| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | toll-like receptor 9|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 54106) |
| External Link | https://ncbi.nlm.nih.gov/gene/54106 |
| Similar Terms | |
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498 genes differentially expressed following the TLR9 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MGP | matrix Gla protein | 0.0172571 |
| SFRP1 | secreted frizzled-related protein 1 | 0.0163192 |
| PEG3 | paternally expressed 3 | 0.0142476 |
| FCGBP | Fc fragment of IgG binding protein | 0.0132639 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0132634 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.0130669 |
| OPHN1 | oligophrenin 1 | 0.0130104 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0125085 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.012301 |
| RGS5 | regulator of G-protein signaling 5 | 0.0121873 |
| GOLGA8A | golgin A8 family, member A | 0.0121285 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0119075 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.0117955 |
| CFD | complement factor D (adipsin) | 0.0111836 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0104369 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.010424 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0103779 |
| MX1 | MX dynamin-like GTPase 1 | 0.0102793 |
| XPO7 | exportin 7 | 0.0102693 |
| MEF2C | myocyte enhancer factor 2C | 0.00987186 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00947294 |
| TFF1 | trefoil factor 1 | 0.00942275 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.009401 |
| MAGEA3 | melanoma antigen family A3 | 0.00937133 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00929091 |
| ACKR3 | atypical chemokine receptor 3 | 0.00924803 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00924723 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00919869 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00915313 |
| TG | thyroglobulin | 0.00912418 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00908321 |
| NRN1 | neuritin 1 | 0.00903862 |
| PNMA8A | PNMA family member 8A | 0.0090277 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.00900013 |
| GUCY2C | guanylate cyclase 2C | 0.00891725 |
| MT1X | metallothionein 1X | 0.00889085 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.00878912 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00870688 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00868827 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00867359 |
| MEN1 | multiple endocrine neoplasia I | 0.0086559 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00865005 |
| CHGB | chromogranin B | 0.00862838 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00861236 |
| FMO1 | flavin containing monooxygenase 1 | 0.00859213 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.0085228 |
| NID2 | nidogen 2 (osteonidogen) | 0.00843332 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00842698 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00842295 |
| GOLGA8H | golgin A8 family, member H | 0.00841503 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.00828568 |
| HOXC6 | homeobox C6 | 0.00827974 |
| ZNF721 | zinc finger protein 721 | 0.00825212 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 0.00824706 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00822247 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00820993 |
| NES | nestin | 0.00813674 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00808561 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.00806336 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00804468 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00798881 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00791686 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00789237 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.00782149 |
| ZNF160 | zinc finger protein 160 | 0.00781987 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00781572 |
| PADI2 | peptidyl arginine deiminase, type II | 0.00778744 |
| MT1H | metallothionein 1H | 0.00777376 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00776885 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00771805 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.00771633 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00771156 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00769538 |
| SSPN | sarcospan | 0.00767105 |
| NRCAM | neuronal cell adhesion molecule | 0.00765565 |
| FMOD | fibromodulin | 0.00759579 |
| RGS4 | regulator of G-protein signaling 4 | 0.00759031 |
| PRPH | peripherin | 0.00755098 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00752459 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00745362 |
| EDN3 | endothelin 3 | 0.00744094 |
| MT1F | metallothionein 1F | 0.00742369 |
| PRR11 | proline rich 11 | 0.00730563 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00727344 |
| TCP1 | t-complex 1 | 0.00727165 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00725159 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00724284 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00723902 |
| THBS4 | thrombospondin 4 | 0.00723275 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.00720705 |
| MCAM | melanoma cell adhesion molecule | 0.00720276 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.0071994 |
| LAMB1 | laminin, beta 1 | 0.00715415 |
| VLDLR | very low density lipoprotein receptor | 0.00715216 |
| KRT15 | keratin 15, type I | 0.00714115 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00711648 |
| RET | ret proto-oncogene | 0.00707382 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0070293 |
