| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-like receptor 4|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 7099) |
| External Link | https://ncbi.nlm.nih.gov/gene/7099 |
| Similar Terms | |
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497 genes differentially expressed following the TLR4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| METRN | meteorin, glial cell differentiation regulator | 0.0112538 |
| DENND2D | DENN/MADD domain containing 2D | 0.0110263 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00929892 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00869018 |
| LTF | lactotransferrin | 0.00771762 |
| EREG | epiregulin | 0.00721154 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00681622 |
| C7 | complement component 7 | 0.00676545 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00662469 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00656212 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.00642983 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.00626541 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | 0.00626319 |
| AQP9 | aquaporin 9 | 0.0059607 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00538126 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00535939 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00534823 |
| PON2 | paraoxonase 2 | 0.00529317 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00523665 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.00522461 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.00519844 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | 0.00511592 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00509262 |
| CTBP2 | C-terminal binding protein 2 | 0.00502598 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 0.00501734 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00500731 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00498902 |
| PLVAP | plasmalemma vesicle associated protein | 0.00495276 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00489939 |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.00489904 |
| CDA | cytidine deaminase | 0.00482077 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 0.0048108 |
| LYPLA1 | lysophospholipase I | 0.00473792 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00473601 |
| RBM47 | RNA binding motif protein 47 | 0.0047327 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00469681 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00467472 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00465496 |
| UPK1B | uroplakin 1B | 0.00461443 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00460573 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00457365 |
| LYZ | lysozyme | 0.00456901 |
| QDPR | quinoid dihydropteridine reductase | 0.00455793 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00454287 |
| KRT8 | keratin 8, type II | 0.0045162 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.00451111 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00449365 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00449141 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00448482 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00445743 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00445177 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00445119 |
| MPO | myeloperoxidase | 0.00440735 |
| CD19 | CD19 molecule | 0.00440284 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00440237 |
| ANXA3 | annexin A3 | 0.00439603 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00439008 |
| TPD52 | tumor protein D52 | 0.00437841 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | 0.00436898 |
| RAB20 | RAB20, member RAS oncogene family | 0.00436626 |
| ADD3 | adducin 3 (gamma) | 0.00435706 |
| MMP9 | matrix metallopeptidase 9 | 0.00434272 |
| IL18 | interleukin 18 | 0.00432182 |
| NUP50 | nucleoporin 50kDa | 0.00430378 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00425943 |
| GOLM1 | golgi membrane protein 1 | 0.00425782 |
| CD38 | CD38 molecule | 0.00424993 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | 0.00424075 |
| NFIC | nuclear factor I/C (CCAAT-binding transcription factor) | 0.00422725 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00421934 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00415995 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00414761 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | 0.00414077 |
| IL7R | interleukin 7 receptor | 0.00413114 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00408874 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.00408157 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.00406984 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 0.00405366 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00404878 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.0040432 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00404144 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.0040381 |
| GALE | UDP-galactose-4-epimerase | 0.00403176 |
| CNTN1 | contactin 1 | 0.00402649 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00401189 |
| PAX5 | paired box 5 | 0.00400809 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.00399867 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00396998 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | 0.00396462 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.003955 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00394954 |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.00394439 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00392899 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00392727 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.003904 |
