TNFSF9 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tumor necrosis factor (ligand) superfamily, member 9|The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 8744)
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Genes

310 genes differentially expressed following the TNFSF9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SMIM35 small integral membrane protein 35 2.65231
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.65231
HSPA1L heat shock 70kDa protein 1-like 2.65231
PRTN3 proteinase 3 2.65231
FERMT3 fermitin family member 3 2.65231
DMRT1 doublesex and mab-3 related transcription factor 1 2.65231
ARHGAP20 Rho GTPase activating protein 20 2.65231
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.65231
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.65231
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.65231
C17ORF99 chromosome 17 open reading frame 99 2.65231
PGAM2 phosphoglycerate mutase 2 (muscle) 2.65231
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.65231
CCR4 chemokine (C-C motif) receptor 4 2.65231
BTG4 B-cell translocation gene 4 2.65231
ADGRE3 adhesion G protein-coupled receptor E3 2.65231
DCST2 DC-STAMP domain containing 2 2.65231
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.65231
RS1 retinoschisin 1 2.65231
DSG3 desmoglein 3 2.58907
GJA10 gap junction protein, alpha 10, 62kDa 2.58907
NME8 NME/NM23 family member 8 2.58907
NOTO notochord homeobox 2.58907
EPB42 erythrocyte membrane protein band 4.2 2.58907
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.58907
USP26 ubiquitin specific peptidase 26 2.58907
CXORF65 chromosome X open reading frame 65 2.58907
SLC25A45 solute carrier family 25, member 45 2.58907
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.58907
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.58907
HES7 hes family bHLH transcription factor 7 2.58907
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.58907
FAM90A1 family with sequence similarity 90, member A1 2.58907
SOWAHB sosondowah ankyrin repeat domain family member B 2.58907
LGI1 leucine-rich, glioma inactivated 1 2.58907
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.58907
ATOH8 atonal homolog 8 (Drosophila) 2.58907
LGALS2 lectin, galactoside-binding, soluble, 2 2.58907
SPAG8 sperm associated antigen 8 2.58907
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.58907
MYL7 myosin, light chain 7, regulatory 2.58907
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.58907
TRDN triadin 2.58907
C6ORF58 chromosome 6 open reading frame 58 2.58907
MOGAT3 monoacylglycerol O-acyltransferase 3 2.58907
CEP295NL CEP295 N-terminal like 2.58907
FOLR3 folate receptor 3 (gamma) 2.58907
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.58907
ALPK2 alpha-kinase 2 2.58907
CXCL2 chemokine (C-X-C motif) ligand 2 2.58907
SFTPB surfactant protein B 2.58907
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.58907
RPL3L ribosomal protein L3-like 2.58907
TDRD6 tudor domain containing 6 2.58907
LVRN laeverin 2.58907
LOC124909439 uncharacterized LOC124909439 2.58907
GBP2 guanylate binding protein 2, interferon-inducible 2.58907
PNLIPRP1 pancreatic lipase-related protein 1 2.58907
VN1R1 vomeronasal 1 receptor 1 2.58907
CXCL13 chemokine (C-X-C motif) ligand 13 2.58907
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.58907
FRG2C FSHD region gene 2 family, member C 2.58907
OR9G4 olfactory receptor, family 9, subfamily G, member 4 2.58907
ASB9 ankyrin repeat and SOCS box containing 9 2.58907
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.58907
GBP6 guanylate binding protein family, member 6 2.58907
GBP4 guanylate binding protein 4 2.58907
GNG14 G protein subunit gamma 14 2.58907
TEX53 testis expressed 53 2.58907
DEFB109B defensin beta 109B 2.58907
H3-7 H3.7 histone (putative) 2.58907
