TNFSF11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tumor necrosis factor (ligand) superfamily, member 11|This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8600)
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Genes

356 genes differentially expressed following the TNFSF11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL20A1 collagen, type XX, alpha 1 2.81752
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.81752
CAMP cathelicidin antimicrobial peptide 2.81752
CD40LG CD40 ligand 2.81752
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.81752
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.81752
DSG3 desmoglein 3 2.81752
PTH2 parathyroid hormone 2 2.81752
PAX2 paired box 2 2.81752
PAX6 paired box 6 2.81752
CD14 CD14 molecule 2.81752
CD19 CD19 molecule 2.81752
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.81752
ZACN zinc activated ligand-gated ion channel 2.81752
CD96 CD96 molecule 2.81752
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 2.81752
NAPSA napsin A aspartic peptidase 2.81752
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B 2.81752
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.81752
GPR52 G protein-coupled receptor 52 2.81752
SIGLECL1 SIGLEC family like 1 2.81752
ADGRE3 adhesion G protein-coupled receptor E3 2.81752
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.81752
FETUB fetuin B 2.81752
KCNU1 potassium channel, subfamily U, member 1 2.81752
IL18R1 interleukin 18 receptor 1 2.81752
SLC10A5 solute carrier family 10, member 5 2.81752
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.81752
RAVER2 ribonucleoprotein, PTB-binding 2 2.81752
TECTB tectorin beta 2.81752
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.81752
BTBD19 BTB (POZ) domain containing 19 2.81752
DSPP dentin sialophosphoprotein 2.81752
HMX1 H6 family homeobox 1 2.81752
PRDM13 PR domain containing 13 2.81752
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.81752
LRG1 leucine-rich alpha-2-glycoprotein 1 2.81752
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.81752
MFAP4 microfibrillar-associated protein 4 2.81752
PBOV1 prostate and breast cancer overexpressed 1 2.81752
C12ORF71 chromosome 12 open reading frame 71 2.81752
GFI1 growth factor independent 1 transcription repressor 2.81752
UBA7 ubiquitin-like modifier activating enzyme 7 2.81752
CRH corticotropin releasing hormone 2.81752
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.81752
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.81752
LRTM3 leucine rich repeat transmembrane protein 3 2.81752
GSTT4 glutathione S-transferase theta 4 2.81752
ODAPH odontogenesis associated phosphoprotein 2.81752
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.81752
KASH5 KASH domain containing 5 2.81752
H3C1 H3 clustered histone 1 2.81752
PNMA8B PNMA family member 8B 2.81752
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.81752
MT3 metallothionein 3 2.81752
AVPR1B arginine vasopressin receptor 1B 2.81752
TMEM225B transmembrane protein 225B 2.81752
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.81752
LY6L lymphocyte antigen 6 family member L 2.81752
SMIM47 small integral membrane protein 47 2.81752
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.81752
PRRT1B proline rich transmembrane protein 1B 2.81752
LOC124902436 talanin 2.81752
CFAP97D2 CFAP97 domain containing 2 2.81752
RHEX regulator of hemoglobinization and erythroid cell expansion 2.81752
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.81752
MINDY4B MINDY family member 4B 2.81752
MYMK myomaker, myoblast fusion factor 2.81752
HTRA4 HtrA serine peptidase 4 2.81752
FRG2C FSHD region gene 2 family, member C 2.81752
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.81752
C1QL2 complement component 1, q subcomponent-like 2 2.81752
TPTE transmembrane phosphatase with tensin homology 2.81752
OVOL3 ovo-like zinc finger 3 2.81752
DMP1 dentin matrix acidic phosphoprotein 1 2.81752
KLHL30 kelch-like family member 30 2.81752
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.81752
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.81752
GJA3 gap junction protein, alpha 3, 46kDa 2.81752
PRR4 proline rich 4 (lacrimal) 2.81752
S100G S100 calcium binding protein G 2.81752
OR10K2 olfactory receptor, family 10, subfamily K, member 2 2.81752
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.81752
