TNFRSF1A Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description tumor necrosis factor receptor superfamily, member 1A|The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7132)
External Link http://www.ncbi.nlm.nih.gov/gene/7132
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168 interacting proteins for hub protein TNFRSF1A from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ACTG1 actin gamma 1
AFG3L2 AFG3-like AAA ATPase 2
AGTRAP angiotensin II receptor-associated protein
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATAD3A ATPase family, AAA domain containing 3A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
AZI2 5-azacytidine induced 2
BAG2 BCL2-associated athanogene 2
BAG4 BCL2-associated athanogene 4
BCL10 B-cell CLL/lymphoma 10
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C1QBP complement component 1, q subcomponent binding protein
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCP110 centriolar coiled coil protein 110kDa
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CHUK conserved helix-loop-helix ubiquitous kinase
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CSNK1A1 casein kinase 1, alpha 1
DAB2IP DAB2 interacting protein
DAP death-associated protein
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EPPK1 epiplakin 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERLEC1 endoplasmic reticulum lectin 1
ERN1 endoplasmic reticulum to nucleus signaling 1
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FANCD2 Fanconi anemia, complementation group D2
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLN2 fibulin 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRB2 growth factor receptor-bound protein 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAX1 HCLS1 associated protein X-1
HIST1H2AB histone cluster 1, H2ab
HIST1H2AE histone cluster 1, H2ae
HIST1H2BB histone cluster 1, H2bb
HIST1H4A histone cluster 1, H4a
HIST3H3 histone cluster 3, H3
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IPO8 importin 8
JAK1 Janus kinase 1
JAK2 Janus kinase 2
LRRC59 leucine rich repeat containing 59
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MADD MAP-kinase activating death domain
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAP1 mitogen-activated protein kinase associated protein 1
MOAP1 modulator of apoptosis 1
MON2 MON2 homolog (S. cerevisiae)
MSN moesin
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO6 myosin VI
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAP1L1 nucleosome assembly protein 1-like 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
ODC1 ornithine decarboxylase 1
OPTN optineurin
PFKL phosphofructokinase, liver
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPID peptidylprolyl isomerase D
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RALBP1 ralA binding protein 1
RARS arginyl-tRNA synthetase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF111 ring finger protein 111
RPL23 ribosomal protein L23
RPS16 ribosomal protein S16
RPS27 ribosomal protein S27
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RUVBL1 RuvB-like AAA ATPase 1
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SH3KBP1 SH3-domain kinase binding protein 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SON SON DNA binding protein
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSR4 signal sequence receptor, delta
STAT1 signal transducer and activator of transcription 1, 91kDa
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF5 TNF receptor-associated factor 5
TRAP1 TNF receptor-associated protein 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB4A tubulin, beta 4A class IVa
TUBB6 tubulin, beta 6 class V
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XPOT exportin, tRNA