| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-like receptor 3|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7098) |
| External Link | https://ncbi.nlm.nih.gov/gene/7098 |
| Similar Terms | |
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499 genes differentially expressed following the TLR3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.0190809 |
| MAP7 | microtubule-associated protein 7 | 0.0141816 |
| FASN | fatty acid synthase | 0.0141052 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0139519 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0139473 |
| FOXF1 | forkhead box F1 | 0.0128859 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.0110241 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.010984 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0107178 |
| GOLGA8A | golgin A8 family, member A | 0.0104455 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.0103656 |
| SFTPB | surfactant protein B | 0.0100622 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.00981548 |
| TBL1X | transducin (beta)-like 1X-linked | 0.00964319 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.00960016 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00952553 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00952368 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00924356 |
| CST3 | cystatin C | 0.00924059 |
| CLU | clusterin | 0.00909033 |
| ADCY1 | adenylate cyclase 1 (brain) | 0.00903002 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00899695 |
| TOB1 | transducer of ERBB2, 1 | 0.0089691 |
| AUTS2 | autism susceptibility candidate 2 | 0.00896635 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00895685 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.00881842 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00880635 |
| PAX5 | paired box 5 | 0.0087198 |
| PRKCZ | protein kinase C, zeta | 0.00868865 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00865113 |
| CGA | glycoprotein hormones, alpha polypeptide | 0.00859532 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00852214 |
| METTL7A | methyltransferase like 7A | 0.00850429 |
| BLNK | B-cell linker | 0.00840059 |
| KRT18 | keratin 18, type I | 0.00836916 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00833956 |
| FZD2 | frizzled class receptor 2 | 0.0083095 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.00828514 |
| HELLS | helicase, lymphoid-specific | 0.00826549 |
| EXPH5 | exophilin 5 | 0.00825089 |
| IL7R | interleukin 7 receptor | 0.00820014 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00816555 |
| BRD2 | bromodomain containing 2 | 0.00814269 |
| SFTPC | surfactant protein C | 0.00811867 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00811751 |
| H2AX | H2A.X variant histone | 0.00809785 |
| LMNB1 | lamin B1 | 0.0080783 |
| HMGB3 | high mobility group box 3 | 0.00805692 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | 0.00805257 |
| NOTCH2NL | notch 2 N-terminal like | 0.00804023 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00803631 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.0080108 |
| KIF20A | kinesin family member 20A | 0.00797751 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00797675 |
| CIT | citron rho-interacting serine/threonine kinase | 0.00795904 |
| TMEM259 | transmembrane protein 259 | 0.00793612 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0078875 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00788028 |
| PLXNB1 | plexin B1 | 0.00781177 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.0077957 |
| GPSM2 | G-protein signaling modulator 2 | 0.00778352 |
| CBX6 | chromobox homolog 6 | 0.00769992 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00769972 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | 0.00768628 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00768243 |
| CSK | c-src tyrosine kinase | 0.00766802 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00765785 |
| SDC2 | syndecan 2 | 0.00762873 |
| TBC1D16 | TBC1 domain family, member 16 | 0.0076065 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.00760285 |
| CRLF1 | cytokine receptor-like factor 1 | 0.0074423 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00744112 |
| ZNF12 | zinc finger protein 12 | 0.0074262 |
| PCP4 | Purkinje cell protein 4 | 0.00742462 |
| MYO5C | myosin VC | 0.00741924 |
| CCNF | cyclin F | 0.00740022 |
| CCNL2 | cyclin L2 | 0.00738995 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | 0.00735752 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.00735442 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.00734037 |
| SYNGR3 | synaptogyrin 3 | 0.00733589 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.00730281 |
| CUX1 | cut-like homeobox 1 | 0.0072668 |
| STK39 | serine threonine kinase 39 | 0.00726503 |
| GRK2 | G protein-coupled receptor kinase 2 | 0.00724949 |
| AGRN | agrin | 0.00720876 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00718115 |
| TIMELESS | timeless circadian clock | 0.00711254 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00710496 |
| PRRC2B | proline-rich coiled-coil 2B | 0.00710483 |
| DNM1 | dynamin 1 | 0.00710416 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 0.00710188 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.00705075 |
| MBD1 | methyl-CpG binding domain protein 1 | 0.00700387 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 0.0069953 |
| CHKB | choline kinase beta | 0.00698827 |
