TOP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description topoisomerase (DNA) I|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7150)
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Genes

658 genes differentially expressed following the TOP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.60225
RASA4 RAS p21 protein activator 4 3.60225
SIM1 single-minded family bHLH transcription factor 1 3.60225
CLUL1 clusterin-like 1 (retinal) 3.60225
ATP13A5 ATPase type 13A5 3.60225
TMEM40 transmembrane protein 40 3.60225
UROC1 urocanate hydratase 1 3.60225
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.60225
LEKR1 leucine, glutamate and lysine rich 1 3.60225
PRDM6 PR domain containing 6 3.60225
NTN5 netrin 5 3.60225
ASGR2 asialoglycoprotein receptor 2 3.60225
PLEK2 pleckstrin 2 3.60225
VIT vitrin 3.60225
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.60225
DAO D-amino-acid oxidase 3.60225
UPP2 uridine phosphorylase 2 3.60225
FAM178B family with sequence similarity 178, member B 3.60225
NDRG1 N-myc downstream regulated 1 3.60225
EFCAB12 EF-hand calcium binding domain 12 3.60225
UPK1B uroplakin 1B 3.60225
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.60225
EFCAB3 EF-hand calcium binding domain 3 3.60225
MRPL53 mitochondrial ribosomal protein L53 3.60225
PTAFR platelet-activating factor receptor 3.60225
SLC15A5 solute carrier family 15, member 5 3.60225
MUSK muscle, skeletal, receptor tyrosine kinase 3.60225
ASCL5 achaete-scute family bHLH transcription factor 5 3.60225
BAHCC1 BAH domain and coiled-coil containing 1 3.60225
PDYN prodynorphin 3.56106
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 3.56106
HIC1 hypermethylated in cancer 1 3.56106
R3HDML R3H domain containing-like 3.56106
TNNI1 troponin I type 1 (skeletal, slow) 3.56106
ZNF556 zinc finger protein 556 3.56106
TAL2 T-cell acute lymphocytic leukemia 2 3.56106
ADRA1B adrenoceptor alpha 1B 3.56106
ZNF560 zinc finger protein 560 3.56106
RFPL2 ret finger protein-like 2 3.56106
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 3.56106
MAGED4 melanoma antigen family D4 3.56106
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.56106
IL5RA interleukin 5 receptor, alpha 3.56106
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.56106
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.56106
FFAR4 free fatty acid receptor 4 3.56106
PRL prolactin 3.56106
EVPL envoplakin 3.56106
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.56106
CIB4 calcium and integrin binding family member 4 3.56106
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.56106
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.56106
STOML3 stomatin (EPB72)-like 3 3.56106
GCSAML germinal center-associated, signaling and motility-like 3.56106
ALG10 ALG10, alpha-1,2-glucosyltransferase 3.56106
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.56106
TGM3 transglutaminase 3 3.56106
IFNK interferon, kappa 3.56106
A1CF APOBEC1 complementation factor 3.56106
TMPRSS13 transmembrane protease, serine 13 3.56106
NNMT nicotinamide N-methyltransferase 3.56106
LRRC31 leucine rich repeat containing 31 3.56106
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.56106
ICAM2 intercellular adhesion molecule 2 3.56106
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.56106
EPHB3 EPH receptor B3 3.56106
STAP1 signal transducing adaptor family member 1 3.56106
FGF6 fibroblast growth factor 6 3.56106
TWIST1 twist family bHLH transcription factor 1 3.56106
SPDEF SAM pointed domain containing ETS transcription factor 3.56106
GRM2 glutamate receptor, metabotropic 2 3.56106
ANXA2R annexin A2 receptor 3.56106
KRTAP13-4 keratin associated protein 13-4 3.56106
MMRN1 multimerin 1 3.56106
AREG amphiregulin 3.56106
GHRH growth hormone releasing hormone 3.56106
NEUROD4 neuronal differentiation 4 3.56106
LRRC38 leucine rich repeat containing 38 3.56106
SPATA31H1 SPATA31 subfamily H member 1 3.56106
PNLIPRP2 pancreatic lipase-related protein 2 3.56106
PNLIPRP1 pancreatic lipase-related protein 1 3.56106
