| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/369976 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in TNP-470 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMG2 | semenogelin II | 3.87 |
| HMOX1 | heme oxygenase 1 | 3.21 |
| ACTB | actin, beta | 2.42 |
| FTL | ferritin, light polypeptide | 2.33 |
| PIP | prolactin-induced protein | 1.74 |
| PWWP2B | PWWP domain containing 2B | 1.72 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 1.66 |
| CFAP298 | cilia and flagella associated protein 298 | 1.62 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.39 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 1.35 |
| IFRD1 | interferon-related developmental regulator 1 | 1.35 |
| ENO1 | enolase 1, (alpha) | 1.3 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 1.28 |
| ITM2C | integral membrane protein 2C | 1.27 |
| SRXN1 | sulfiredoxin 1 | 1.22 |
| SBSN | suprabasin | 1.22 |
| ADM | adrenomedullin | 1.2 |
| ITM2B | integral membrane protein 2B | 1.1 |
| ECM1 | extracellular matrix protein 1 | 1.02 |
| GDF15 | growth differentiation factor 15 | 1.0 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.98 |
| ABHD4 | abhydrolase domain containing 4 | 0.97 |
| TSPYL2 | TSPY-like 2 | 0.97 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.9 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.9 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.88 |
| TDG | thymine-DNA glycosylase | 0.87 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.85 |
| MAP2 | microtubule-associated protein 2 | 0.81 |
| RBIS | ribosomal biogenesis factor | 0.79 |
| ANKRD18B | ankyrin repeat domain 18B | 0.78 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.77 |
| FOSL2 | FOS-like antigen 2 | 0.76 |
| MYH15 | myosin, heavy chain 15 | 0.75 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.74 |
| CBR3 | carbonyl reductase 3 | 0.74 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | 0.72 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.71 |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | 0.71 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.71 |
| TGFB1 | transforming growth factor, beta 1 | 0.71 |
| CCNE1 | cyclin E1 | 0.7 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | 0.7 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.7 |
| HBA1 | hemoglobin, alpha 1 | 0.69 |
| CLU | clusterin | 0.68 |
| SESN2 | sestrin 2 | 0.68 |
| PHF1 | PHD finger protein 1 | 0.67 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.67 |
| PSAP | prosaposin | 0.67 |
| ZNF593 | zinc finger protein 593 | 0.66 |
| HGFAC | HGF activator | 0.66 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.65 |
| TP53 | tumor protein p53 | 0.65 |
| HYKK | hydroxylysine kinase | 0.64 |
| HMCN1 | hemicentin 1 | 0.63 |
| KIAA1217 | KIAA1217 | 0.63 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.63 |
| CCND3 | cyclin D3 | 0.62 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.61 |
| PTEN | phosphatase and tensin homolog | 0.61 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.6 |
| NOSIP | nitric oxide synthase interacting protein | 0.6 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.6 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | 0.59 |
| ZNF616 | zinc finger protein 616 | 0.59 |
| TXNRD1 | thioredoxin reductase 1 | 0.58 |
| SOD1 | superoxide dismutase 1, soluble | 0.57 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.57 |
| RND3 | Rho family GTPase 3 | 0.57 |
| GCH1 | GTP cyclohydrolase 1 | 0.57 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.57 |
| ACTR8 | ARP8 actin-related protein 8 homolog (yeast) | 0.56 |
| CBR1 | carbonyl reductase 1 | 0.56 |
| GLRX | glutaredoxin (thioltransferase) | 0.56 |
| HSPA1A | heat shock 70kDa protein 1A | 0.55 |
| OTUD5 | OTU deubiquitinase 5 | 0.55 |
| EIF1AD | eukaryotic translation initiation factor 1A domain containing | 0.55 |
| CLK1 | CDC-like kinase 1 | 0.55 |
| HLA-E | major histocompatibility complex, class I, E | 0.54 |
| CHPF2 | chondroitin polymerizing factor 2 | 0.54 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | 0.53 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.53 |
| NF1 | neurofibromin 1 | 0.53 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | 0.53 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.52 |
| FAS | Fas cell surface death receptor | 0.52 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.52 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.52 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.52 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.52 |
| PCYT1A | phosphate cytidylyltransferase 1, choline, alpha | 0.51 |
| EPDR1 | ependymin related 1 | 0.51 |
| UPP1 | uridine phosphorylase 1 | 0.51 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.51 |
| TXNL1 | thioredoxin-like 1 | 0.51 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.51 |
| ZNF581 | zinc finger protein 581 | 0.51 |
| IRF7 | interferon regulatory factor 7 | 0.5 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRAME | preferentially expressed antigen in melanoma | -4.47 |