| PTCH1 | patched 1 | 0.00698689 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00698035 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.00696845 |
| CTSZ | cathepsin Z | 0.00696841 |
| DGKZ | diacylglycerol kinase, zeta | 0.0069645 |
| CD320 | CD320 molecule | 0.00695985 |
| DVL1 | dishevelled segment polarity protein 1 | 0.0069538 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00695186 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.00693316 |
| PKM | pyruvate kinase, muscle | 0.00691867 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0069127 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.00687599 |
| DHFR | dihydrofolate reductase | 0.00686321 |
| ELAC2 | elaC ribonuclease Z 2 | 0.0068382 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.00681886 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.00677058 |
| PLXNA1 | plexin A1 | 0.0067598 |
| TATDN2 | TatD DNase domain containing 2 | 0.00675493 |
| SCRIB | scribbled planar cell polarity protein | 0.00674007 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.00673449 |
| OLFM1 | olfactomedin 1 | 0.00672778 |
| PRR11 | proline rich 11 | 0.00671566 |
| KRT20 | keratin 20, type I | 0.00669567 |
| FOXF2 | forkhead box F2 | 0.00667925 |
| EPHB2 | EPH receptor B2 | 0.00667722 |
| FOXM1 | forkhead box M1 | 0.00667526 |
| RABL6 | RAB, member RAS oncogene family-like 6 | 0.00666953 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00666456 |
| CTBP1 | C-terminal binding protein 1 | 0.00666313 |
| HIP1 | huntingtin interacting protein 1 | 0.00661045 |
| FRY | furry homolog (Drosophila) | 0.00660703 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.006607 |
| FKBP5 | FK506 binding protein 5 | 0.00655089 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.00653701 |
| NDRG1 | N-myc downstream regulated 1 | 0.00653184 |
| INTS1 | integrator complex subunit 1 | 0.00652962 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.00643616 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.0064271 |
| CBS | cystathionine-beta-synthase | 0.00642546 |
| KIF5B | kinesin family member 5B | 0.00641243 |
| ADCY9 | adenylate cyclase 9 | 0.00641196 |
| PRRC2A | proline-rich coiled-coil 2A | 0.00640923 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00640877 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00640003 |
| KIF14 | kinesin family member 14 | 0.00638205 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.00637776 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00636204 |
| HOXC6 | homeobox C6 | 0.00635478 |
| DGCR8 | DGCR8 microprocessor complex subunit | 0.00635045 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00631923 |
| USP48 | ubiquitin specific peptidase 48 | 0.00631299 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | 0.00628073 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.00627074 |
| CPE | carboxypeptidase E | 0.00626722 |
| PDE10A | phosphodiesterase 10A | 0.00626706 |
| MTMR1 | myotubularin related protein 1 | 0.00626368 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00626011 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.00624431 |
| LMNB2 | lamin B2 | 0.00623822 |
| TPI1 | triosephosphate isomerase 1 | 0.00622103 |
| NUP210 | nucleoporin 210kDa | 0.0062121 |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.00619963 |
| CDC7 | cell division cycle 7 | 0.00619436 |
| SFTPD | surfactant protein D | 0.00617999 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00617432 |
| PTK2 | protein tyrosine kinase 2 | 0.0061534 |
| TPBG | trophoblast glycoprotein | 0.00614597 |
| PPL | periplakin | 0.00614528 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.00614499 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.00614314 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00614261 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0061317 |
| TRIM28 | tripartite motif containing 28 | 0.00612566 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.00612105 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.00610919 |
| KIF11 | kinesin family member 11 | 0.00609152 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.00609094 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00608947 |
| CA12 | carbonic anhydrase XII | 0.00608937 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.00608784 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.00607483 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.0060667 |
| APMAP | adipocyte plasma membrane associated protein | 0.00605104 |
| TYMS | thymidylate synthetase | 0.00603947 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00602698 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.00602436 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.00601984 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.00601703 |
| E2F2 | E2F transcription factor 2 | 0.00601561 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.00600312 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.00600038 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.00599823 |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.0059946 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00598599 |
| ZNF160 | zinc finger protein 160 | 0.00598137 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.00596989 |
| SETD6 | SET domain containing 6 | 0.00596943 |
| DEK | DEK proto-oncogene | 0.00595283 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.00595164 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00593947 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 0.00593717 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.00593563 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.00593141 |