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 3.56106
RHCG Rh family, C glycoprotein 3.56106
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.56106
IGSF22 immunoglobulin superfamily, member 22 3.56106
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.56106
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.56106
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 3.56106
LRRC72 leucine rich repeat containing 72 3.56106
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.56106
TAS1R1 taste receptor, type 1, member 1 3.56106
ALX4 ALX homeobox 4 3.56106
ZNF726 zinc finger protein 726 3.56106
GBP4 guanylate binding protein 4 3.56106
MAP3K4-AS1 MAP3K4 antisense RNA 1 3.56106
CIMAP1B ciliary microtubule associated protein 1B 3.56106
C17ORF113 chromosome 17 open reading frame 113 3.56106
LOC124903372 uncharacterized LOC124903372 3.56106
MDFIC2 MyoD family inhibitor domain containing 2 3.56106
H4C12 H4 clustered histone 12 3.56106
GLYATL1B glycine-N-acyltransferase like 1B 3.56106
ARMH2 armadillo like helical domain containing 2 3.56106
ODAPH odontogenesis associated phosphoprotein 3.56106
DEPP1 DEPP autophagy regulator 1 3.56106
STING1 stimulator of interferon response cGAMP interactor 1 3.56106
NECTIN4 nectin cell adhesion molecule 4 3.56106
OR2D2 olfactory receptor, family 2, subfamily D, member 2 3.56106
GJD2 gap junction protein, delta 2, 36kDa 3.56106
PRR4 proline rich 4 (lacrimal) 3.56106
GJA3 gap junction protein, alpha 3, 46kDa 3.56106
CST11 cystatin 11 3.56106
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.56106
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.56106
MAP3K7CL MAP3K7 C-terminal like 3.56106
VTN vitronectin 3.56106
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.56106
CELF3 CUGBP, Elav-like family member 3 3.56106
SPINK6 serine peptidase inhibitor, Kazal type 6 3.56106
SCGB3A1 secretoglobin, family 3A, member 1 3.56106
DNASE1L2 deoxyribonuclease I-like 2 3.56106
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.56106
GJA5 gap junction protein, alpha 5, 40kDa 3.56106
PLVAP plasmalemma vesicle associated protein 3.56106
BAX BCL2-associated X protein 3.56106
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.56106
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.56106
NHLRC4 NHL repeat containing 4 3.56106
IL6 interleukin 6 3.56106
SCRT2 scratch family zinc finger 2 3.56106
MAG myelin associated glycoprotein 3.56106
ARL5C ADP-ribosylation factor-like 5C 3.56106
PCDHB14 protocadherin beta 14 3.56106
LOC107986837 uncharacterized LOC107986837 3.56106
IZUMO4 IZUMO family member 4 3.56106
PTTG2 pituitary tumor-transforming 2 3.56106
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.56106
CELA3B chymotrypsin-like elastase family, member 3B 3.56106
CTXN3 cortexin 3 3.56106
CAGE1 cancer antigen 1 3.56106
LAMB4 laminin, beta 4 3.56106
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 3.56106
LMX1A LIM homeobox transcription factor 1, alpha 3.56106
ALAS2 5'-aminolevulinate synthase 2 3.56106
ZNF843 zinc finger protein 843 3.56106
SPATA25 spermatogenesis associated 25 3.56106
TEX12 testis expressed 12 3.56106
EVPLL envoplakin-like 3.56106
CALML6 calmodulin-like 6 3.56106
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.56106
IER5L immediate early response 5-like 3.56106
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.56106
FAM25A family with sequence similarity 25, member A 3.56106
EGR2 early growth response 2 3.56106
C17ORF99 chromosome 17 open reading frame 99 3.56106
TYR tyrosinase 3.56106
NYX nyctalopin 3.56106
PLA2G5 phospholipase A2, group V 3.56106
S100A14 S100 calcium binding protein A14 3.56106
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.56106
GRK1 G protein-coupled receptor kinase 1 3.56106
TF transferrin 3.56106
C18ORF63 chromosome 18 open reading frame 63 3.56106
NLRC3 NLR family, CARD domain containing 3 3.56106
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.56106
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.56106
