TP53 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tumor protein p53|This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013] (NCBI Entrez Gene Database, 7157)
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Genes

331 genes differentially expressed following the TP53 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ART1 ADP-ribosyltransferase 1 2.38655
SYNGR4 synaptogyrin 4 2.38655
PCDHA2 protocadherin alpha 2 2.38655
DES desmin 2.38655
LCNL1 lipocalin-like 1 2.38655
PTPRC protein tyrosine phosphatase, receptor type, C 2.38655
TRIM15 tripartite motif containing 15 2.38655
TMEM176B transmembrane protein 176B 2.38655
C9 complement component 9 2.38655
SIX2 SIX homeobox 2 2.38655
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.38655
TDRD9 tudor domain containing 9 2.38655
SOST sclerostin 2.38655
TPPP tubulin polymerization promoting protein 2.38655
TCF21 transcription factor 21 2.38655
ACKR3 atypical chemokine receptor 3 2.38655
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.38655
TSPAN19 tetraspanin 19 2.38655
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.38655
AKAP6 A kinase (PRKA) anchor protein 6 2.37498
FFAR2 free fatty acid receptor 2 2.37498
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.37498
UPK3A uroplakin 3A 2.37498
LIPC lipase, hepatic 2.37498
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.37498
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.37498
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.37498
PCDHA3 protocadherin alpha 3 2.37498
GJD2 gap junction protein, delta 2, 36kDa 2.37498
CCDC17 coiled-coil domain containing 17 2.37498
C4ORF17 chromosome 4 open reading frame 17 2.37498
ACOT1 acyl-CoA thioesterase 1 2.37498
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.37498
P3H1 prolyl 3-hydroxylase 1 2.37498
TKTL2 transketolase-like 2 2.37498
ADAM33 ADAM metallopeptidase domain 33 2.37498
RSPO1 R-spondin 1 2.37498
BIRC7 baculoviral IAP repeat containing 7 2.37498
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.37498
TMEM217 transmembrane protein 217 2.37498
RLN3 relaxin 3 2.37498
HBB hemoglobin, beta 2.37498
MMP20 matrix metallopeptidase 20 2.37498
WT1 Wilms tumor 1 2.37498
ZNF560 zinc finger protein 560 2.37498
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.37498
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.37498
USP26 ubiquitin specific peptidase 26 2.37498
TNRC6C trinucleotide repeat containing 6C 2.37498
CTRC chymotrypsin C (caldecrin) 2.37498
TM4SF1 transmembrane 4 L six family member 1 2.37498
HES7 hes family bHLH transcription factor 7 2.37498
HES5 hes family bHLH transcription factor 5 2.37498
APLN apelin 2.37498
ATOH1 atonal homolog 1 (Drosophila) 2.37498
TMEM236 transmembrane protein 236 2.37498
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.37498
SMIM38 small integral membrane protein 38 2.37498
CCN3 cellular communication network factor 3 2.37498
ESS2 ess-2 splicing factor homolog 2.37498
H2BC1 H2B clustered histone 1 2.37498
GPX5 glutathione peroxidase 5 2.37498
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.37498
OTOR otoraplin 2.37498
PKD2L1 polycystic kidney disease 2-like 1 2.37498
C20ORF202 chromosome 20 open reading frame 202 2.37498
BRD3OS BRD3 opposite strand 2.37498
JAML junction adhesion molecule like 2.37498
SPATA46 spermatogenesis associated 46 2.37498
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.37498
ERLN endoregulin 2.37498
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.37498
WASH8P WAS protein family homolog 8, pseudogene 2.37498
LINC02268 long intergenic non-protein coding RNA 2268 2.37498
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 2.37498
H3-7 H3.7 histone (putative) 2.37498
H3C3 H3 clustered histone 3 2.37498
H2BW1 H2B.W histone 1 2.37498
TBC1D3B TBC1 domain family, member 3B 2.37498
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.37498
PRR11 proline rich 11 2.37498
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.37498