| INSR | insulin receptor | 0.00699642 |
| GLG1 | golgi glycoprotein 1 | 0.00697282 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00695097 |
| GAS1 | growth arrest-specific 1 | 0.00691628 |
| TP63 | tumor protein p63 | 0.00689979 |
| PCDH9 | protocadherin 9 | 0.00686961 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00685779 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.00685199 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00684655 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00677467 |
| KLHDC8A | kelch domain containing 8A | 0.0067658 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00674231 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0067423 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00671525 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00669384 |
| LAMA4 | laminin, alpha 4 | 0.00664162 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00662093 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.00660147 |
| GLDC | glycine dehydrogenase (decarboxylating) | 0.006598 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | 0.00659205 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 0.00658061 |
| CPE | carboxypeptidase E | 0.00656082 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.0065469 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00653943 |
| PROM1 | prominin 1 | 0.00653764 |
| PTCH1 | patched 1 | 0.00653293 |
| BBX | bobby sox homolog (Drosophila) | 0.00652378 |
| GPM6B | glycoprotein M6B | 0.00652188 |
| GNAS | GNAS complex locus | 0.00646184 |
| IFI44L | interferon-induced protein 44-like | 0.00645587 |
| PDE8B | phosphodiesterase 8B | 0.0064511 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00644344 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00643496 |
| ITM2A | integral membrane protein 2A | 0.00642915 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00641403 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00640237 |
| MT1G | metallothionein 1G | 0.00639281 |
| PDE10A | phosphodiesterase 10A | 0.00638086 |
| TCTN2 | tectonic family member 2 | 0.00637685 |
| GAP43 | growth associated protein 43 | 0.00635358 |
| SCPEP1 | serine carboxypeptidase 1 | 0.00633817 |
| RELN | reelin | 0.00632685 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00630289 |
| FAM46C | family with sequence similarity 46, member C | 0.00628136 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 0.00625466 |
| BMP6 | bone morphogenetic protein 6 | 0.00625188 |
| HK2 | hexokinase 2 | 0.00623831 |
| WNT4 | wingless-type MMTV integration site family, member 4 | 0.00623554 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00622835 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.0062221 |
| EIF6 | eukaryotic translation initiation factor 6 | 0.00621479 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00621446 |
| TXLNA | taxilin alpha | 0.00621042 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.00620722 |
| MAGEA12 | melanoma antigen family A12 | 0.00620568 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.00617593 |
| TSHR | thyroid stimulating hormone receptor | 0.00613938 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00613843 |
| MXRA8 | matrix-remodelling associated 8 | 0.00611147 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00608305 |
| CCNB1 | cyclin B1 | 0.00607894 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00607315 |
| L1CAM | L1 cell adhesion molecule | 0.00606746 |
| ADM | adrenomedullin | 0.00605295 |
| BRD2 | bromodomain containing 2 | 0.00604785 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 0.00604706 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.00603196 |
| DUOX2 | dual oxidase 2 | 0.00602709 |
| MATN2 | matrilin 2 | 0.00600723 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00599812 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00599507 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00599251 |
| MAGEA1 | melanoma antigen family A1 | 0.00595381 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.00595305 |
| NR5A1 | nuclear receptor subfamily 5, group A, member 1 | 0.00594943 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00594305 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00593908 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.00592857 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00592843 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00592828 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00591882 |
| ABLIM1 | actin binding LIM protein 1 | 0.00591834 |
| JAK2 | Janus kinase 2 | 0.00590666 |
| CHPT1 | choline phosphotransferase 1 | 0.00588146 |
| SV2A | synaptic vesicle glycoprotein 2A | 0.0058588 |
| PHIP | pleckstrin homology domain interacting protein | 0.00585188 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 0.00584786 |
| MXRA5 | matrix-remodelling associated 5 | 0.00584375 |
| CLTB | clathrin, light chain B | 0.00583449 |
| RIOX2 | ribosomal oxygenase 2 | 0.00581674 |
| CDC42 | cell division cycle 42 | 0.00580796 |
| SGCE | sarcoglycan, epsilon | 0.00580629 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0058017 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00579101 |
| SRM | spermidine synthase | 0.00578836 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.00578067 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.00577372 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00576434 |
| FHL1 | four and a half LIM domains 1 | 0.00575134 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0057504 |
| FGF9 | fibroblast growth factor 9 | 0.00574295 |
| S100A7 | S100 calcium binding protein A7 | 0.00573562 |
