| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | topoisomerase (DNA) I|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7150) |
| External Link | https://ncbi.nlm.nih.gov/gene/7150 |
| Similar Terms | |
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497 genes differentially expressed following the TOP1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.012452 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0113048 |
| CD320 | CD320 molecule | 0.0111792 |
| CA2 | carbonic anhydrase II | 0.00977204 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00968197 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.00943466 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.0087885 |
| CBR3 | carbonyl reductase 3 | 0.00873611 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00854013 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00797048 |
| MSN | moesin | 0.00791216 |
| HBB | hemoglobin, beta | 0.00787839 |
| PRDX2 | peroxiredoxin 2 | 0.00765327 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00761313 |
| SDC2 | syndecan 2 | 0.00741967 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 0.00739474 |
| THBD | thrombomodulin | 0.00735974 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00731689 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.0072269 |
| PLBD1 | phospholipase B domain containing 1 | 0.00719281 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00708101 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | 0.00706551 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.00705153 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00705056 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.0070157 |
| FASN | fatty acid synthase | 0.00695311 |
| CA12 | carbonic anhydrase XII | 0.00692477 |
| TNS1 | tensin 1 | 0.00690225 |
| MAOA | monoamine oxidase A | 0.00690163 |
| RAPSN | receptor-associated protein of the synapse | 0.00686169 |
| POSTN | periostin, osteoblast specific factor | 0.0068405 |
| NFIB | nuclear factor I/B | 0.00681932 |
| FCGBP | Fc fragment of IgG binding protein | 0.00681361 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00679911 |
| AUTS2 | autism susceptibility candidate 2 | 0.00677896 |
| XPO7 | exportin 7 | 0.00675353 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.00673128 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00662313 |
| PIP | prolactin-induced protein | 0.00661668 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00659917 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00647744 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00644678 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.00639326 |
| STOM | stomatin | 0.00633119 |
| ANOS1 | anosmin 1 | 0.00626959 |
| MAGED1 | melanoma antigen family D1 | 0.00615284 |
| MFAP2 | microfibrillar-associated protein 2 | 0.006072 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00602019 |
| FHL1 | four and a half LIM domains 1 | 0.00598395 |
| MDFIC | MyoD family inhibitor domain containing | 0.00592201 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00589205 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00581617 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00579176 |
| HK1 | hexokinase 1 | 0.00575623 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.00573814 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 0.0056508 |
| NMB | neuromedin B | 0.00558462 |
| RAB38 | RAB38, member RAS oncogene family | 0.00558333 |
| PGC | progastricsin (pepsinogen C) | 0.00557947 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0055485 |
| ITGA6 | integrin, alpha 6 | 0.00554334 |
| S100A4 | S100 calcium binding protein A4 | 0.00552506 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00552103 |
| DNM1L | dynamin 1-like | 0.00547349 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00546839 |
| PLK2 | polo-like kinase 2 | 0.00546196 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.00545241 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 0.00540404 |
| ADIRF | adipogenesis regulatory factor | 0.00538101 |
| PLPP3 | phospholipid phosphatase 3 | 0.0053618 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.00535175 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00532705 |
| RDX | radixin | 0.00532642 |
| EDNRB | endothelin receptor type B | 0.00531295 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 0.00530969 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 0.0053074 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00529528 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00526924 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00524943 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00523025 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00522678 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.00522332 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 0.00521866 |
| BCHE | butyrylcholinesterase | 0.00519948 |
| TPBG | trophoblast glycoprotein | 0.00518784 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00507676 |
| RNF144A | ring finger protein 144A | 0.00507363 |
| HOXC10 | homeobox C10 | 0.00507172 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00505686 |
| RRM1 | ribonucleotide reductase M1 | 0.00504489 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00503934 |
| NAV2 | neuron navigator 2 | 0.00502576 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 0.00502145 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00502071 |
| COL9A3 | collagen, type IX, alpha 3 | 0.00499456 |
| PLS3 | plastin 3 | 0.00497562 |