KLHL41 kelch-like family member 41 3.56106
PHLDA3 pleckstrin homology-like domain, family A, member 3 3.56106
CD200R1 CD200 receptor 1 3.56106
CDH10 cadherin 10, type 2 (T2-cadherin) 3.56106
EPHA5 EPH receptor A5 3.56106
TBX1 T-box 1 3.56106
DMRT1 doublesex and mab-3 related transcription factor 1 3.56106
TRIM55 tripartite motif containing 55 3.56106
TTC22 tetratricopeptide repeat domain 22 3.56106
CHRM1 cholinergic receptor, muscarinic 1 3.56106
POTEI POTE ankyrin domain family, member I 3.56106
GOLGA8K golgin A8 family, member K 3.56106
CHAT choline O-acetyltransferase 3.56106
FGF10 fibroblast growth factor 10 3.56106
VTCN1 V-set domain containing T cell activation inhibitor 1 3.56106
CXCR6 chemokine (C-X-C motif) receptor 6 3.56106
PATE2 prostate and testis expressed 2 3.56106
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.56106
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.56106
BTG4 B-cell translocation gene 4 3.56106
LAMP3 lysosomal-associated membrane protein 3 3.56106
NUTM2A NUT family member 2A 3.56106
POTEF POTE ankyrin domain family, member F 3.56106
SST somatostatin 3.56106
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.56106
ADGRF5 adhesion G protein-coupled receptor F5 3.56106
IGFBP3 insulin-like growth factor binding protein 3 3.50846
TRAM1L1 translocation associated membrane protein 1-like 1 3.50846
F8A1 coagulation factor VIII-associated 1 3.44374
ITGA1 integrin, alpha 1 3.41352
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 3.32238
NEK10 NIMA-related kinase 10 3.32238
ATL3 atlastin GTPase 3 3.32238
KERA keratocan 3.30459
FAM133A family with sequence similarity 133, member A 3.27107
GFRA1 GDNF family receptor alpha 1 3.22619
RMI2 RecQ mediated genome instability 2 3.19476
BMPER BMP binding endothelial regulator 3.14223
RPLP1 ribosomal protein, large, P1 3.05267
TPM1 tropomyosin 1 (alpha) 3.02915
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.01321
RPL41 ribosomal protein L41 3.01321
TNC tenascin C 2.97143
ATL1 atlastin GTPase 1 2.95657
PMVK phosphomevalonate kinase 2.95623
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.95206
APELA apelin receptor early endogenous ligand 2.94984
NRBP2 nuclear receptor binding protein 2 2.8952
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.888
DYNC2I2 dynein 2 intermediate chain 2 2.888
PRELID1 PRELI domain containing 1 2.86039
DALRD3 DALR anticodon binding domain containing 3 2.85614
PARP1 poly (ADP-ribose) polymerase 1 2.84844
BKGD beta-keto-L-gulonate decarboxylase 2.83647
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.80226
C11ORF58 chromosome 11 open reading frame 58 2.76765
MTMR14 myotubularin related protein 14 2.74647
PRKCE protein kinase C, epsilon 2.74647
TMEM150C transmembrane protein 150C 2.74287
INPPL1 inositol polyphosphate phosphatase-like 1 2.74084
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 2.72502
XTBD1 XRN2 binding domain containing 1 2.7208
CCDC172 coiled-coil domain containing 172 2.71685
PFN1 profilin 1 2.70901
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.697
NRIP2 nuclear receptor interacting protein 2 2.697
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.697
LOC122526780 uncharacterized LOC122526780 2.697
ECT2L epithelial cell transforming 2 like 2.697
CA4 carbonic anhydrase IV 2.697
SLC35E3 solute carrier family 35, member E3 2.697
VCX variable charge, X-linked 2.697
JPT1 Jupiter microtubule associated homolog 1 2.68408
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 2.65794
ZNF75D zinc finger protein 75D 2.64585
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.64415
ZBTB41 zinc finger and BTB domain containing 41 2.64199
PLXNB2 plexin B2 2.63479
ZNF610 zinc finger protein 610 2.62719
GAL galanin/GMAP prepropeptide 2.60149
MSRB3 methionine sulfoxide reductase B3 2.58656
RND3 Rho family GTPase 3 2.58065
BCLAF1 BCL2-associated transcription factor 1 2.57485
SUCO SUN domain containing ossification factor 2.55404
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 2.55028
CPA2 carboxypeptidase A2 (pancreatic) 2.54172
