| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | tumor necrosis factor (ligand) superfamily, member 11|This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8600) |
| External Link | https://ncbi.nlm.nih.gov/gene/8600 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the TNFSF11 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0256217 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0201762 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.014576 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0136466 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.0132197 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0127724 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0127508 |
| KRT7 | keratin 7, type II | 0.0127036 |
| CP | ceruloplasmin (ferroxidase) | 0.0124713 |
| KYNU | kynureninase | 0.0116311 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.0112287 |
| TFDP1 | transcription factor Dp-1 | 0.0110994 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.0110092 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0109281 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.0107324 |
| ALB | albumin | 0.0103942 |
| KRT23 | keratin 23, type I | 0.01031 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0102943 |
| PSCA | prostate stem cell antigen | 0.0102888 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.0100499 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.0100408 |
| FOXG1 | forkhead box G1 | 0.00994031 |
| CRIP2 | cysteine-rich protein 2 | 0.00989374 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00984819 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.00981806 |
| IFRD2 | interferon-related developmental regulator 2 | 0.0096219 |
| RRM2 | ribonucleotide reductase M2 | 0.00950757 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00945553 |
| TNS3 | tensin 3 | 0.00941569 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00925005 |
| CA2 | carbonic anhydrase II | 0.00919886 |
| CCNA2 | cyclin A2 | 0.00911176 |
| MAGEA3 | melanoma antigen family A3 | 0.00905 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.00903722 |
| SDC2 | syndecan 2 | 0.00892604 |
| PRKD3 | protein kinase D3 | 0.00887767 |
| PAH | phenylalanine hydroxylase | 0.00879489 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00872438 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00871455 |
| CANX | calnexin | 0.00868602 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00863924 |
| TMEM45A | transmembrane protein 45A | 0.00860912 |
| ANXA10 | annexin A10 | 0.00860397 |
| CCNE2 | cyclin E2 | 0.00858277 |
| CADM1 | cell adhesion molecule 1 | 0.00853772 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00852363 |
| CTSS | cathepsin S | 0.00850993 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.00848658 |
| CALML5 | calmodulin-like 5 | 0.00847082 |
| PERP | PERP, TP53 apoptosis effector | 0.00845546 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00842786 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.00838903 |
| RIDA | reactive intermediate imine deaminase A homolog | 0.00834463 |
| SDC1 | syndecan 1 | 0.00825324 |
| PITX1 | paired-like homeodomain 1 | 0.00810396 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00796269 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00795241 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00790958 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00790216 |
| PURA | purine-rich element binding protein A | 0.00780991 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00777982 |
| TYMS | thymidylate synthetase | 0.00775455 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00766355 |
| GLUD2 | glutamate dehydrogenase 2 | 0.00765371 |
| GPM6A | glycoprotein M6A | 0.00764265 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.00763375 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.00761147 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00760261 |
| FMO3 | flavin containing monooxygenase 3 | 0.00755415 |
| METTL7A | methyltransferase like 7A | 0.00754904 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00751618 |
| MSLN | mesothelin | 0.00751435 |
| MAP7 | microtubule-associated protein 7 | 0.00751339 |
| KRT8 | keratin 8, type II | 0.00751288 |
| CA9 | carbonic anhydrase IX | 0.00747633 |
| CLCA2 | chloride channel accessory 2 | 0.00744237 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00738849 |
| CD14 | CD14 molecule | 0.0072521 |
| S100P | S100 calcium binding protein P | 0.00722399 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00720073 |
| SCAND1 | SCAN domain containing 1 | 0.00712722 |
| MRPL36 | mitochondrial ribosomal protein L36 | 0.00711006 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.00710552 |
| TSPAN6 | tetraspanin 6 | 0.00708743 |
| RAB4A | RAB4A, member RAS oncogene family | 0.00708559 |
| TMPO | thymopoietin | 0.00705303 |
| DHFR | dihydrofolate reductase | 0.00704748 |
| ZNF750 | zinc finger protein 750 | 0.00704429 |
| CPB2 | carboxypeptidase B2 (plasma) | 0.00704383 |
| SNX5 | sorting nexin 5 | 0.0070065 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0070016 |
| PAX6 | paired box 6 | 0.00699245 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00695632 |
| DMD | dystrophin | 0.00693265 |
| GPR87 | G protein-coupled receptor 87 | 0.0069124 |
| MUC16 | mucin 16, cell surface associated | 0.00691073 |
| SNX7 | sorting nexin 7 | 0.00690766 |
| LYZ | lysozyme | 0.00690449 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.00690269 |
| FDX1 | ferredoxin 1 | 0.00688537 |
| FZD6 | frizzled class receptor 6 | 0.00687245 |