| MOK | MOK protein kinase | 0.00592265 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00591342 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.00590737 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00589911 |
| DGS2 | DiGeorge syndrome/velocardiofacial syndrome complex 2 | 0.00589825 |
| ESRP2 | epithelial splicing regulatory protein 2 | 0.00588728 |
| CLSTN1 | calsyntenin 1 | 0.00588667 |
| BCL7A | B-cell CLL/lymphoma 7A | 0.00586644 |
| HOXC10 | homeobox C10 | 0.00585273 |
| ZNF721 | zinc finger protein 721 | 0.00583142 |
| FEN1 | flap structure-specific endonuclease 1 | 0.00582556 |
| TLE2 | transducin-like enhancer of split 2 | 0.0058234 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.00582253 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.00581856 |
| DAZAP1 | DAZ associated protein 1 | 0.00580965 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | 0.00580935 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | 0.00580904 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.00580895 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00580594 |
| UBE4B | ubiquitination factor E4B | 0.00578332 |
| SRRT | serrate, RNA effector molecule | 0.00577876 |
| CD81 | CD81 molecule | 0.00577263 |
| EPN2 | epsin 2 | 0.0057691 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.00575588 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00575452 |
| ELANE | elastase, neutrophil expressed | 0.00574163 |
| REV1 | REV1, polymerase (DNA directed) | 0.00573677 |
| TLN1 | talin 1 | 0.00573604 |
| CTBP2 | C-terminal binding protein 2 | 0.00572956 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.00572278 |
| HIRA | histone cell cycle regulator | 0.00572181 |
| TGFB1 | transforming growth factor, beta 1 | 0.00571846 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 0.00571645 |
| EMP2 | epithelial membrane protein 2 | 0.00571482 |
| VARS | valyl-tRNA synthetase | 0.00571196 |
| TARDBP | TAR DNA binding protein | 0.00570788 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.00570175 |
| CERK | ceramide kinase | 0.00569688 |
| NOTCH2 | notch 2 | 0.00568662 |
| ZNF580 | zinc finger protein 580 | 0.00567894 |
| RHOT2 | ras homolog family member T2 | 0.00567743 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.00567227 |
| ABHD2 | abhydrolase domain containing 2 | 0.0056698 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.00566962 |
| FBXW12 | F-box and WD repeat domain containing 12 | 0.00566213 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.00565783 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.00565745 |
| TSPAN5 | tetraspanin 5 | 0.00565142 |
| HMG20B | high mobility group 20B | 0.00564116 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | 0.00563152 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | -0.0218834 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0215268 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0195424 |
| ATF3 | activating transcription factor 3 | -0.0195264 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0179415 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0171429 |
| IFI44 | interferon-induced protein 44 | -0.016392 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0160792 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0160571 |
| LCN2 | lipocalin 2 | -0.0160385 |
| IFI44L | interferon-induced protein 44-like | -0.0158754 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.0157536 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.0155232 |
| LTF | lactotransferrin | -0.0153238 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0151381 |
| MX1 | MX dynamin-like GTPase 1 | -0.0151217 |
| ANXA1 | annexin A1 | -0.0146759 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0141263 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0135394 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.0131561 |
| LY96 | lymphocyte antigen 96 | -0.0129792 |
| PLIN2 | perilipin 2 | -0.0128155 |
| ICAM2 | intercellular adhesion molecule 2 | -0.0127276 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0124527 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0124442 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.012342 |
| HIST1H2AC | histone cluster 1, H2ac | -0.0123191 |
| MT1G | metallothionein 1G | -0.0123038 |
| MYO1C | myosin IC | -0.0121449 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.0121264 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0120197 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.0119317 |
| CFI | complement factor I | -0.0119303 |
| MT1F | metallothionein 1F | -0.011928 |
| CLEC2B | C-type lectin domain family 2, member B | -0.0117855 |
| MT1E | metallothionein 1E | -0.0117315 |
| DEFB1 | defensin, beta 1 | -0.0116935 |
| DAPK1 | death-associated protein kinase 1 | -0.0116497 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0116093 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.0115021 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0114105 |
| BEX4 | brain expressed, X-linked 4 | -0.0113672 |
| RTP4 | receptor (chemosensory) transporter protein 4 | -0.0113141 |
| PITX3 | paired-like homeodomain 3 | -0.0112564 |
| S100A7 | S100 calcium binding protein A7 | -0.0112556 |
| PEG3 | paternally expressed 3 | -0.0111913 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0110809 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.0110556 |
| CRYAB | crystallin, alpha B | -0.0110053 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0109872 |