| XIC | X chromosome inactivation center | 0.00497431 |
| SPEN | spen family transcriptional repressor | 0.00496435 |
| NPY1R | neuropeptide Y receptor Y1 | 0.0049412 |
| CHEK1 | checkpoint kinase 1 | 0.00493959 |
| HELLS | helicase, lymphoid-specific | 0.00491385 |
| FSTL1 | follistatin-like 1 | 0.00490727 |
| ANXA10 | annexin A10 | 0.00488929 |
| ASPN | asporin | 0.00486934 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.00486344 |
| ZNF395 | zinc finger protein 395 | 0.0048481 |
| GSPT2 | G1 to S phase transition 2 | 0.00480422 |
| CCDC92 | coiled-coil domain containing 92 | 0.00480314 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00479441 |
| COLEC12 | collectin sub-family member 12 | 0.00478981 |
| EFNB2 | ephrin-B2 | 0.00478336 |
| CDC42 | cell division cycle 42 | 0.00477425 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.00476314 |
| IL27RA | interleukin 27 receptor, alpha | 0.00475916 |
| TENM1 | teneurin transmembrane protein 1 | 0.00474556 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | 0.00474209 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.00473493 |
| CRYAB | crystallin, alpha B | 0.00473275 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.00472038 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00469664 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00469575 |
| ACLY | ATP citrate lyase | 0.00468886 |
| CTSG | cathepsin G | 0.00468477 |
| CEP170 | centrosomal protein 170kDa | 0.0046812 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.0046712 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00466776 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00466743 |
| DCX | doublecortin | 0.00466431 |
| TUBB6 | tubulin, beta 6 class V | 0.00465973 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | 0.00465228 |
| MICALL1 | MICAL-like 1 | 0.00464949 |
| CTSK | cathepsin K | 0.00464192 |
| RAB4A | RAB4A, member RAS oncogene family | 0.00463743 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00463108 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00463048 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.00462347 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.00462198 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.00461097 |
| PRNP | prion protein | 0.0046075 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0045917 |
| BEX1 | brain expressed, X-linked 1 | 0.00459073 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | 0.00455941 |
| DUOX2 | dual oxidase 2 | 0.00455141 |
| GTF2I | general transcription factor IIi | 0.00454664 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00454477 |
| B3GNT1 | 0.00452703 | |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 0.00451474 |
| ZW10 | zw10 kinetochore protein | 0.00450158 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.00449575 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00449183 |
| RCAN1 | regulator of calcineurin 1 | 0.00447608 |
| KIF23 | kinesin family member 23 | 0.00447167 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.00446942 |
| EGFR | epidermal growth factor receptor | 0.00445385 |
| HAT1 | histone acetyltransferase 1 | 0.00445204 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00444965 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.00444132 |
| CAPN6 | calpain 6 | 0.00440888 |
| SCAMP1 | secretory carrier membrane protein 1 | 0.00440214 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.00439279 |
| ADRA2A | adrenoceptor alpha 2A | 0.00438856 |
| KRT14 | keratin 14, type I | 0.00438071 |
| CAV2 | caveolin 2 | 0.00437251 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.00436666 |
| SPAG9 | sperm associated antigen 9 | 0.00436486 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.00436022 |
| LEPR | leptin receptor | 0.00435997 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00435645 |
| MT1E | metallothionein 1E | 0.00435337 |
| GPM6A | glycoprotein M6A | 0.00434358 |
| RPA1 | replication protein A1, 70kDa | 0.00434138 |
| CCNB1 | cyclin B1 | 0.00434109 |
| MATN2 | matrilin 2 | 0.00432902 |
| CNN3 | calponin 3, acidic | 0.00432611 |
| MYO1B | myosin IB | 0.00432483 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00431837 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00430841 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00430628 |
| TFDP1 | transcription factor Dp-1 | 0.0043061 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.00428739 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.0042784 |
| ACADL | acyl-CoA dehydrogenase, long chain | 0.00427011 |
| MAGEA11 | melanoma antigen family A11 | 0.00426741 |
| TG | thyroglobulin | 0.00426698 |
| VIM | vimentin | 0.00425586 |
| FAM189A2 | family with sequence similarity 189, member A2 | 0.00425295 |
| WDR6 | WD repeat domain 6 | 0.00425276 |
| PGD | phosphogluconate dehydrogenase | 0.00425243 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00423782 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0042305 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.00422638 |
| QKI | QKI, KH domain containing, RNA binding | 0.0042247 |
| CDCA4 | cell division cycle associated 4 | 0.00421996 |
| CDC27 | cell division cycle 27 | 0.00421713 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.00421107 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00420696 |
| RGS1 | regulator of G-protein signaling 1 | 0.00420474 |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | 0.00419955 |
| NOTCH2 | notch 2 | 0.00419324 |
| CORO1C | coronin, actin binding protein, 1C | 0.00419186 |