| RGS20 | regulator of G-protein signaling 20 | 0.00390323 |
| MALL | mal, T-cell differentiation protein-like | 0.00389895 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.00389511 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00387512 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | 0.00385287 |
| CCNB1 | cyclin B1 | 0.00382415 |
| CD27 | CD27 molecule | 0.00380122 |
| RGS13 | regulator of G-protein signaling 13 | 0.0037867 |
| ABHD2 | abhydrolase domain containing 2 | 0.00375205 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00375123 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.00372819 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00372723 |
| CYP4F2 | cytochrome P450, family 4, subfamily F, polypeptide 2 | 0.00371856 |
| NUP85 | nucleoporin 85kDa | 0.00369368 |
| FBLN1 | fibulin 1 | 0.0036699 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00363773 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00363216 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00363116 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00361588 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein | 0.00361451 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00360829 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00358485 |
| SRM | spermidine synthase | 0.00358453 |
| PLA2G2D | phospholipase A2, group IID | 0.00358414 |
| TSPAN13 | tetraspanin 13 | 0.00358143 |
| EPHB2 | EPH receptor B2 | 0.00357903 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.00357632 |
| CD72 | CD72 molecule | 0.00357122 |
| XIC | X chromosome inactivation center | 0.00355844 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.00354012 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0035356 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00353408 |
| PFKP | phosphofructokinase, platelet | 0.00353262 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00351976 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.00351524 |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | 0.00350921 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00350853 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00350183 |
| NELL2 | NEL-like 2 (chicken) | 0.00350138 |
| SORD | sorbitol dehydrogenase | 0.00349955 |
| TLR4 | toll-like receptor 4 | 0.00349795 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.00349487 |
| HGD | homogentisate 1,2-dioxygenase | 0.00348668 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.00347452 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00346865 |
| PARK7 | parkinson protein 7 | 0.00346776 |
| TNS3 | tensin 3 | 0.00346263 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 0.00341918 |
| GPM6B | glycoprotein M6B | 0.00341653 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.00341419 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00339964 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00339511 |
| EFNB2 | ephrin-B2 | 0.00339479 |
| MMD | monocyte to macrophage differentiation-associated | 0.00338205 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00337566 |
| CBFB | core-binding factor, beta subunit | 0.00336887 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.003359 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.0033548 |
| SLC16A2 | solute carrier family 16, member 2 (thyroid hormone transporter) | 0.00334875 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 0.00334676 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.00332014 |
| CD8A | CD8a molecule | 0.00331768 |
| FOXF1 | forkhead box F1 | 0.00331521 |
| CTSK | cathepsin K | 0.00331009 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.00330536 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00330274 |
| KIAA0753 | KIAA0753 | 0.0033008 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00329505 |
| MGAM | maltase-glucoamylase | 0.00329156 |
| VPREB3 | pre-B lymphocyte 3 | 0.00329073 |
| TYMP | thymidine phosphorylase | 0.00328092 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.00328075 |
| STMN1 | stathmin 1 | 0.00325487 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.00324525 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00321882 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00321303 |
| RBM23 | RNA binding motif protein 23 | 0.00320915 |
| NID2 | nidogen 2 (osteonidogen) | 0.00320452 |
| RPIA | ribose 5-phosphate isomerase A | 0.00319455 |
| TLR2 | toll-like receptor 2 | 0.00318604 |
| STOM | stomatin | 0.00317979 |
| ATXN10 | ataxin 10 | 0.00317773 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | 0.00317594 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 0.0031698 |
| GRAMD1C | GRAM domain containing 1C | 0.00316509 |
| CTSS | cathepsin S | 0.00316503 |
| IL15 | interleukin 15 | 0.00315751 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00313243 |
| APOL6 | apolipoprotein L, 6 | 0.00313237 |
| TSPYL5 | TSPY-like 5 | 0.0031219 |
| PLEK2 | pleckstrin 2 | 0.00311802 |
| HMG20B | high mobility group 20B | 0.00311757 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 0.00311512 |
| TRMT5 | tRNA methyltransferase 5 | 0.00310773 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | 0.00310665 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.00310389 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00309986 |
| RARA | retinoic acid receptor, alpha | 0.00309824 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00308496 |
| NPY | neuropeptide Y | 0.00308422 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.0030839 |