CNTFR ciliary neurotrophic factor receptor 2.54172
RORA RAR-related orphan receptor A 2.5399
REP15 RAB15 effector protein 2.5399
MICU2 mitochondrial calcium uptake 2 2.53989
EDNRB endothelin receptor type B 2.53572
TOLLIP toll interacting protein 2.53485
ZNF70 zinc finger protein 70 2.52777
FAM81A family with sequence similarity 81, member A 2.52596
MERTK MER proto-oncogene, tyrosine kinase 2.51906
SLC71A1 solute carrier family 71 member 1 2.50408
LETMD1 LETM1 domain containing 1 2.49483
CNOT4 CCR4-NOT transcription complex, subunit 4 2.49297
NOP2 NOP2 nucleolar protein 2.49297
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.49083
NMT2 N-myristoyltransferase 2 2.49083
SACK1H scaffolding CK1 anchoring protein H 2.48346
VCL vinculin 2.48346
DPY19L3 dpy-19-like 3 (C. elegans) 2.47058
RGS7BP regulator of G-protein signaling 7 binding protein 2.47058
RBP1 retinol binding protein 1, cellular 2.45721
SERF2 small EDRK-rich factor 2 2.45569
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.45569
MRFAP1L2 Morf4 family associated protein 1 like 2 2.45192
UXT ubiquitously-expressed, prefoldin-like chaperone 2.45079
TTLL2 tubulin tyrosine ligase-like family member 2 2.44966
PMEL premelanosome protein 2.44966
TMCO1 transmembrane and coiled-coil domains 1 2.44162
DDIT4L DNA-damage-inducible transcript 4-like 2.43542
WDR55 WD repeat domain 55 2.432
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.4291
MTERF4 mitochondrial transcription termination factor 4 2.42695
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.42683
TXNDC16 thioredoxin domain containing 16 2.42683
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.41549
RNASE4 ribonuclease, RNase A family, 4 2.41549
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.4089
DSC3 desmocollin 3 2.40742
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 2.39722
CARD11 caspase recruitment domain family, member 11 2.38351
PLIN2 perilipin 2 2.38351
PLPP6 phospholipid phosphatase 6 2.3793
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.36873
FAM131B family with sequence similarity 131, member B 2.36629
CFAP298 cilia and flagella associated protein 298 2.3596
MRPL22 mitochondrial ribosomal protein L22 2.3596
RPS27L ribosomal protein S27-like 2.35895
NFIB nuclear factor I/B 2.35623
PLAAT5 phospholipase A and acyltransferase 5 2.34056
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 2.3348
VSIG1 V-set and immunoglobulin domain containing 1 2.3348
CPVL carboxypeptidase, vitellogenic-like 2.31785
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 2.31186
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.30476
PAQR3 progestin and adipoQ receptor family member III 2.30476
UNC119 unc-119 homolog (C. elegans) 2.28259
SORBS2 sorbin and SH3 domain containing 2 2.27684
ZFYVE16 zinc finger, FYVE domain containing 16 2.27194
EBPL emopamil binding protein-like 2.27176
CORO1A coronin, actin binding protein, 1A 2.27144
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 2.27144
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.27144
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.27144
RAB5IF RAB5 interacting factor 2.27144
CLMP CXADR-like membrane protein 2.26814
FOXH1 forkhead box H1 2.25311
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.25307
NPM3 nucleophosmin/nucleoplasmin 3 2.25293
OSTM1 osteopetrosis associated transmembrane protein 1 2.25065
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.24677
TRIML2 tripartite motif family-like 2 2.24336
AKNA AT-hook transcription factor 2.24336
CLEC2D C-type lectin domain family 2, member D 2.243
SNX7 sorting nexin 7 2.23494
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.23494
CLHC1 clathrin heavy chain linker domain containing 1 2.23494
TES testin LIM domain protein 2.23149
TMEM255B transmembrane protein 255B 2.22627
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.22619
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 2.22557
MTG1 mitochondrial ribosome-associated GTPase 1 2.21913