| EXOC7 | exocyst complex component 7 | 0.00419042 |
| CHPT1 | choline phosphotransferase 1 | 0.00417105 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00416334 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00416216 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.00416083 |
| ST7 | suppression of tumorigenicity 7 | 0.0041598 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.00414959 |
| EPHA2 | EPH receptor A2 | 0.00413759 |
| ZNF532 | zinc finger protein 532 | 0.00413505 |
| OLFM4 | olfactomedin 4 | 0.00413483 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | 0.00412363 |
| KCTD14 | potassium channel tetramerization domain containing 14 | 0.00412045 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00411922 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0041156 |
| METTL9 | methyltransferase like 9 | 0.00411192 |
| NRN1 | neuritin 1 | 0.00411048 |
| CD200 | CD200 molecule | 0.00410326 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00410205 |
| TIMELESS | timeless circadian clock | 0.00410138 |
| PNMA8A | PNMA family member 8A | 0.00409951 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0040679 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | 0.00406647 |
| EMP3 | epithelial membrane protein 3 | 0.00406628 |
| FZD1 | frizzled class receptor 1 | 0.00405779 |
| TLR4 | toll-like receptor 4 | 0.00405374 |
| CD96 | CD96 molecule | 0.00405057 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00404503 |
| MCM5 | minichromosome maintenance complex component 5 | 0.00404312 |
| SAE1 | SUMO1 activating enzyme subunit 1 | 0.00402897 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00400772 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | 0.00400682 |
| USP48 | ubiquitin specific peptidase 48 | 0.00399741 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00399633 |
| TSPYL5 | TSPY-like 5 | 0.00399358 |
| TP73-AS1 | TP73 antisense RNA 1 | 0.00398476 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00397554 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.00397398 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00396614 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.00395992 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00395843 |
| THPO | thrombopoietin | 0.00395803 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.00395441 |
| LPXN | leupaxin | 0.00395328 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00393805 |
| KAZN | kazrin, periplakin interacting protein | 0.0039344 |
| GLA | galactosidase, alpha | 0.0039327 |
| MEOX1 | mesenchyme homeobox 1 | 0.00391637 |
| SLITRK5 | SLIT and NTRK-like family, member 5 | 0.00391423 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.00390156 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLK1 | delta-like 1 homolog (Drosophila) | -0.0132646 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0120559 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0120555 |
| ATF3 | activating transcription factor 3 | -0.0113474 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0107205 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0106348 |
| MUC16 | mucin 16, cell surface associated | -0.0104501 |
| ASS1 | argininosuccinate synthase 1 | -0.0104056 |
| GUCY2C | guanylate cyclase 2C | -0.0102471 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00964705 |
| CP | ceruloplasmin (ferroxidase) | -0.00963264 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00938907 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00932501 |
| CNTN1 | contactin 1 | -0.00901397 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00894999 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00869398 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00835881 |
| CLDN10 | claudin 10 | -0.0082552 |
| NRCAM | neuronal cell adhesion molecule | -0.00807137 |
| KRT19 | keratin 19, type I | -0.00794718 |
| YBX3 | Y box binding protein 3 | -0.00788952 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.00771648 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0076782 |
| EPCAM | epithelial cell adhesion molecule | -0.00760364 |
| KRT23 | keratin 23, type I | -0.00753299 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.00748168 |
| ADA | adenosine deaminase | -0.0074413 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00740296 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00739275 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00725573 |
| APOB | apolipoprotein B | -0.00718937 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00713408 |
| C7 | complement component 7 | -0.00710769 |
| PERP | PERP, TP53 apoptosis effector | -0.00703335 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00702815 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00700748 |
| IER5 | immediate early response 5 | -0.00698019 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00692509 |
| ANXA4 | annexin A4 | -0.00687363 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0068633 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0068387 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00681366 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00679598 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00678975 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00675147 |
| APOA2 | apolipoprotein A-II | -0.00673899 |
| RHOB | ras homolog family member B | -0.00668082 |
| IL1R1 | interleukin 1 receptor, type I | -0.00667349 |
| FGG | fibrinogen gamma chain | -0.00665252 |
