TOV112D Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description TOV-112D is a human epithelial cell line initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer. (Experimental Factor Ontology, EFO_0005263)
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Genes

301 gene knockdowns changing fitness of TOV112D relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
MCTP2 multiple C2 domains, transmembrane 2 2.81657
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.71818
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 2.70204
FGD4 FYVE, RhoGEF and PH domain containing 4 2.64565
RAB28 RAB28, member RAS oncogene family 2.36966
PREB prolactin regulatory element binding 2.31066
DPP3 dipeptidyl-peptidase 3 2.24732
RNF112 ring finger protein 112 2.20381
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.19851
UBL3 ubiquitin-like 3 2.19621
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.18677
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 2.14353
ACTL6A actin-like 6A 2.03955
SMAD2 SMAD family member 2 1.82243
RASL11B RAS-like, family 11, member B 1.76859
HNRNPL heterogeneous nuclear ribonucleoprotein L 1.75316
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.72884
FOXA1 forkhead box A1 1.69539
PAPOLG poly(A) polymerase gamma 1.66088
MKX mohawk homeobox 1.63253
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.59818
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 1.59467
CAMK1G calcium/calmodulin-dependent protein kinase IG 1.58104
REG1B regenerating islet-derived 1 beta 1.55306
TCF19 transcription factor 19 1.553
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.52887
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 1.52385
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 1.51295
ZNF100 zinc finger protein 100 1.50799
PGAP1 post-GPI attachment to proteins 1 1.50131
AADAC arylacetamide deacetylase 1.49346
TOM1 target of myb1 (chicken) 1.48825
CARM1 coactivator-associated arginine methyltransferase 1 1.48278
SLC16A6 solute carrier family 16, member 6 1.47502
CNTF ciliary neurotrophic factor 1.46771
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.45154
KCNT2 potassium channel, sodium activated subfamily T, member 2 1.45102
TULP3 tubby like protein 3 1.44816
TMPRSS5 transmembrane protease, serine 5 1.44768
NES nestin 1.44708
CIB3 calcium and integrin binding family member 3 1.44485
KIFC1 kinesin family member C1 1.43983
UBE2E3 ubiquitin-conjugating enzyme E2E 3 1.43778
ZCCHC3 zinc finger, CCHC domain containing 3 1.419
WDR83 WD repeat domain 83 1.41665
ERH enhancer of rudimentary homolog (Drosophila) 1.41616
ALX3 ALX homeobox 3 1.41031
SAP30L SAP30-like 1.39013
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.37808
TSHZ1 teashirt zinc finger homeobox 1 1.37686
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 1.36897
POLN polymerase (DNA directed) nu 1.36582
ZNF322 zinc finger protein 322 1.35196
ZNF449 zinc finger protein 449 1.34857
TPR translocated promoter region, nuclear basket protein 1.34708
GREB1 growth regulation by estrogen in breast cancer 1 1.34372
HIST1H2BM histone cluster 1, H2bm 1.33612
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.32704
PRDX6 peroxiredoxin 6 1.32286
KITLG KIT ligand 1.3109
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 1.30598
LPAR3 lysophosphatidic acid receptor 3 1.30129
STX19 syntaxin 19 1.30062
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 1.29269
CXCR3 chemokine (C-X-C motif) receptor 3 1.29025
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.28456
MAP3K14 mitogen-activated protein kinase kinase kinase 14 1.28416
SUOX sulfite oxidase 1.28249
HCAR1 hydroxycarboxylic acid receptor 1 1.27734
DOCK2 dedicator of cytokinesis 2 1.27402
