TPM2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tropomyosin 2 (beta)|This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7169)
Similar Terms
Downloads & Tools

Genes

335 genes differentially expressed following the TPM2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.27074
TLE6 transducin-like enhancer of split 6 3.27074
CABP4 calcium binding protein 4 3.27074
IFITM10 interferon induced transmembrane protein 10 3.27074
FAM167A family with sequence similarity 167, member A 3.27074
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.27074
FAM209B family with sequence similarity 209, member B 3.27074
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.27074
CIITA class II, major histocompatibility complex, transactivator 3.27074
HBA1 hemoglobin, alpha 1 3.27074
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.27074
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.27074
LOC112694756 uncharaterized LOC112694756 3.27074
SLC10A4 solute carrier family 10, member 4 3.27074
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.27074
CD6 CD6 molecule 3.27074
SPMIP3 sperm microtubule inner protein 3 3.27074
FOLR1 folate receptor 1 (adult) 3.27074
CPLX3 complexin 3 3.27074
CDCP2 CUB domain containing protein 2 3.27074
TSPAN12 tetraspanin 12 3.25881
CD19 CD19 molecule 3.25222
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.25222
SPINK4 serine peptidase inhibitor, Kazal type 4 3.25222
SPINK6 serine peptidase inhibitor, Kazal type 6 3.25222
ENTHD1 ENTH domain containing 1 3.25222
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.25222
DNER delta/notch-like EGF repeat containing 3.25222
GJA3 gap junction protein, alpha 3, 46kDa 3.25222
TMPRSS11A transmembrane protease, serine 11A 3.25222
CARD18 caspase recruitment domain family, member 18 3.25222
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.25222
PLEK pleckstrin 3.25222
GUCY2F guanylate cyclase 2F, retinal 3.25222
PRELP proline/arginine-rich end leucine-rich repeat protein 3.25222
CRYGA crystallin, gamma A 3.25222
TAS2R13 taste receptor, type 2, member 13 3.25222
TAS2R10 taste receptor, type 2, member 10 3.25222
TAS2R19 taste receptor, type 2, member 19 3.25222
CORO6 coronin 6 3.25222
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.25222
CPLX4 complexin 4 3.25222
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 3.25222
DNAI7 dynein axonemal intermediate chain 7 3.25222
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.25222
TSGA13 testis specific, 13 3.25222
EPPIN epididymal peptidase inhibitor 3.25222
PRODH2 proline dehydrogenase (oxidase) 2 3.25222
ADTRP androgen-dependent TFPI-regulating protein 3.25222
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 3.25222
LRRC52 leucine rich repeat containing 52 3.25222
TRIM74 tripartite motif containing 74 3.25222
NPIPA3 nuclear pore complex interacting protein family, member A3 3.25222
GRP gastrin-releasing peptide 3.25222
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.25222
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.25222
HBG2 hemoglobin, gamma G 3.25222
GPR35 G protein-coupled receptor 35 3.25222
VN1R2 vomeronasal 1 receptor 2 3.25222
TCERG1L transcription elongation regulator 1-like 3.25222
DNAAF1 dynein, axonemal, assembly factor 1 3.25222
FMOD fibromodulin 3.25222
C20ORF202 chromosome 20 open reading frame 202 3.25222
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.25222
ERVW-1 endogenous retrovirus group W, member 1 3.25222
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.25222
H1-6 H1.6 linker histone, cluster member 3.25222
SPMIP1 sperm microtubule inner protein 1 3.25222
CFAP97D2 CFAP97 domain containing 2 3.25222
SEPTIN12 septin 12 3.25222
H2BW2 H2B.W histone 2 3.25222
DIPK1C divergent protein kinase domain 1C 3.25222
CIROP ciliated left-right organizer metallopeptidase 3.25222
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.25222
CCDC198 coiled-coil domain containing 198 3.25222
LORICRIN loricrin cornified envelope precursor protein 3.25222
MYEOV myeloma overexpressed 3.25222
MIOX myo-inositol oxygenase 3.25222
IL31RA interleukin 31 receptor A 3.25222
CCDC17 coiled-coil domain containing 17 3.25222
