TLR3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description toll-like receptor 3|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7098)
External Link http://www.ncbi.nlm.nih.gov/gene/7098
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Genes

42 interacting proteins for TLR3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CSK c-src tyrosine kinase
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK2 interleukin-1 receptor-associated kinase 2
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBL2 mannose-binding lectin (protein C) 2, soluble
MYD88 myeloid differentiation primary response 88
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RNF216 ring finger protein 216
RPS27A ribosomal protein S27a
SARM1 sterile alpha and TIR motif containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TOLLIP toll interacting protein
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIL TLR4 interactor with leucine-rich repeats
TRIM69 tripartite motif containing 69
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1