| MYBPC1 | myosin binding protein C, slow type | -0.0109339 |
| THBS2 | thrombospondin 2 | -0.0107787 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0107531 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.0107506 |
| CTSS | cathepsin S | -0.0106969 |
| DUSP5 | dual specificity phosphatase 5 | -0.0106651 |
| HSPA2 | heat shock 70kDa protein 2 | -0.010616 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.0105295 |
| KLK5 | kallikrein-related peptidase 5 | -0.0104937 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0103505 |
| S100A9 | S100 calcium binding protein A9 | -0.0102735 |
| EVI2A | ecotropic viral integration site 2A | -0.010271 |
| MAL | mal, T-cell differentiation protein | -0.0101709 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0101591 |
| IL1RN | interleukin 1 receptor antagonist | -0.0101439 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0101421 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.010104 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.0100964 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0100875 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00996303 |
| OPTN | optineurin | -0.00988691 |
| TSPAN8 | tetraspanin 8 | -0.00984054 |
| SELL | selectin L | -0.00981744 |
| OLFML3 | olfactomedin-like 3 | -0.00981525 |
| MMP7 | matrix metallopeptidase 7 | -0.00966646 |
| KRT14 | keratin 14, type I | -0.00966326 |
| KLK10 | kallikrein-related peptidase 10 | -0.00946801 |
| OAT | ornithine aminotransferase | -0.00942365 |
| MX2 | MX dynamin-like GTPase 2 | -0.00941239 |
| LXN | latexin | -0.00940272 |
| FOSL2 | FOS-like antigen 2 | -0.00936233 |
| MT1H | metallothionein 1H | -0.00935864 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.00925198 |
| HBB | hemoglobin, beta | -0.00921637 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | -0.00919846 |
| RGS4 | regulator of G-protein signaling 4 | -0.00918021 |
| RALB | v-ral simian leukemia viral oncogene homolog B | -0.00912172 |
| DCN | decorin | -0.00911043 |
| FN1 | fibronectin 1 | -0.00909153 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00906303 |
| MT1HL1 | metallothionein 1H-like 1 | -0.00906239 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00905265 |
| PLP1 | proteolipid protein 1 | -0.00895016 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | -0.00894958 |
| IRF1 | interferon regulatory factor 1 | -0.00893754 |
| RRAGD | Ras-related GTP binding D | -0.00892078 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.00888308 |
| LAMC2 | laminin, gamma 2 | -0.00881644 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00875454 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00875018 |
| RNF144A | ring finger protein 144A | -0.00874292 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00873751 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00871194 |
| MT1X | metallothionein 1X | -0.00867564 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00866732 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00863021 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00862967 |
| GPR65 | G protein-coupled receptor 65 | -0.00860409 |
| PPA1 | pyrophosphatase (inorganic) 1 | -0.00851354 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00851114 |
| GPX7 | glutathione peroxidase 7 | -0.00849078 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.00847424 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | -0.00846427 |
| ASS1 | argininosuccinate synthase 1 | -0.00842424 |
| TMEM140 | transmembrane protein 140 | -0.00840286 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00838506 |
| MXRA5 | matrix-remodelling associated 5 | -0.00837088 |
| SELENOW | selenoprotein W | -0.00835681 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00832012 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.00830301 |
| CLDN10 | claudin 10 | -0.00829669 |
| GLOD4 | glyoxalase domain containing 4 | -0.00826965 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.00826261 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0082446 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00821978 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00820748 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00817698 |
| SP110 | SP110 nuclear body protein | -0.00817541 |
| KYNU | kynureninase | -0.00816146 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.00815341 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00813539 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00812717 |
| PHF11 | PHD finger protein 11 | -0.00809335 |
| KRT7 | keratin 7, type II | -0.00807282 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00806403 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00805048 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | -0.00805035 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00804029 |
| TRIM22 | tripartite motif containing 22 | -0.00803849 |
| SAR1B | secretion associated, Ras related GTPase 1B | -0.00803227 |
| IL15 | interleukin 15 | -0.00803201 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00803115 |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent | -0.00801647 |
| SP100 | SP100 nuclear antigen | -0.00800312 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00799819 |
| LSP1 | lymphocyte-specific protein 1 | -0.00798615 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.0079852 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00797039 |
