TOM1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description target of myb1 (chicken)|This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 10043)
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Genes

325 genes differentially expressed following the TOM1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DCST1 DC-STAMP domain containing 1 2.92548
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.92548
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.92548
SIX3 SIX homeobox 3 2.92548
CELF6 CUGBP, Elav-like family member 6 2.92548
ZNF575 zinc finger protein 575 2.92548
PCDHGA2 protocadherin gamma subfamily A, 2 2.92548
RRH retinal pigment epithelium-derived rhodopsin homolog 2.92548
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.92548
ARFGEF3 ARFGEF family member 3 2.92548
SNTN sentan, cilia apical structure protein 2.92548
NPIPA8 nuclear pore complex interacting protein family, member A8 2.92548
APOA1 apolipoprotein A-I 2.92548
LY6G6F lymphocyte antigen 6 complex, locus G6F 2.92548
ZNF396 zinc finger protein 396 2.92548
OXER1 oxoeicosanoid (OXE) receptor 1 2.92548
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.92548
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.92548
SLC25A45 solute carrier family 25, member 45 2.92548
PRDM7 PR domain containing 7 2.92548
RAD9B RAD9 homolog B (S. pombe) 2.92548
SRGN serglycin 2.92548
SMIM38 small integral membrane protein 38 2.92548
MISP3 MISP family member 3 2.92548
GFY golgi-associated, olfactory signaling regulator 2.92548
VN1R1 vomeronasal 1 receptor 1 2.92548
AANAT aralkylamine N-acetyltransferase 2.92548
FOXN4 forkhead box N4 2.92548
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.87969
OLIG3 oligodendrocyte transcription factor 3 2.80321
CCDC187 coiled-coil domain containing 187 2.80321
C6ORF58 chromosome 6 open reading frame 58 2.80321
ARHGAP36 Rho GTPase activating protein 36 2.80321
GJB5 gap junction protein, beta 5, 31.1kDa 2.80321
PTTG2 pituitary tumor-transforming 2 2.80321
SLC16A11 solute carrier family 16, member 11 2.80321
SOX14 SRY (sex determining region Y)-box 14 2.80321
ZNF560 zinc finger protein 560 2.80321
TMEM191B transmembrane protein 191B 2.80321
MAGEA6 melanoma antigen family A6 2.80321
PCDHB8 protocadherin beta 8 2.80321
GPR151 G protein-coupled receptor 151 2.80321
PDZD9 PDZ domain containing 9 2.80321
SPESP1 sperm equatorial segment protein 1 2.80321
MRTFA myocardin related transcription factor A 2.80321
C19ORF67 chromosome 19 open reading frame 67 2.80321
LDHC lactate dehydrogenase C 2.80321
BRICD5 BRICHOS domain containing 5 2.80321
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.80321
BFSP2 beaded filament structural protein 2, phakinin 2.80321
TRPC5OS TRPC5 opposite strand 2.80321
PRDM12 PR domain containing 12 2.80321
LGALS2 lectin, galactoside-binding, soluble, 2 2.80321
CLCN1 chloride channel, voltage-sensitive 1 2.80321
LOC122526780 uncharacterized LOC122526780 2.80321
NFILZ NFIL3 like basic leucine zipper 2.80321
PLAAT4 phospholipase A and acyltransferase 4 2.80321
NRROS negative regulator of reactive oxygen species 2.80321
LORICRIN loricrin cornified envelope precursor protein 2.80321
GCKR glucokinase (hexokinase 4) regulator 2.80321
KASH5 KASH domain containing 5 2.80321
NCKAP1L NCK-associated protein 1-like 2.80321
BSX brain-specific homeobox 2.80321
NPIPA7 nuclear pore complex interacting protein family, member A7 2.80321
CPLX1 complexin 1 2.80321
ROPN1B rhophilin associated tail protein 1B 2.80321
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.80321
SPEM1 spermatid maturation 1 2.80321
CCR4 chemokine (C-C motif) receptor 4 2.80321
TACR2 tachykinin receptor 2 2.80321
SAA2 serum amyloid A2 2.80321
TARM1 T cell-interacting, activating receptor on myeloid cells 1 2.80321
TAS1R2 taste receptor, type 1, member 2 2.80321
FIMP1 fertilization-influencing membrane protein 1 2.80321
HAL histidine ammonia-lyase 2.80321
GPR85 G protein-coupled receptor 85 2.80321
LRRN4CL LRRN4 C-terminal like 2.80321
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.80321
