TPM3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tropomyosin 3|This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 7170)
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Genes

353 genes differentially expressed following the TPM3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SP7 Sp7 transcription factor 3.71709
HNF1B HNF1 homeobox B 3.71709
C8ORF74 chromosome 8 open reading frame 74 3.71709
DYNAP dynactin associated protein 3.71709
MYO1G myosin IG 3.71709
CPLX4 complexin 4 3.71709
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.71709
LDHC lactate dehydrogenase C 3.71709
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.71709
CLEC5A C-type lectin domain family 5, member A 3.71709
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.71709
CELA2A chymotrypsin-like elastase family, member 2A 3.71709
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.71709
FGFR3 fibroblast growth factor receptor 3 3.71709
TPSD1 tryptase delta 1 3.71709
GUCY2F guanylate cyclase 2F, retinal 3.71709
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.71709
GMFG glia maturation factor, gamma 3.71709
TAS1R2 taste receptor, type 1, member 2 3.71709
NKX2-8 NK2 homeobox 8 3.71709
TRPA1 transient receptor potential cation channel, subfamily A, member 1 3.71709
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.71709
LRRC31 leucine rich repeat containing 31 3.71709
FOXP3 forkhead box P3 3.71709
OTOR otoraplin 3.71709
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 3.71709
FEV FEV (ETS oncogene family) 3.71709
SNTN sentan, cilia apical structure protein 3.71709
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.71709
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.71709
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.71709
ALLC allantoicase 3.71709
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.71709
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.71709
GPR37L1 G protein-coupled receptor 37 like 1 3.71709
IL17B interleukin 17B 3.71709
WDR64 WD repeat domain 64 3.71709
LMNTD1 lamin tail domain containing 1 3.71709
TGM6 transglutaminase 6 3.71709
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.71709
LAMP5 lysosomal-associated membrane protein family, member 5 3.71709
NKX2-5 NK2 homeobox 5 3.71709
TACSTD2 tumor-associated calcium signal transducer 2 3.71709
TLR4 toll-like receptor 4 3.71709
ADGRE3 adhesion G protein-coupled receptor E3 3.71709
SLC46A2 solute carrier family 46, member 2 3.71709
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.71709
TFEC transcription factor EC 3.71709
CELF6 CUGBP, Elav-like family member 6 3.71709
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.71709
ZIC4 Zic family member 4 3.71709
ULBP1 UL16 binding protein 1 3.71709
OR56B2 olfactory receptor family 56 subfamily B member 2 3.71709
CLEC3A C-type lectin domain family 3, member A 3.71709
SYCP2 synaptonemal complex protein 2 3.71709
CD6 CD6 molecule 3.71709
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 3.71709
NAPSA napsin A aspartic peptidase 3.71709
TXLNB taxilin beta 3.71709
OLAH oleoyl-ACP hydrolase 3.71709
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.71709
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.71709
BTC betacellulin 3.71709
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.71709
PRR18 proline rich 18 3.71709
NPFF neuropeptide FF-amide peptide precursor 3.71709
MUSK muscle, skeletal, receptor tyrosine kinase 3.71709
PRR4 proline rich 4 (lacrimal) 3.71709
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 3.71709
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.71709
PLXNB3 plexin B3 3.71709
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.71709
PAX4 paired box 4 3.71709
ZEB2 zinc finger E-box binding homeobox 2 3.71709
RAX retina and anterior neural fold homeobox 3.71709
TPTE transmembrane phosphatase with tensin homology 3.71709
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.71709
SLC45A2 solute carrier family 45, member 2 3.71709
GSTM5 glutathione S-transferase mu 5 3.71709
PROB1 proline-rich basic protein 1 3.71709
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.71709
HCRTR2 hypocretin (orexin) receptor 2 3.71709
APOL4 apolipoprotein L, 4 3.71709
OLFML1 olfactomedin-like 1 3.71709
PLA1A phospholipase A1 member A 3.71709
MEIKIN meiotic kinetochore factor 3.71709
