TNNT2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description troponin T type 2 (cardiac)|The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7139)
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Genes

290 genes differentially expressed following the TNNT2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CHRM4 cholinergic receptor, muscarinic 4 2.66299
FETUB fetuin B 2.66299
FAM90A1 family with sequence similarity 90, member A1 2.66299
ZFP28 ZFP28 zinc finger protein 2.66299
MYZAP myocardial zonula adherens protein 2.66299
NPIPA3 nuclear pore complex interacting protein family, member A3 2.66299
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.66299
ABHD15 abhydrolase domain containing 15 2.66299
HRH1 histamine receptor H1 2.66299
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.66299
SOWAHD sosondowah ankyrin repeat domain family member D 2.66299
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.66299
FNDC9 fibronectin type III domain containing 9 2.66299
GZMM granzyme M (lymphocyte met-ase 1) 2.66299
SLC35D3 solute carrier family 35, member D3 2.66299
XCL1 chemokine (C motif) ligand 1 2.66299
SMIM41 small integral membrane protein 41 2.66299
C1QTNF12 C1q and TNF related 12 2.66299
TNS1-AS1 TNS1 antisense RNA 1 2.66299
CFAP90 cilia and flagella associated protein 90 2.66299
INSL3 insulin-like 3 (Leydig cell) 2.66299
MID2 midline 2 2.66299
STRC stereocilin 2.66299
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.64941
SIX2 SIX homeobox 2 2.6236
PDILT protein disulfide isomerase-like, testis expressed 2.6236
NLRP10 NLR family, pyrin domain containing 10 2.6236
CIITA class II, major histocompatibility complex, transactivator 2.6236
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.6236
SNRPN small nuclear ribonucleoprotein polypeptide N 2.6236
TCP11 t-complex 11, testis-specific 2.6236
FOXA2 forkhead box A2 2.6236
CAPN14 calpain 14 2.6236
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.6236
PCDHA3 protocadherin alpha 3 2.6236
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.6236
UPK3B uroplakin 3B 2.6236
GYPB glycophorin B (MNS blood group) 2.6236
C6ORF58 chromosome 6 open reading frame 58 2.6236
GPR21 G protein-coupled receptor 21 2.6236
MTTP microsomal triglyceride transfer protein 2.6236
FFAR4 free fatty acid receptor 4 2.6236
SLC25A41 solute carrier family 25, member 41 2.6236
SLC25A47 solute carrier family 25, member 47 2.6236
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.6236
MUC6 mucin 6, oligomeric mucus/gel-forming 2.6236
TNIP3 TNFAIP3 interacting protein 3 2.6236
GPR55 G protein-coupled receptor 55 2.6236
REN renin 2.6236
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.6236
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.6236
IL4I1 interleukin 4 induced 1 2.6236
IL12RB1 interleukin 12 receptor, beta 1 2.6236
MDFIC2 MyoD family inhibitor domain containing 2 2.6236
H3-5 H3.5 histone 2.6236
MAIP1 matrix AAA peptidase interacting protein 1 2.6236
PHF24 PHD finger protein 24 2.6236
SPATS1 spermatogenesis associated, serine-rich 1 2.6236
HAO2 hydroxyacid oxidase 2 (long chain) 2.6236
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.6236
CAPN9 calpain 9 2.6236
FMOD fibromodulin 2.6236
MYOCOS myocilin opposite strand 2.6236
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.6236
CD8B2 CD8b2 molecule 2.6236
H3C3 H3 clustered histone 3 2.6236
CFAP276 cilia and flagella associated protein 276 2.6236
CPHXL cytoplasmic polyadenylated homeobox like 2.6236
GARIN4 golgi associated RAB2 interactor family member 4 2.6236
FNDC11 fibronectin type III domain containing 11 2.6236
KASH5 KASH domain containing 5 2.6236
CFAP119 cilia and flagella associated protein 119 2.6236
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.6236
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.6236
RAB36 RAB36, member RAS oncogene family 2.6236
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.6236
MYH13 myosin, heavy chain 13, skeletal muscle 2.6236
ZIC4 Zic family member 4 2.6236
CXCL14 chemokine (C-X-C motif) ligand 14 2.6236
CATSPER1 cation channel, sperm associated 1 2.6236
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.6236
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.6236
AMBP alpha-1-microglobulin/bikunin precursor 2.6236
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.6236
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.6236
MYL10 myosin, light chain 10, regulatory 2.6236
SPATA25 spermatogenesis associated 25 2.6236
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.6236
GPR85 G protein-coupled receptor 85 2.6236
PGA5 pepsinogen 5, group I (pepsinogen A) 2.6236
SBSN suprabasin 2.6236
CCR8 chemokine (C-C motif) receptor 8 2.6236
RASAL3 RAS protein activator like 3 2.6236
CCDC17 coiled-coil domain containing 17 2.6236