VSIG2 V-set and immunoglobulin domain containing 2 2.80321
REP15 RAB15 effector protein 2.80321
LY6S lymphocyte antigen 6 family member S 2.80321
ACSL5 acyl-CoA synthetase long-chain family member 5 2.80321
TMPRSS6 transmembrane protease, serine 6 2.80321
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.80321
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.80321
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.80321
NPAP1 nuclear pore associated protein 1 2.80321
ASB15 ankyrin repeat and SOCS box containing 15 2.80321
LY86 lymphocyte antigen 86 2.80321
PROP1 PROP paired-like homeobox 1 2.80321
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.80321
UPK3B uroplakin 3B 2.80321
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.80321
TAS2R5 taste receptor, type 2, member 5 2.80321
SLC22A14 solute carrier family 22, member 14 2.80321
ACER1 alkaline ceramidase 1 2.80321
LIPJ lipase, family member J 2.80321
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 2.80321
ACTL10 actin-like 10 2.80321
CFAP99 cilia and flagella associated protein 99 2.80321
TSGA10IP testis specific, 10 interacting protein 2.80321
VSX2 visual system homeobox 2 2.80321
MYH13 myosin, heavy chain 13, skeletal muscle 2.80321
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.80321
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.80321
PRM1 protamine 1 2.80321
FAM177B family with sequence similarity 177, member B 2.80321
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.80321
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.80321
IL1B interleukin 1, beta 2.80321
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.80321
KLK12 kallikrein-related peptidase 12 2.80321
C20ORF144 chromosome 20 open reading frame 144 2.80321
CRYBB3 crystallin, beta B3 2.80321
ADGRA1 adhesion G protein-coupled receptor A1 2.80321
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.80321
ANKRD62 ankyrin repeat domain 62 2.80321
CIDEA cell death-inducing DFFA-like effector a 2.80321
ONECUT3 one cut homeobox 3 2.80321
KRT17 keratin 17, type I 2.80321
CLEC7A C-type lectin domain family 7, member A 2.80321
MYF6 myogenic factor 6 (herculin) 2.80321
KRTAP5-11 keratin associated protein 5-11 2.80321
CH25H cholesterol 25-hydroxylase 2.80321
TBX1 T-box 1 2.80321
ZC3H11D zinc finger CCCH-type containing 11D 2.80321
TM4SF19 transmembrane 4 L six family member 19 2.80321
ADAM12 ADAM metallopeptidase domain 12 2.80321
CNGB1 cyclic nucleotide gated channel beta 1 2.80321
EOMES eomesodermin 2.80321
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.80321
GOLGA8M golgin A8 family, member M 2.80321
GOLGA8R golgin A8 family, member R 2.80321
GOLGA8T golgin A8 family, member T 2.80321
LAMB4 laminin, beta 4 2.80321
GPR150 G protein-coupled receptor 150 2.80321
MOBP myelin-associated oligodendrocyte basic protein 2.80321
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.80321
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.80321
FCRL2 Fc receptor-like 2 2.80321
RHBDD3 rhomboid domain containing 3 2.80321
NT5C1A 5'-nucleotidase, cytosolic IA 2.80321
ZIM2 zinc finger, imprinted 2 2.80321
LHX2 LIM homeobox 2 2.80321
BCL2L15 BCL2-like 15 2.80321
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.80321
PASD1 PAS domain containing 1 2.80321
LEP leptin 2.80321
TGM6 transglutaminase 6 2.80321
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.80321
CCDC87 coiled-coil domain containing 87 2.80321
GREM1 gremlin 1, DAN family BMP antagonist 2.80321
LXN latexin 2.80321
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.80321
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.80321
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.80321
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.80321
HPGDS hematopoietic prostaglandin D synthase 2.80321
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.80321
MYOZ2 myozenin 2 2.80321
ASCL1 achaete-scute family bHLH transcription factor 1 2.80321
SNX18 sorting nexin 18 2.80321
TGM3 transglutaminase 3 2.80321
POTEI POTE ankyrin domain family, member I 2.80321
