TNFSF10 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description tumor necrosis factor (ligand) superfamily, member 10|The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 8743)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_TNFSF10
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Genes

30 co-expressed genes for TNFSF10 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AIF1 allograft inflammatory factor 1
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ARRB2 arrestin, beta 2
C5AR1 complement component 5a receptor 1
CCR1 chemokine (C-C motif) receptor 1
CLEC7A C-type lectin domain family 7, member A
CSF3R colony stimulating factor 3 receptor (granulocyte)
DPEP2 dipeptidase 2
EVI2B ecotropic viral integration site 2B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FPR1 formyl peptide receptor 1
HCK HCK proto-oncogene, Src family tyrosine kinase
IGSF6 immunoglobulin superfamily, member 6
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LST1 leukocyte specific transcript 1
LY96 lymphocyte antigen 96
MNDA myeloid cell nuclear differentiation antigen
MYO1F myosin IF
NCF2 neutrophil cytosolic factor 2
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PILRA paired immunoglobin-like type 2 receptor alpha
PLXNC1 plexin C1
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SDCBP syndecan binding protein (syntenin)
SECTM1 secreted and transmembrane 1
SPI1 Spi-1 proto-oncogene
TLR1 toll-like receptor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE2D1 ubiquitin-conjugating enzyme E2D 1