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.37498
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.37498
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.37498
MYH13 myosin, heavy chain 13, skeletal muscle 2.37498
TLR7 toll-like receptor 7 2.37498
IL5 interleukin 5 2.37498
IL4 interleukin 4 2.37498
INSRR insulin receptor-related receptor 2.37498
TCF23 transcription factor 23 2.37498
TACR2 tachykinin receptor 2 2.37498
FOXC1 forkhead box C1 2.37498
GATA2 GATA binding protein 2 2.37498
ZNF687 zinc finger protein 687 2.37498
ASIC3 acid sensing (proton gated) ion channel 3 2.37498
WNT9B wingless-type MMTV integration site family, member 9B 2.37498
GPR83 G protein-coupled receptor 83 2.37498
FGFBP2 fibroblast growth factor binding protein 2 2.37498
SPAG4 sperm associated antigen 4 2.37498
RGS21 regulator of G-protein signaling 21 2.37498
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.37498
MYO1G myosin IG 2.37498
CD80 CD80 molecule 2.37498
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.37498
SPZ1 spermatogenic leucine zipper 1 2.37498
CCDC158 coiled-coil domain containing 158 2.37498
MYF6 myogenic factor 6 (herculin) 2.37498
CLIC3 chloride intracellular channel 3 2.37498
TNR tenascin R 2.37498
BTNL3 butyrophilin-like 3 2.37498
KNCN kinocilin 2.37498
CTAGE4 CTAGE family, member 4 2.37498
PLA2G4E phospholipase A2, group IVE 2.37498
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.37498
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 2.37498
PXT1 peroxisomal, testis specific 1 2.37498
USP17L7 ubiquitin specific peptidase 17-like family member 7 2.37498
AMER3 APC membrane recruitment protein 3 2.37498
FAM25G family with sequence similarity 25, member G 2.37498
ACKR2 atypical chemokine receptor 2 2.37498
TBC1D26 TBC1 domain family, member 26 2.37498
IHH indian hedgehog 2.37498
ZNF479 zinc finger protein 479 2.37498
CPSF4L cleavage and polyadenylation specific factor 4-like 2.37498
ANKRD63 ankyrin repeat domain 63 2.37498
IDI2 isopentenyl-diphosphate delta isomerase 2 2.37498
TRIM7 tripartite motif containing 7 2.37498
CPN2 carboxypeptidase N, polypeptide 2 2.37498
ADAM18 ADAM metallopeptidase domain 18 2.37498
CCDC70 coiled-coil domain containing 70 2.37498
TEX26 testis expressed 26 2.37498
SLC17A2 solute carrier family 17, member 2 2.37498
MB myoglobin 2.37498
GOLGA8O golgin A8 family, member O 2.37498
PGR progesterone receptor 2.37498
IGF2 insulin-like growth factor 2 2.37498
SCML4 sex comb on midleg-like 4 (Drosophila) 2.37498
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.37498
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.37498
C16ORF78 chromosome 16 open reading frame 78 2.37498
CPA5 carboxypeptidase A5 2.37498
APOC4 apolipoprotein C-IV 2.37498
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.37498
PCDHGA4 protocadherin gamma subfamily A, 4 2.37498
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.37498
CFI complement factor I 2.37498
PTCRA pre T-cell antigen receptor alpha 2.37498
MRGPRX3 MAS-related GPR, member X3 2.37498
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.37498
MMEL1 membrane metallo-endopeptidase-like 1 2.37498
MMP13 matrix metallopeptidase 13 2.37498
NKPD1 NTPase, KAP family P-loop domain containing 1 2.37498
OXER1 oxoeicosanoid (OXE) receptor 1 2.37498
AREG amphiregulin 2.37498
MNX1 motor neuron and pancreas homeobox 1 2.37498
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.37498
CLEC2A C-type lectin domain family 2, member A 2.37498
CD226 CD226 molecule 2.37498
TMEM52B transmembrane protein 52B 2.37498
TEX35 testis expressed 35 2.37498
SP9 Sp9 transcription factor 2.37498
RXRG retinoid X receptor, gamma 2.37498
DUOXA1 dual oxidase maturation factor 1 2.37498
TDO2 tryptophan 2,3-dioxygenase 2.37498
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 2.37498
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.37498
STOML3 stomatin (EPB72)-like 3 2.37498
CLCNKA chloride channel, voltage-sensitive Ka 2.37498
