TRAF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description TNF receptor-associated factor 2|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7186)
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Genes

290 genes differentially expressed following the TRAF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM167A family with sequence similarity 167, member A 2.22333
PAX9 paired box 9 2.22333
PTH2 parathyroid hormone 2 2.22333
TYRP1 tyrosinase-related protein 1 2.22333
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.22333
SIGLEC7 sialic acid binding Ig-like lectin 7 2.22333
CHGA chromogranin A 2.22333
NFAM1 NFAT activating protein with ITAM motif 1 2.22333
ANKRD34A ankyrin repeat domain 34A 2.22333
C11ORF87 chromosome 11 open reading frame 87 2.22333
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.22333
ADTRP androgen-dependent TFPI-regulating protein 2.22333
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.22333
TREM2 triggering receptor expressed on myeloid cells 2 2.22333
IYD iodotyrosine deiodinase 2.22333
SCGN secretagogin, EF-hand calcium binding protein 2.22333
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.22333
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.22333
TMEM176A transmembrane protein 176A 2.22333
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.22333
PDYN prodynorphin 2.22333
PCDHB4 protocadherin beta 4 2.22333
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.22333
ADAMTSL5 ADAMTS-like 5 2.22333
BSX brain-specific homeobox 2.22333
THSD1 thrombospondin, type I, domain containing 1 2.22333
SP9 Sp9 transcription factor 2.22333
SPX spexin hormone 2.22333
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.22333
NMUR2 neuromedin U receptor 2 2.22333
CENPK centromere protein K 2.22333
TPRX1 tetra-peptide repeat homeobox 1 2.22333
MEIG1 meiosis/spermiogenesis associated 1 2.22333
RHOJ ras homolog family member J 2.22333
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.22333
NEMF nuclear export mediator factor 2.22333
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.22333
GUCY2F guanylate cyclase 2F, retinal 2.22333
NLRP10 NLR family, pyrin domain containing 10 2.22333
KIAA2012 KIAA2012 2.22333
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.22333
DPPA3 developmental pluripotency associated 3 2.22333
PTK6 protein tyrosine kinase 6 2.22333
OXT oxytocin/neurophysin I prepropeptide 2.22333
BFSP2 beaded filament structural protein 2, phakinin 2.22333
ACOT12 acyl-CoA thioesterase 12 2.22333
ANXA2R annexin A2 receptor 2.22333
CLEC12A C-type lectin domain family 12, member A 2.22333
FAM90A24 family with sequence similarity 90 member A24 2.22333
PMIS2 PMIS2 transmembrane protein 2.22333
HTD2 hydroxyacyl-thioester dehydratase type 2 2.22333
TWNK twinkle mtDNA helicase 2.22333
CLDN16 claudin 16 2.22333
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.22333
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.22333
TBC1D3L TBC1 domain family, member 3L 2.22333
C20ORF202 chromosome 20 open reading frame 202 2.22333
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.22333
DEPP1 DEPP autophagy regulator 1 2.22333
GASK1B golgi associated kinase 1B 2.22333
CCDC198 coiled-coil domain containing 198 2.22333
ZNF892 zinc finger protein 892 2.22333
FAM240C family with sequence similarity 240 member C 2.22333
DUSP13B dual specificity phosphatase 13B 2.22333
RHEX regulator of hemoglobinization and erythroid cell expansion 2.22333
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.22333
LY6L lymphocyte antigen 6 family member L 2.22333
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.22333
ODAPH odontogenesis associated phosphoprotein 2.22333
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.22333
WDR64 WD repeat domain 64 2.22333
WNT16 wingless-type MMTV integration site family, member 16 2.22333
TSPAN1 tetraspanin 1 2.22333
PCDHA7 protocadherin alpha 7 2.22333
IL12RB1 interleukin 12 receptor, beta 1 2.22333
IL36G interleukin 36, gamma 2.22333
RLBP1 retinaldehyde binding protein 1 2.22333
RS1 retinoschisin 1 2.22333
ZNF98 zinc finger protein 98 2.22333
SLC22A14 solute carrier family 22, member 14 2.22333
LOC107986837 uncharacterized LOC107986837 2.22333
SIX6 SIX homeobox 6 2.22333
C5ORF58 chromosome 5 open reading frame 58 2.22333
CFAP99 cilia and flagella associated protein 99 2.22333
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.22333
GPR37L1 G protein-coupled receptor 37 like 1 2.22333
GATA3 GATA binding protein 3 2.22333
LRRN4CL LRRN4 C-terminal like 2.22333
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.22333
BARX1 BARX homeobox 1 2.22333
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.22333
TFEC transcription factor EC 2.22333
HOXC4 homeobox C4 2.22333
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.22333
OSBPL1A oxysterol binding protein-like 1A 2.22333
CLEC2A C-type lectin domain family 2, member A 2.22333