TENT5D terminal nucleotidyltransferase 5D 2.58907
SPACDR sperm acrosome developmental regulator 2.58907
EIPR1 EARP complex and GARP complex interacting protein 1 2.58907
SPATS1 spermatogenesis associated, serine-rich 1 2.58907
MT4 metallothionein 4 2.58907
NDP Norrie disease (pseudoglioma) 2.58907
CSF3 colony stimulating factor 3 (granulocyte) 2.58907
LGSN lengsin, lens protein with glutamine synthetase domain 2.58907
CHRD chordin 2.58907
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.58907
ATP13A4 ATPase type 13A4 2.58907
ERBB4 erb-b2 receptor tyrosine kinase 4 2.58907
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.58907
CBLN3 cerebellin 3 precursor 2.58907
SRL sarcalumenin 2.58907
GJA4 gap junction protein, alpha 4, 37kDa 2.58907
GJA3 gap junction protein, alpha 3, 46kDa 2.58907
OR6C2 olfactory receptor, family 6, subfamily C, member 2 2.58907
IL31RA interleukin 31 receptor A 2.58907
BLNK B-cell linker 2.58907
RBM44 RNA binding motif protein 44 2.58907
RASAL3 RAS protein activator like 3 2.58907
TBX3 T-box 3 2.58907
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.58907
TACSTD2 tumor-associated calcium signal transducer 2 2.58907
SCRT1 scratch family zinc finger 1 2.58907
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.58907
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.58907
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.58907
TLDC2 TBC/LysM-associated domain containing 2 2.58907
VAX2 ventral anterior homeobox 2 2.58907
CRYBB2 crystallin, beta B2 2.58907
CTAGE9 CTAGE family, member 9 2.58907
NOX1 NADPH oxidase 1 2.58907
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.58907
ADAM7 ADAM metallopeptidase domain 7 2.58907
NPFFR1 neuropeptide FF receptor 1 2.58907
ODF1 outer dense fiber of sperm tails 1 2.58907
EVPLL envoplakin-like 2.58907
C11ORF96 chromosome 11 open reading frame 96 2.58907
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.58907
CIDEA cell death-inducing DFFA-like effector a 2.58907
ONECUT3 one cut homeobox 3 2.58907
NPIPB15 nuclear pore complex interacting protein family, member B15 2.58907
MANSC1 MANSC domain containing 1 2.58907
CCDC159 coiled-coil domain containing 159 2.58907
EDN3 endothelin 3 2.58907
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.58907
OTC ornithine carbamoyltransferase 2.58907
PLEKHN1 pleckstrin homology domain containing, family N member 1 2.58907
CHI3L2 chitinase 3-like 2 2.58907
RIBC1 RIB43A domain with coiled-coils 1 2.58907
GBX2 gastrulation brain homeobox 2 2.58907
WNT4 wingless-type MMTV integration site family, member 4 2.58907
MARCO macrophage receptor with collagenous structure 2.58907
STRC stereocilin 2.58907
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.58907
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.58907
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.58907
LHX2 LIM homeobox 2 2.58907
PGR progesterone receptor 2.58907
PTGR2 prostaglandin reductase 2 2.58907
SELL selectin L 2.58907
TBX1 T-box 1 2.58907
BEAN1 brain expressed, associated with NEDD4, 1 2.58907
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.58907
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.58907
TF transferrin 2.58907
CA5A carbonic anhydrase VA, mitochondrial 2.58907
NTSR2 neurotensin receptor 2 2.58907
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.58907
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.58907
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.58907
BANF2 barrier to autointegration factor 2 2.58907
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.58907
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.58907
NELL1 NEL-like 1 (chicken) 2.58907
CIB4 calcium and integrin binding family member 4 2.58907
FGF18 fibroblast growth factor 18 2.58907
TMPRSS13 transmembrane protease, serine 13 2.58907
