TP63 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description tumor protein p63|This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8626)
External Link http://www.ncbi.nlm.nih.gov/gene/8626
Similar Terms
Downloads & Tools

Genes

163 interacting proteins for TP63 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGBL2 ATP/GTP binding protein-like 2
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG14 autophagy related 14
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATR ATR serine/threonine kinase
BAG6 BCL2-associated athanogene 6
BECN1 beclin 1, autophagy related
BRCA1 breast cancer 1, early onset
BRD8 bromodomain containing 8
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CABLES1 Cdk5 and Abl enzyme substrate 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CARM1 coactivator-associated arginine methyltransferase 1
CCNC cyclin C
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
COPS6 COP9 signalosome subunit 6
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
DAB2IP DAB2 interacting protein
DAXX death-domain associated protein
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPH1 diphthamide biosynthesis 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EMX1 empty spiracles homeobox 1
EP300 E1A binding protein p300
ETV4 ets variant 4
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBXW11 F-box and WD repeat domain containing 11
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLNC filamin C, gamma
FUS FUS RNA binding protein
GAS8 growth arrest-specific 8
GCGR glucagon receptor
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOLGA4 golgin A4
GRB2 growth factor receptor-bound protein 2
HIPK2 homeodomain interacting protein kinase 2
HIST1H1D histone cluster 1, H1d
HMGB1 high mobility group box 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HP haptoglobin
HPX hemopexin
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITCH itchy E3 ubiquitin protein ligase
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JPH1 junctophilin 1
KRT5 keratin 5, type II
KRT6C keratin 6C, type II
MAP1A microtubule-associated protein 1A
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL9 myosin, light chain 9, regulatory
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
N4BP2 NEDD4 binding protein 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NIPSNAP3A nipsnap homolog 3A (C. elegans)
NONO non-POU domain containing, octamer-binding
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
ORM1 orosomucoid 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLK1 polo-like kinase 1
PLS3 plastin 3
PML promyelocytic leukemia
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF38 ring finger protein 38
RPL12 ribosomal protein L12
RPL13A ribosomal protein L13a
RPL24 ribosomal protein L24
RPL3 ribosomal protein L3
RPLP0 ribosomal protein, large, P0
RPS27A ribosomal protein S27a
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPSA ribosomal protein SA
S1PR5 sphingosine-1-phosphate receptor 5
SACS sacsin molecular chaperone
SAFB scaffold attachment factor B
SATB2 SATB homeobox 2
SCAF4 SR-related CTD-associated factor 4
SEC24C SEC24 family member C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SIRT1 sirtuin 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNRPA small nuclear ribonucleoprotein polypeptide A
STK11 serine/threonine kinase 11
STXBP4 syntaxin binding protein 4
SUMO1 small ubiquitin-like modifier 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFBR1 transforming growth factor, beta receptor 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TRAPPC11 trafficking protein particle complex 11
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TTK TTK protein kinase
TUBA1C tubulin, alpha 1c
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE4B ubiquitination factor E4B
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UVRAG UV radiation resistance associated
VCP valosin containing protein
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
WWOX WW domain containing oxidoreductase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YAP1 Yes-associated protein 1
ZBTB4 zinc finger and BTB domain containing 4
ZNF676 zinc finger protein 676