TSSK1B testis-specific serine kinase 1B 2.37498
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.37498
C14ORF180 chromosome 14 open reading frame 180 2.37498
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.35145
THOP1 thimet oligopeptidase 1 2.31273
SVIL supervillin 2.3122
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.29942
SELENOO selenoprotein O 2.29942
REP15 RAB15 effector protein 2.29437
GDI1 GDP dissociation inhibitor 1 2.27944
WIF1 WNT inhibitory factor 1 2.27017
YPEL3 yippee-like 3 (Drosophila) 2.25532
SIK1 salt-inducible kinase 1 2.19433
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.19433
GPC6 glypican 6 2.18789
CRTC2 CREB regulated transcription coactivator 2 2.18789
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.18738
EPS8 epidermal growth factor receptor pathway substrate 8 2.18738
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.18705
ZNF274 zinc finger protein 274 2.18705
ATP5F1B ATP synthase F1 subunit beta 2.173
ZNF669 zinc finger protein 669 2.15493
DAP3 death associated protein 3 2.15493
IL17RC interleukin 17 receptor C 2.1373
LCMT1 leucine carboxyl methyltransferase 1 2.1373
LIN7C lin-7 homolog C (C. elegans) 2.13617
OSBPL3 oxysterol binding protein-like 3 2.13351
RARA retinoic acid receptor, alpha 2.13261
TADA2B transcriptional adaptor 2B 2.13261
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 2.11424
ZFYVE28 zinc finger, FYVE domain containing 28 2.10776
LIFR leukemia inhibitory factor receptor alpha 2.10493
CNOT4 CCR4-NOT transcription complex, subunit 4 2.08888
DCPH1 damage control phosphatase 1 2.07391
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.07391
EPHB6 EPH receptor B6 2.05515
HP1BP3 heterochromatin protein 1, binding protein 3 2.04886
TBC1D14 TBC1 domain family, member 14 2.04886
CCL28 chemokine (C-C motif) ligand 28 2.04654
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.04601
DPP10 dipeptidyl-peptidase 10 (non-functional) 2.03838
MRPS18C mitochondrial ribosomal protein S18C 2.02671
SSH2 slingshot protein phosphatase 2 2.02671
BMPR1A bone morphogenetic protein receptor, type IA 2.01525
STAG2 stromal antigen 2 2.00664
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.00434
CHML choroideremia-like (Rab escort protein 2) 2.00119
PTPRN protein tyrosine phosphatase, receptor type, N 2.00119

decreased expression

Symbol Name Standardized Value
KISS1 KiSS-1 metastasis-suppressor -2.38655
KIF11 kinesin family member 11 -2.38655
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.38655
MUC19 mucin 19, oligomeric -2.38655
PCDHA1 protocadherin alpha 1 -2.38655
BTC betacellulin -2.38655
CCDC154 coiled-coil domain containing 154 -2.38655
CTSO cathepsin O -2.38655
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.37498
MYOM2 myomesin 2 -2.37498
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.37498
SLC46A3 solute carrier family 46, member 3 -2.37498
C1ORF162 chromosome 1 open reading frame 162 -2.37498
TMEM132C transmembrane protein 132C -2.37498
ARL17B ADP-ribosylation factor-like 17B -2.37498
THSD1 thrombospondin, type I, domain containing 1 -2.37498
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.37498
VCX variable charge, X-linked -2.37498
MRC1 mannose receptor, C type 1 -2.37498
TRIM46 tripartite motif containing 46 -2.37498
MEIKIN meiotic kinetochore factor -2.37498
DLX4 distal-less homeobox 4 -2.37498
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 -2.37498
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.37498
SCN2B sodium channel, voltage gated, type II beta subunit -2.37498
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.37498
FGF22 fibroblast growth factor 22 -2.37498
CBLIF cobalamin binding intrinsic factor -2.37498
DOP1B DOP1 leucine zipper like protein B -2.37498
ATP5MJ ATP synthase membrane subunit j -2.37498
PANK1 pantothenate kinase 1 -2.37498
CAPN9 calpain 9 -2.37498
PHF14 PHD finger protein 14 -2.37498
PLN phospholamban -2.37498