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.81752
TMPRSS7 transmembrane protease, serine 7 2.81752
SAG S-antigen; retina and pineal gland (arrestin) 2.81752
GCSAM germinal center-associated, signaling and motility 2.81752
CSAG3 CSAG family, member 3 2.81752
C4ORF50 chromosome 4 open reading frame 50 2.81752
CNTN6 contactin 6 2.81752
C9 complement component 9 2.81752
HLX H2.0-like homeobox 2.81752
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.81752
ARHGAP20 Rho GTPase activating protein 20 2.81752
CYS1 cystin 1 2.81752
C22ORF42 chromosome 22 open reading frame 42 2.81752
TMEM139 transmembrane protein 139 2.81752
COX7B2 cytochrome c oxidase subunit VIIb2 2.81752
TAT tyrosine aminotransferase 2.81752
BCO1 beta-carotene oxygenase 1 2.81752
COL6A5 collagen, type VI, alpha 5 2.81752
FBXO40 F-box protein 40 2.81752
CDH19 cadherin 19, type 2 2.81752
SPATA4 spermatogenesis associated 4 2.81752
PRM1 protamine 1 2.81752
SHOX2 short stature homeobox 2 2.81752
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.81752
EXTL1 exostosin-like glycosyltransferase 1 2.81752
CYSLTR1 cysteinyl leukotriene receptor 1 2.81752
SCML4 sex comb on midleg-like 4 (Drosophila) 2.81752
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.81752
KLHL41 kelch-like family member 41 2.81752
PRM3 protamine 3 2.81752
FSHR follicle stimulating hormone receptor 2.81752
LRRC15 leucine rich repeat containing 15 2.81752
RASL11A RAS-like, family 11, member A 2.81752
NKX6-2 NK6 homeobox 2 2.81752
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.81752
ERVV-1 endogenous retrovirus group V, member 1 2.81752
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.81752
PLA2G2C phospholipase A2, group IIC 2.81752
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.81752
OTP orthopedia homeobox 2.81752
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.81752
MYLK2 myosin light chain kinase 2 2.81752
SLC38A3 solute carrier family 38, member 3 2.81752
DAW1 dynein assembly factor with WDR repeat domains 1 2.81752
ANKRD53 ankyrin repeat domain 53 2.81752
PDCD1LG2 programmed cell death 1 ligand 2 2.81752
PLA2G12B phospholipase A2, group XIIB 2.81752
GSTA2 glutathione S-transferase alpha 2 2.81752
MAGED4B melanoma antigen family D4B 2.81752
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.81752
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.81752
LY9 lymphocyte antigen 9 2.81752
HLA-DMB major histocompatibility complex, class II, DM beta 2.81752
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.81752
POPDC2 popeye domain containing 2 2.81752
MMP10 matrix metallopeptidase 10 2.81752
ANGPTL5 angiopoietin-like 5 2.81752
TAS2R41 taste receptor, type 2, member 41 2.81752
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.81752
PLIN1 perilipin 1 2.81752
ALOX15B arachidonate 15-lipoxygenase, type B 2.81752
CETP cholesteryl ester transfer protein, plasma 2.81752
ANKRD33 ankyrin repeat domain 33 2.81752
DMTN dematin actin binding protein 2.81752
ROM1 retinal outer segment membrane protein 1 2.81752
EPX eosinophil peroxidase 2.81752
NUTM2F NUT family member 2F 2.81752
TMEM132E transmembrane protein 132E 2.81752
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.81752
LRRC46 leucine rich repeat containing 46 2.81752
PALMD palmdelphin 2.81752
NRGN neurogranin (protein kinase C substrate, RC3) 2.81752
LST1 leukocyte specific transcript 1 2.81752
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.81752
EDNRB endothelin receptor type B 2.79193
CAMK4 calcium/calmodulin-dependent protein kinase IV 2.73651
KIF15 kinesin family member 15 2.70877
IL10RB interleukin 10 receptor, beta 2.67642
ZC3H13 zinc finger CCCH-type containing 13 2.64487
TADA2B transcriptional adaptor 2B 2.57829
USP53 ubiquitin specific peptidase 53 2.57389
MRPL3 mitochondrial ribosomal protein L3 2.57389
MED12 mediator complex subunit 12 2.56803
LATS1 large tumor suppressor kinase 1 2.48349
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 2.47169
RSBN1L round spermatid basic protein 1-like 2.44829
C5ORF47 chromosome 5 open reading frame 47 2.44165
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.42447
MYO1H myosin IH 2.39815
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.39088
DNAAF19 dynein axonemal assembly factor 19 2.39088
EPN1 epsin 1 2.39064
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.3623
