TNF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description tumor necrosis factor|This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7124)
External Link http://www.ncbi.nlm.nih.gov/gene/7124
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Genes

100 interacting proteins for TNF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADAM9 ADAM metallopeptidase domain 9
AGO2 argonaute RISC catalytic component 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BGN biglycan
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CARS cysteinyl-tRNA synthetase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
CHUK conserved helix-loop-helix ubiquitous kinase
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CSF1 colony stimulating factor 1 (macrophage)
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
EED embryonic ectoderm development
ELAVL1 ELAV like RNA binding protein 1
ERICH2 glutamate-rich 2
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FBXW11 F-box and WD repeat domain containing 11
FYN FYN proto-oncogene, Src family tyrosine kinase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HDAC3 histone deacetylase 3
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
KHSRP KH-type splicing regulatory protein
LAMP2 lysosomal-associated membrane protein 2
LIN54 lin-54 DREAM MuvB core complex component
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MRPS33 mitochondrial ribosomal protein S33
NEFL neurofilament, light polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRK Nik related kinase
NT5DC3 5'-nucleotidase domain containing 3
OPTN optineurin
PDIK1L PDLIM1 interacting kinase 1 like
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRTN3 proteinase 3
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB5A RAB5A, member RAS oncogene family
RALBP1 ralA binding protein 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF31 ring finger protein 31
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS18 ribosomal protein S18
SCG2 secretogranin II
SEC16A SEC16 homolog A (S. cerevisiae)
SHARPIN SHANK-associated RH domain interactor
SLU7 SLU7 splicing factor homolog (S. cerevisiae)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SPARCL1 SPARC-like 1 (hevin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAT1 signal transducer and activator of transcription 1, 91kDa
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBK1 TANK-binding kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNIK TRAF2 and NCK interacting kinase
TNIP1 TNFAIP3 interacting protein 1
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TXN thioredoxin
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
VCAM1 vascular cell adhesion molecule 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZFP36 ZFP36 ring finger protein