TMEM70 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transmembrane protein 70|This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 54968)
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Genes

329 genes differentially expressed following the TMEM70 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PVRIG poliovirus receptor related immunoglobulin domain containing 2.678
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.678
CDH5 cadherin 5, type 2 (vascular endothelium) 2.678
SLC46A2 solute carrier family 46, member 2 2.678
RAX retina and anterior neural fold homeobox 2.678
HES7 hes family bHLH transcription factor 7 2.678
AFM afamin 2.678
LRRC56 leucine rich repeat containing 56 2.678
ZNF180 zinc finger protein 180 2.678
CA6 carbonic anhydrase VI 2.678
NAPSA napsin A aspartic peptidase 2.678
CD274 CD274 molecule 2.678
FPR2 formyl peptide receptor 2 2.678
PRB1 proline-rich protein BstNI subfamily 1 2.678
TBX22 T-box 22 2.678
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.678
RNF151 ring finger protein 151 2.678
HNF4A hepatocyte nuclear factor 4, alpha 2.678
SRPX2 sushi-repeat containing protein, X-linked 2 2.678
TMEM212 transmembrane protein 212 2.678
UPK3B uroplakin 3B 2.678
SP7 Sp7 transcription factor 2.678
ADAMTSL5 ADAMTS-like 5 2.678
PCDH9 protocadherin 9 2.678
CRYGA crystallin, gamma A 2.678
ATOH1 atonal homolog 1 (Drosophila) 2.678
BMP2 bone morphogenetic protein 2 2.678
BMP3 bone morphogenetic protein 3 2.678
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.678
SERTM1 serine-rich and transmembrane domain containing 1 2.678
NWD2 NACHT and WD repeat domain containing 2 2.678
FGF7 fibroblast growth factor 7 2.678
FAM81B family with sequence similarity 81, member B 2.678
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.678
SLC44A4 solute carrier family 44, member 4 2.678
C9ORF152 chromosome 9 open reading frame 152 2.678
C9ORF153 chromosome 9 open reading frame 153 2.678
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.678
KIAA2012 KIAA2012 2.678
C1QB complement component 1, q subcomponent, B chain 2.678
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.678
F2 coagulation factor II (thrombin) 2.678
PLK5 polo-like kinase 5 2.678
HBZ hemoglobin, zeta 2.678
HRG histidine-rich glycoprotein 2.678
ZNF436 zinc finger protein 436 2.678
SPATA31G1 SPATA31 subfamily G member 1 2.678
GARS1 glycyl-tRNA synthetase 1 2.678
FYB1 FYN binding protein 1 2.678
OTOF otoferlin 2.678
RAG2 recombination activating gene 2 2.678
MLN motilin 2.678
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.678
TRIM31 tripartite motif containing 31 2.678
MYEOV myeloma overexpressed 2.678
C10ORF53 chromosome 10 open reading frame 53 2.678
DEPP1 DEPP autophagy regulator 1 2.678
H2BC3 H2B clustered histone 3 2.678
FAM240A family with sequence similarity 240 member A 2.678
CPNE8-AS1 CPNE8 antisense RNA 1 2.678
CFAP97D2 CFAP97 domain containing 2 2.678
LHFPL7 LHFPL tetraspan subfamily member 7 2.678
ACP4 acid phosphatase 4 2.678
CFAP276 cilia and flagella associated protein 276 2.678
GARIN6 golgi associated RAB2 interactor family member 6 2.678
CFAP206 cilia and flagella associated protein 206 2.678
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.678
DYNLRB2 dynein, light chain, roadblock-type 2 2.678
LTA lymphotoxin alpha 2.678
GPR84 G protein-coupled receptor 84 2.678
CBLN4 cerebellin 4 precursor 2.678
C3ORF80 chromosome 3 open reading frame 80 2.678
MAG myelin associated glycoprotein 2.678
EDAR ectodysplasin A receptor 2.678
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.678
SNX20 sorting nexin 20 2.678
TUBA3D tubulin, alpha 3d 2.678
PRB2 proline-rich protein BstNI subfamily 2 2.678
FOXD1 forkhead box D1 2.678
SIM2 single-minded family bHLH transcription factor 2 2.678
ZNF575 zinc finger protein 575 2.678
FRK fyn-related Src family tyrosine kinase 2.678