| CFB | complement factor B | -0.00796804 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0079405 |
| H1-2 | H1.2 linker histone, cluster member | -0.0079171 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00789668 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00787924 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -0.00787645 |
| CYTIP | cytohesin 1 interacting protein | -0.0078734 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00783932 |
| KLK6 | kallikrein-related peptidase 6 | -0.00783781 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -0.00782952 |
| ANXA3 | annexin A3 | -0.00781938 |
| INHBA | inhibin, beta A | -0.00781756 |
| NID2 | nidogen 2 (osteonidogen) | -0.007798 |
| TMEM135 | transmembrane protein 135 | -0.00778995 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00778636 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.00777134 |
| SSPN | sarcospan | -0.00776073 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.0077516 |
| IQCG | IQ motif containing G | -0.00771288 |
| CD93 | CD93 molecule | -0.00770247 |
| VCAN | versican | -0.00768144 |
| MT1M | metallothionein 1M | -0.00768096 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.007679 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0076597 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00765547 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00762423 |
| PLK2 | polo-like kinase 2 | -0.00761249 |
| HDAC9 | histone deacetylase 9 | -0.00759098 |
| CD53 | CD53 molecule | -0.00759014 |
| LUM | lumican | -0.00758369 |
| C1ORF115 | chromosome 1 open reading frame 115 | -0.00757561 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00756754 |
| RPS27L | ribosomal protein S27-like | -0.00756227 |
| EMP1 | epithelial membrane protein 1 | -0.00756166 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0075575 |
| CD86 | CD86 molecule | -0.00755658 |
| CREM | cAMP responsive element modulator | -0.00754268 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00753573 |
| ADD3 | adducin 3 (gamma) | -0.00749183 |
| CD300A | CD300a molecule | -0.00746398 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00744396 |
| CSTA | cystatin A (stefin A) | -0.00744327 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00741141 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | -0.00740012 |
| STK38L | serine/threonine kinase 38 like | -0.00739322 |
| EGR2 | early growth response 2 | -0.00738596 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.00738517 |
| KIFAP3 | kinesin-associated protein 3 | -0.00733467 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00732668 |
| KLF2 | Kruppel-like factor 2 | -0.00729373 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.00728713 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | -0.00727994 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0072763 |
| BCL2A1 | BCL2-related protein A1 | -0.00727261 |
| KRT5 | keratin 5, type II | -0.00725198 |
| S100A12 | S100 calcium binding protein A12 | -0.00721773 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00721255 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 | -0.0072106 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.00718082 |
| MIA | melanoma inhibitory activity | -0.00717762 |
| SST | somatostatin | -0.00715422 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00713976 |
| RIN3 | Ras and Rab interactor 3 | -0.0071391 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00713344 |
| DOK5 | docking protein 5 | -0.007132 |
| CCK | cholecystokinin | -0.00712695 |
| EGR3 | early growth response 3 | -0.00712447 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.00711812 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00710617 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00709643 |
| IL2RG | interleukin 2 receptor, gamma | -0.00709521 |
| GTF2B | general transcription factor IIB | -0.0070892 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00706691 |
| THBS1 | thrombospondin 1 | -0.007063 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00706193 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00704343 |
| C3ORF14 | chromosome 3 open reading frame 14 | -0.00703274 |
| ABLIM1 | actin binding LIM protein 1 | -0.00700184 |
| GIMAP4 | GTPase, IMAP family member 4 | -0.0069987 |
| SLN | sarcolipin | -0.00699848 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00698584 |
| KLK8 | kallikrein-related peptidase 8 | -0.00698132 |
| IFI35 | interferon-induced protein 35 | -0.00698001 |
| S100A8 | S100 calcium binding protein A8 | -0.00697076 |
| PLXNC1 | plexin C1 | -0.00695057 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.00694907 |
| XIC | X chromosome inactivation center | -0.00694471 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00693427 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | -0.0069339 |
| ATP5F1C | ATP synthase F1 subunit gamma | -0.00693161 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00692917 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0069246 |
| NCF2 | neutrophil cytosolic factor 2 | -0.00691023 |
| GMFG | glia maturation factor, gamma | -0.00690522 |
| IL32 | interleukin 32 | -0.00690048 |
| GALC | galactosylceramidase | -0.00689732 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.0068972 |
| FABP7 | fatty acid binding protein 7, brain | -0.00684855 |
| MYRF | myelin regulatory factor | -0.00683673 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00681942 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | -0.00681259 |
| RGS10 | regulator of G-protein signaling 10 | -0.00679778 |