| ORC1 | origin recognition complex, subunit 1 | 0.00684996 |
| KIF11 | kinesin family member 11 | 0.00683604 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.00683436 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00683421 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00681622 |
| KIF20A | kinesin family member 20A | 0.00681185 |
| GNAS | GNAS complex locus | 0.00679351 |
| TRAM1 | translocation associated membrane protein 1 | 0.0067662 |
| ARMC1 | armadillo repeat containing 1 | 0.00671049 |
| FBXO21 | F-box protein 21 | 0.00668368 |
| CHEK1 | checkpoint kinase 1 | 0.00667027 |
| GRHPR | glyoxylate reductase/hydroxypyruvate reductase | 0.00666049 |
| MST1 | macrophage stimulating 1 | 0.00664921 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.00664802 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00662695 |
| FABP7 | fatty acid binding protein 7, brain | 0.00660312 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | 0.00660163 |
| H1-10 | H1.10 linker histone | 0.00659693 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00657687 |
| CYP4A11 | cytochrome P450, family 4, subfamily A, polypeptide 11 | 0.00657597 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.00656736 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00656682 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00653639 |
| H2AX | H2A.X variant histone | 0.00653222 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00653176 |
| DAPK1 | death-associated protein kinase 1 | 0.00653103 |
| MPZL2 | myelin protein zero-like 2 | 0.00651772 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00646768 |
| FAM120A | family with sequence similarity 120A | 0.00645237 |
| ISOC1 | isochorismatase domain containing 1 | 0.00643946 |
| TPBG | trophoblast glycoprotein | 0.00643494 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00642091 |
| ANOS1 | anosmin 1 | 0.0064129 |
| ADORA2B | adenosine A2b receptor | 0.00641054 |
| AKAP1 | A kinase (PRKA) anchor protein 1 | 0.00639586 |
| ELP1 | elongator acetyltransferase complex subunit 1 | 0.00638902 |
| OIP5 | Opa interacting protein 5 | 0.00638876 |
| SLBP | stem-loop binding protein | 0.00637164 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00636602 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00636523 |
| HNMT | histamine N-methyltransferase | 0.00635817 |
| SET | SET nuclear proto-oncogene | 0.00634512 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.00634309 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | 0.00634218 |
| PER3 | period circadian clock 3 | 0.00631507 |
| PFKP | phosphofructokinase, platelet | 0.00631408 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00630789 |
| E2F8 | E2F transcription factor 8 | 0.00630545 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | 0.00630128 |
| RAD51C | RAD51 paralog C | 0.0062863 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.00627764 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00626167 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | 0.00626011 |
| SLC38A4 | solute carrier family 38, member 4 | 0.00625438 |
| MARCO | macrophage receptor with collagenous structure | 0.00624471 |
| FZD5 | frizzled class receptor 5 | 0.00624175 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00622987 |
| DONSON | downstream neighbor of SON | 0.0062162 |
| GLO1 | glyoxalase I | 0.00621477 |
| ITGB4 | integrin, beta 4 | 0.00621463 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.00619011 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.00618991 |
| DIAPH1 | diaphanous-related formin 1 | 0.00618893 |
| MBD2 | methyl-CpG binding domain protein 2 | 0.00618473 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 0.00618468 |
| SLC2A2 | solute carrier family 2 (facilitated glucose transporter), member 2 | 0.00618382 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0061677 |
| CFH | complement factor H | 0.00615992 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.00615552 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 0.00613335 |
| UPK1B | uroplakin 1B | 0.0061331 |
| GCH1 | GTP cyclohydrolase 1 | 0.00609141 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.0060914 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | 0.00606026 |
| PWP1 | PWP1 homolog (S. cerevisiae) | 0.00605786 |
| EPHA2 | EPH receptor A2 | 0.00604612 |
| CLINT1 | clathrin interactor 1 | 0.006043 |
| PRDX4 | peroxiredoxin 4 | 0.00604128 |
| KIF14 | kinesin family member 14 | 0.0060354 |
| CLDN10 | claudin 10 | 0.00601667 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.00600987 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 0.00600809 |
| NCOA3 | nuclear receptor coactivator 3 | 0.00600484 |
| AHSG | alpha-2-HS-glycoprotein | 0.00597483 |
| CRP | C-reactive protein, pentraxin-related | 0.00597197 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.00596591 |
| TRIM29 | tripartite motif containing 29 | 0.00594722 |
| IL18 | interleukin 18 | 0.00594362 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00594116 |
| SIK1 | salt-inducible kinase 1 | 0.00592994 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00591038 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00588396 |
| HHEX | hematopoietically expressed homeobox | 0.00586981 |
| IPO7 | importin 7 | 0.00586566 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00586267 |
| SOD1 | superoxide dismutase 1, soluble | 0.00585978 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.00583196 |
| PLS1 | plastin 1 | 0.00582891 |
| H3F3B | H3 histone, family 3B (H3.3B) | 0.00582638 |