SRSF8 serine/arginine-rich splicing factor 8 2.2094
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.20483
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.19687
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.19687
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 2.1919
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.18063
CKLF chemokine-like factor 2.17477
MRI1 methylthioribose-1-phosphate isomerase 1 2.16263
PCGF5 polycomb group ring finger 5 2.15098
ITGB1BP1 integrin beta 1 binding protein 1 2.13821
CNOT11 CCR4-NOT transcription complex, subunit 11 2.12056
BBLN bublin coiled coil protein 2.11775
DSEL dermatan sulfate epimerase-like 2.11701
GEM GTP binding protein overexpressed in skeletal muscle 2.1141
DNM1L dynamin 1-like 2.1141
PURG purine-rich element binding protein G 2.10699
PRDM10 PR domain containing 10 2.10667
TMEM185A transmembrane protein 185A 2.10484
MSH4 mutS homolog 4 2.10484
TMEM160 transmembrane protein 160 2.10484
ZNF440 zinc finger protein 440 2.10238
LZTR1 leucine-zipper-like transcription regulator 1 2.10238
INTS14 integrator complex subunit 14 2.10238
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 2.09768
APLP1 amyloid beta (A4) precursor-like protein 1 2.091
COBLL1 cordon-bleu WH2 repeat protein-like 1 2.08339
GALC galactosylceramidase 2.07873
MARK4 MAP/microtubule affinity-regulating kinase 4 2.07666
RPS23 ribosomal protein S23 2.07208
CLIC1 chloride intracellular channel 1 2.07208
IFITM2 interferon induced transmembrane protein 2 2.07208
MYL9 myosin, light chain 9, regulatory 2.07012
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.06776
NPW neuropeptide W 2.06776
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.06776
PLPPR5 phospholipid phosphatase related 5 2.0611
TCEA1 transcription elongation factor A (SII), 1 2.06105
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) 2.0597
BTG2 BTG family, member 2 2.05668
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 2.05532
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.05532
ZSCAN20 zinc finger and SCAN domain containing 20 2.05532
ARMC9 armadillo repeat containing 9 2.05393
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 2.05393
ZBTB4 zinc finger and BTB domain containing 4 2.04431
ANKRD9 ankyrin repeat domain 9 2.04241
ERLIN2 ER lipid raft associated 2 2.04241
DOCK2 dedicator of cytokinesis 2 2.04216
CCDC59 coiled-coil domain containing 59 2.04183
RAB6B RAB6B, member RAS oncogene family 2.04183
PCOLCE procollagen C-endopeptidase enhancer 2.04183
SPRED1 sprouty-related, EVH1 domain containing 1 2.03596
NR2F6 nuclear receptor subfamily 2, group F, member 6 2.03408
PNP purine nucleoside phosphorylase 2.03408
STMP1 short transmembrane mitochondrial protein 1 2.02301
PAN3 PAN3 poly(A) specific ribonuclease subunit 2.01834
KDSR 3-ketodihydrosphingosine reductase 2.01787
SETDB2 SET domain, bifurcated 2 2.01576
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.00252
INTS1 integrator complex subunit 1 2.00252
MRPS7 mitochondrial ribosomal protein S7 2.00239

decreased expression

Symbol Name Standardized Value
NATD1 N-acetyltransferase domain containing 1 -3.60225
SAXO1 stabilizer of axonemal microtubules 1 -3.60225
SPN sialophorin -3.56106
RASL10A RAS-like, family 10, member A -3.56106
RPL23 ribosomal protein L23 -3.56106
GPAT3 glycerol-3-phosphate acyltransferase 3 -3.56106
CTPS1 CTP synthase 1 -3.56106
SMAD9 SMAD family member 9 -3.56106
RPS14 ribosomal protein S14 -3.51705
BTBD1 BTB (POZ) domain containing 1 -3.47844
PILRA paired immunoglobin-like type 2 receptor alpha -3.43858
PANK1 pantothenate kinase 1 -3.39559
SYN3 synapsin III -3.37709
PTMA prothymosin, alpha -3.35563
GADD45B growth arrest and DNA-damage-inducible, beta -3.32361
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.32238
TBXA2R thromboxane A2 receptor -3.32238
IL11 interleukin 11 -3.32238
SLC22A14 solute carrier family 22, member 14 -3.32238
AMN amnion associated transmembrane protein -3.32238
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -3.32238