MAJIN membrane anchored junction protein 3.71709
IL9R interleukin 9 receptor 3.71709
CRYBA1 crystallin, beta A1 3.71709
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 3.71709
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.71709
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.71709
PDZRN4 PDZ domain containing ring finger 4 3.71709
CBY2 chibby family member 2 3.71709
ISL2 ISL LIM homeobox 2 3.71709
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.71709
LMX1B LIM homeobox transcription factor 1, beta 3.71709
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.71709
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.71709
TREH trehalase (brush-border membrane glycoprotein) 3.71709
CLEC4D C-type lectin domain family 4, member D 3.71709
FIBIN fin bud initiation factor homolog (zebrafish) 3.71709
CCDC185 coiled-coil domain containing 185 3.71709
DLX5 distal-less homeobox 5 3.71709
CTXND1 cortexin domain containing 1 3.71709
WNT1 wingless-type MMTV integration site family, member 1 3.71709
C1ORF232 chromosome 1 open reading frame 230 3.71709
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.71709
GOLGA8K golgin A8 family, member K 3.71709
EXOC1L exocyst complex component 1 like 3.71709
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.71709
THSD8 thrombospondin type 1 domain containing 8 3.71709
SIDT1 SID1 transmembrane family, member 1 3.71709
LRRN4 leucine rich repeat neuronal 4 3.71709
GAS2L2 growth arrest-specific 2 like 2 3.71709
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.71709
DND1 DND microRNA-mediated repression inhibitor 1 3.71709
SLC22A31 solute carrier family 22, member 31 3.71709
CTRB1 chymotrypsinogen B1 3.71709
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.71709
PNMA8C PNMA family member 8C 3.71709
LGALS12 lectin, galactoside-binding, soluble, 12 3.71709
PRRT1B proline rich transmembrane protein 1B 3.71709
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.71709
AKNAD1 AKNA domain containing 1 3.71709
POTEJ POTE ankyrin domain family, member J 3.71709
CPO carboxypeptidase O 3.71709
SMIM22 small integral membrane protein 22 3.71709
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.71709
SPTBN5 spectrin, beta, non-erythrocytic 5 3.71709
CTF1 cardiotrophin 1 3.71709
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.71709
GPR35 G protein-coupled receptor 35 3.71709
ALDOB aldolase B, fructose-bisphosphate 3.71709
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.71709
PLA2G4E phospholipase A2, group IVE 3.71709
NUTM2D NUT family member 2D 3.71709
SPI1 Spi-1 proto-oncogene 3.71709
FAM25A family with sequence similarity 25, member A 3.71709
C9ORF57 chromosome 9 open reading frame 57 3.71709
ANKRD33 ankyrin repeat domain 33 3.71709
FZD1 frizzled class receptor 1 3.71709
MAPK11 mitogen-activated protein kinase 11 3.71709
IER5L immediate early response 5-like 3.71709
APLNR apelin receptor 3.71709
IGFBP7 insulin-like growth factor binding protein 7 3.71709
PLN phospholamban 3.71709
SPANXC SPANX family, member C 3.71709
DQX1 DEAQ box RNA-dependent ATPase 1 3.71709
TOMT transmembrane O-methyltransferase 3.71709
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.71709
CCN6 cellular communication network factor 6 3.71709
TBC1D10C TBC1 domain family, member 10C 3.71709
LCN1 lipocalin 1 3.71709
LRRC32 leucine rich repeat containing 32 3.71709
CFAP65 cilia and flagella associated protein 65 3.71709
MRLN myoregulin 3.71709
NOG noggin 3.71709
CLRN1 clarin 1 3.71709
CSTA cystatin A (stefin A) 3.71709
OXSM 3-oxoacyl-ACP synthase, mitochondrial 3.66279
BRWD1 bromodomain and WD repeat domain containing 1 3.35551
SAR1B secretion associated, Ras related GTPase 1B 3.30377
GPN1 GPN-loop GTPase 1 3.16248
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 2.98493
TSKS testis-specific serine kinase substrate 2.93321
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.90558
CSRNP2 cysteine-serine-rich nuclear protein 2 2.77315
NFX1 nuclear transcription factor, X-box binding 1 2.7731
POU2F3 POU class 2 homeobox 3 2.77193
TTC16 tetratricopeptide repeat domain 16 2.77193
IRF4 interferon regulatory factor 4 2.77193
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.65204
CLTC clathrin, heavy chain (Hc) 2.58758
NPM3 nucleophosmin/nucleoplasmin 3 2.58036
TEX14 testis expressed 14 2.57179
TXNL4A thioredoxin-like 4A 2.56407