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -2.37498
KL klotho -2.37498
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.37498
VCX3B variable charge, X-linked 3B -2.37498
GZMM granzyme M (lymphocyte met-ase 1) -2.37498
CXCL14 chemokine (C-X-C motif) ligand 14 -2.37498
LTBP1 latent transforming growth factor beta binding protein 1 -2.37498
UBAP2 ubiquitin associated protein 2 -2.37498
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.37498
TCP11L2 t-complex 11, testis-specific-like 2 -2.37498
FAM240A family with sequence similarity 240 member A -2.37498
NTN5 netrin 5 -2.37498
ECM1 extracellular matrix protein 1 -2.37498
GCOM1 GRINL1A complex locus 1 -2.37498
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.37498
GAL3ST2 galactose-3-O-sulfotransferase 2 -2.37498
TM4SF19 transmembrane 4 L six family member 19 -2.37498
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.37498
PLET1 placenta expressed transcript 1 -2.37498
AKNAD1 AKNA domain containing 1 -2.37498
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -2.37498
CD244 CD244 molecule, natural killer cell receptor 2B4 -2.37498
KLK14 kallikrein-related peptidase 14 -2.37498
PHOX2A paired-like homeobox 2a -2.37498
SST somatostatin -2.37498
SCN3A sodium channel, voltage gated, type III alpha subunit -2.37498
DAND5 DAN domain family member 5, BMP antagonist -2.37498
NICN1 nicolin 1 -2.37498
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 -2.37498
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -2.37498
LMBR1L limb development membrane protein 1-like -2.37498
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.37498
GRIP1 glutamate receptor interacting protein 1 -2.37498
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 -2.37498
NUP43 nucleoporin 43kDa -2.37498
VSTM2B V-set and transmembrane domain containing 2B -2.35318
GSTM2 glutathione S-transferase mu 2 (muscle) -2.35318
TAOK3 TAO kinase 3 -2.33334
DDB2 damage-specific DNA binding protein 2, 48kDa -2.3122
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.27944
RPS21 ribosomal protein S21 -2.27098
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.27016
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.2496
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.24474
ARL5B ADP-ribosylation factor-like 5B -2.21996
ATL3 atlastin GTPase 3 -2.19433
RAB6B RAB6B, member RAS oncogene family -2.19433
SDHAF2 succinate dehydrogenase complex assembly factor 2 -2.19433
DRAM1 DNA-damage regulated autophagy modulator 1 -2.18738
MANSC4 MANSC domain containing 4 -2.18738
MUC16 mucin 16, cell surface associated -2.18705
NAPRT nicotinate phosphoribosyltransferase -2.17288
CCDC146 coiled-coil domain containing 146 -2.16941
BFAR bifunctional apoptosis regulator -2.15195
FAAH fatty acid amide hydrolase -2.13617
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -2.13351
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.13351
ARL8A ADP-ribosylation factor-like 8A -2.13351
ZNF587 zinc finger protein 587 -2.12352
SERBP1 SERPINE1 mRNA binding protein 1 -2.12057
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa -2.11842
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.11842
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.11698
SEC14L1 SEC14-like 1 (S. cerevisiae) -2.10473
RPS19 ribosomal protein S19 -2.10473
DAB2IP DAB2 interacting protein -2.09964
EML5 echinoderm microtubule associated protein like 5 -2.08888
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.08449
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.08449
WDR90 WD repeat domain 90 -2.06924
DENND6A DENN/MADD domain containing 6A -2.06637
LPIN2 lipin 2 -2.06464
MSH5 mutS homolog 5 -2.05966
RANBP3 RAN binding protein 3 -2.04909
FRMPD1 FERM and PDZ domain containing 1 -2.04886
BAX BCL2-associated X protein -2.03437
ELF2 E74-like factor 2 (ets domain transcription factor) -2.01108
HPS1 Hermansky-Pudlak syndrome 1 -2.00591
TRIM9 tripartite motif containing 9 -2.00434
RYK receptor-like tyrosine kinase -2.00321