| SMAD3 | SMAD family member 3 | 0.00573423 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.00570576 |
| XPNPEP2 | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound | 0.00568531 |
| PPIF | peptidylprolyl isomerase F | 0.00567352 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00566959 |
| ACACB | acetyl-CoA carboxylase beta | 0.00566224 |
| PRAME | preferentially expressed antigen in melanoma | 0.00565927 |
| SLN | sarcolipin | 0.00565239 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.00565068 |
| CALML3 | calmodulin-like 3 | 0.00564787 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00564324 |
| NCALD | neurocalcin delta | 0.00563538 |
| USP11 | ubiquitin specific peptidase 11 | 0.00563276 |
| VDAC2 | voltage-dependent anion channel 2 | 0.00562129 |
| PNN | pinin, desmosome associated protein | 0.0056165 |
| SFRP4 | secreted frizzled-related protein 4 | 0.00560565 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.00559869 |
| RAB29 | RAB29, member RAS oncogene family | 0.00559699 |
| NELL2 | NEL-like 2 (chicken) | 0.00557907 |
| PLIN1 | perilipin 1 | 0.00557168 |
| MX2 | MX dynamin-like GTPase 2 | 0.00557138 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.0055683 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00555505 |
| VSNL1 | visinin-like 1 | 0.0055483 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00554107 |
| SARAF | store-operated calcium entry-associated regulatory factor | 0.00554069 |
| OLFM1 | olfactomedin 1 | 0.00552561 |
| RAP1GAP | RAP1 GTPase activating protein | 0.00552248 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00552077 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 0.0055206 |
| CRYAB | crystallin, alpha B | 0.0055118 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 0.00549704 |
| KYNU | kynureninase | 0.00549373 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.00548362 |
| FOXE1 | forkhead box E1 | 0.00548024 |
| TYRP1 | tyrosinase-related protein 1 | 0.00547857 |
| SRPRB | signal recognition particle receptor, B subunit | 0.00547209 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00547092 |
| MYL4 | myosin, light chain 4, alkali; atrial, embryonic | 0.0054526 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.00544467 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 0.00543957 |
| CLCA1 | chloride channel accessory 1 | 0.00543136 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.00543079 |
| GPC3 | glypican 3 | 0.0054301 |
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 0.00538623 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.0053846 |
| NDRG1 | N-myc downstream regulated 1 | 0.00536795 |
| CIRBP | cold inducible RNA binding protein | 0.00535482 |
| DIO1 | deiodinase, iodothyronine, type I | 0.00535306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNDC9 | thioredoxin domain containing 9 | -0.02102 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0154491 |
| SLC25A46 | solute carrier family 25, member 46 | -0.0146329 |
| DCK | deoxycytidine kinase | -0.0139428 |
| RHOB | ras homolog family member B | -0.013205 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.0127785 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.0126094 |
| NNMT | nicotinamide N-methyltransferase | -0.0121263 |
| TGM2 | transglutaminase 2 | -0.0119391 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.0119036 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0115336 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0114622 |
| ANXA4 | annexin A4 | -0.0112532 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.010947 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.0107522 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0106444 |
| SIRT3 | sirtuin 3 | -0.0106168 |
| S100A2 | S100 calcium binding protein A2 | -0.0104328 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -0.0104194 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0103597 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.0103594 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0101174 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00996992 |
| ANXA3 | annexin A3 | -0.00973272 |
| KRT18 | keratin 18, type I | -0.00970138 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | -0.00965025 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00932315 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00927293 |
| C5ORF28 | chromosome 5 open reading frame 28 | -0.00903126 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | -0.00901801 |
| SAR1B | secretion associated, Ras related GTPase 1B | -0.00893799 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00889474 |
| MALL | mal, T-cell differentiation protein-like | -0.00888083 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00881133 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | -0.00880904 |
| KLF10 | Kruppel-like factor 10 | -0.00880476 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00876376 |
| PON2 | paraoxonase 2 | -0.00875081 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00853647 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | -0.00849649 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00845649 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00838465 |
| TCTA | T-cell leukemia translocation altered | -0.00834167 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.00833888 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00829107 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.00827877 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.0082397 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.00822751 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00819294 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.00815438 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00809876 |