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.6236
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.6236
SCML4 sex comb on midleg-like 4 (Drosophila) 2.6236
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.6236
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.6236
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.6236
NPFFR1 neuropeptide FF receptor 1 2.6236
CBX8 chromobox homolog 8 2.6236
DRD2 dopamine receptor D2 2.6236
NUPR1 nuclear protein, transcriptional regulator, 1 2.6236
BTNL3 butyrophilin-like 3 2.6236
TESPA1 thymocyte expressed, positive selection associated 1 2.6236
SLA2 Src-like-adaptor 2 2.6236
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.6236
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 2.6236
FGF16 fibroblast growth factor 16 2.6236
USP17L2 ubiquitin specific peptidase 17-like family member 2 2.6236
WDFY4 WDFY family member 4 2.6236
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.6236
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 2.6236
SAP130 Sin3A-associated protein, 130kDa 2.6236
LMOD3 leiomodin 3 (fetal) 2.6236
TAT tyrosine aminotransferase 2.6236
CIMIP7 ciliary microtubule inner protein 7 2.6236
KLHDC1 kelch domain containing 1 2.6236
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.6236
CNR2 cannabinoid receptor 2 (macrophage) 2.6236
C10ORF105 chromosome 10 open reading frame 105 2.6236
C14ORF119 chromosome 14 open reading frame 119 2.6236
GJC2 gap junction protein, gamma 2, 47kDa 2.6236
LRRC24 leucine rich repeat containing 24 2.6236
MZB1 marginal zone B and B1 cell-specific protein 2.6236
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 2.6236
LGALS14 lectin, galactoside-binding, soluble, 14 2.6236
CTRB1 chymotrypsinogen B1 2.6236
GPS1 G protein pathway suppressor 1 2.6236
KLK6 kallikrein-related peptidase 6 2.6236
MSR1 macrophage scavenger receptor 1 2.6236
CHIT1 chitinase 1 (chitotriosidase) 2.6236
RBM28 RNA binding motif protein 28 2.6236
TPPP2 tubulin polymerization-promoting protein family member 2 2.6236
PRSS38 protease, serine, 38 2.6236
F13B coagulation factor XIII, B polypeptide 2.6236
SHOX short stature homeobox 2.6236
KIAA1755 KIAA1755 2.6236
HMX3 H6 family homeobox 3 2.6236
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.6236
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.6236
ATOH1 atonal homolog 1 (Drosophila) 2.6236
SPAG8 sperm associated antigen 8 2.6236
YEATS4 YEATS domain containing 4 2.6236
APOA1 apolipoprotein A-I 2.6236
PITX2 paired-like homeodomain 2 2.6236
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.6236
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.6236
IL23R interleukin 23 receptor 2.6236
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.6236
LOC102724877 uncharacterized LOC102724877 2.6236
FGF4 fibroblast growth factor 4 2.6236
PLA2G10 phospholipase A2, group X 2.6236
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.6236
LRRC61 leucine rich repeat containing 61 2.6236
BHMT2 betaine--homocysteine S-methyltransferase 2 2.6236
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.6236
ADAM29 ADAM metallopeptidase domain 29 2.6236
GSTO1 glutathione S-transferase omega 1 2.6236
RGPD5 RANBP2-like and GRIP domain containing 5 2.6236
BIN2 bridging integrator 2 2.6236
TAS2R13 taste receptor, type 2, member 13 2.6236
TAS2R43 taste receptor, type 2, member 43 2.6236
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.6236
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.6236
NECTIN1 nectin cell adhesion molecule 1 2.49703
CARF calcium responsive transcription factor 2.48652
VWA8 von Willebrand factor A domain containing 8 2.48626
C11ORF52 chromosome 11 open reading frame 52 2.46206
NOXO1 NADPH oxidase organizer 1 2.46206
EIF5A2 eukaryotic translation initiation factor 5A2 2.45934
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.45774
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.45127
LATS2 large tumor suppressor kinase 2 2.40785
CSPG4 chondroitin sulfate proteoglycan 4 2.40416
EIF3M eukaryotic translation initiation factor 3, subunit M 2.39191
PRRC2B proline-rich coiled-coil 2B 2.38036
SP100 SP100 nuclear antigen 2.34993
C18ORF32 chromosome 18 open reading frame 32 2.29574
NOMO1 NODAL modulator 1 2.28322
PRKX protein kinase, X-linked 2.26849
YPEL2 yippee-like 2 (Drosophila) 2.24675
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.24675
GSR glutathione reductase 2.24409
OVCH2 ovochymase 2 (gene/pseudogene) 2.23887
CFAP99 cilia and flagella associated protein 99 2.22431
NPM2 nucleophosmin/nucleoplasmin 2 2.22431
WDR81 WD repeat domain 81 2.22028
CEPT1 choline/ethanolamine phosphotransferase 1 2.20926
RIOX1 ribosomal oxygenase 1 2.20837
MYO7A myosin VIIA 2.15955
PRB2 proline-rich protein BstNI subfamily 2 2.15955
SINHCAF SIN3-HDAC complex associated factor 2.15824