LOC105378220 macrophage receptor MARCO-like 2.80321
TRAF3IP3 TRAF3 interacting protein 3 2.80321
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.80321
AK8 adenylate kinase 8 2.80321
TBC1D26 TBC1 domain family, member 26 2.80321
NOS2 nitric oxide synthase 2, inducible 2.80321
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.80321
AGBL4 ATP/GTP binding protein-like 4 2.80321
LAMA3 laminin, alpha 3 2.73827
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.69231
ATF7 activating transcription factor 7 2.68654
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.6817
SP140 SP140 nuclear body protein 2.6817
ACOXL acyl-CoA oxidase-like 2.659
SETDB1 SET domain, bifurcated 1 2.52397
HORMAD2 HORMA domain containing 2 2.50001
FAIM2 Fas apoptotic inhibitory molecule 2 2.50001
TMEM121 transmembrane protein 121 2.50001
HPS4 Hermansky-Pudlak syndrome 4 2.44907
LDOC1 leucine zipper, down-regulated in cancer 1 2.42288
DCST2 DC-STAMP domain containing 2 2.40223
SCIN scinderin 2.40223
TEKT2 tektin 2 (testicular) 2.40223
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.39794
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.39794
CCDC194 coiled-coil domain containing 194 2.39794
RSPH3 radial spoke 3 homolog (Chlamydomonas) 2.39036
ZBTB8B zinc finger and BTB domain containing 8B 2.39036
CCDC85A coiled-coil domain containing 85A 2.36585
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.34334
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.33926
ELAC2 elaC ribonuclease Z 2 2.29202
MOB2 MOB kinase activator 2 2.28387
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.27876
PLS1 plastin 1 2.26108
GREB1L growth regulation by estrogen in breast cancer-like 2.259
RSPRY1 ring finger and SPRY domain containing 1 2.25287
PLD5 phospholipase D family, member 5 2.24208
FURIN furin (paired basic amino acid cleaving enzyme) 2.21093
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.20543
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.19985
JAG2 jagged 2 2.19985
RTL8C retrotransposon Gag like 8C 2.18214
ZNF460 zinc finger protein 460 2.17598
USP37 ubiquitin specific peptidase 37 2.16046
KCNK6 potassium channel, two pore domain subfamily K, member 6 2.13482
SCAMP4 secretory carrier membrane protein 4 2.11812
EVI5 ecotropic viral integration site 5 2.10653
CTDNEP1 CTD nuclear envelope phosphatase 1 2.08946
ISY1 ISY1 splicing factor homolog (S. cerevisiae) 2.07227
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.04815
TM2D2 TM2 domain containing 2 2.03444
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.03348
HAUS5 HAUS augmin-like complex, subunit 5 2.02923
PCBP1 poly(rC) binding protein 1 2.02923
AARSD1 alanyl-tRNA synthetase domain containing 1 2.00323
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.00323
DMXL1 Dmx-like 1 2.00323

decreased expression

Symbol Name Standardized Value
FOXJ1 forkhead box J1 -2.92548
CYB561D1 cytochrome b561 family, member D1 -2.92548
PODNL1 podocan-like 1 -2.92548
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -2.92548
ZNF319 zinc finger protein 319 -2.92548
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -2.92548
PTH2R parathyroid hormone 2 receptor -2.92548
EXD1 exonuclease 3'-5' domain containing 1 -2.92548
SOST sclerostin -2.92548
ZNF764 zinc finger protein 764 -2.92548
KCTD12 potassium channel tetramerization domain containing 12 -2.88058
GHRL ghrelin/obestatin prepropeptide -2.80321
PRSS50 protease, serine, 50 -2.80321
NOD2 nucleotide-binding oligomerization domain containing 2 -2.80321
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.80321
HCRTR1 hypocretin (orexin) receptor 1 -2.80321
EBF2 early B-cell factor 2 -2.80321
AKAP10 A kinase (PRKA) anchor protein 10 -2.80321
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.80321
SLC16A6 solute carrier family 16, member 6 -2.80321
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.80321
GRAPL GRB2-related adaptor protein-like -2.80321
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.80321