| MB | myoglobin | -0.00665195 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00663653 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00662591 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -0.00659773 |
| KLHL41 | kelch-like family member 41 | -0.00659125 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00652295 |
| S100A14 | S100 calcium binding protein A14 | -0.00649433 |
| CKM | creatine kinase, muscle | -0.00648761 |
| CFB | complement factor B | -0.00647836 |
| TTR | transthyretin | -0.00642095 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00640885 |
| APOA1 | apolipoprotein A-I | -0.0063782 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00637796 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00635425 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00635271 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.00634152 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00633689 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.0062468 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00619251 |
| C1S | complement component 1, s subcomponent | -0.00618238 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.00611643 |
| AHSG | alpha-2-HS-glycoprotein | -0.00609805 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00607926 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00607899 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.00607213 |
| DSP | desmoplakin | -0.00606782 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00605923 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00605469 |
| SLN | sarcolipin | -0.0060393 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00603104 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00598001 |
| H1-2 | H1.2 linker histone, cluster member | -0.00597753 |
| SIK1 | salt-inducible kinase 1 | -0.00596061 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.0059465 |
| CALB1 | calbindin 1, 28kDa | -0.0059326 |
| VTN | vitronectin | -0.0059233 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.00591001 |
| TOX | thymocyte selection-associated high mobility group box | -0.00590292 |
| S100P | S100 calcium binding protein P | -0.00589047 |
| PODXL | podocalyxin-like | -0.00586152 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00584116 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00582395 |
| DEFB1 | defensin, beta 1 | -0.00580042 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00578286 |
| MEIS1 | Meis homeobox 1 | -0.00576034 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.0057571 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00574153 |
| TNNC1 | troponin C type 1 (slow) | -0.0057332 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00569355 |
| CLEC11A | C-type lectin domain family 11, member A | -0.00568698 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.00568686 |
| ADM | adrenomedullin | -0.00566965 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.00564589 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00564023 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00563554 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00561843 |
| ECM1 | extracellular matrix protein 1 | -0.00559217 |
| MAMLD1 | mastermind-like domain containing 1 | -0.00558943 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00557599 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.00556197 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0055598 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.0055573 |
| MSLN | mesothelin | -0.00552122 |
| CLDN7 | claudin 7 | -0.00551236 |
| AFP | alpha-fetoprotein | -0.00549021 |
| TSC22D3 | TSC22 domain family, member 3 | -0.005482 |
| OPTN | optineurin | -0.005458 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00542878 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00541967 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00541937 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | -0.00541402 |
| SERINC3 | serine incorporator 3 | -0.00538507 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.0053832 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00537841 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00536792 |
| FDXR | ferredoxin reductase | -0.00536176 |
| TTN | titin | -0.00535872 |
| GMPR | guanosine monophosphate reductase | -0.00535868 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00534764 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.00533681 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -0.00533637 |
| C3 | complement component 3 | -0.00532435 |
| MOSPD1 | motile sperm domain containing 1 | -0.00532231 |
| BSG | basigin (Ok blood group) | -0.00531883 |
| HIST2H2BE | histone cluster 2, H2be | -0.00529951 |
| HSPA12A | heat shock 70kDa protein 12A | -0.00525336 |
| CTH | cystathionine gamma-lyase | -0.0052517 |
| DCN | decorin | -0.00523755 |
| JUNB | jun B proto-oncogene | -0.00521 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.00520768 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00518602 |
| FGB | fibrinogen beta chain | -0.00518318 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00516669 |
| UFM1 | ubiquitin-fold modifier 1 | -0.00516079 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00514545 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00514196 |
| PEG3 | paternally expressed 3 | -0.00513091 |
| LCN2 | lipocalin 2 | -0.00512727 |
| PITX3 | paired-like homeodomain 3 | -0.00511144 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00510918 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00510407 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0050725 |