STPG1 sperm-tail PG-rich repeat containing 1 2.15683
ANLN anillin, actin binding protein 2.15683
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 2.15683
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.15505
DYDC2 DPY30 domain containing 2 2.13434
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.13282
SELENOV selenoprotein V 2.12989
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.12023
FBLIM1 filamin binding LIM protein 1 2.06633
ARHGAP12 Rho GTPase activating protein 12 2.05281
ELF1 E74-like factor 1 (ets domain transcription factor) 2.03115
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) 2.01516

decreased expression

Symbol Name Standardized Value
LHX6 LIM homeobox 6 -2.66299
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.66299
CLTRN collectrin, amino acid transport regulator -2.6236
TMEM171 transmembrane protein 171 -2.6236
LBP lipopolysaccharide binding protein -2.6236
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.6236
GMFG glia maturation factor, gamma -2.6236
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.6236
C8ORF74 chromosome 8 open reading frame 74 -2.6236
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.6236
FAM216B family with sequence similarity 216, member B -2.6236
TECTA tectorin alpha -2.6236
VWC2L von Willebrand factor C domain containing protein 2-like -2.6236
ACAN aggrecan -2.6236
MBLAC1 metallo-beta-lactamase domain containing 1 -2.6236
CD163L1 CD163 molecule-like 1 -2.6236
IZUMO3 IZUMO family member 3 -2.6236
DEFB131B defensin beta 131B -2.6236
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.6236
PRXL2A peroxiredoxin like 2A -2.6236
ABHD14B abhydrolase domain containing 14B -2.6236
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.6236
SCIMP SLP adaptor and CSK interacting membrane protein -2.6236
REC114 REC114 meiotic recombination protein -2.6236
TMEM230 transmembrane protein 230 -2.6236
IDO2 indoleamine 2,3-dioxygenase 2 -2.6236
TLE2 transducin-like enhancer of split 2 -2.6236
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.6236
CPED1 cadherin-like and PC-esterase domain containing 1 -2.6236
FAM153A family with sequence similarity 153, member A -2.6236
PRIMA1 proline rich membrane anchor 1 -2.6236
EPN3 epsin 3 -2.6236
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.6236
CCDC152 coiled-coil domain containing 152 -2.6236
SPDL1 spindle apparatus coiled-coil protein 1 -2.6236
LSMEM1 leucine-rich single-pass membrane protein 1 -2.6236
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.6236
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.6236
STAMBP STAM binding protein -2.6236
VSTM1 V-set and transmembrane domain containing 1 -2.6236
ADCY7 adenylate cyclase 7 -2.6236
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.6236
ADGRA3 adhesion G protein-coupled receptor A3 -2.6236
CRTAP cartilage associated protein -2.6236
G0S2 G0/G1 switch 2 -2.6236
LIF leukemia inhibitory factor -2.6236
MGP matrix Gla protein -2.6236
POU3F4 POU class 3 homeobox 4 -2.6236
ANKRD36 ankyrin repeat domain 36 -2.6236
PPCS phosphopantothenoylcysteine synthetase -2.6236
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.6236
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.6236
SPRYD4 SPRY domain containing 4 -2.6236
GABARAPL1 GABA(A) receptor-associated protein like 1 -2.58622
ZNF343 zinc finger protein 343 -2.41137
SETDB1 SET domain, bifurcated 1 -2.36487
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.35457
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.3517
SEC13 SEC13 homolog (S. cerevisiae) -2.29574
PAQR8 progestin and adipoQ receptor family member VIII -2.293
TMEM70 transmembrane protein 70 -2.24959
YAF2 YY1 associated factor 2 -2.24522
PRSS35 protease, serine, 35 -2.24522
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.24522
CCDC73 coiled-coil domain containing 73 -2.24522
SPN sialophorin -2.24409
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.24409
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.24409
MCF2 MCF.2 cell line derived transforming sequence -2.24204
CFAP58 cilia and flagella associated protein 58 -2.22177
COMMD8 COMM domain containing 8 -2.17385
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.14487
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.12989
RBM22 RNA binding motif protein 22 -2.12071
ASB18 ankyrin repeat and SOCS box containing 18 -2.1018
SPTAN1 spectrin, alpha, non-erythrocytic 1 -2.07921
H2BC13 H2B clustered histone 13 -2.07687
UNC13D unc-13 homolog D (C. elegans) -2.07687
PIAS3 protein inhibitor of activated STAT, 3 -2.07571
CFAP92 cilia and flagella associated protein 92 (putative) -2.05782
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.05281
MYG1 MYG1 exonuclease -2.05281
FNDC5 fibronectin type III domain containing 5 -2.04346
DSTYK dual serine/threonine and tyrosine protein kinase -2.03963