MBD5 methyl-CpG binding domain protein 5 2.51232
ZNF630 zinc finger protein 630 2.51232
FANCD2 Fanconi anemia, complementation group D2 2.51159
C16ORF89 chromosome 16 open reading frame 89 2.50814
UNC45A unc-45 homolog A (C. elegans) 2.50526
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.49997
PHOX2A paired-like homeobox 2a 2.48616
WASHC2A WASH complex subunit 2A 2.45346
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 2.45346
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.44746
LBR lamin B receptor 2.44055
UHMK1 U2AF homology motif (UHM) kinase 1 2.39382
C14ORF93 chromosome 14 open reading frame 93 2.38567
ZDHHC19 zinc finger, DHHC-type containing 19 2.37216
CCL2 chemokine (C-C motif) ligand 2 2.36309
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 2.35921
GSG1L GSG1-like 2.3535
IGSF10 immunoglobulin superfamily, member 10 2.3535
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.3535
SEC31B SEC31 homolog B (S. cerevisiae) 2.34118
ZNF718 zinc finger protein 718 2.33974
NANOS1 nanos homolog 1 (Drosophila) 2.29377
FOSL1 FOS-like antigen 1 2.24261
MDK midkine (neurite growth-promoting factor 2) 2.21925
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.19682
TM2D2 TM2 domain containing 2 2.19363
ATP5F1E ATP synthase F1 subunit epsilon 2.17159
GAR1 GAR1 ribonucleoprotein 2.17058
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 2.16937
RHOQ ras homolog family member Q 2.1632
GRB10 growth factor receptor-bound protein 10 2.15713
ZNF501 zinc finger protein 501 2.14616
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.13115
MRPL54 mitochondrial ribosomal protein L54 2.13057
TFCP2L1 transcription factor CP2-like 1 2.12584
SEC14L1 SEC14-like 1 (S. cerevisiae) 2.1242
RPP21 ribonuclease P/MRP 21kDa subunit 2.10976
TAOK2 TAO kinase 2 2.10849
NPIPA1 nuclear pore complex interacting protein family, member A1 2.1072
LYAR Ly1 antibody reactive 2.10512
TCF20 transcription factor 20 (AR1) 2.09427
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.0901
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.08282
PHF23 PHD finger protein 23 2.07899
STAU1 staufen double-stranded RNA binding protein 1 2.07348
FGD4 FYVE, RhoGEF and PH domain containing 4 2.07342
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.05648
HDGFL3 HDGF like 3 2.05625
RBM8A RNA binding motif protein 8A 2.05392
NBDY negative regulator of P-body association 2.03933
URM1 ubiquitin related modifier 1 2.02239
BRD3 bromodomain containing 3 2.01935
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.01548
PLXND1 plexin D1 2.01548
AXL AXL receptor tyrosine kinase 2.01548
RAB42 RAB42, member RAS oncogene family 2.00099
RARA retinoic acid receptor, alpha 2.00099

decreased expression

Symbol Name Standardized Value
PLAGL2 pleiomorphic adenoma gene-like 2 -3.71709
TMEM221 transmembrane protein 221 -3.71709
BEAN1 brain expressed, associated with NEDD4, 1 -3.71709
PCDH19 protocadherin 19 -3.71709
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -3.71709
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -3.61803
ALOXE3 arachidonate lipoxygenase 3 -3.52953
TMEM176B transmembrane protein 176B -3.52953
VWA3A von Willebrand factor A domain containing 3A -3.52953
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -3.52953
BHLHE40 basic helix-loop-helix family, member e40 -3.52953
C6ORF163 chromosome 6 open reading frame 163 -3.52953
GAB3 GRB2-associated binding protein 3 -3.52953
CLCNKB chloride channel, voltage-sensitive Kb -3.52953
TAS2R46 taste receptor, type 2, member 46 -3.52953
ADIRF adipogenesis regulatory factor -3.52953
POPDC2 popeye domain containing 2 -3.52953
FAM216B family with sequence similarity 216, member B -3.52953
ACADL acyl-CoA dehydrogenase, long chain -3.52953
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -3.52953
TMC2 transmembrane channel-like 2 -3.52953
LRRC38 leucine rich repeat containing 38 -3.52953
SPATA9 spermatogenesis associated 9 -3.52953
CHRND cholinergic receptor, nicotinic, delta (muscle) -3.52953
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.52953
CDH26 cadherin 26 -3.52953
PKD2L1 polycystic kidney disease 2-like 1 -3.52953
RIN1 Ras and Rab interactor 1 -3.52953
FAM151A family with sequence similarity 151, member A -3.52953
SLC49A3 solute carrier family 49 member 3 -3.52953
C20ORF204 chromosome 20 open reading frame 204 -3.52953