| RCAN1 | regulator of calcineurin 1 | 0.00306964 |
| PF4 | platelet factor 4 | 0.00306832 |
| CORO1A | coronin, actin binding protein, 1A | 0.00306328 |
| CAV2 | caveolin 2 | 0.0030607 |
| SNX5 | sorting nexin 5 | 0.00305816 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.00305474 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.003053 |
| CS | citrate synthase | 0.00304948 |
| DSE | dermatan sulfate epimerase | 0.00304731 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00304271 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00303302 |
| NGRN | neugrin, neurite outgrowth associated | 0.00303118 |
| WDR77 | WD repeat domain 77 | 0.00302886 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00302843 |
| COL1A2 | collagen, type I, alpha 2 | 0.00302452 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00302313 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | 0.00301 |
| TUFM | Tu translation elongation factor, mitochondrial | 0.00299395 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00299259 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00299252 |
| SMC4 | structural maintenance of chromosomes 4 | 0.00298107 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.00297795 |
| FSTL1 | follistatin-like 1 | 0.00297643 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.00297124 |
| IL21R | interleukin 21 receptor | 0.00297 |
| GATA2 | GATA binding protein 2 | 0.00296418 |
| THY1 | Thy-1 cell surface antigen | 0.00296263 |
| SMOX | spermine oxidase | 0.0029605 |
| CDC6 | cell division cycle 6 | 0.00295967 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 0.0029571 |
| PRKCH | protein kinase C, eta | 0.00295646 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 0.00295103 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.00294194 |
| TAGLN2 | transgelin 2 | 0.00293996 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.00293884 |
| MRPL19 | mitochondrial ribosomal protein L19 | 0.00293679 |
| PLXNB2 | plexin B2 | 0.00293395 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.00293297 |
| TBXA2R | thromboxane A2 receptor | 0.00292799 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | 0.00292615 |
| TMEM243 | transmembrane protein 243, mitochondrial | 0.00292213 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.00292049 |
| CEP55 | centrosomal protein 55kDa | 0.00291794 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00291071 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00290485 |
| IPO13 | importin 13 | 0.00289419 |
| ISL1 | ISL LIM homeobox 1 | 0.0028854 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00288417 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.00288011 |
| RAB13 | RAB13, member RAS oncogene family | 0.00287647 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.0028654 |
| SALL1 | spalt-like transcription factor 1 | 0.00285808 |
| RPA3 | replication protein A3, 14kDa | 0.00285209 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FABP4 | fatty acid binding protein 4, adipocyte | -0.0103596 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00909304 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00763783 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00751026 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00726226 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00713643 |
| CLIC5 | chloride intracellular channel 5 | -0.0070945 |
| GNAS | GNAS complex locus | -0.00691664 |
| KRT14 | keratin 14, type I | -0.00659201 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00634896 |
| MMP7 | matrix metallopeptidase 7 | -0.00634682 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00623203 |
| ASS1 | argininosuccinate synthase 1 | -0.00622308 |
| APOD | apolipoprotein D | -0.00621778 |
| SYNM | synemin, intermediate filament protein | -0.00599554 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00595747 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00593894 |
| PITX3 | paired-like homeodomain 3 | -0.00590021 |
| KRT5 | keratin 5, type II | -0.00587803 |
| AHNAK | AHNAK nucleoprotein | -0.0058556 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00571277 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00570099 |
| RTN2 | reticulon 2 | -0.00567593 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.0054684 |
| PERP | PERP, TP53 apoptosis effector | -0.00544206 |
| OBSL1 | obscurin-like 1 | -0.00540463 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00540383 |
| CALML3 | calmodulin-like 3 | -0.00532964 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00532542 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0053123 |
| MIR22HG | MIR22 host gene | -0.00527958 |
| KLK6 | kallikrein-related peptidase 6 | -0.00527007 |
| CAVIN3 | caveolae associated protein 3 | -0.00526209 |
| RGCC | regulator of cell cycle | -0.00524282 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00522798 |
| DUSP5 | dual specificity phosphatase 5 | -0.00519225 |
| HOXC6 | homeobox C6 | -0.00517304 |
| OXTR | oxytocin receptor | -0.00517051 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.00514748 |
| MFAP5 | microfibrillar associated protein 5 | -0.00514442 |
| GDF15 | growth differentiation factor 15 | -0.00513284 |
| STON1 | stonin 1 | -0.00510053 |
| DOK5 | docking protein 5 | -0.00509053 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00508465 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.00507826 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0050628 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.005057 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00505147 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00503007 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00499175 |