BMP5 bone morphogenetic protein 5 1.27176
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 1.27073
IGSF8 immunoglobulin superfamily, member 8 1.26997
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 1.26955
CDC5L cell division cycle 5-like 1.26468
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 1.25075
CDC34 cell division cycle 34 1.25055
CALML5 calmodulin-like 5 1.23479
LMBR1 limb development membrane protein 1 1.23153
PFAS phosphoribosylformylglycinamidine synthase 1.22424
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 1.21819
FGF8 fibroblast growth factor 8 (androgen-induced) 1.21804
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.20081
ANK2 ankyrin 2, neuronal 1.20006
UBE2D3 ubiquitin-conjugating enzyme E2D 3 1.19826
TFRC transferrin receptor 1.19261
ZNF250 zinc finger protein 250 1.18584
ANAPC5 anaphase promoting complex subunit 5 1.17974
RECQL4 RecQ protein-like 4 1.17537
CELF2 CUGBP, Elav-like family member 2 1.17258
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 1.17037
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 1.17015
LEPROT leptin receptor overlapping transcript 1.16899
RGS9 regulator of G-protein signaling 9 1.16727
PPT2-EGFL8 PPT2-EGFL8 readthrough (NMD candidate) 1.16714
PZP pregnancy-zone protein 1.15608
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 1.15404
ABHD2 abhydrolase domain containing 2 1.15361
ZNF25 zinc finger protein 25 1.15314
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1.15206
CDH7 cadherin 7, type 2 1.15063
BPGM 2,3-bisphosphoglycerate mutase 1.13411
PAQR8 progestin and adipoQ receptor family member VIII 1.13379
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1.13181
DLX1 distal-less homeobox 1 1.1301
TLR5 toll-like receptor 5 1.12685
INSR insulin receptor 1.12549
CHDH choline dehydrogenase 1.12383
UROD uroporphyrinogen decarboxylase 1.12095
RAB11FIP4 RAB11 family interacting protein 4 (class II) 1.12034
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 1.11793
C10ORF10 chromosome 10 open reading frame 10 1.11446
SLC16A4 solute carrier family 16, member 4 1.10573
TNPO1 transportin 1 1.10505
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 1.10488
CD151 CD151 molecule (Raph blood group) 1.10366
RBM8A RNA binding motif protein 8A 1.10349
FBXO5 F-box protein 5 1.1032
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 1.10248
SCN1B sodium channel, voltage gated, type I beta subunit 1.10058
ZNF107 zinc finger protein 107 1.09951
TSN translin 1.09906
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 1.09762
ZFP91-CNTF ZFP91-CNTF readthrough (NMD candidate) 1.09599
CDX4 caudal type homeobox 4 1.09568
GDF11 growth differentiation factor 11 1.0891
IFNA6 interferon, alpha 6 1.08803
DPP9 dipeptidyl-peptidase 9 1.08553
ULK2 unc-51 like autophagy activating kinase 2 1.08478
ZNF195 zinc finger protein 195 1.08159
POLL polymerase (DNA directed), lambda 1.07805
ING2 inhibitor of growth family, member 2 1.07764
RHPN2 rhophilin, Rho GTPase binding protein 2 1.0767
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.07463
ZNF254 zinc finger protein 254 1.07169
ZBTB45 zinc finger and BTB domain containing 45 1.07001
HIST1H3F histone cluster 1, H3f 1.06455
ELF1 E74-like factor 1 (ets domain transcription factor) 1.06213
POU2F2 POU class 2 homeobox 2 1.06165
PLCB2 phospholipase C, beta 2 1.06145
ATF4 activating transcription factor 4 1.05722
KRT19 keratin 19, type I 1.0529
ARF4 ADP-ribosylation factor 4 1.05247
MDFI MyoD family inhibitor 1.05107
MAPK14 mitogen-activated protein kinase 14 1.04874
KLRC3 killer cell lectin-like receptor subfamily C, member 3 1.0482
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.04635
ZNF211 zinc finger protein 211 1.04506