PCDHB10 protocadherin beta 10 3.25222
PTPRC protein tyrosine phosphatase, receptor type, C 3.25222
PCDHA3 protocadherin alpha 3 3.25222
RAB44 RAB44, member RAS oncogene family 3.25222
TSPO2 translocator protein 2 3.25222
PRB1 proline-rich protein BstNI subfamily 1 3.25222
WEE2 WEE1 homolog 2 (S. pombe) 3.25222
SCRT1 scratch family zinc finger 1 3.25222
TLR8 toll-like receptor 8 3.25222
RNF113B ring finger protein 113B 3.25222
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.25222
GATA3 GATA binding protein 3 3.25222
RNF183 ring finger protein 183 3.25222
LRRN4CL LRRN4 C-terminal like 3.25222
LTA lymphotoxin alpha 3.25222
LRRC73 leucine rich repeat containing 73 3.25222
LRRC72 leucine rich repeat containing 72 3.25222
C7ORF57 chromosome 7 open reading frame 57 3.25222
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.25222
FOXL1 forkhead box L1 3.25222
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.25222
NTSR2 neurotensin receptor 2 3.25222
MAPK11 mitogen-activated protein kinase 11 3.25222
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.25222
IL36R interleukin 36 receptor 3.25222
C5AR2 complement component 5a receptor 2 3.25222
POU2AF1 POU class 2 associating factor 1 3.25222
DAND5 DAN domain family member 5, BMP antagonist 3.25222
KRTAP10-8 keratin associated protein 10-8 3.25222
GCM1 glial cells missing homolog 1 (Drosophila) 3.25222
LMOD2 leiomodin 2 (cardiac) 3.25222
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.25222
RTN4RL1 reticulon 4 receptor-like 1 3.25222
OR10G4 olfactory receptor, family 10, subfamily G, member 4 3.25222
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.25222
TCF21 transcription factor 21 3.25222
SPINK9 serine peptidase inhibitor, Kazal type 9 3.25222
DKK4 dickkopf WNT signaling pathway inhibitor 4 3.25222
TESPA1 thymocyte expressed, positive selection associated 1 3.25222
BTNL2 butyrophilin-like 2 3.25222
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.25222
AQP7 aquaporin 7 3.25222
UBE3C ubiquitin protein ligase E3C 3.25222
KLF2 Kruppel-like factor 2 3.25222
PCDHGB5 protocadherin gamma subfamily B, 5 3.25222
VAX2 ventral anterior homeobox 2 3.25222
IGFALS insulin-like growth factor binding protein, acid labile subunit 3.25222
HAVCR1 hepatitis A virus cellular receptor 1 3.25222
SMYD1 SET and MYND domain containing 1 3.25222
HSF4 heat shock transcription factor 4 3.25222
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.25222
CCDC179 coiled-coil domain containing 179 3.25222
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.25222
HEPACAM hepatic and glial cell adhesion molecule 3.25222
SLC38A11 solute carrier family 38, member 11 3.25222
GPR179 G protein-coupled receptor 179 3.25222
NCR3 natural cytotoxicity triggering receptor 3 3.25222
MROH2A maestro heat-like repeat family member 2A 3.25222
DCST1 DC-STAMP domain containing 1 3.25222
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.25222
CISH cytokine inducible SH2-containing protein 3.25222
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.25222
SOST sclerostin 3.25222
C1ORF105 chromosome 1 open reading frame 105 3.25222
ESPNL espin-like 3.25222
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 3.25222
GOLGA8T golgin A8 family, member T 3.25222
CFB complement factor B 3.25222
HES2 hes family bHLH transcription factor 2 3.25222
IL1B interleukin 1, beta 3.25222
LHB luteinizing hormone beta polypeptide 3.25222
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.25222
THBD thrombomodulin 3.25222
RAB40AL RAB40A, member RAS oncogene family-like 3.25222
BPIFC BPI fold containing family C 3.25222
TGM6 transglutaminase 6 3.25222
KLK6 kallikrein-related peptidase 6 3.25222
C8B complement component 8, beta polypeptide 3.25222
PIP prolactin-induced protein 3.25222
DMRT1 doublesex and mab-3 related transcription factor 1 3.25222
OTOP1 otopetrin 1 3.25222
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 3.22269
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 3.19457
ADGRD1 adhesion G protein-coupled receptor D1 3.15049
CELA2B chymotrypsin-like elastase family, member 2B 3.15049
AOC2 amine oxidase, copper containing 2 (retina-specific) 3.09198