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -3.32238
PCDHB10 protocadherin beta 10 -3.32238
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -3.32238
PIWIL3 piwi-like RNA-mediated gene silencing 3 -3.32238
NPPA natriuretic peptide A -3.32238
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.32238
RP1 retinitis pigmentosa 1 (autosomal dominant) -3.32238
SOX4 SRY (sex determining region Y)-box 4 -3.32238
LY6L lymphocyte antigen 6 family member L -3.32238
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -3.32238
TMEM225B transmembrane protein 225B -3.32238
BTBD19 BTB (POZ) domain containing 19 -3.32238
NLRP10 NLR family, pyrin domain containing 10 -3.32238
H4C13 H4 clustered histone 13 -3.32238
CFAP119 cilia and flagella associated protein 119 -3.32238
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.32238
C5ORF58 chromosome 5 open reading frame 58 -3.32238
RAI2 retinoic acid induced 2 -3.32238
SLC46A2 solute carrier family 46, member 2 -3.32238
DCST2 DC-STAMP domain containing 2 -3.32238
FAM229A family with sequence similarity 229, member A -3.32238
LOXL4 lysyl oxidase-like 4 -3.32238
GSG1 germ cell associated 1 -3.32238
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -3.31016
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -3.30926
PKP4 plakophilin 4 -3.29206
ADPRHL1 ADP-ribosylhydrolase like 1 -3.27709
PPIG peptidylprolyl isomerase G (cyclophilin G) -3.14157
C22ORF39 chromosome 22 open reading frame 39 -3.08183
BNC2 basonuclin 2 -3.06379
GRK6 G protein-coupled receptor kinase 6 -3.03307
ALOX12B arachidonate 12-lipoxygenase, 12R type -3.03307
CATSPERQ catsper channel auxiliary subunit theta -3.03307
VDAC1 voltage-dependent anion channel 1 -3.02121
NCAM1 neural cell adhesion molecule 1 -3.0196
NCK2 NCK adaptor protein 2 -3.01328
ANKRD11 ankyrin repeat domain 11 -3.01328
CNOT1 CCR4-NOT transcription complex, subunit 1 -3.01321
UBE2K ubiquitin-conjugating enzyme E2K -2.98325
CD46 CD46 molecule, complement regulatory protein -2.97761
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -2.96388
ATF4 activating transcription factor 4 -2.93358
IFI27L1 interferon, alpha-inducible protein 27-like 1 -2.92226
PADI3 peptidyl arginine deiminase, type III -2.91299
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.90146
KCTD1 potassium channel tetramerization domain containing 1 -2.89761
RPS10 ribosomal protein S10 -2.8952
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.88661
EIF1 eukaryotic translation initiation factor 1 -2.87807
RPL5 ribosomal protein L5 -2.87807
PHGDH phosphoglycerate dehydrogenase -2.87231
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.84953
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.83647
TTK TTK protein kinase -2.79107
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.79107
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.78358
HESX1 HESX homeobox 1 -2.74994
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -2.74647
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.74647
RPL37 ribosomal protein L37 -2.70974
C10ORF88 chromosome 10 open reading frame 88 -2.70599
RPS2 ribosomal protein S2 -2.70571
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.69862
RPL26 ribosomal protein L26 -2.69055
CDH13 cadherin 13 -2.67438
PHF21B PHD finger protein 21B -2.6574
ZMYM2 zinc finger, MYM-type 2 -2.63479
TNS2 tensin 2 -2.63389
WDR5B WD repeat domain 5B -2.63389
RPL6 ribosomal protein L6 -2.63104
RNGTT RNA guanylyltransferase and 5'-phosphatase -2.62719
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -2.62719
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.57312
LRP6 low density lipoprotein receptor-related protein 6 -2.55614
SKIL SKI-like proto-oncogene -2.55213
WWC2 WW and C2 domain containing 2 -2.55168
RPL22L1 ribosomal protein L22-like 1 -2.5504
SPATS2 spermatogenesis associated, serine-rich 2 -2.54342
DAP3 death associated protein 3 -2.53485
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.50408
RBPMS RNA binding protein with multiple splicing -2.50095