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.80321
PLK3 polo-like kinase 3 -2.80321
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.80321
FLACC1 flagellum associated containing coiled-coil domains 1 -2.80321
TSHR thyroid stimulating hormone receptor -2.80321
TSNAXIP1 translin-associated factor X interacting protein 1 -2.80321
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.80321
MISO1 mitochondrial inner membrane subdomain organizer 1 -2.80321
IRGM immunity-related GTPase family, M -2.80321
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.80321
ADGRG3 adhesion G protein-coupled receptor G3 -2.80321
UTS2B urotensin 2B -2.80321
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B -2.80321
C20ORF204 chromosome 20 open reading frame 204 -2.80321
ADIPOR1 adiponectin receptor 1 -2.80321
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.80321
CBX8 chromobox homolog 8 -2.80321
TREH trehalase (brush-border membrane glycoprotein) -2.80321
SPATA4 spermatogenesis associated 4 -2.80321
ZNF285 zinc finger protein 285 -2.80321
ACOT1 acyl-CoA thioesterase 1 -2.80321
PEX12 peroxisomal biogenesis factor 12 -2.80321
TNS1-AS1 TNS1 antisense RNA 1 -2.80321
C6ORF163 chromosome 6 open reading frame 163 -2.80321
KLHL8 kelch-like family member 8 -2.80321
PRRT1 proline-rich transmembrane protein 1 -2.80321
GLIPR1L2 GLI pathogenesis-related 1 like 2 -2.80321
NIPAL4 NIPA-like domain containing 4 -2.80321
SMAD5 SMAD family member 5 -2.69616
SPATA2L spermatogenesis associated 2-like -2.63389
KPNA6 karyopherin alpha 6 (importin alpha 7) -2.59717
UBA2 ubiquitin-like modifier activating enzyme 2 -2.55112
TOM1 target of myb1 (chicken) -2.55112
MCUR1 mitochondrial calcium uniporter regulator 1 -2.53443
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.52397
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.52397
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.51216
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -2.50432
MRPL4 mitochondrial ribosomal protein L4 -2.50001
EWSR1 EWS RNA-binding protein 1 -2.48606
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.48597
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) -2.48533
ACAT1 acetyl-CoA acetyltransferase 1 -2.44397
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.41915
TMEM54 transmembrane protein 54 -2.41609
PGK1 phosphoglycerate kinase 1 -2.36585
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.34334
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.32914
SH2D2A SH2 domain containing 2A -2.30231
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.30112
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.294
PGAM5 phosphoglycerate mutase family member 5 -2.294
PREPL prolyl endopeptidase-like -2.2862
RGS14 regulator of G-protein signaling 14 -2.25928
MAML1 mastermind-like 1 (Drosophila) -2.24111
GAL3ST1 galactose-3-O-sulfotransferase 1 -2.22892
ARHGAP12 Rho GTPase activating protein 12 -2.20601
DDRGK1 DDRGK domain containing 1 -2.19495
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.18485
MLX MLX, MAX dimerization protein -2.16703
RHOBTB1 Rho-related BTB domain containing 1 -2.15774
TNNC2 troponin C type 2 (fast) -2.15727
SLC2A4RG SLC2A4 regulator -2.15552
ZFYVE28 zinc finger, FYVE domain containing 28 -2.15552
BICDL1 BICD family like cargo adaptor 1 -2.15552
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.13482
ZNF284 zinc finger protein 284 -2.13016
PTAFR platelet-activating factor receptor -2.13016
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.11195
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.10706
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.09898
COA6 cytochrome c oxidase assembly factor 6 -2.07976
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.04525
UTP4 UTP4 small subunit processome component -2.03138
HIF3A hypoxia inducible factor 3, alpha subunit -2.00791
CLDN3 claudin 3 -2.00587
TMSB15B thymosin beta 15B -2.0028
ZNF350 zinc finger protein 350 -2.00203
TTC27 tetratricopeptide repeat domain 27 -2.00203
HSDL1 hydroxysteroid dehydrogenase like 1 -2.00203