ARHGAP20 Rho GTPase activating protein 20 2.22333
BPIFB4 BPI fold containing family B, member 4 2.22333
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.22333
TDRD10 tudor domain containing 10 2.22333
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.22333
HKDC1 hexokinase domain containing 1 2.22333
CD53 CD53 molecule 2.22333
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.22333
CDH10 cadherin 10, type 2 (T2-cadherin) 2.22333
MSMP microseminoprotein, prostate associated 2.22333
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.22333
HAMP hepcidin antimicrobial peptide 2.22333
ESPNL espin-like 2.22333
CSTA cystatin A (stefin A) 2.22333
CST7 cystatin F (leukocystatin) 2.22333
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.22333
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.22333
CCDC74B coiled-coil domain containing 74B 2.22333
KLF1 Kruppel-like factor 1 (erythroid) 2.22333
PAGE2 P antigen family, member 2 (prostate associated) 2.22333
NDNF neuron-derived neurotrophic factor 2.22333
RPS29 ribosomal protein S29 2.22333
DHH desert hedgehog 2.22333
LHX5 LIM homeobox 5 2.22333
SPRED3 sprouty-related, EVH1 domain containing 3 2.22333
SLC38A3 solute carrier family 38, member 3 2.22333
SAMD8 sterile alpha motif domain containing 8 2.22333
GSTA1 glutathione S-transferase alpha 1 2.22333
CRYBA4 crystallin, beta A4 2.22333
RASL11A RAS-like, family 11, member A 2.22333
IL1A interleukin 1, alpha 2.22333
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.22333
PFN4 profilin family, member 4 2.22333
CD27 CD27 molecule 2.22333
MUC17 mucin 17, cell surface associated 2.22333
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.22333
CCL15 chemokine (C-C motif) ligand 15 2.22333
BCO1 beta-carotene oxygenase 1 2.22333
C17ORF99 chromosome 17 open reading frame 99 2.22333
CLEC18C C-type lectin domain family 18, member C 2.22333
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.22333
TMEM132E transmembrane protein 132E 2.22333
ADGRF5 adhesion G protein-coupled receptor F5 2.22333
CXCR6 chemokine (C-X-C motif) receptor 6 2.22333
TGM6 transglutaminase 6 2.22333
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.22333
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.22333
ALLC allantoicase 2.22333
GPNMB glycoprotein (transmembrane) nmb 2.22333
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.22333
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.22333
ZPLD1 zona pellucida-like domain containing 1 2.22333
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.22333
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.22333
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.22333
NRGN neurogranin (protein kinase C substrate, RC3) 2.22333
P3H2 prolyl 3-hydroxylase 2 2.22333
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.22333
ASCL3 achaete-scute family bHLH transcription factor 3 2.22333
NLRP5 NLR family, pyrin domain containing 5 2.22333
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.22333
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.22333
GOLGA8N golgin A8 family, member N 2.22333
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.22333
RUFY4 RUN and FYVE domain containing 4 2.22333
KPNA6 karyopherin alpha 6 (importin alpha 7) 2.22333
HSF4 heat shock transcription factor 4 2.22333
MEIS2 Meis homeobox 2 2.22333
KRT17 keratin 17, type I 2.22333
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.22333
BMX BMX non-receptor tyrosine kinase 2.22333
LMOD2 leiomodin 2 (cardiac) 2.22333
PTGDR prostaglandin D2 receptor (DP) 2.22333
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.22333
WFDC10B WAP four-disulfide core domain 10B 2.22333
ADRA2A adrenoceptor alpha 2A 2.22333
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.22333
GXYLT2 glucoside xylosyltransferase 2 2.22333
SFTA2 surfactant associated 2 2.22333
LRRN4 leucine rich repeat neuronal 4 2.22333
PAGE2B P antigen family, member 2B 2.22333
NUTM2A NUT family member 2A 2.22333
SLC25A52 solute carrier family 25, member 52 2.22333
H2BC21 H2B clustered histone 21 2.2164
NPY1R neuropeptide Y receptor Y1 2.20495
TTC23L tetratricopeptide repeat domain 23-like 2.19509
XYLT2 xylosyltransferase II 2.18543
ACAD9 acyl-CoA dehydrogenase family, member 9 2.17431
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.15585
ZFP69B ZFP69 zinc finger protein B 2.15585
NELL1 NEL-like 1 (chicken) 2.15585
STN1 STN1 subunit of CST complex 2.14578
C20ORF203 chromosome 20 open reading frame 203 2.13562
MED13 mediator complex subunit 13 2.11753
IFT80 intraflagellar transport 80 2.11674
CILK1 ciliogenesis associated kinase 1 2.10654
DENND2A DENN/MADD domain containing 2A 2.08576
OLFML3 olfactomedin-like 3 2.07022
GCHFR GTP cyclohydrolase I feedback regulator 2.06672
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.03847
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0368
WNK3 WNK lysine deficient protein kinase 3 2.03596