| BMP7 | bone morphogenetic protein 7 | -0.00497451 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00496425 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00494439 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -0.00483442 |
| KRT23 | keratin 23, type I | -0.00482093 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00474691 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00474482 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00471937 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.00469402 |
| CLIC3 | chloride intracellular channel 3 | -0.00462364 |
| REXO2 | RNA exonuclease 2 | -0.00460473 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00459811 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00459361 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0045748 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | -0.00455693 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00455495 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.00455263 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0045371 |
| MX1 | MX dynamin-like GTPase 1 | -0.00451295 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0045113 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00450696 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00450082 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00447563 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.00446989 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0044494 |
| PRKCA | protein kinase C, alpha | -0.00442853 |
| PROM1 | prominin 1 | -0.00442816 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.00438524 |
| PKN1 | protein kinase N1 | -0.00436309 |
| JUND | jun D proto-oncogene | -0.00436232 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00435508 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.00435092 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | -0.00433884 |
| PKP1 | plakophilin 1 | -0.00433046 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00433028 |
| H1-2 | H1.2 linker histone, cluster member | -0.00430595 |
| JMJD1C | jumonji domain containing 1C | -0.00428833 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00428274 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.00427025 |
| EPHA2 | EPH receptor A2 | -0.00426146 |
| KRT15 | keratin 15, type I | -0.0042539 |
| CALHM2 | calcium homeostasis modulator 2 | -0.0042525 |
| LILRA4 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 | -0.00424348 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.00421541 |
| AFP | alpha-fetoprotein | -0.00418202 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00416332 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.00415089 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00413537 |
| TNS1 | tensin 1 | -0.00413309 |
| KRT17 | keratin 17, type I | -0.00412053 |
| FOLR1 | folate receptor 1 (adult) | -0.00410011 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00409949 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.00409691 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0040927 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00408894 |
| TRIM2 | tripartite motif containing 2 | -0.00408042 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -0.00407896 |
| TXLNA | taxilin alpha | -0.00407836 |
| STK38L | serine/threonine kinase 38 like | -0.00407755 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.0040766 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00407638 |
| FZD10 | frizzled class receptor 10 | -0.00400536 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00400181 |
| ZNF331 | zinc finger protein 331 | -0.00399508 |
| TXN | thioredoxin | -0.00398143 |
| ACVR2A | activin A receptor, type IIA | -0.00394206 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00393771 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00390313 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00390017 |
| INAVA | innate immunity activator | -0.00389257 |
| MYO1D | myosin ID | -0.00387228 |
| PPL | periplakin | -0.00386854 |
| CHRDL1 | chordin-like 1 | -0.00386625 |
| SESN1 | sestrin 1 | -0.00386188 |
| USP32P2 | ubiquitin specific peptidase 32 pseudogene 2 | -0.00385133 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00384451 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00384057 |
| NNMT | nicotinamide N-methyltransferase | -0.00380808 |
| CRYAB | crystallin, alpha B | -0.00379815 |
| SCP2 | sterol carrier protein 2 | -0.00376407 |
| TEX2 | testis expressed 2 | -0.003764 |
| KLK5 | kallikrein-related peptidase 5 | -0.00376203 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00374563 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | -0.00374166 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00374077 |
| SIK1 | salt-inducible kinase 1 | -0.00373349 |
| NXT2 | nuclear transport factor 2-like export factor 2 | -0.00373208 |
| MX2 | MX dynamin-like GTPase 2 | -0.00372765 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00370336 |
| PHTF2 | putative homeodomain transcription factor 2 | -0.00370227 |
| SEPTIN10 | septin 10 | -0.00369845 |
| DCTN3 | dynactin 3 (p22) | -0.00369759 |
| KRT16 | keratin 16, type I | -0.00368839 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00367395 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00367332 |
| COLEC12 | collectin sub-family member 12 | -0.00366492 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00365924 |
| C14ORF132 | chromosome 14 open reading frame 132 | -0.00365437 |
