TRAF2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TNF receptor-associated factor 2|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7186)
External Link http://www.ncbi.nlm.nih.gov/gene/7186
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380 interacting proteins for TRAF2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ACAD11 acyl-CoA dehydrogenase family, member 11
ACTG1 actin gamma 1
ACVR1 activin A receptor, type I
AFF4 AF4/FMR2 family, member 4
AGO2 argonaute RISC catalytic component 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALK anaplastic lymphoma receptor tyrosine kinase
ALPL alkaline phosphatase, liver/bone/kidney
ANKRD11 ankyrin repeat domain 11
ANKRD36BP1 ankyrin repeat domain 36B pseudogene 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APIP APAF1 interacting protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATG9A autophagy related 9A
ATXN1 ataxin 1
ATXN7 ataxin 7
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
AZI2 5-azacytidine induced 2
BAG2 BCL2-associated athanogene 2
BAG6 BCL2-associated athanogene 6
BAHD1 bromo adjacent homology domain containing 1
BANP BTG3 associated nuclear protein
BCL10 B-cell CLL/lymphoma 10
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2K BMP2 inducible kinase
C20ORF195 chromosome 20 open reading frame 195
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMLG calcium modulating ligand
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC130 coiled-coil domain containing 130
CCDC33 coiled-coil domain containing 33
CD27 CD27 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDC37 cell division cycle 37
CDC40 cell division cycle 40
CDC42 cell division cycle 42
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDCA3 cell division cycle associated 3
CDK9 cyclin-dependent kinase 9
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP2B charged multivesicular body protein 2B
CHUK conserved helix-loop-helix ubiquitous kinase
CLTC clathrin, heavy chain (Hc)
COG5 component of oligomeric golgi complex 5
COG7 component of oligomeric golgi complex 7
COPS5 COP9 signalosome subunit 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRY1 cryptochrome circadian clock 1
CYLD cylindromatosis (turban tumor syndrome)
DAB2IP DAB2 interacting protein
DCAF7 DDB1 and CUL4 associated factor 7
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGCR6 DiGeorge syndrome critical region gene 6
DIABLO diablo, IAP-binding mitochondrial protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTNB dystrobrevin, beta
DVL2 dishevelled segment polarity protein 2
EDAR ectodysplasin A receptor
EDARADD EDAR-associated death domain
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENKD1 enkurin domain containing 1
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
EPS15 epidermal growth factor receptor pathway substrate 15
ERN1 endoplasmic reticulum to nucleus signaling 1
EXOC3-AS1 EXOC3 antisense RNA 1
FADD Fas (TNFRSF6)-associated via death domain
FAM107A family with sequence similarity 107, member A
FAM120B family with sequence similarity 120B
FATE1 fetal and adult testis expressed 1
FBF1 Fas (TNFRSF6) binding factor 1
FBXO28 F-box protein 28
FBXO7 F-box protein 7
FCHO2 FCH domain only 2
FER fer (fps/fes related) tyrosine kinase
FLNA filamin A, alpha
FMR1 fragile X mental retardation 1
FXR2 fragile X mental retardation, autosomal homolog 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GCKR glucokinase (hexokinase 4) regulator
GOLGA3 golgin A3
GORASP2 golgi reassembly stacking protein 2, 55kDa
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HINFP histone H4 transcription factor
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA1 homeobox A1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB2 heat shock 27kDa protein 2
HTRA2 HtrA serine peptidase 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15RA interleukin 15 receptor, alpha
IP6K2 inositol hexakisphosphate kinase 2
IPO11 importin 11
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
IRF7 interferon regulatory factor 7
ITPK1 inositol-tetrakisphosphate 1-kinase
JAK1 Janus kinase 1
JUN jun proto-oncogene
KANSL1 KAT8 regulatory NSL complex subunit 1
KIAA0408 KIAA0408
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT33A keratin 33A, type I
KRT36 keratin 36, type I
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LNX2 ligand of numb-protein X 2
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LZTS2 leucine zipper, putative tumor suppressor 2
MALT1 MALT1 paracaspase
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAST2 microtubule associated serine/threonine kinase 2
