| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/44249042 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in TMN 355 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 2.03 |
| APOE | apolipoprotein E | 1.57 |
| ANKRD24 | ankyrin repeat domain 24 | 1.51 |
| C4BPA | complement component 4 binding protein, alpha | 1.4 |
| F10 | coagulation factor X | 1.19 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 1.13 |
| LPIN1 | lipin 1 | 1.09 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.99 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.79 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.7 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.55 |
| HAS3 | hyaluronan synthase 3 | 0.49 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.48 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.48 |
| SQLE | squalene epoxidase | 0.46 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.46 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | 0.45 |
| RPL26 | ribosomal protein L26 | 0.44 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.44 |
| DNM1 | dynamin 1 | 0.42 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.42 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.41 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.41 |
| MID2 | midline 2 | 0.41 |
| TIGD1 | tigger transposable element derived 1 | 0.4 |
| MSMO1 | methylsterol monooxygenase 1 | 0.4 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | 0.39 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.38 |
| ZNF275 | zinc finger protein 275 | 0.37 |
| ZNF511 | zinc finger protein 511 | 0.37 |
| NEK4 | NIMA-related kinase 4 | 0.37 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.37 |
| RHBDD1 | rhomboid domain containing 1 | 0.37 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.36 |
| ACTBL2 | actin, beta-like 2 | 0.35 |
| CEP112 | centrosomal protein 112kDa | 0.35 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.35 |
| HES1 | hes family bHLH transcription factor 1 | 0.34 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.34 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.34 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.34 |
| OSMR | oncostatin M receptor | 0.33 |
| ZHX3 | zinc fingers and homeoboxes 3 | 0.33 |
| GLMP | glycosylated lysosomal membrane protein | 0.32 |
| ONECUT2 | one cut homeobox 2 | 0.32 |
| FAT3 | FAT atypical cadherin 3 | 0.32 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.32 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.32 |
| COQ3 | coenzyme Q3 methyltransferase | 0.31 |
| PTMA | prothymosin, alpha | 0.31 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.31 |
| ZNF267 | zinc finger protein 267 | 0.31 |
| TMTC4 | transmembrane and tetratricopeptide repeat containing 4 | 0.31 |
| SLC10A4 | solute carrier family 10, member 4 | 0.31 |
| RNF185 | ring finger protein 185 | 0.3 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.3 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.3 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.3 |
| KIF23 | kinesin family member 23 | 0.29 |
| JAK2 | Janus kinase 2 | 0.29 |
| DPY30 | dpy-30 homolog (C. elegans) | 0.29 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.29 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.28 |
| SPRTN | SprT-like N-terminal domain | 0.28 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.28 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.28 |
| CCDC85B | coiled-coil domain containing 85B | 0.28 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.28 |
| TBC1D32 | TBC1 domain family, member 32 | 0.28 |
| PPME1 | protein phosphatase methylesterase 1 | 0.28 |
| CD58 | CD58 molecule | 0.28 |
| H1-2 | H1.2 linker histone, cluster member | 0.27 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.27 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.27 |
| ERCC8 | excision repair cross-complementation group 8 | 0.27 |
| GORASP1 | golgi reassembly stacking protein 1, 65kDa | 0.27 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 0.26 |
| GAS8 | growth arrest-specific 8 | 0.26 |
| ZNF576 | zinc finger protein 576 | 0.26 |
| DUOX1 | dual oxidase 1 | 0.26 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.26 |
| SMIM12 | small integral membrane protein 12 | 0.26 |
| DPF1 | D4, zinc and double PHD fingers family 1 | 0.26 |
| FANCL | Fanconi anemia, complementation group L | 0.26 |
| KLHL18 | kelch-like family member 18 | 0.26 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.26 |
| ZNF692 | zinc finger protein 692 | 0.26 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.26 |
| FBXO41 | F-box protein 41 | 0.26 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.25 |
| SLC49A4 | solute carrier family 49 member 4 | 0.25 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.25 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.25 |
| TP53 | tumor protein p53 | 0.25 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | 0.25 |
| ATF3 | activating transcription factor 3 | 0.25 |