KSR2 kinase suppressor of ras 2 -2.49483
SUGCT succinyl-CoA:glutarate-CoA transferase -2.48975
PRRT1 proline-rich transmembrane protein 1 -2.48346
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.48346
CCK cholecystokinin -2.48346
ZNF385D zinc finger protein 385D -2.48346
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -2.47366
ATG4B autophagy related 4B, cysteine peptidase -2.4718
FAM217A family with sequence similarity 217, member A -2.47058
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.47058
SNX18 sorting nexin 18 -2.46996
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.4653
LRRC4 leucine rich repeat containing 4 -2.44966
PLAC1 placenta-specific 1 -2.44673
ZNF496 zinc finger protein 496 -2.44673
RPS24 ribosomal protein S24 -2.43195
ARNT aryl hydrocarbon receptor nuclear translocator -2.42824
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.42824
DPH6 diphthamine biosynthesis 6 -2.42683
CD248 CD248 molecule, endosialin -2.40907
STAC3 SH3 and cysteine rich domain 3 -2.40907
PCBP2 poly(rC) binding protein 2 -2.40791
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.39642
ITGB5 integrin, beta 5 -2.39157
PTBP2 polypyrimidine tract binding protein 2 -2.38725
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -2.3853
RPS4X ribosomal protein S4, X-linked -2.38071
SEC11C SEC11 homolog C (S. cerevisiae) -2.3793
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled -2.3774
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.37586
STAT5B signal transducer and activator of transcription 5B -2.36873
LDHB lactate dehydrogenase B -2.36873
WNK2 WNK lysine deficient protein kinase 2 -2.36568
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.35239
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.34487
RPL3 ribosomal protein L3 -2.34487
ZFP36L2 ZFP36 ring finger protein-like 2 -2.34487
KNL1 kinetochore scaffold 1 -2.33754
EIF4E eukaryotic translation initiation factor 4E -2.31799
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.29945
CDK4 cyclin-dependent kinase 4 -2.297
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -2.29564
EHBP1 EH domain binding protein 1 -2.29564
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.29331
CSNK2A1 casein kinase 2, alpha 1 polypeptide -2.2923
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -2.28926
MCM4 minichromosome maintenance complex component 4 -2.28926
LASP1 LIM and SH3 protein 1 -2.28259
BTD biotinidase -2.28259
ZBTB7B zinc finger and BTB domain containing 7B -2.27689
KPNA1 karyopherin alpha 1 (importin alpha 5) -2.27432
DYDC2 DPY30 domain containing 2 -2.27432
NFIA nuclear factor I/A -2.27176
ELMO3 engulfment and cell motility 3 -2.27144
ACP1 acid phosphatase 1, soluble -2.27144
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.27144
FEZF1 FEZ family zinc finger 1 -2.27144
OPCML opioid binding protein/cell adhesion molecule-like -2.27144
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.27144
KLHL10 kelch-like family member 10 -2.27144
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.26814
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.26371
RPL21 ribosomal protein L21 -2.25849
RAB24 RAB24, member RAS oncogene family -2.25307
PCLAF PCNA clamp associated factor -2.25293
CCDC134 coiled-coil domain containing 134 -2.25209
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.24488
WDR91 WD repeat domain 91 -2.24381
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.24134
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.24134
NSF N-ethylmaleimide-sensitive factor -2.23962
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.23528
FAM43A family with sequence similarity 43, member A -2.23494
MYORG myogenesis regulating glycosidase (putative) -2.23494
ARHGAP9 Rho GTPase activating protein 9 -2.23494
LDHAL6A lactate dehydrogenase A-like 6A -2.23494
TEX11 testis expressed 11 -2.23494
KIAA2012 KIAA2012 -2.23494
TMEM121B transmembrane protein 121B -2.23494
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.23494
CD52 CD52 molecule -2.23494