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.58907
MAEL maelstrom spermatogenic transposon silencer 2.58907
IL37 interleukin 37 2.58907
PSD2 pleckstrin and Sec7 domain containing 2 2.58907
TMEM45B transmembrane protein 45B 2.58907
PITX3 paired-like homeodomain 3 2.58907
ASCL1 achaete-scute family bHLH transcription factor 1 2.58907
KIF12 kinesin family member 12 2.58907
LPA lipoprotein, Lp(a) 2.58907
LPAR3 lysophosphatidic acid receptor 3 2.58907
CD80 CD80 molecule 2.58907
CCDC166 coiled-coil domain containing 166 2.58907
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.559
PPP1R42 protein phosphatase 1, regulatory subunit 42 2.53721
RPGRIP1L RPGRIP1-like 2.48289
SLX4IP SLX4 interacting protein 2.46584
RAB12 RAB12, member RAS oncogene family 2.46277
OXTR oxytocin receptor 2.44239
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.44239
CSF1 colony stimulating factor 1 (macrophage) 2.44239
ANKRD7 ankyrin repeat domain 7 2.44239
DUSP2 dual specificity phosphatase 2 2.44239
PRSS53 protease, serine, 53 2.44239
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.4318
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.39527
DENND6B DENN/MADD domain containing 6B 2.37366
AKR1B15 aldo-keto reductase family 1, member B15 2.37366
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.37366
C8ORF48 chromosome 8 open reading frame 48 2.37366
FAM3B family with sequence similarity 3, member B 2.37366
MEPE matrix extracellular phosphoglycoprotein 2.37366
PLB1 phospholipase B1 2.37366
GFY golgi-associated, olfactory signaling regulator 2.37366
RNF122 ring finger protein 122 2.36176
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.32665
BSPRY B-box and SPRY domain containing 2.26392
CBR1 carbonyl reductase 1 2.2577
TWIST2 twist family bHLH transcription factor 2 2.24216
ZNF470 zinc finger protein 470 2.24216
NUB1 negative regulator of ubiquitin-like proteins 1 2.23869
SYNJ2 synaptojanin 2 2.23428
PEX11A peroxisomal biogenesis factor 11 alpha 2.22296
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 2.22086
CFAP20DC CFAP20 domain containing 2.20535
PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 2.19053
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.18648
AKAP9 A kinase (PRKA) anchor protein 9 2.18111
GRTP1 growth hormone regulated TBC protein 1 2.17591
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 2.17045
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 2.16735
POM121C POM121 transmembrane nucleoporin C 2.16735
CHM choroideremia (Rab escort protein 1) 2.15309
STIMATE STIM activating enhancer 2.15193
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.13196
CSAD cysteine sulfinic acid decarboxylase 2.11807
NOL6 nucleolar protein 6 (RNA-associated) 2.1092
LMO4 LIM domain only 4 2.10336
SLC61A1 solute carrier family 61 member 1 2.09568
COG5 component of oligomeric golgi complex 5 2.08505
METTL16 methyltransferase like 16 2.05788
ZFX zinc finger protein, X-linked 2.04306
TTLL4 tubulin tyrosine ligase-like family member 4 2.04073
DSTN destrin (actin depolymerizing factor) 2.02858
DCPH1 damage control phosphatase 1 2.02858
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.01532
SH2D3C SH2 domain containing 3C 2.0125
CNBD1 cyclic nucleotide binding domain containing 1 2.0092

decreased expression

Symbol Name Standardized Value
G0S2 G0/G1 switch 2 -2.65231
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.65231
NHLH1 nescient helix loop helix 1 -2.65231
MOG myelin oligodendrocyte glycoprotein -2.65231
CDH26 cadherin 26 -2.65231
RUNDC3A RUN domain containing 3A -2.65231
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 -2.65231
IL32 interleukin 32 -2.65231
HSH2D hematopoietic SH2 domain containing -2.65231
FAM221B family with sequence similarity 221, member B -2.58907
CA1 carbonic anhydrase I -2.58907
CD300A CD300a molecule -2.58907