| BCCIP | BRCA2 and CDKN1A interacting protein | 0.00577128 |
| PON3 | paraoxonase 3 | 0.00575049 |
| MYRF | myelin regulatory factor | 0.00574058 |
| RAB25 | RAB25, member RAS oncogene family | 0.0057374 |
| OBSL1 | obscurin-like 1 | 0.0057216 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00571767 |
| SELENOT | selenoprotein T | 0.00571749 |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | 0.00571163 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.00570552 |
| MTDH | metadherin | 0.00570464 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.00569876 |
| COMT | catechol-O-methyltransferase | 0.0056919 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 0.00568878 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.00566658 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00565998 |
| ARG1 | arginase 1 | 0.00565507 |
| C14ORF105 | chromosome 14 open reading frame 105 | 0.00564694 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00564005 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00561804 |
| SLC35F2 | solute carrier family 35, member F2 | 0.00561112 |
| FAM162A | family with sequence similarity 162, member A | 0.00559631 |
| RAI14 | retinoic acid induced 14 | 0.00558861 |
| PCLAF | PCNA clamp associated factor | 0.00558417 |
| CENPX | centromere protein X | 0.00558126 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00557655 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00555855 |
| PRC1 | protein regulator of cytokinesis 1 | 0.00555684 |
| GRAMD1C | GRAM domain containing 1C | 0.0055548 |
| FERMT1 | fermitin family member 1 | 0.00555396 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.00553829 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | 0.0055357 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | 0.00551711 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00551099 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.00550979 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.00550965 |
| TMEM259 | transmembrane protein 259 | 0.00550925 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00550762 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00550517 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.00550367 |
| TASOR | transcription activation suppressor | 0.00549907 |
| PLXNB1 | plexin B1 | 0.0054965 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | 0.00549403 |
| GAMT | guanidinoacetate N-methyltransferase | 0.00548545 |
| TGFB1 | transforming growth factor, beta 1 | 0.00548123 |
| RPS5 | ribosomal protein S5 | 0.00548051 |
| ZNF204P | zinc finger protein 204, pseudogene | 0.00547636 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | 0.00546966 |
| CCDC47 | coiled-coil domain containing 47 | 0.0054528 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | 0.00543708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| XIC | X chromosome inactivation center | -0.0185666 |
| THBS4 | thrombospondin 4 | -0.01412 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.013224 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0127973 |
| APOD | apolipoprotein D | -0.0124864 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.0123496 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0120003 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.011985 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0112711 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0112328 |
| CRYAB | crystallin, alpha B | -0.01106 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0110559 |
| NEFH | neurofilament, heavy polypeptide | -0.010944 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.0106649 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.0106428 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.0105262 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.0103626 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00991979 |
| ANK2 | ankyrin 2, neuronal | -0.0097968 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00968617 |
| NAV3 | neuron navigator 3 | -0.00966073 |
| EGR3 | early growth response 3 | -0.00952325 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00946178 |
| CD320 | CD320 molecule | -0.00944635 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00944589 |
| PLAT | plasminogen activator, tissue | -0.00932401 |
| VWF | von Willebrand factor | -0.00928654 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00923032 |
| RGS4 | regulator of G-protein signaling 4 | -0.00907987 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00907613 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00897106 |
| COL5A2 | collagen, type V, alpha 2 | -0.00890873 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00885156 |
| BTG2 | BTG family, member 2 | -0.00884955 |
| AREG | amphiregulin | -0.0087832 |
| RGS5 | regulator of G-protein signaling 5 | -0.00877404 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00869422 |
| IL7R | interleukin 7 receptor | -0.00862235 |
| REG1A | regenerating islet-derived 1 alpha | -0.00861754 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00858656 |
| TSPYL5 | TSPY-like 5 | -0.00858015 |
| SRGN | serglycin | -0.00852981 |
| FBLN1 | fibulin 1 | -0.00850167 |
| TBX3 | T-box 3 | -0.00847067 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0084239 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00834576 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00833886 |
| STMN2 | stathmin 2 | -0.00833758 |
| HSPA12A | heat shock 70kDa protein 12A | -0.0081906 |