| USP20 | ubiquitin specific peptidase 20 | 0.25 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.24 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAH2 | dynein, axonemal, heavy chain 2 | -1.4 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -1.01 |
| ANO8 | anoctamin 8 | -0.98 |
| KRT222 | keratin 222, type II | -0.91 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.84 |
| ZBED6 | zinc finger, BED-type containing 6 | -0.83 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.82 |
| ZNF778 | zinc finger protein 778 | -0.79 |
| SLC2A4RG | SLC2A4 regulator | -0.68 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.58 |
| ZNF652 | zinc finger protein 652 | -0.52 |
| MTSS1 | metastasis suppressor 1 | -0.51 |
| PROSER1 | proline and serine rich 1 | -0.51 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.49 |
| PROS1 | protein S (alpha) | -0.49 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | -0.49 |
| STOML1 | stomatin (EPB72)-like 1 | -0.46 |
| COBL | cordon-bleu WH2 repeat protein | -0.46 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.45 |
| MKRN4P | makorin ring finger protein 4, pseudogene | -0.45 |
| ATXN1L | ataxin 1-like | -0.45 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.44 |
| PIP | prolactin-induced protein | -0.44 |
| PMF1 | polyamine-modulated factor 1 | -0.44 |
| ZNF77 | zinc finger protein 77 | -0.44 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.43 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.41 |
| NCOA1 | nuclear receptor coactivator 1 | -0.41 |
| WDYHV1 | WDYHV motif containing 1 | -0.41 |
| ZNF600 | zinc finger protein 600 | -0.4 |
| CCN2 | cellular communication network factor 2 | -0.4 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.4 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.4 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.4 |
| MAPK7 | mitogen-activated protein kinase 7 | -0.38 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.38 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.37 |
| SNAP91 | synaptosomal-associated protein, 91kDa | -0.36 |
| TBC1D16 | TBC1 domain family, member 16 | -0.36 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | -0.35 |
| ADM | adrenomedullin | -0.35 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | -0.35 |
| GORAB | golgin, RAB6-interacting | -0.35 |
| TMX2 | thioredoxin-related transmembrane protein 2 | -0.35 |
| MAP2 | microtubule-associated protein 2 | -0.34 |
| SH3D19 | SH3 domain containing 19 | -0.34 |
| RGS12 | regulator of G-protein signaling 12 | -0.34 |
| LIPH | lipase, member H | -0.34 |
| FTL | ferritin, light polypeptide | -0.34 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.33 |
| ZNF518A | zinc finger protein 518A | -0.33 |
| EPHA5 | EPH receptor A5 | -0.33 |
| HPCAL4 | hippocalcin like 4 | -0.32 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.32 |
| TSC22D2 | TSC22 domain family, member 2 | -0.32 |
| HKDC1 | hexokinase domain containing 1 | -0.32 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.32 |
| FAT4 | FAT atypical cadherin 4 | -0.32 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.31 |
| DCLRE1A | DNA cross-link repair 1A | -0.31 |
| TPST2 | tyrosylprotein sulfotransferase 2 | -0.3 |
| XYLT2 | xylosyltransferase II | -0.3 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.3 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.3 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.3 |
| TRAF5 | TNF receptor-associated factor 5 | -0.3 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.3 |
| RCAN3 | RCAN family member 3 | -0.3 |
| HGFAC | HGF activator | -0.29 |
| MEF2A | myocyte enhancer factor 2A | -0.29 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -0.29 |
| CHKB | choline kinase beta | -0.29 |
| IPP | intracisternal A particle-promoted polypeptide | -0.29 |
| SNX21 | sorting nexin family member 21 | -0.29 |
| ZNF480 | zinc finger protein 480 | -0.29 |
| CUL9 | cullin 9 | -0.29 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.29 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.29 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.28 |
| ZIC2 | Zic family member 2 | -0.28 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.28 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.28 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | -0.28 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | -0.27 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | -0.27 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.27 |
| PRMT6 | protein arginine methyltransferase 6 | -0.27 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -0.27 |
| PCTP | phosphatidylcholine transfer protein | -0.27 |
| ATP9A | ATPase, class II, type 9A | -0.27 |
| SLC41A3 | solute carrier family 41, member 3 | -0.27 |
| ZNF430 | zinc finger protein 430 | -0.27 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.27 |
| AXL | AXL receptor tyrosine kinase | -0.27 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.26 |
| BSN | bassoon presynaptic cytomatrix protein | -0.26 |
| EPHB3 | EPH receptor B3 | -0.26 |
| LYRM1 | LYR motif containing 1 | -0.26 |
| ANGPTL4 | angiopoietin-like 4 | -0.26 |
| ABRAXAS1 | abraxas 1, BRCA1 A complex subunit | -0.26 |