| MYO6 | myosin VI | -0.00506915 |
| TNNC2 | troponin C type 2 (fast) | -0.00506668 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.00506563 |
| SDC4 | syndecan 4 | -0.00506169 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00503953 |
| LAMB1 | laminin, beta 1 | -0.00502527 |
| COQ8A | coenzyme Q8A | -0.00502109 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.0050108 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.00500846 |
| HOPX | HOP homeobox | -0.00500282 |
| AOC1 | amine oxidase, copper containing 1 | -0.00499414 |
| FILIP1L | filamin A interacting protein 1-like | -0.00499125 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.00494942 |
| CAST | calpastatin | -0.00494441 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | -0.00493905 |
| DUSP2 | dual specificity phosphatase 2 | -0.00492383 |
| LETMD1 | LETM1 domain containing 1 | -0.00491227 |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | -0.00489999 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00488257 |
| ANKRD28 | ankyrin repeat domain 28 | -0.00486701 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | -0.00486297 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00485971 |
| PAEP | progestagen-associated endometrial protein | -0.00484311 |
| FOLR1 | folate receptor 1 (adult) | -0.00483688 |
| RAB5IF | RAB5 interacting factor | -0.00483479 |
| MEG3 | maternally expressed 3 (non-protein coding) | -0.00482651 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00481722 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00479551 |
| ATF4 | activating transcription factor 4 | -0.00479477 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00476886 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.00475492 |
| CCNG1 | cyclin G1 | -0.00475096 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.0047502 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00472565 |
| PITX1 | paired-like homeodomain 1 | -0.00471618 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.00471594 |
| ALB | albumin | -0.00471447 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00469813 |
| ALPP | alkaline phosphatase, placental | -0.00469511 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | -0.0046877 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -0.00467867 |
| BUD31 | BUD31 homolog (S. cerevisiae) | -0.00466032 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.00465789 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00463594 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.00462729 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.00461799 |
| IFT20 | intraflagellar transport 20 | -0.00461684 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0046164 |
| NDRG1 | N-myc downstream regulated 1 | -0.00460993 |
| VAMP5 | vesicle-associated membrane protein 5 | -0.00458182 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.0045781 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.00456998 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00456989 |
| RAI14 | retinoic acid induced 14 | -0.00456477 |
| RPIA | ribose 5-phosphate isomerase A | -0.00454711 |
| MAGEA3 | melanoma antigen family A3 | -0.00454134 |
| MAGEB2 | melanoma antigen family B2 | -0.00452633 |
| LGALS9 | lectin, galactoside-binding, soluble, 9 | -0.00452218 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.00451689 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00451618 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.00450794 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | -0.00450574 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00449929 |
| TMEM165 | transmembrane protein 165 | -0.004489 |
| LDHA | lactate dehydrogenase A | -0.00445852 |
| MVP | major vault protein | -0.00445708 |
| STX16 | syntaxin 16 | -0.00441195 |
| CTSV | cathepsin V | -0.00439342 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.00437537 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0043734 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00437327 |
| G0S2 | G0/G1 switch 2 | -0.00436662 |
| S100A8 | S100 calcium binding protein A8 | -0.00435544 |
| TPD52L2 | tumor protein D52-like 2 | -0.00433769 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.00433677 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | -0.0043241 |
| LIAS | lipoic acid synthetase | -0.0043206 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.0043187 |
| IER2 | immediate early response 2 | -0.00431246 |
| RUNX1 | runt-related transcription factor 1 | -0.00430936 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00430719 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00429981 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00429887 |
| TUFT1 | tuftelin 1 | -0.00429396 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.00428986 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00428693 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00428692 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00427613 |
| TRIB3 | tribbles pseudokinase 3 | -0.00427611 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00427499 |
| MMP1 | matrix metallopeptidase 1 | -0.00427257 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00426755 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.0042637 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00425583 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00423497 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00423229 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.00422592 |