FAM240C family with sequence similarity 240 member C 2.36212
HMGB1 high mobility group box 1 2.35965
ATP5F1B ATP synthase F1 subunit beta 2.32511
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.28861
HLA-C major histocompatibility complex, class I, C 2.27976
CD8B CD8b molecule 2.24372
TRIM47 tripartite motif containing 47 2.24372
TMEM14B transmembrane protein 14B 2.22709
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.21982
MT1H metallothionein 1H 2.21982
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.21982
SNAP23 synaptosomal-associated protein, 23kDa 2.21886
FUBP1 far upstream element (FUSE) binding protein 1 2.21697
ZBTB40 zinc finger and BTB domain containing 40 2.2001
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.19876
EBP emopamil binding protein (sterol isomerase) 2.19678
LRR1 leucine rich repeat protein 1 2.19678
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.18771
THAP5 THAP domain containing 5 2.18771
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 2.18094
PURG purine-rich element binding protein G 2.16227
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 2.16227
XRN2 5'-3' exoribonuclease 2 2.15797
ABHD17C abhydrolase domain containing 17C 2.15147
VDAC3 voltage-dependent anion channel 3 2.15147
ACTMAP actin maturation protease 2.1475
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.14612
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.09621
DGCR2 DiGeorge syndrome critical region gene 2 2.09477
ZNF608 zinc finger protein 608 2.09371
PROCR protein C receptor, endothelial 2.08674
MYH14 myosin, heavy chain 14, non-muscle 2.07733
PHB2 prohibitin 2 2.07322
PCNP PEST proteolytic signal containing nuclear protein 2.0653
RAB5B RAB5B, member RAS oncogene family 2.0653
H2AC11 H2A clustered histone 11 2.0653
FECH ferrochelatase 2.05658
RPL22L1 ribosomal protein L22-like 1 2.03659
HPF1 histone PARylation factor 1 2.03237
LAYN layilin 2.03237
OPTN optineurin 2.03237
RPL36 ribosomal protein L36 2.03159
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.02385
TMEM161A transmembrane protein 161A 2.02279
SELENOV selenoprotein V 2.01362
ERICH1 glutamate-rich 1 2.00912

decreased expression

Symbol Name Standardized Value
SHISA7 shisa family member 7 -2.81752
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.81752
TMEM171 transmembrane protein 171 -2.81752
POTEF POTE ankyrin domain family, member F -2.81752
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.81752
RASA4B RAS p21 protein activator 4B -2.81752
NXPH3 neurexophilin 3 -2.81752
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.81752
MPZL2 myelin protein zero-like 2 -2.81752
C17ORF107 chromosome 17 open reading frame 107 -2.81752
ELF4 E74-like factor 4 (ets domain transcription factor) -2.81752
ZNF436 zinc finger protein 436 -2.81752
NIM1K NIM1 serine/threonine protein kinase -2.81752
PCDHB14 protocadherin beta 14 -2.81752
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.81752
ANKRD9 ankyrin repeat domain 9 -2.81752
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.81752
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.81752
MGARP mitochondria-localized glutamic acid-rich protein -2.81752
MMP28 matrix metallopeptidase 28 -2.81752
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.81752
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.81752
BSX brain-specific homeobox -2.81752
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.81752
MAST2 microtubule associated serine/threonine kinase 2 -2.81752
CYGB cytoglobin -2.81752
KIF12 kinesin family member 12 -2.81752
THY1 Thy-1 cell surface antigen -2.81752
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.81752
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.81752
PCDHB11 protocadherin beta 11 -2.81752
NRP1 neuropilin 1 -2.81752
CRACDL CRACD like -2.81752
SPMAP2L sperm microtubule associated protein 2 like -2.81752
SAMD5 sterile alpha motif domain containing 5 -2.81752
ANO3 anoctamin 3 -2.81752
ERICH6 glutamate-rich 6 -2.81752
SIM1 single-minded family bHLH transcription factor 1 -2.81752
ENTREP3 endosomal transmembrane epsin interactor 3 -2.81752
ZNF837 zinc finger protein 837 -2.81752
SLC49A3 solute carrier family 49 member 3 -2.81752
SKIL SKI-like proto-oncogene -2.81752
CCNI2 cyclin I family, member 2 -2.81752
IL1A interleukin 1, alpha -2.81752
ITM2A integral membrane protein 2A -2.81752