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.58907
MROH6 maestro heat-like repeat family member 6 -2.58907
PLK5 polo-like kinase 5 -2.58907
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.58907
PRR22 proline rich 22 -2.58907
CLCF1 cardiotrophin-like cytokine factor 1 -2.58907
APOA1 apolipoprotein A-I -2.58907
ZBBX zinc finger, B-box domain containing -2.58907
COL16A1 collagen, type XVI, alpha 1 -2.58907
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.58907
DNAI3 dynein axonemal intermediate chain 3 -2.58907
SCAND3 SCAN domain containing 3 -2.58907
MCHR1 melanin-concentrating hormone receptor 1 -2.58907
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.58907
CD72 CD72 molecule -2.58907
REC114 REC114 meiotic recombination protein -2.58907
ACOT1 acyl-CoA thioesterase 1 -2.58907
JHY junctional cadherin complex regulator -2.58907
MYBPHL myosin binding protein H-like -2.58907
FGF23 fibroblast growth factor 23 -2.58907
MLXIP MLX interacting protein -2.58907
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.58907
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -2.58907
FHIT fragile histidine triad -2.58907
SCARF1 scavenger receptor class F, member 1 -2.58907
UFSP1 UFM1-specific peptidase 1 (non-functional) -2.58907
HDAC6 histone deacetylase 6 -2.58907
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.58907
UBQLNL ubiquilin-like -2.58907
VILL villin-like -2.58907
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.58907
FERMT2 fermitin family member 2 -2.58907
NOS2 nitric oxide synthase 2, inducible -2.58907
NYX nyctalopin -2.58907
UPK1A uroplakin 1A -2.58907
INSL6 insulin-like 6 -2.58907
TMEM86B transmembrane protein 86B -2.58907
UBXN10 UBX domain protein 10 -2.58907
DPPA4 developmental pluripotency associated 4 -2.56602
ESPN espin -2.53849
FITM2 fat storage-inducing transmembrane protein 2 -2.47504
MFSD1 major facilitator superfamily domain containing 1 -2.45595
ZNF776 zinc finger protein 776 -2.43429
IL3RA interleukin 3 receptor, alpha (low affinity) -2.37366
MNMIP1 manchette microtubule inner protein 1 -2.37366
ZNF846 zinc finger protein 846 -2.30043
UBA1 ubiquitin-like modifier activating enzyme 1 -2.27331
OSBPL7 oxysterol binding protein-like 7 -2.25758
IL18BP interleukin 18 binding protein -2.25758
BTN3A2 butyrophilin, subfamily 3, member A2 -2.25758
PHF20L1 PHD finger protein 20-like 1 -2.24654
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -2.21866
TBCCD1 TBCC domain containing 1 -2.21692
CACNG6 calcium channel, voltage-dependent, gamma subunit 6 -2.20945
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.20535
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -2.20535
TPRG1 tumor protein p63 regulated 1 -2.20535
SQLE squalene epoxidase -2.20535
GFUS GDP-L-fucose synthase -2.19878
SSB Sjogren syndrome antigen B (autoantigen La) -2.17591
LPL lipoprotein lipase -2.17591
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.16735
ADRA1D adrenoceptor alpha 1D -2.16735
ZNF382 zinc finger protein 382 -2.15309
SLC35G2 solute carrier family 35, member G2 -2.13196
SIK1 salt-inducible kinase 1 -2.10394
PDZD4 PDZ domain containing 4 -2.10038
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.09369
STK17A serine/threonine kinase 17a -2.08395
SLITRK4 SLIT and NTRK-like family, member 4 -2.06774
ZCWPW2 zinc finger, CW type with PWWP domain 2 -2.06774
NDN necdin, melanoma antigen (MAGE) family member -2.03455
AXL AXL receptor tyrosine kinase -2.03251
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -2.02858
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.02049
EHD1 EH-domain containing 1 -2.01799
FZD2 frizzled class receptor 2 -2.0092
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.00488
DOCK10 dedicator of cytokinesis 10 -2.00488
COG2 component of oligomeric golgi complex 2 -2.00311