| EXPH5 | exophilin 5 | -0.00805267 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.00801851 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00796976 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00791935 |
| TSPAN6 | tetraspanin 6 | -0.00789389 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00784439 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00782641 |
| MSMB | microseminoprotein, beta- | -0.00781505 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00780673 |
| TMEM126B | transmembrane protein 126B | -0.00780103 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00779973 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00778498 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00777592 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | -0.00775226 |
| GRSF1 | G-rich RNA sequence binding factor 1 | -0.0074958 |
| IL18 | interleukin 18 | -0.00749344 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.00747824 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.00747527 |
| RPIA | ribose 5-phosphate isomerase A | -0.00740588 |
| NMU | neuromedin U | -0.00736893 |
| PFDN4 | prefoldin subunit 4 | -0.00735863 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00733084 |
| TRAPPC3 | trafficking protein particle complex 3 | -0.00730601 |
| CUX2 | cut-like homeobox 2 | -0.00730264 |
| C1D | C1D nuclear receptor corepressor | -0.00729667 |
| SFTPD | surfactant protein D | -0.00728573 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.0072788 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | -0.00726014 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.00721197 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00720576 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00716875 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00715589 |
| EAF2 | ELL associated factor 2 | -0.00715389 |
| SFTPC | surfactant protein C | -0.007153 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.00714668 |
| PDCD10 | programmed cell death 10 | -0.0070938 |
| SUMO1 | small ubiquitin-like modifier 1 | -0.00709281 |
| CTSH | cathepsin H | -0.00707924 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00706727 |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | -0.00701765 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00700612 |
| AREG | amphiregulin | -0.00699894 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00697569 |
| RGS2 | regulator of G-protein signaling 2 | -0.00694053 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | -0.00693102 |
| PAEP | progestagen-associated endometrial protein | -0.00686295 |
| PTER | phosphotriesterase related | -0.00686013 |
| MTX2 | metaxin 2 | -0.00682676 |
| TMPRSS2 | transmembrane protease, serine 2 | -0.0068265 |
| RAB20 | RAB20, member RAS oncogene family | -0.00681949 |
| ORC4 | origin recognition complex, subunit 4 | -0.00680166 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00678349 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00675063 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00673684 |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) | -0.00668036 |
| EMX2 | empty spiracles homeobox 2 | -0.00665233 |
| RBM7 | RNA binding motif protein 7 | -0.00664528 |
| PGC | progastricsin (pepsinogen C) | -0.0066407 |
| SORD | sorbitol dehydrogenase | -0.00663328 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00662514 |
| C1QA | complement component 1, q subcomponent, A chain | -0.00662445 |
| HSPB8 | heat shock 22kDa protein 8 | -0.0066193 |
| NPTN | neuroplastin | -0.00657731 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00653785 |
| RAB38 | RAB38, member RAS oncogene family | -0.00653593 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | -0.00651162 |
| RP2 | retinitis pigmentosa 2 (X-linked recessive) | -0.00650034 |
| DAPK1 | death-associated protein kinase 1 | -0.00649161 |
| SLC12A7 | solute carrier family 12 (potassium/chloride transporter), member 7 | -0.00648578 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.00641702 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | -0.00641045 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00640037 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.0063733 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00637048 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0063439 |
| PDGFC | platelet derived growth factor C | -0.00634 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00633788 |
| CPD | carboxypeptidase D | -0.00633614 |
| PANK3 | pantothenate kinase 3 | -0.00631602 |
| ADIRF | adipogenesis regulatory factor | -0.00631221 |
| CHKB | choline kinase beta | -0.00630777 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00630544 |
| APOC1 | apolipoprotein C-I | -0.00628384 |
| CD52 | CD52 molecule | -0.00627592 |
| HAT1 | histone acetyltransferase 1 | -0.00627545 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00626695 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | -0.00624201 |
| EZR | ezrin | -0.00623567 |
| NPAT | nuclear protein, ataxia-telangiectasia locus | -0.00621708 |
| KRCC1 | lysine-rich coiled-coil 1 | -0.00619024 |
| ZNF468 | zinc finger protein 468 | -0.00617375 |
| HNMT | histamine N-methyltransferase | -0.0061644 |
| CETN2 | centrin, EF-hand protein, 2 | -0.00615921 |
| STK26 | serine/threonine protein kinase 26 | -0.00610536 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00608274 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00608071 |
| SEC24A | SEC24 family member A | -0.00607709 |