GSG1L GSG1-like -2.23494
LHX1 LIM homeobox 1 -2.23494
KIF1A kinesin family member 1A -2.23494
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.22656
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.22627
RPUSD4 RNA pseudouridylate synthase domain containing 4 -2.22619
CDR2 cerebellar degeneration-related protein 2, 62kDa -2.22493
NLRP12 NLR family, pyrin domain containing 12 -2.21913
MEGF9 multiple EGF-like-domains 9 -2.21255
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.21251
NF1 neurofibromin 1 -2.20684
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.20293
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.1947
RPL9 ribosomal protein L9 -2.19329
MYSM1 Myb-like, SWIRM and MPN domains 1 -2.1919
NYNRIN NYN domain and retroviral integrase containing -2.17857
TOX3 TOX high mobility group box family member 3 -2.17225
STOML2 stomatin (EPB72)-like 2 -2.1466
RPLP0 ribosomal protein, large, P0 -2.1466
TUG1 taurine up-regulated 1 (non-protein coding) -2.14324
PANK3 pantothenate kinase 3 -2.13895
SCN5A sodium channel, voltage gated, type V alpha subunit -2.13893
RABGAP1L RAB GTPase activating protein 1-like -2.13314
FANCB Fanconi anemia, complementation group B -2.13017
ZFP36L1 ZFP36 ring finger protein-like 1 -2.1276
TOP1 topoisomerase (DNA) I -2.12598
MRPL30 mitochondrial ribosomal protein L30 -2.12598
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.12263
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -2.11958
ZNF571 zinc finger protein 571 -2.11875
JPH1 junctophilin 1 -2.1141
SIRAL1 SIR2 antiphage like 1 -2.1141
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.1124
MSH2 mutS homolog 2 -2.1101
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.10699
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -2.10699
EAPP E2F-associated phosphoprotein -2.10502
TNPO3 transportin 3 -2.10146
MOB1B MOB kinase activator 1B -2.09736
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.09694
ZNF514 zinc finger protein 514 -2.07989
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -2.07944
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.07944
HOMER2 homer scaffolding protein 2 -2.07944
GIGYF1 GRB10 interacting GYF protein 1 -2.07944
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.07944
AUTS2 autism susceptibility candidate 2 -2.07873
PCDHB16 protocadherin beta 16 -2.07873
STIP1 stress-induced phosphoprotein 1 -2.07873
CNPPD1 cyclin Pas1/PHO80 domain containing 1 -2.07783
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.07666
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.07638
RPL24 ribosomal protein L24 -2.07353
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.06776
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.06776
ADRA1A adrenoceptor alpha 1A -2.06529
DYNLT3 dynein, light chain, Tctex-type 3 -2.06133
AKAP8L A kinase (PRKA) anchor protein 8-like -2.06105
LAMB2 laminin, beta 2 (laminin S) -2.05946
SMIM3 small integral membrane protein 3 -2.05668
RAB5B RAB5B, member RAS oncogene family -2.05532
GTF2IRD1 GTF2I repeat domain containing 1 -2.05532
FICD FIC domain containing -2.05393
BTN3A2 butyrophilin, subfamily 3, member A2 -2.05393
ZNF484 zinc finger protein 484 -2.05393
VEGFA vascular endothelial growth factor A -2.04958
C18ORF25 chromosome 18 open reading frame 25 -2.04958
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.04734
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.04734
DGKK diacylglycerol kinase, kappa -2.04611
EDARADD EDAR-associated death domain -2.04183
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -2.04007
NUDCD1 NudC domain containing 1 -2.03762
WRN Werner syndrome, RecQ helicase-like -2.03408
RNASEH1 ribonuclease H1 -2.03408
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.02652
CBX2 chromobox homolog 2 -2.01764
CNOT3 CCR4-NOT transcription complex, subunit 3 -2.01658
VCAN versican -2.01347
CKAP5 cytoskeleton associated protein 5 -2.01072
ZNF638 zinc finger protein 638 -2.00645
RPL7A ribosomal protein L7a -2.00388
ZNF10 zinc finger protein 10 -2.00252