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.678
OOSP1 oocyte secreted protein 1, pseudogene 2.678
C7 complement component 7 2.678
CCR7 chemokine (C-C motif) receptor 7 2.678
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.678
TLR9 toll-like receptor 9 2.678
TLR8 toll-like receptor 8 2.678
SYK spleen tyrosine kinase 2.678
RAB44 RAB44, member RAS oncogene family 2.678
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.678
RSAD2 radical S-adenosyl methionine domain containing 2 2.678
TBX1 T-box 1 2.678
APOF apolipoprotein F 2.678
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.678
IL9R interleukin 9 receptor 2.678
ARL13A ADP-ribosylation factor-like 13A 2.678
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.678
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.678
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.678
IGIP IgA-inducing protein 2.678
XIRP2 xin actin binding repeat containing 2 2.678
PRSS57 protease, serine, 57 2.678
SYNGR4 synaptogyrin 4 2.678
NOBOX NOBOX oogenesis homeobox 2.678
NCR3 natural cytotoxicity triggering receptor 3 2.678
SLC38A3 solute carrier family 38, member 3 2.678
IGFBP7 insulin-like growth factor binding protein 7 2.678
LOC124901449 uncharacterized LOC124901449 2.678
ERICH3 glutamate-rich 3 2.678
TMSB4X thymosin beta 4, X-linked 2.678
CPA3 carboxypeptidase A3 (mast cell) 2.678
SPATA4 spermatogenesis associated 4 2.678
SERINC4 serine incorporator 4 2.678
NPFFR1 neuropeptide FF receptor 1 2.678
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.678
PCDHGA7 protocadherin gamma subfamily A, 7 2.678
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.678
CYSLTR1 cysteinyl leukotriene receptor 1 2.678
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.678
CATIP ciliogenesis associated TTC17 interacting protein 2.678
IGF2 insulin-like growth factor 2 2.678
ADORA1 adenosine A1 receptor 2.678
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.678
NXNL1 nucleoredoxin-like 1 2.678
EDN1 endothelin 1 2.678
TBC1D21 TBC1 domain family, member 21 2.678
TBC1D26 TBC1 domain family, member 26 2.678
SH2D1B SH2 domain containing 1B 2.678
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.678
CLRN1 clarin 1 2.678
TGM7 transglutaminase 7 2.678
MEPE matrix extracellular phosphoglycoprotein 2.678
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.678
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.678
CNGB1 cyclic nucleotide gated channel beta 1 2.678
TEX26 testis expressed 26 2.678
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.678
IRX1 iroquois homeobox 1 2.678
CD3D CD3d molecule, delta (CD3-TCR complex) 2.678
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.678
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.678
TPH1 tryptophan hydroxylase 1 2.678
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.678
NUTM2G NUT family member 2G 2.678
TGM3 transglutaminase 3 2.678
TTC36 tetratricopeptide repeat domain 36 2.678
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.678
C9ORF57 chromosome 9 open reading frame 57 2.678
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.678
SLC25A34 solute carrier family 25, member 34 2.678
MYADML2 myeloid-associated differentiation marker-like 2 2.678
ADAP1 ArfGAP with dual PH domains 1 2.678
HHIPL2 HHIP-like 2 2.678
DEFB134 defensin, beta 134 2.678
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.678
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.678
CD8A CD8a molecule 2.678
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.6415
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 2.62867
TMEM82 transmembrane protein 82 2.60628
IFT70B intraflagellar transport 70B 2.60628
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.60628
GREB1L growth regulation by estrogen in breast cancer-like 2.60628
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.60628
SLC35F1 solute carrier family 35, member F1 2.56116
