2.30346
RHCE Rh blood group, CcEe antigens -2.30346
RPL26 ribosomal protein L26 -2.30346
PHYH phytanoyl-CoA 2-hydroxylase -2.30346
RDM1 RAD52 motif containing 1 -2.30346
RTRAF RNA transcription, translation and transport factor -2.30346
CNTD1 cyclin N-terminal domain containing 1 -2.30346
CCDC73 coiled-coil domain containing 73 -2.30346
GLB1L2 galactosidase, beta 1-like 2 -2.30346
ZBTB35 zinc finger and BTB domain containing 35 -2.30346
CD96 CD96 molecule -2.28835
TRIM73 tripartite motif containing 73 -2.28835
F2 coagulation factor II (thrombin) -2.28835
C2ORF72 chromosome 2 open reading frame 72 -2.28835
SPATS1 spermatogenesis associated, serine-rich 1 -2.28835
BLNK B-cell linker -2.28835
RIPK4 receptor-interacting serine-threonine kinase 4 -2.28835
ZNF892 zinc finger protein 892 -2.28835
LRRC73 leucine rich repeat containing 73 -2.28835
LECT2 leukocyte cell-derived chemotaxin 2 -2.28835
GDF6 growth differentiation factor 6 -2.28835
PARVG parvin, gamma -2.28835
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.28835
ULBP3 UL16 binding protein 3 -2.28835
FPGT fucose-1-phosphate guanylyltransferase -2.28835
GJA5 gap junction protein, alpha 5, 40kDa -2.28835
STK31 serine/threonine kinase 31 -2.28835
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.28835
DNAH8 dynein, axonemal, heavy chain 8 -2.28835
ALOXE3 arachidonate lipoxygenase 3 -2.28835
ZNF365 zinc finger protein 365 -2.28835
C17ORF99 chromosome 17 open reading frame 99 -2.28835
COL17A1 collagen, type XVII, alpha 1 -2.28835
RELN reelin -2.28835
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.28835
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.28835
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.28835
EXD1 exonuclease 3'-5' domain containing 1 -2.28835
IL17D interleukin 17D -2.28835
SORBS2 sorbin and SH3 domain containing 2 -2.27467
CCDC106 coiled-coil domain containing 106 -2.27411
PLTP phospholipid transfer protein -2.27029
FH fumarate hydratase -2.2642
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.26317
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.23889
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.23889
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.22334
CIBAR1 CBY1 interacting BAR domain containing 1 -2.21479
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.21479
EFS embryonal Fyn-associated substrate -2.21352
C1QL1 complement component 1, q subcomponent-like 1 -2.21352
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.17403
CRLS1 cardiolipin synthase 1 -2.16815
SPN sialophorin -2.15333
NCR1 natural cytotoxicity triggering receptor 1 -2.15333
LRATD1 LRAT domain containing 1 -2.14495
SMIM18 small integral membrane protein 18 -2.14495
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.13013
RPL12 ribosomal protein L12 -2.1224
TYMP thymidine phosphorylase -2.12109
ADAM23 ADAM metallopeptidase domain 23 -2.11373
TTF1 transcription termination factor, RNA polymerase I -2.10575
ZNF875 zinc finger protein 875 -2.10575
PCCA propionyl CoA carboxylase, alpha polypeptide -2.09936
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.08912
SFN stratifin -2.08579
TK2 thymidine kinase 2, mitochondrial -2.07375
RASGEF1C RasGEF domain family, member 1C -2.06897
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.04892
ARMCX4 armadillo repeat containing, X-linked 4 -2.02165
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.01894
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.00133
XK X-linked Kx blood group -2.00133
CRB3 crumbs family member 3 -2.00039