| Dataset | Guide to Pharmacology Protein Ligands of Receptors |
| Category | physical interactions |
| Type | ligand (protein) |
| Description | tumor necrosis factor|This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7124) |
| External Link | http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7124 |
| Similar Terms | |
| Downloads & Tools |
2 receptors of the TNF ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.