| VGF | VGF nerve growth factor inducible | -3.63 |
| NPHP3 | nephronophthisis 3 (adolescent) | -1.82 |
| C12ORF60 | chromosome 12 open reading frame 60 | -1.73 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.61 |
| SARDH | sarcosine dehydrogenase | -1.44 |
| SETD9 | SET domain containing 9 | -1.32 |
| WWC3 | WWC family member 3 | -1.29 |
| GATA6 | GATA binding protein 6 | -1.22 |
| CDCA4 | cell division cycle associated 4 | -1.07 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -1.06 |
| TMEM132A | transmembrane protein 132A | -0.97 |
| LIX1L | Lix1 homolog (chicken) like | -0.95 |
| ESPN | espin | -0.92 |
| PCLAF | PCNA clamp associated factor | -0.91 |
| HOXB9 | homeobox B9 | -0.91 |
| DDN | dendrin | -0.9 |
| DPH6 | diphthamine biosynthesis 6 | -0.89 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | -0.88 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.88 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.88 |
| RTTN | rotatin | -0.87 |
| RBP7 | retinol binding protein 7, cellular | -0.86 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.86 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.85 |
| FAM241B | family with sequence similarity 241 member B | -0.84 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.84 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.84 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.84 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.83 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.83 |
| CEP72 | centrosomal protein 72kDa | -0.82 |
| ACTL8 | actin-like 8 | -0.8 |
| SARS | seryl-tRNA synthetase | -0.79 |
| NPNT | nephronectin | -0.77 |
| PEG10 | paternally expressed 10 | -0.73 |
| DIAPH3 | diaphanous-related formin 3 | -0.73 |
| C1ORF226 | chromosome 1 open reading frame 226 | -0.72 |
| SCARA3 | scavenger receptor class A, member 3 | -0.71 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.71 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.71 |
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | -0.71 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.71 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.71 |
| KIF18B | kinesin family member 18B | -0.7 |
| TBC1D31 | TBC1 domain family, member 31 | -0.7 |
| FZD1 | frizzled class receptor 1 | -0.7 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -0.7 |
| GALNS | galactosamine (N-acetyl)-6-sulfatase | -0.69 |
| OMA1 | OMA1 zinc metallopeptidase | -0.69 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.68 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | -0.68 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.68 |
| DONSON | downstream neighbor of SON | -0.67 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.67 |
| ZNF428 | zinc finger protein 428 | -0.67 |
| MLXIPL | MLX interacting protein-like | -0.67 |
| TMEM200A | transmembrane protein 200A | -0.67 |
| CHPF | chondroitin polymerizing factor | -0.67 |
| PCBP4 | poly(rC) binding protein 4 | -0.67 |
| PRR11 | proline rich 11 | -0.67 |
| PPP1R35 | protein phosphatase 1, regulatory subunit 35 | -0.66 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -0.66 |
| BCORL1 | BCL6 corepressor-like 1 | -0.66 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.65 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.65 |
| REEP1 | receptor accessory protein 1 | -0.64 |
| FANCG | Fanconi anemia, complementation group G | -0.64 |
| GEN1 | GEN1 Holliday junction 5' flap endonuclease | -0.64 |
| ZNF770 | zinc finger protein 770 | -0.63 |
| FANCA | Fanconi anemia, complementation group A | -0.63 |
| ZFHX4 | zinc finger homeobox 4 | -0.63 |
| FOXM1 | forkhead box M1 | -0.63 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.62 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.62 |
| ARG2 | arginase 2 | -0.62 |
| ARSG | arylsulfatase G | -0.62 |
| RNF141 | ring finger protein 141 | -0.62 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.62 |
| ARMC4 | armadillo repeat containing 4 | -0.61 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.61 |
| TRIM7 | tripartite motif containing 7 | -0.61 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.6 |
| KMT5A | lysine methyltransferase 5A | -0.6 |
| COL6A1 | collagen, type VI, alpha 1 | -0.6 |
| ZMYM3 | zinc finger, MYM-type 3 | -0.6 |
| JUN | jun proto-oncogene | -0.6 |
| AOC1 | amine oxidase, copper containing 1 | -0.59 |
| PRSS8 | protease, serine, 8 | -0.59 |
| VIM | vimentin | -0.59 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.59 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.58 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.58 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.58 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.58 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.58 |
| DPYD | dihydropyrimidine dehydrogenase | -0.58 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.58 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.57 |
| FANCI | Fanconi anemia, complementation group I | -0.57 |