PANK4 pantothenate kinase 4 2.54149
YJEFN3 YjeF N-terminal domain containing 3 2.52546
NPNT nephronectin 2.44673
FAM131A family with sequence similarity 131, member A 2.44673
TULP4 tubby like protein 4 2.42581
AAK1 AP2 associated kinase 1 2.42024
GARIN2 golgi associated RAB2 interactor family member 2 2.4091
CA8 carbonic anhydrase VIII 2.33862
CDH7 cadherin 7, type 2 2.32434
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.318
FZD2 frizzled class receptor 2 2.28774
P4HB prolyl 4-hydroxylase, beta polypeptide 2.2863
TRMT5 tRNA methyltransferase 5 2.28355
EVI5L ecotropic viral integration site 5-like 2.2822
MB21D2 Mab-21 domain containing 2 2.28114
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.26583
PCNX4 pecanex 4 2.2648
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.25483
SALL2 spalt-like transcription factor 2 2.25053
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.24411
CDKL3 cyclin-dependent kinase-like 3 2.24104
SUN1 Sad1 and UNC84 domain containing 1 2.23284
TSLIG2 tRNA splicing ligase complex subunit 2 2.23284
METTL15 methyltransferase like 15 2.22058
CCDC85A coiled-coil domain containing 85A 2.21658
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.20607
RECQL4 RecQ protein-like 4 2.1949
CDHR2 cadherin-related family member 2 2.1946
LRRC1 leucine rich repeat containing 1 2.15188
TSPAN18 tetraspanin 18 2.1508
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.14917
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.14348
KLHDC8B kelch domain containing 8B 2.13169
FAM217A family with sequence similarity 217, member A 2.11647
TPH2 tryptophan hydroxylase 2 2.1144
CYB5R2 cytochrome b5 reductase 2 2.11223
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.10549
NRG1 neuregulin 1 2.09674
RWDD1 RWD domain containing 1 2.07613
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.04941
CNOT6L CCR4-NOT transcription complex, subunit 6-like 2.04682
IRGQ immunity-related GTPase family, Q 2.04682
RMDN2 regulator of microtubule dynamics 2 2.04669
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 2.04669
TPM2 tropomyosin 2 (beta) 2.04388
APIP APAF1 interacting protein 2.03169
CCDC8 coiled-coil domain containing 8 2.02672
NT5DC3 5'-nucleotidase domain containing 3 2.01734
HRK harakiri, BCL2 interacting protein 2.01275
DOK5 docking protein 5 2.00998

decreased expression

Symbol Name Standardized Value
KLK14 kallikrein-related peptidase 14 -2.678
DDTL D-dopachrome tautomerase-like -2.678
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.678
HAP1 huntingtin-associated protein 1 -2.678
MEDAG mesenteric estrogen-dependent adipogenesis -2.678
SCFD1 sec1 family domain containing 1 -2.678
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -2.678
ZNF311 zinc finger protein 311 -2.678
ADAMTSL4 ADAMTS-like 4 -2.678
AARD alanine and arginine rich domain containing protein -2.678
CASR calcium-sensing receptor -2.678
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.678
HPCA hippocalcin -2.678
KCTD17 potassium channel tetramerization domain containing 17 -2.678
CBY3 chibby homolog 3 (Drosophila) -2.678
CNTN3 contactin 3 (plasmacytoma associated) -2.678
FMO5 flavin containing monooxygenase 5 -2.678
DNAH5 dynein, axonemal, heavy chain 5 -2.678
ZNF282 zinc finger protein 282 -2.65652
ZNF853 zinc finger protein 853 -2.62543
BTN2A1 butyrophilin, subfamily 2, member A1 -2.60735
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.60628
XKRX XK, Kell blood group complex subunit-related, X-linked -2.60628
ATP8B4 ATPase, class I, type 8B, member 4 -2.60628
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.60628
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.60628
BRICD5 BRICHOS domain containing 5 -2.60628
TSHZ1 teashirt zinc finger homeobox 1 -2.60628
GALR3 galanin receptor 3 -2.60628
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.60628