EBAG9 estrogen receptor binding site associated, antigen, 9 1.04384
JMJD6 jumonji domain containing 6 1.03873
CCNK cyclin K 1.03465
TRAIP TRAF interacting protein 1.0327
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.02869
NUCB1 nucleobindin 1 1.0263
ISX intestine-specific homeobox 1.02353
IGFBP6 insulin-like growth factor binding protein 6 1.01941
UBC ubiquitin C 1.01754
WNK3 WNK lysine deficient protein kinase 3 1.01625
RBM19 RNA binding motif protein 19 1.01368
GNA14 guanine nucleotide binding protein (G protein), alpha 14 1.01203
GSK3B glycogen synthase kinase 3 beta 1.01192
ADAM17 ADAM metallopeptidase domain 17 1.00901
ZNF566 zinc finger protein 566 1.00345
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 1.0024
ADNP activity-dependent neuroprotector homeobox 1.00168

decreased fitness

Symbol Name Standardized Value
CYB5A cytochrome b5 type A (microsomal) -2.9957
AANAT aralkylamine N-acetyltransferase -2.6877
CLEC7A C-type lectin domain family 7, member A -2.03681
BAZ1B bromodomain adjacent to zinc finger domain, 1B -1.90573
ADCK3 aarF domain containing kinase 3 -1.87933
VPS13B vacuolar protein sorting 13 homolog B (yeast) -1.82683
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -1.8098
B3GAT3 beta-1,3-glucuronyltransferase 3 -1.7928
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.76271
NOTCH1 notch 1 -1.73067
PARK2 parkin RBR E3 ubiquitin protein ligase -1.72913
LYZL1 lysozyme-like 1 -1.72127
C8A complement component 8, alpha polypeptide -1.61835
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -1.5962
GTSE1 G-2 and S-phase expressed 1 -1.58358
KISS1 KiSS-1 metastasis-suppressor -1.57704
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 -1.52991
BCAS2 breast carcinoma amplified sequence 2 -1.5123
BPTF bromodomain PHD finger transcription factor -1.50963
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -1.50454
GYS2 glycogen synthase 2 (liver) -1.50121
ZIC5 Zic family member 5 -1.49197
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -1.48996
ATCAY ataxia, cerebellar, Cayman type -1.48496
CECR1 cat eye syndrome chromosome region, candidate 1 -1.48465
ZBTB33 zinc finger and BTB domain containing 33 -1.4676
PRKCE protein kinase C, epsilon -1.46613
LUC7L LUC7-like (S. cerevisiae) -1.4574
IL6R interleukin 6 receptor -1.44184
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.43107
GUCA1A guanylate cyclase activator 1A (retina) -1.41039
MYNN myoneurin -1.38646
NTAN1 N-terminal asparagine amidase -1.38414
RUNDC3A RUN domain containing 3A -1.36473
WNT1 wingless-type MMTV integration site family, member 1 -1.35774
HAL histidine ammonia-lyase -1.34353
ULBP1 UL16 binding protein 1 -1.34302
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -1.34025
ODC1 ornithine decarboxylase 1 -1.32459
LHX5 LIM homeobox 5 -1.32205
CRYBB1 crystallin, beta B1 -1.32103
TATDN2 TatD DNase domain containing 2 -1.31814
IMPACT impact RWD domain protein -1.31085
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 -1.30955
AWAT2 acyl-CoA wax alcohol acyltransferase 2 -1.30914
TMPO thymopoietin -1.29347
NEIL2 nei endonuclease VIII-like 2 (E. coli) -1.28811
SLC17A4 solute carrier family 17, member 4 -1.28709
ZNF721 zinc finger protein 721 -1.28168
TRIP11 thyroid hormone receptor interactor 11 -1.28084
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -1.27865
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -1.2774
INTS6 integrator complex subunit 6 -1.27637
UVRAG UV radiation resistance associated -1.27584
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -1.27209
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.26951
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -1.26871
GTF2A2 general transcription factor IIA, 2, 12kDa -1.2637
