TLR4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description toll-like receptor 4|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 7099)
External Link http://www.ncbi.nlm.nih.gov/gene/7099
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Genes

87 interacting proteins for TLR4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARAF A-Raf proto-oncogene, serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC47 coiled-coil domain containing 47
CD14 CD14 molecule
CD180 CD180 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CNPY4 canopy FGF signaling regulator 4
DEFB4A defensin, beta 4A
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
EGFR epidermal growth factor receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMGB1 high mobility group box 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
JAK1 Janus kinase 1
LTN1 listerin E3 ubiquitin protein ligase 1
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MYD88 myeloid differentiation primary response 88
NF1 neurofibromin 1
NOX4 NADPH oxidase 4
PDS5A PDS5 cohesin associated factor A
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP4C protein phosphatase 4, catalytic subunit
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF216 ring finger protein 216
RPS27A ribosomal protein S27a
RPTOR regulatory associated protein of MTOR, complex 1
SAMHD1 SAM domain and HD domain 1
SARM1 sterile alpha and TIR motif containing 1
SERTAD1 SERTA domain containing 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SMAD3 SMAD family member 3
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SOCS1 suppressor of cytokine signaling 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11IP serine/threonine kinase 11 interacting protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR5 toll-like receptor 5
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOLLIP toll interacting protein
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM69 tripartite motif containing 69
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2