| PLA1A | phospholipase A1 member A | -0.00818181 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00816148 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00810819 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -0.00810054 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00805592 |
| HMOX1 | heme oxygenase 1 | -0.00802742 |
| MGP | matrix Gla protein | -0.00800367 |
| PEG10 | paternally expressed 10 | -0.00799152 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00796499 |
| PDGFD | platelet derived growth factor D | -0.00794978 |
| ADGRL4 | adhesion G protein-coupled receptor L4 | -0.00792602 |
| TARP | TCR gamma alternate reading frame protein | -0.00789676 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00789392 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00788254 |
| RNF167 | ring finger protein 167 | -0.00783963 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00781907 |
| MAGED1 | melanoma antigen family D1 | -0.00778423 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00769127 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00765616 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | -0.00762526 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.00755958 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00754825 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00753987 |
| MX1 | MX dynamin-like GTPase 1 | -0.00752651 |
| GPM6B | glycoprotein M6B | -0.00752537 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | -0.00746867 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0074495 |
| KIF1A | kinesin family member 1A | -0.00743414 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00741001 |
| NID2 | nidogen 2 (osteonidogen) | -0.00740972 |
| CALCA | calcitonin-related polypeptide alpha | -0.00739541 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00738789 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00736234 |
| MMP1 | matrix metallopeptidase 1 | -0.00734946 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.00732535 |
| GATA6 | GATA binding protein 6 | -0.00732383 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00730604 |
| HIST1H2BK | histone cluster 1, H2bk | -0.0072774 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00726933 |
| HEPH | hephaestin | -0.00725329 |
| ITPKB | inositol-trisphosphate 3-kinase B | -0.00724956 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00717174 |
| LAMB1 | laminin, beta 1 | -0.00713664 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00708972 |
| ZNF423 | zinc finger protein 423 | -0.00702715 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0070177 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0070134 |
| PCDH9 | protocadherin 9 | -0.00700104 |
| AGR2 | anterior gradient 2 | -0.00695884 |
| NRIP3 | nuclear receptor interacting protein 3 | -0.00692252 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.00691171 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00691007 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.00690526 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | -0.00690411 |
| PENK | proenkephalin | -0.00689098 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00687694 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00687277 |
| MMP19 | matrix metallopeptidase 19 | -0.00686897 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.00684424 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00683322 |
| CIDEC | cell death-inducing DFFA-like effector c | -0.00682331 |
| COPG1 | coatomer protein complex, subunit gamma 1 | -0.00680635 |
| RHOBTB1 | Rho-related BTB domain containing 1 | -0.00680612 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | -0.00679485 |
| BIN1 | bridging integrator 1 | -0.00678938 |
| FOXO1 | forkhead box O1 | -0.00677107 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00676679 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.00671316 |
| RTN2 | reticulon 2 | -0.00671216 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00670693 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | -0.00669624 |
| COL16A1 | collagen, type XVI, alpha 1 | -0.00668057 |
| NEFM | neurofilament, medium polypeptide | -0.00666973 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00665498 |
| IL1R1 | interleukin 1 receptor, type I | -0.00660818 |
| FOSL2 | FOS-like antigen 2 | -0.00660469 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00658576 |
| TRIB2 | tribbles pseudokinase 2 | -0.00658242 |
| TFF1 | trefoil factor 1 | -0.00656394 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.0065592 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -0.00652958 |
| GIMAP4 | GTPase, IMAP family member 4 | -0.00649307 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | -0.00647729 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.00646871 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -0.00646239 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00645394 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.0064239 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.00641956 |
| LAMA2 | laminin, alpha 2 | -0.0064132 |
| FAM117A | family with sequence similarity 117, member A | -0.00639849 |
| CCL4 | chemokine (C-C motif) ligand 4 | -0.00638865 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00637649 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | -0.00636938 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.00636332 |
| QDPR | quinoid dihydropteridine reductase | -0.00635587 |
| AMDHD2 | amidohydrolase domain containing 2 | -0.00634122 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00631108 |
| SST | somatostatin | -0.00629365 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.00627129 |