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 -1.25852
NIN ninein (GSK3B interacting protein) -1.2564
CXORF23 chromosome X open reading frame 23 -1.25028
IFNGR1 interferon gamma receptor 1 -1.23075
KRT23 keratin 23, type I -1.23058
CEPT1 choline/ethanolamine phosphotransferase 1 -1.21926
TBX4 T-box 4 -1.21646
GPR183 G protein-coupled receptor 183 -1.21562
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -1.21133
FOXD2 forkhead box D2 -1.20593
FGF12 fibroblast growth factor 12 -1.19631
HIPK4 homeodomain interacting protein kinase 4 -1.19469
PCDHGA10 protocadherin gamma subfamily A, 10 -1.18588
RNF24 ring finger protein 24 -1.18142
GPBAR1 G protein-coupled bile acid receptor 1 -1.17807
ARHGAP29 Rho GTPase activating protein 29 -1.17779
AMDHD2 amidohydrolase domain containing 2 -1.17714
KIF5A kinesin family member 5A -1.17448
ZNF500 zinc finger protein 500 -1.17137
STYX serine/threonine/tyrosine interacting protein -1.17067
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -1.1697
HCAR2 hydroxycarboxylic acid receptor 2 -1.16708
HIATL1 hippocampus abundant transcript-like 1 -1.16139
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -1.16119
R3HDM2 R3H domain containing 2 -1.15796
UBXN6 UBX domain protein 6 -1.15632
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -1.15272
EDAR ectodysplasin A receptor -1.15203
MYO3A myosin IIIA -1.15091
UCN urocortin -1.14843
ZRANB2 zinc finger, RAN-binding domain containing 2 -1.14709
AMELX amelogenin, X-linked -1.14624
PDCD1 programmed cell death 1 -1.14043
PRKD3 protein kinase D3 -1.13819
MORF4L1 mortality factor 4 like 1 -1.13535
MMP26 matrix metallopeptidase 26 -1.13408
ZWILCH zwilch kinetochore protein -1.12644
DNASE1L2 deoxyribonuclease I-like 2 -1.12114
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -1.11703
FIP1L1 factor interacting with PAPOLA and CPSF1 -1.11194
NAPSA napsin A aspartic peptidase -1.11087
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -1.11053
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -1.10387
EP300 E1A binding protein p300 -1.10287
OR2J2 olfactory receptor, family 2, subfamily J, member 2 -1.10262
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -1.10098
DOPEY1 dopey family member 1 -1.09631
MSH2 mutS homolog 2 -1.09269
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -1.0882
NPHP4 nephronophthisis 4 -1.08393
HOMEZ homeobox and leucine zipper encoding -1.08298
RGS4 regulator of G-protein signaling 4 -1.08158
SLC17A2 solute carrier family 17, member 2 -1.07315
ERP44 endoplasmic reticulum protein 44 -1.06993
SEC24B SEC24 family member B -1.06496
HYOU1 hypoxia up-regulated 1 -1.06463
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 -1.06021
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -1.05121
KRT28 keratin 28, type I -1.04955
PPID peptidylprolyl isomerase D -1.04682
INHBB inhibin, beta B -1.04222
DGKH diacylglycerol kinase, eta -1.04115
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -1.03575
L3MBTL2 l(3)mbt-like 2 (Drosophila) -1.0356
ZNF248 zinc finger protein 248 -1.03231
CABLES1 Cdk5 and Abl enzyme substrate 1 -1.0319
RARB retinoic acid receptor, beta -1.02861
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -1.02722
CSNK1G3 casein kinase 1, gamma 3 -1.0262
NRL neural retina leucine zipper -1.02387
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.02241
FBXL19 F-box and leucine-rich repeat protein 19 -1.02173
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -1.02037
SERHL2 serine hydrolase-like 2 -1.01682
GPR155 G protein-coupled receptor 155 -1.01622
ARHGAP15 Rho GTPase activating protein 15 -1.01244
LPPR3 lipid phosphate phosphatase-related protein type 3 -1.00733
REXO2 RNA exonuclease 2 -1.00003