| ACOT9 | acyl-CoA thioesterase 9 | -0.00606832 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00604301 |
| TUFT1 | tuftelin 1 | -0.00601773 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00600381 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00598728 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00598368 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.00597143 |
| SDC4 | syndecan 4 | -0.00596885 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00596856 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.00596192 |
| LY96 | lymphocyte antigen 96 | -0.00595348 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -0.00591893 |
| HOXB2 | homeobox B2 | -0.00589273 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.00585784 |
| SC5D | sterol-C5-desaturase | -0.00585597 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.00585212 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00585096 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.0058087 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00580279 |
| COMMD8 | COMM domain containing 8 | -0.00579714 |
| GPI | glucose-6-phosphate isomerase | -0.00578008 |
| AMACR | alpha-methylacyl-CoA racemase | -0.00578003 |
| VEGFA | vascular endothelial growth factor A | -0.00576796 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00576295 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.00576143 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.00572888 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | -0.00572131 |
| MRPS2 | mitochondrial ribosomal protein S2 | -0.00572052 |
| TRIB3 | tribbles pseudokinase 3 | -0.00570489 |
| PRKCI | protein kinase C, iota | -0.00570279 |
| LACTB2 | lactamase, beta 2 | -0.00569391 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.00569193 |
| RAD51C | RAD51 paralog C | -0.00567924 |
| PAGE4 | P antigen family, member 4 (prostate associated) | -0.00566953 |
| ASF1A | anti-silencing function 1A histone chaperone | -0.00566897 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | -0.00566106 |
| MED21 | mediator complex subunit 21 | -0.00564767 |
| CCNG2 | cyclin G2 | -0.00564515 |
| DCP2 | decapping mRNA 2 | -0.00564294 |
| LRRC15 | leucine rich repeat containing 15 | -0.00563752 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00563197 |
| PRSS8 | protease, serine, 8 | -0.00561856 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00561148 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00561147 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | -0.00561032 |
| MDFIC | MyoD family inhibitor domain containing | -0.00560226 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.00558249 |
| BCL2L1 | BCL2-like 1 | -0.00557806 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00557441 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | -0.00557335 |
| TEX30 | testis expressed 30 | -0.00557127 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.00557057 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00556936 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00556093 |
| AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | -0.00554906 |
| RAB32 | RAB32, member RAS oncogene family | -0.00554866 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00554734 |
| DHCR24 | 24-dehydrocholesterol reductase | -0.00554726 |
| MEIS2 | Meis homeobox 2 | -0.00554238 |
| NOP10 | NOP10 ribonucleoprotein | -0.00554091 |
| COX7B | cytochrome c oxidase subunit VIIb | -0.00553173 |
| CLDN3 | claudin 3 | -0.00553039 |
| TRAF5 | TNF receptor-associated factor 5 | -0.00551894 |
| SEPTIN10 | septin 10 | -0.00550537 |
| TTC33 | tetratricopeptide repeat domain 33 | -0.00550384 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -0.00550341 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00550082 |
| CRYM | crystallin, mu | -0.00548817 |
| LPXN | leupaxin | -0.00547253 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | -0.00545898 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.00545868 |
| UBL3 | ubiquitin-like 3 | -0.00545242 |
| NEK7 | NIMA-related kinase 7 | -0.00544519 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -0.00544396 |
| INSIG2 | insulin induced gene 2 | -0.00543711 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00542346 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.00539835 |
| INHBA | inhibin, beta A | -0.00539519 |
| CST3 | cystatin C | -0.0053917 |
| MED7 | mediator complex subunit 7 | -0.00538311 |
| SPAG16 | sperm associated antigen 16 | -0.00538232 |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 | -0.00537819 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -0.00536099 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -0.00536082 |
| CD46 | CD46 molecule, complement regulatory protein | -0.00534921 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.00534408 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -0.00533255 |
| NDNF | neuron-derived neurotrophic factor | -0.00533226 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00532993 |
| FASTKD3 | FAST kinase domains 3 | -0.00531986 |
| MLPH | melanophilin | -0.00531188 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.0053076 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00530756 |
| PXDC1 | PX domain containing 1 | -0.00529817 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.00527294 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0052708 |
| TRIM13 | tripartite motif containing 13 | -0.0052678 |
| FMO5 | flavin containing monooxygenase 5 | -0.00525862 |
| TSPAN8 | tetraspanin 8 | -0.00525472 |
| WASF1 | WAS protein family, member 1 | -0.00525396 |
| ARG1 | arginase 1 | -0.00525387 |