| TLK2 | tousled-like kinase 2 | -0.00365131 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00364734 |
| PGC | progastricsin (pepsinogen C) | -0.00364688 |
| TRIM29 | tripartite motif containing 29 | -0.00364121 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00363756 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.0036292 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00361197 |
| TUFT1 | tuftelin 1 | -0.00361061 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -0.00360679 |
| HELZ | helicase with zinc finger | -0.00360491 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00360142 |
| NCALD | neurocalcin delta | -0.00359851 |
| SOSTDC1 | sclerostin domain containing 1 | -0.00359147 |
| ANGPTL2 | angiopoietin-like 2 | -0.00358931 |
| S100A9 | S100 calcium binding protein A9 | -0.00358593 |
| MMP3 | matrix metallopeptidase 3 | -0.00358178 |
| RTN3 | reticulon 3 | -0.00355787 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -0.00355786 |
| ANOS1 | anosmin 1 | -0.00355511 |
| SYCP2 | synaptonemal complex protein 2 | -0.00355359 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00355106 |
| PDLIM4 | PDZ and LIM domain 4 | -0.00353559 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00353389 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.00352672 |
| S100A8 | S100 calcium binding protein A8 | -0.00352542 |
| MAOB | monoamine oxidase B | -0.00352513 |
| SERTAD2 | SERTA domain containing 2 | -0.00349743 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00348235 |
| SIKE1 | suppressor of IKBKE 1 | -0.00347982 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00347453 |
| RGS2 | regulator of G-protein signaling 2 | -0.00346767 |
| GSTA4 | glutathione S-transferase alpha 4 | -0.00346597 |
| EFNB3 | ephrin-B3 | -0.00346266 |
| GAB2 | GRB2-associated binding protein 2 | -0.00345872 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00344814 |
| SOGA1 | suppressor of glucose, autophagy associated 1 | -0.00344144 |
| DNM1L | dynamin 1-like | -0.00344013 |
| EMP1 | epithelial membrane protein 1 | -0.00343841 |
| PLAT | plasminogen activator, tissue | -0.00343655 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.00343623 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00343366 |
| MAP1A | microtubule-associated protein 1A | -0.00342714 |
| ZNF83 | zinc finger protein 83 | -0.00342522 |
| EGR2 | early growth response 2 | -0.00342445 |
| DUSP10 | dual specificity phosphatase 10 | -0.0034219 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -0.00340633 |
| BACE1 | beta-site APP-cleaving enzyme 1 | -0.00339322 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.00339164 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.00338989 |
| KLK8 | kallikrein-related peptidase 8 | -0.00338827 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00338425 |
| TNC | tenascin C | -0.00337922 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.003377 |
| DMAC2L | distal membrane arm assembly component 2 like | -0.00337451 |
| DKK4 | dickkopf WNT signaling pathway inhibitor 4 | -0.00337012 |
| NOTCH2NL | notch 2 N-terminal like | -0.00336495 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.00336091 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00334654 |
| AK1 | adenylate kinase 1 | -0.00334483 |
| KRT6B | keratin 6B, type II | -0.00333416 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00333116 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00332394 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.00331769 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00329915 |
| C5ORF28 | chromosome 5 open reading frame 28 | -0.00329906 |
| RNF11 | ring finger protein 11 | -0.00329032 |
| THBS2 | thrombospondin 2 | -0.00328914 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00328807 |
| CD99 | CD99 molecule | -0.00328426 |
| SPRR1B | small proline-rich protein 1B | -0.00328415 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.00328339 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0032814 |
| TAC1 | tachykinin, precursor 1 | -0.00328005 |
| NEK7 | NIMA-related kinase 7 | -0.00327822 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00327635 |
| IL17RB | interleukin 17 receptor B | -0.00327269 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.00326287 |
| EMC3 | ER membrane protein complex subunit 3 | -0.00326244 |
| MAPK9 | mitogen-activated protein kinase 9 | -0.00326233 |
| NUCB2 | nucleobindin 2 | -0.00326175 |
| LPPR1 | lipid phosphate phosphatase-related protein type 1 | -0.00325403 |
| BEX4 | brain expressed, X-linked 4 | -0.00325124 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.00324934 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.00323721 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00323385 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00322686 |
| ZFP36 | ZFP36 ring finger protein | -0.00322484 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.00322414 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00322389 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00321545 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.0032154 |
| IER5 | immediate early response 5 | -0.00321031 |
| PIH1D1 | PIH1 domain containing 1 | -0.00321014 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.00320341 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00320094 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.00318797 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00318032 |
| RRAGC | Ras-related GTP binding C | -0.00317401 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.00316926 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00316552 |