MVB12B multivesicular body subunit 12B 2.9788
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.94156
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.90883
RCAN2 regulator of calcineurin 2 2.89907
SUFU suppressor of fused homolog (Drosophila) 2.87847
ELOA elongin A 2.82567
ZNF548 zinc finger protein 548 2.63827
SFMBT2 Scm-like with four mbt domains 2 2.63267
FBXO43 F-box protein 43 2.63267
PROM2 prominin 2 2.63267
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.60817
AHI1 Abelson helper integration site 1 2.60513
CRYL1 crystallin, lambda 1 2.53377
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.46054
WDR5B WD repeat domain 5B 2.46054
TOMM34 translocase of outer mitochondrial membrane 34 2.42979
G6PD glucose-6-phosphate dehydrogenase 2.42979
KYNU kynureninase 2.42979
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.41482
NUP62 nucleoporin 62kDa 2.40745
PABIR3 PABIR family member 3 2.34513
KCNRG potassium channel regulator 2.33706
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.33706
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.32715
EML6 echinoderm microtubule associated protein like 6 2.32715
HLF hepatic leukemia factor 2.32553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.31342
TTC5 tetratricopeptide repeat domain 5 2.25605
PLXNB1 plexin B1 2.25309
KHNYN KH and NYN domain containing 2.25295
RNLS renalase, FAD-dependent amine oxidase 2.2472
VSTM4 V-set and transmembrane domain containing 4 2.21705
TMEM80 transmembrane protein 80 2.14372
MLANA melan-A 2.14218
ETNPPL ethanolamine-phosphate phospho-lyase 2.14218
ACKR3 atypical chemokine receptor 3 2.14218
BMP8B bone morphogenetic protein 8b 2.14218
LCN15 lipocalin 15 2.14218
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.13842
KRTCAP3 keratinocyte associated protein 3 2.13275
BRD3 bromodomain containing 3 2.13273
TTC14 tetratricopeptide repeat domain 14 2.13273
NPTXR neuronal pentraxin receptor 2.12477
TOE1 target of EGR1, member 1 (nuclear) 2.12243
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.11911
ITFG2 integrin alpha FG-GAP repeat containing 2 2.11785
HIPK2 homeodomain interacting protein kinase 2 2.11091
NUP160 nucleoporin 160kDa 2.11091
CYYR1 cysteine/tyrosine-rich 1 2.11091
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.11088
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.11088
TRIB3 tribbles pseudokinase 3 2.07318
LBH limb bud and heart development 2.07318
KCNIP3 Kv channel interacting protein 3, calsenilin 2.05898
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 2.05788
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 2.04154
EMD emerin 2.0358
LHFPL5 lipoma HMGIC fusion partner-like 5 2.02862
HMGN5 high mobility group nucleosome binding domain 5 2.02176

decreased expression

Symbol Name Standardized Value
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -3.27074
CHD5 chromodomain helicase DNA binding protein 5 -3.27074
STXBP5 syntaxin binding protein 5 (tomosyn) -3.27074
TPM2 tropomyosin 2 (beta) -3.27074
SCT secretin -3.27074
NLRC4 NLR family, CARD domain containing 4 -3.27074
TMEM82 transmembrane protein 82 -3.27074
CCDC22 coiled-coil domain containing 22 -3.26984
WNT9A wingless-type MMTV integration site family, member 9A -3.25222
PRPF39 pre-mRNA processing factor 39 -3.25222
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -3.25222
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -3.25222
TBC1D26 TBC1 domain family, member 26 -3.25222
TAS2R5 taste receptor, type 2, member 5 -3.25222
SOX7 SRY (sex determining region Y)-box 7 -3.25222
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -3.25222
BTC betacellulin -3.25222
NOXO1 NADPH oxidase organizer 1 -3.25222
MYO1A myosin IA -3.25222
SLC44A2 solute carrier family 44 (choline transporter), member 2 -3.25222
THSD1 thrombospondin, type I, domain containing 1 -3.25222
LOC105378220 macrophage receptor MARCO-like -3.25222
SERTM1 serine-rich and transmembrane domain containing 1 -3.25222
FAM161B family with sequence similarity 161, member B -3.25222
PCDHGA11 protocadherin gamma subfamily A, 11 -3.25222
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -3.25222
