TNFSF11 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description tumor necrosis factor (ligand) superfamily, member 11|This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8600)
External Link http://www.ncbi.nlm.nih.gov/gene/8600
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Genes

32 interacting proteins for TNFSF11 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
AKT1 v-akt murine thymoma viral oncogene homolog 1
BBS10 Bardet-Biedl syndrome 10
CEP126 centrosomal protein 126kDa
DDAH2 dimethylarginine dimethylaminohydrolase 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM213B family with sequence similarity 213, member B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LMO4 LIM domain only 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MBTPS1 membrane-bound transcription factor peptidase, site 1
MED24 mediator complex subunit 24
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHAX phosphorylated adaptor for RNA export
PLK1 polo-like kinase 1
SBF1 SET binding factor 1
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
ZC3HC1 zinc finger, C3HC-type containing 1