TOP1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description topoisomerase (DNA) I|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7150)
External Link http://www.ncbi.nlm.nih.gov/gene/7150
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Genes

107 interacting proteins for hub protein TOP1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACO1 aconitase 1, soluble
ALK anaplastic lymphoma receptor tyrosine kinase
ALYREF Aly/REF export factor
APLF aprataxin and PNKP like factor
AQP9 aquaporin 9
BTBD1 BTB (POZ) domain containing 1
BTBD2 BTB (POZ) domain containing 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EFTUD2 elongation factor Tu GTP binding domain containing 2
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
EXOSC10 exosome component 10
FBL fibrillarin
FSHR follicle stimulating hormone receptor
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
H1FX H1 histone family, member X
H2AFY H2A histone family, member Y
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H2BI histone cluster 1, H2bi
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
INSL5 insulin-like 5
JUN jun proto-oncogene
MGMT O-6-methylguanine-DNA methyltransferase
MKI67 marker of proliferation Ki-67
MYC v-myc avian myelocytomatosis viral oncogene homolog
NABP1 nucleic acid binding protein 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NAT8B N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
NCL nucleolin
NCOA6 nuclear receptor coactivator 6
NHP2 NHP2 ribonucleoprotein
NONO non-POU domain containing, octamer-binding
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PA2G4 proliferation-associated 2G4, 38kDa
PARP1 poly (ADP-ribose) polymerase 1
PITX2 paired-like homeodomain 2
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF8 pre-mRNA processing factor 8
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBM25 RNA binding motif protein 25
RBM39 RNA binding motif protein 39
RFC1 replication factor C (activator 1) 1, 145kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL21 ribosomal protein L21
RPL7A ribosomal protein L7a
RRP1B ribosomal RNA processing 1B
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFPQ splicing factor proline/glutamine-rich
SMAD2 SMAD family member 2
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF11 serine/arginine-rich splicing factor 11
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TAL1 T-cell acute lymphocytic leukemia 1
TBL3 transducin (beta)-like 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TRIM21 tripartite motif containing 21
TROVE2 TROVE domain family, member 2
TYR tyrosinase
UBE2I ubiquitin-conjugating enzyme E2I
WDR36 WD repeat domain 36
ZPR1 ZPR1 zinc finger