LIPG lipase, endothelial -3.25222
ACOT6 acyl-CoA thioesterase 6 -3.25222
FAM131C family with sequence similarity 131, member C -3.25222
MAP3K4-AS1 MAP3K4 antisense RNA 1 -3.25222
FIBIN fin bud initiation factor homolog (zebrafish) -3.25222
DRD3 dopamine receptor D3 -3.25222
BST1 bone marrow stromal cell antigen 1 -3.25222
ZNF226 zinc finger protein 226 -3.25222
LOC124902436 talanin -3.25222
UBXN10 UBX domain protein 10 -3.25222
BBS10 Bardet-Biedl syndrome 10 -3.25222
IGIP IgA-inducing protein -3.25222
CATSPER3 cation channel, sperm associated 3 -3.25222
PCDHA5 protocadherin alpha 5 -3.25222
EDN1 endothelin 1 -3.25222
ZIC4 Zic family member 4 -3.25222
RABGGTA Rab geranylgeranyltransferase, alpha subunit -3.25222
ANGPT1 angiopoietin 1 -3.1743
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -3.13083
ANKRD61 ankyrin repeat domain 61 -3.07979
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.85352
NAT14 N-acetyltransferase 14 (GCN5-related, putative) -2.64047
CDCA2 cell division cycle associated 2 -2.64047
H3-3A H3.3 histone A -2.63782
RPS6 ribosomal protein S6 -2.61255
TPST2 tyrosylprotein sulfotransferase 2 -2.58135
PSRC1 proline/serine-rich coiled-coil 1 -2.57914
ESYT2 extended synaptotagmin-like protein 2 -2.54555
AKAP10 A kinase (PRKA) anchor protein 10 -2.50893
ZFAND4 zinc finger, AN1-type domain 4 -2.49944
PGBD2 piggyBac transposable element derived 2 -2.46054
MAN1A2 mannosidase, alpha, class 1A, member 2 -2.42491
CORO7 coronin 7 -2.41244
SAP18 Sin3A-associated protein, 18kDa -2.41237
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.3893
SACK1F scaffolding CK1 anchoring protein F -2.38276
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.37551
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -2.37551
NEFH neurofilament, heavy polypeptide -2.37065
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -2.35952
TSSK6 testis-specific serine kinase 6 -2.30664
NBPF14 neuroblastoma breakpoint family, member 14 -2.29484
ZFP36 ZFP36 ring finger protein -2.26994
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.25988
COX18 COX18 cytochrome c oxidase assembly factor -2.25619
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.25605
FIG4 FIG4 phosphoinositide 5-phosphatase -2.24979
MRPL20 mitochondrial ribosomal protein L20 -2.23808
UBIAD1 UbiA prenyltransferase domain containing 1 -2.22255
PCDHB3 protocadherin beta 3 -2.21654
NUTM1 NUT midline carcinoma, family member 1 -2.21654
C1ORF202 chromosome 1 open reading frame 202 -2.21654
SFRP4 secreted frizzled-related protein 4 -2.21654
PNLIPRP2 pancreatic lipase-related protein 2 -2.21654
GEMIN2 gem (nuclear organelle) associated protein 2 -2.21441
RPS27L ribosomal protein S27-like -2.19374
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.18174
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.18172
ISOC2 isochorismatase domain containing 2 -2.18046
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -2.17458
SLC6A16 solute carrier family 6, member 16 -2.15699
ZNF471 zinc finger protein 471 -2.14372
ZNF395 zinc finger protein 395 -2.13774
NTHL1 nth endonuclease III-like 1 (E. coli) -2.13766
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.12524
MRPS30 mitochondrial ribosomal protein S30 -2.12358
MRPS22 mitochondrial ribosomal protein S22 -2.12243
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -2.12165
CDCA8 cell division cycle associated 8 -2.12165
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.11911
GLI2 GLI family zinc finger 2 -2.11827
RAB11A RAB11A, member RAS oncogene family -2.09285
LAPTM4A lysosomal protein transmembrane 4 alpha -2.0928
ZNF160 zinc finger protein 160 -2.08836
CHMP1B charged multivesicular body protein 1B -2.08262
FRS2 fibroblast growth factor receptor substrate 2 -2.07763
PDLIM7 PDZ and LIM domain 7 (enigma) -2.06568
SNUPN snurportin 1 -2.05788
CELF5 CUGBP, Elav-like family member 5 -2.04463
RNF19B ring finger protein 19B -2.03601
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.03063
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.02487
ZNF585A zinc finger protein 585A -2.01494
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.00247