CIMAP1D CIMAP1 family member D -3.52953
IDI2 isopentenyl-diphosphate delta isomerase 2 -3.52953
C10ORF53 chromosome 10 open reading frame 53 -3.52953
INSM1 insulinoma-associated 1 -3.52953
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -3.52953
ACTL8 actin-like 8 -3.52953
CKM creatine kinase, muscle -3.52953
ITGA11 integrin, alpha 11 -3.52953
COX8C cytochrome c oxidase subunit VIIIC -3.52953
REP15 RAB15 effector protein -3.52953
SEZ6L seizure related 6 homolog (mouse)-like -3.52953
ZSCAN25 zinc finger and SCAN domain containing 25 -3.48825
NGEF neuronal guanine nucleotide exchange factor -3.39057
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -3.39057
DPF1 D4, zinc and double PHD fingers family 1 -3.12405
SRP72 signal recognition particle 72kDa -3.0884
C14ORF39 chromosome 14 open reading frame 39 -2.98493
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.95505
PDE9A phosphodiesterase 9A -2.91185
ADAM21 ADAM metallopeptidase domain 21 -2.81088
SLC38A12 solute carrier family 38 member 12 -2.77896
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -2.75819
EHBP1 EH domain binding protein 1 -2.75554
FUCA1 fucosidase, alpha-L- 1, tissue -2.74706
FANCC Fanconi anemia, complementation group C -2.72958
RALYL RALY RNA binding protein-like -2.68254
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.6801
COL21A1 collagen, type XXI, alpha 1 -2.59608
GRIP1 glutamate receptor interacting protein 1 -2.58634
FKBP14 FK506 binding protein 14, 22 kDa -2.56407
NUP205 nucleoporin 205kDa -2.55213
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -2.50993
PHEX phosphate regulating endopeptidase homolog, X-linked -2.50006
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -2.50006
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.49727
EFR3B EFR3 homolog B (S. cerevisiae) -2.48616
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C -2.47123
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -2.44482
CDCA4 cell division cycle associated 4 -2.42068
RACGAP1 Rac GTPase activating protein 1 -2.40121
INSIG1 insulin induced gene 1 -2.39807
SORT1 sortilin 1 -2.39599
TSPAN12 tetraspanin 12 -2.38932
LRRC17 leucine rich repeat containing 17 -2.37216
TLR3 toll-like receptor 3 -2.37216
CNGA1 cyclic nucleotide gated channel alpha 1 -2.37216
PRAM1 PML-RARA regulated adaptor molecule 1 -2.3542
KEL Kell blood group, metallo-endopeptidase -2.33974
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.33642
FYTTD1 forty-two-three domain containing 1 -2.32884
ZNF574 zinc finger protein 574 -2.32884
GPR158 G protein-coupled receptor 158 -2.32237
STIL SCL/TAL1 interrupting locus -2.32054
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.32054
SPATA20 spermatogenesis associated 20 -2.31863
CNTD1 cyclin N-terminal domain containing 1 -2.31598
ARID5A AT rich interactive domain 5A (MRF1-like) -2.31598
SLC44A4 solute carrier family 44, member 4 -2.31598
PVALEF parvalbumin like EF-hand containing -2.31598
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.31598
DHDH dihydrodiol dehydrogenase (dimeric) -2.31598
PAWR PRKC, apoptosis, WT1, regulator -2.29564
NPIPB4 nuclear pore complex interacting protein family, member B4 -2.25563
CHEK1 checkpoint kinase 1 -2.25333
OFD1 oral-facial-digital syndrome 1 -2.25114
SRPRB signal recognition particle receptor, B subunit -2.25082
CRIP1 cysteine-rich protein 1 (intestinal) -2.2022
CRHR2 corticotropin releasing hormone receptor 2 -2.2022
ZNF215 zinc finger protein 215 -2.18448
SDF4 stromal cell derived factor 4 -2.17279
NTN4 netrin 4 -2.17279
FCHO1 FCH domain only 1 -2.17058
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.17058
CTNND2 catenin (cadherin-associated protein), delta 2 -2.12573
LIN9 lin-9 DREAM MuvB core complex component -2.1213
INCENP inner centromere protein antigens 135/155kDa -2.1072
COPS3 COP9 signalosome subunit 3 -2.1072
INO80C INO80 complex subunit C -2.09307
MOK MOK protein kinase -2.09177
TTC27 tetratricopeptide repeat domain 27 -2.08523
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.0583
CRLF3 cytokine receptor-like factor 3 -2.05648
TTC39A tetratricopeptide repeat domain 39A -2.05412
RFTN1 raftlin, lipid raft linker 1 -2.03004
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.01935
H1-2 H1.2 linker histone, cluster member -2.01548
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.01211
AGRN agrin -2.01106