| LBH | limb bud and heart development | -0.00626748 |
| CHRDL1 | chordin-like 1 | -0.00625815 |
| CAVIN3 | caveolae associated protein 3 | -0.0062575 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00625156 |
| ICAM2 | intercellular adhesion molecule 2 | -0.00624655 |
| COLEC12 | collectin sub-family member 12 | -0.00624408 |
| LSP1 | lymphocyte-specific protein 1 | -0.00622539 |
| GALC | galactosylceramidase | -0.00621896 |
| GDF15 | growth differentiation factor 15 | -0.00621805 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00619164 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00618909 |
| JAG1 | jagged 1 | -0.00617719 |
| ATF3 | activating transcription factor 3 | -0.00617647 |
| EGR2 | early growth response 2 | -0.00614794 |
| RAB5B | RAB5B, member RAS oncogene family | -0.00614072 |
| RNF144A | ring finger protein 144A | -0.0061388 |
| PIR | pirin (iron-binding nuclear protein) | -0.00613586 |
| HOPX | HOP homeobox | -0.00613313 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.00612989 |
| RNF19B | ring finger protein 19B | -0.00612628 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00612083 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00611162 |
| PRSS3 | protease, serine, 3 | -0.00611021 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00610999 |
| MT1M | metallothionein 1M | -0.00610624 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.00609729 |
| PRAME | preferentially expressed antigen in melanoma | -0.00607709 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -0.00607605 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00607242 |
| S100A11 | S100 calcium binding protein A11 | -0.00606857 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.0060608 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.00605006 |
| GPX7 | glutathione peroxidase 7 | -0.00603785 |
| MXRA8 | matrix-remodelling associated 8 | -0.00603231 |
| CSRP1 | cysteine and glycine-rich protein 1 | -0.00603094 |
| REG1B | regenerating islet-derived 1 beta | -0.006004 |
| KLHL24 | kelch-like family member 24 | -0.00598128 |
| GPA33 | glycoprotein A33 (transmembrane) | -0.00597743 |
| CST7 | cystatin F (leukocystatin) | -0.00597593 |
| GAB2 | GRB2-associated binding protein 2 | -0.005952 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.00594245 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | -0.00594147 |
| OLFML3 | olfactomedin-like 3 | -0.00594075 |
| CTSZ | cathepsin Z | -0.00594056 |
| EMP1 | epithelial membrane protein 1 | -0.00592464 |
| CAPN6 | calpain 6 | -0.00592023 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.00589408 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.00586764 |
| MEG3 | maternally expressed 3 (non-protein coding) | -0.00585477 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00584748 |
| OPN3 | opsin 3 | -0.00583858 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00582972 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.00582949 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0058203 |
| UNC13B | unc-13 homolog B (C. elegans) | -0.00581283 |
| DACH1 | dachshund family transcription factor 1 | -0.00581139 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00580011 |
| STAT5A | signal transducer and activator of transcription 5A | -0.00579487 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00579079 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00573195 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00571569 |
| XYLT1 | xylosyltransferase I | -0.00571057 |
| EFNB2 | ephrin-B2 | -0.00570414 |
| ZNF410 | zinc finger protein 410 | -0.00569808 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00569374 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00569371 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00568902 |
| PLIN1 | perilipin 1 | -0.0056848 |
| LAMA4 | laminin, alpha 4 | -0.0056625 |
| TEK | TEK tyrosine kinase, endothelial | -0.00565543 |
| WLS | wntless Wnt ligand secretion mediator | -0.00565437 |
| TSPAN14 | tetraspanin 14 | -0.00561727 |
| NES | nestin | -0.00561654 |
| MSN | moesin | -0.00561395 |
| TNNC2 | troponin C type 2 (fast) | -0.0056019 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00558814 |
| PNMA8A | PNMA family member 8A | -0.00557768 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -0.00557524 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00557426 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00556653 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00556498 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00556048 |
| SYNPO | synaptopodin | -0.0055548 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.00554553 |
| LXN | latexin | -0.00553189 |
| PLIN2 | perilipin 2 | -0.00552834 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 | -0.00551966 |
| GPR183 | G protein-coupled receptor 183 | -0.00551052 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00550692 |
| JUND | jun D proto-oncogene | -0.00548074 |
| PTN | pleiotrophin | -0.00547919 |
| MALL | mal, T-cell differentiation protein-like | -0.0054762 |
| FBLN5 | fibulin 5 | -0.00547536 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.0054722 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00547129 |
| CLCN4 | chloride channel, voltage-sensitive 4 | -0.00546528 |
| JMJD1C | jumonji domain containing 1C | -0.00544992 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00544617 |
| NPC2 | Niemann-Pick disease, type C2 | -0.00544554 |
| TAC1 | tachykinin, precursor 1 | -0.00543021 |
| MT1X | metallothionein 1X | -0.00542648 |