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.03235
RAB40B RAB40B, member RAS oncogene family 2.02465
KIF26B kinesin family member 26B 2.01964

decreased expression

Symbol Name Standardized Value
TEDC1 tubulin epsilon and delta complex 1 -2.22333
CASP6 caspase 6, apoptosis-related cysteine peptidase -2.22333
OLFM3 olfactomedin 3 -2.22333
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.22333
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.22333
TUSC3 tumor suppressor candidate 3 -2.22333
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.22333
NPTX1 neuronal pentraxin I -2.22333
HBEGF heparin-binding EGF-like growth factor -2.22333
DCHS1 dachsous cadherin-related 1 -2.22333
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.22333
STRADB STE20-related kinase adaptor beta -2.22333
MLKL mixed lineage kinase domain-like -2.22333
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.22333
IER3 immediate early response 3 -2.22333
NOXO1 NADPH oxidase organizer 1 -2.22333
TASOR2 transcription activation suppressor family member 2 -2.22333
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.22333
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -2.22333
METTL5 methyltransferase like 5 -2.22333
MYOCD myocardin -2.22333
PGLYRP1 peptidoglycan recognition protein 1 -2.22333
PPP4C protein phosphatase 4, catalytic subunit -2.22333
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.22333
TIMCC TIM double twin CX3C motif chaperone -2.22333
RNF150 ring finger protein 150 -2.22333
EIF2A eukaryotic translation initiation factor 2A, 65kDa -2.22333
MED27 mediator complex subunit 27 -2.22333
PEMT phosphatidylethanolamine N-methyltransferase -2.22333
GXYLT1 glucoside xylosyltransferase 1 -2.22333
C19ORF81 chromosome 19 open reading frame 81 -2.22333
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.22333
ZBTB7B zinc finger and BTB domain containing 7B -2.22333
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.22333
SYNGR2 synaptogyrin 2 -2.22333
ZSCAN1 zinc finger and SCAN domain containing 1 -2.22333
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.22333
SV2A synaptic vesicle glycoprotein 2A -2.22333
ZC3H12A zinc finger CCCH-type containing 12A -2.22333
PAWR PRKC, apoptosis, WT1, regulator -2.22333
MPLKIP M-phase specific PLK1 interacting protein -2.22333
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.22333
INO80 INO80 complex subunit -2.22333
CCDC71 coiled-coil domain containing 71 -2.22333
HLA-E major histocompatibility complex, class I, E -2.22333
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) -2.22333
SMYD2 SET and MYND domain containing 2 -2.22333
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -2.22333
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -2.22333
STOML1 stomatin (EPB72)-like 1 -2.21732
CCDC160 coiled-coil domain containing 160 -2.21189
TRAF2 TNF receptor-associated factor 2 -2.20495
RBMXL1 RNA binding motif protein, X-linked-like 1 -2.20137
KLHL26 kelch-like family member 26 -2.19202
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -2.18746
EEF1AKMT4 EEF1A lysine methyltransferase 4 -2.18746
VAT1L vesicle amine transport 1-like -2.18746
DLEU7 deleted in lymphocytic leukemia, 7 -2.17558
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.17431
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.16986
BOC BOC cell adhesion associated, oncogene regulated -2.16294
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome -2.15641
GPHN gephyrin -2.15585
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -2.14053
FAM13A family with sequence similarity 13, member A -2.14053
STRAP serine/threonine kinase receptor associated protein -2.14053
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.13775
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 -2.13594
ZNF34 zinc finger protein 34 -2.1347
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.11615
C10ORF88 chromosome 10 open reading frame 88 -2.0928
RSL24D1 ribosomal L24 domain containing 1 -2.0893
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.08576
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.08576
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.08576
SET SET nuclear proto-oncogene -2.08534
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.08528
COX20 COX20 cytochrome c oxidase assembly factor -2.07825
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.06672
PNMT phenylethanolamine N-methyltransferase -2.06672
RBBP5 retinoblastoma binding protein 5 -2.06387
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -2.06115
GTF2H5 general transcription factor IIH, polypeptide 5 -2.0485
CGGBP1 CGG triplet repeat binding protein 1 -2.0485
OPRD1 opioid receptor, delta 1 -2.0368
NPAT nuclear protein, ataxia-telangiectasia locus -2.0368
FBLIM1 filamin binding LIM protein 1 -2.02703
CFAP298 cilia and flagella associated protein 298 -2.01964
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.00348