CLCN1 chloride channel, voltage-sensitive 1 -2.60628
TMEM70 transmembrane protein 70 -2.60628
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.60628
ALX1 ALX homeobox 1 -2.60628
TBC1D3L TBC1 domain family, member 3L -2.60628
TEDC1 tubulin epsilon and delta complex 1 -2.60628
ZAR1L zygote arrest 1-like -2.60628
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.60628
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.60628
RP1L1 retinitis pigmentosa 1-like 1 -2.60628
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.60628
MAGEA4 melanoma antigen family A4 -2.60628
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) -2.60628
SNAP25 synaptosomal-associated protein, 25kDa -2.60628
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.60628
SCIN scinderin -2.60628
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.60628
UBXN10 UBX domain protein 10 -2.60628
EFCC1 EF-hand and coiled-coil domain containing 1 -2.60628
CSPG4 chondroitin sulfate proteoglycan 4 -2.60628
BEAN1 brain expressed, associated with NEDD4, 1 -2.60628
CAMK2B calcium/calmodulin-dependent protein kinase II beta -2.60628
PCDHA13 protocadherin alpha 13 -2.60628
MAEL maelstrom spermatogenic transposon silencer -2.60628
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.60628
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.60628
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -2.60628
GRM2 glutamate receptor, metabotropic 2 -2.60628
MTO1 mitochondrial tRNA translation optimization 1 -2.60628
CYB561D1 cytochrome b561 family, member D1 -2.58443
STIP1 stress-induced phosphoprotein 1 -2.53227
CCNJL cyclin J-like -2.51877
PF4 platelet factor 4 -2.50979
SEPTIN4 septin 4 -2.4968
CRIP2 cysteine-rich protein 2 -2.44569
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.44569
BLTP3A bridge-like lipid transfer protein family member 3A -2.4348
COMMD3 COMM domain containing 3 -2.41668
ADGRD2 adhesion G protein-coupled receptor D2 -2.4091
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.39783
STX3 syntaxin 3 -2.39726
NID1 nidogen 1 -2.39156
ZNF638 zinc finger protein 638 -2.36862
DEDD2 death effector domain containing 2 -2.35413
ENOSF1 enolase superfamily member 1 -2.34545
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -2.28936
ZNF154 zinc finger protein 154 -2.2863
ELP4 elongator acetyltransferase complex subunit 4 -2.26538
MYO5C myosin VC -2.26538
LIG3 ligase III, DNA, ATP-dependent -2.25053
SLX4IP SLX4 interacting protein -2.22085
ARHGAP26 Rho GTPase activating protein 26 -2.21489
ZNF618 zinc finger protein 618 -2.21489
RNF13 ring finger protein 13 -2.20302
ZNF682 zinc finger protein 682 -2.19567
EIF5 eukaryotic translation initiation factor 5 -2.19549
ISCA2 iron-sulfur cluster assembly 2 -2.187
PROSER3 proline and serine rich 3 -2.18282
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -2.16857
DKC1 dyskeratosis congenita 1, dyskerin -2.1674
PLSCR2 phospholipid scramblase 2 -2.16632
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.16546
GLA galactosidase, alpha -2.16546
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.16546
RPS11 ribosomal protein S11 -2.16237
WDFY1 WD repeat and FYVE domain containing 1 -2.15814
GRIPAP1 GRIP1 associated protein 1 -2.15627
BTBD7 BTB (POZ) domain containing 7 -2.14654
KIF21A kinesin family member 21A -2.14348
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.13501
CALN1 calneuron 1 -2.13366
PPHLN1 periphilin 1 -2.13093
TIMP2 TIMP metallopeptidase inhibitor 2 -2.10622
SDC1 syndecan 1 -2.10549
RAB3C RAB3C, member RAS oncogene family -2.09796
CCDC175 coiled-coil domain containing 175 -2.08954
IQSEC3 IQ motif and Sec7 domain 3 -2.07683
NUDCD3 NudC domain containing 3 -2.04682
JAM3 junctional adhesion molecule 3 -2.03818
SYT16 synaptotagmin XVI -2.03404
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.01604
INSYN2A inhibitory synaptic factor 2A -2.01023