CDHR5 cadherin-related family member 5 -2.81752
MYH15 myosin, heavy chain 15 -2.81752
WFDC8 WAP four-disulfide core domain 8 -2.81752
NLN neurolysin (metallopeptidase M3 family) -2.81752
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.81752
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.81752
PP2D1 protein phosphatase 2C-like domain containing 1 -2.81752
CCDC183 coiled-coil domain containing 183 -2.81752
ZNF548 zinc finger protein 548 -2.81752
ATG3 autophagy related 3 -2.78059
ZXDB zinc finger, X-linked, duplicated B -2.76022
EHBP1L1 EH domain binding protein 1-like 1 -2.70297
NICN1 nicolin 1 -2.69008
KIAA2012 KIAA2012 -2.69008
AHRR aryl-hydrocarbon receptor repressor -2.69008
TTPA tocopherol (alpha) transfer protein -2.69008
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.69008
IFI35 interferon-induced protein 35 -2.69008
NLRP2 NLR family, pyrin domain containing 2 -2.69008
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.69008
AQP5 aquaporin 5 -2.69008
ZNF324 zinc finger protein 324 -2.69008
CHKB choline kinase beta -2.68783
WDCP WD repeat and coiled coil containing -2.66603
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.65117
PRRC2A proline-rich coiled-coil 2A -2.59346
F8 coagulation factor VIII, procoagulant component -2.57389
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.56022
PTH2R parathyroid hormone 2 receptor -2.5092
DUSP16 dual specificity phosphatase 16 -2.50131
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.49733
DCDC2 doublecortin domain containing 2 -2.48537
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.44812
TMEM53 transmembrane protein 53 -2.39052
CYB5D2 cytochrome b5 domain containing 2 -2.3661
SH3RF1 SH3 domain containing ring finger 1 -2.36212
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.32609
GTF2IRD2 GTF2I repeat domain containing 2 -2.32511
SPIN2B spindlin family, member 2B -2.32511
SUN1 Sad1 and UNC84 domain containing 1 -2.32141
USP10 ubiquitin specific peptidase 10 -2.31312
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.29028
C4ORF33 chromosome 4 open reading frame 33 -2.27976
CELA2B chymotrypsin-like elastase family, member 2B -2.27976
ATAD3C ATPase family, AAA domain containing 3C -2.27976
TNN tenascin N -2.27976
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.24677
FAM86B1 family with sequence similarity 86, member B1 -2.22709
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.22709
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -2.21697
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.2144
FAT3 FAT atypical cadherin 3 -2.21033
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.2001
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.18771
DNAAF3 dynein, axonemal, assembly factor 3 -2.18771
PGF placental growth factor -2.18771
CASP8 caspase 8, apoptosis-related cysteine peptidase -2.18771
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.1801
WDR89 WD repeat domain 89 -2.17616
HIPK2 homeodomain interacting protein kinase 2 -2.17302
RIN2 Ras and Rab interactor 2 -2.16478
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.15876
AASS aminoadipate-semialdehyde synthase -2.15147
ANO9 anoctamin 9 -2.15026
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.14502
SV2B synaptic vesicle glycoprotein 2B -2.13814
ZIC1 Zic family member 1 -2.13814
FGF22 fibroblast growth factor 22 -2.13814
UBA2 ubiquitin-like modifier activating enzyme 2 -2.13335
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -2.12828
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.12828
SS18 synovial sarcoma translocation, chromosome 18 -2.11236
RUNDC1 RUN domain containing 1 -2.07898
ZMYM5 zinc finger, MYM-type 5 -2.07733
SAE1 SUMO1 activating enzyme subunit 1 -2.07672
ICMT isoprenylcysteine carboxyl methyltransferase -2.0684
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.0653
FAR2 fatty acyl CoA reductase 2 -2.0653
HSPA8 heat shock 70kDa protein 8 -2.0562
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.0562
ZSWIM6 zinc finger, SWIM-type containing 6 -2.05485
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -2.03382
RNF182 ring finger protein 182 -2.03237
NOA1 nitric oxide associated 1 -2.03237
ZNF8 zinc finger protein 8 -2.02188
HDAC1 histone deacetylase 1 -2.02174
CORT cortistatin -2.01176
QRICH2 glutamine rich 2 -2.01176
ITGB4 integrin, beta 4 -2.01176