MAVS mitochondrial antiviral signaling protein
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MERTK MER proto-oncogene, tyrosine kinase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MST1R macrophage stimulating 1 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTPAP mitochondrial poly(A) polymerase
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVP major vault protein
MYD88 myeloid differentiation primary response 88
MYLK2 myosin light chain kinase 2
NAP1L1 nucleosome assembly protein 1-like 1
NCAPH2 non-SMC condensin II complex, subunit H2
NECAP2 NECAP endocytosis associated 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRIP1 nuclear receptor interacting protein 1
NRK Nik related kinase
NT5DC2 5'-nucleotidase domain containing 2
NUAK1 NUAK family, SNF1-like kinase, 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPTN optineurin
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PACS2 phosphofurin acidic cluster sorting protein 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PDS5A PDS5 cohesin associated factor A
PEG3 paternally expressed 3
PFKL phosphofructokinase, liver
PIAS2 protein inhibitor of activated STAT, 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKN1 protein kinase N1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
QARS glutaminyl-tRNA synthetase
RAD23A RAD23 homolog A (S. cerevisiae)
RALBP1 ralA binding protein 1
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RB1CC1 RB1-inducible coiled-coil 1
RBBP5 retinoblastoma binding protein 5
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCOR3 REST corepressor 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RGS14 regulator of G-protein signaling 14
RHEB Ras homolog enriched in brain
RHEBL1 Ras homolog enriched in brain like 1
RIBC2 RIB43A domain with coiled-coils 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF2 ring finger protein 2
RNF31 ring finger protein 31
RPL23 ribosomal protein L23
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SARM1 sterile alpha and TIR motif containing 1
SEC16A SEC16 homolog A (S. cerevisiae)
SETD5 SET domain containing 5
SH3KBP1 SH3-domain kinase binding protein 1
SHARPIN SHANK-associated RH domain interactor
SIAH2 siah E3 ubiquitin protein ligase 2
SIVA1 SIVA1, apoptosis-inducing factor
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLK STE20-like kinase
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX30 SRY (sex determining region Y)-box 30
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK4 serine/threonine kinase 4
STON2 stonin 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TANK TRAF family member-associated NFKB activator
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCEA2 transcription elongation factor A (SII), 2
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDP2 tyrosyl-DNA phosphodiesterase 2
THAP7 THAP domain containing 7
TICAM1 toll-like receptor adaptor molecule 1
TIFA TRAF-interacting protein with forkhead-associated domain
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIK TRAF2 and NCK interacting kinase
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRIM31 tripartite motif containing 31
TRIM37 tripartite motif containing 37
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPT1 tRNA phosphotransferase 1
TUBA3C tubulin, alpha 3c
TUBB tubulin, beta class I
TUBB4A tubulin, beta 4A class IVa
TXLNA taxilin alpha
TXN thioredoxin
TYK2 tyrosine kinase 2
UBA1 ubiquitin-like modifier activating enzyme 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2O ubiquitin-conjugating enzyme E2O
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE2Z ubiquitin-conjugating enzyme E2Z
UBE4A ubiquitination factor E4A
UBQLN4 ubiquilin 4
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN11 UBX domain protein 11
USP15 ubiquitin specific peptidase 15
USP2 ubiquitin specific peptidase 2
USP31 ubiquitin specific peptidase 31
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP53 ubiquitin specific peptidase 53
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
VDAC1 voltage-dependent anion channel 1
WDR1 WD repeat domain 1
WDR61 WD repeat domain 61
WDR82 WD repeat domain 82
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB16 zinc finger and BTB domain containing 16
ZBTB25 zinc finger and BTB domain containing 25
ZBTB43 zinc finger and BTB domain containing 43
ZC3H15 zinc finger CCCH-type containing 15
ZFAND6 zinc finger, AN1-type domain 6
ZFP36 ZFP36 ring finger protein
ZMYND11 zinc finger, MYND-type containing 11
ZNF205 zinc finger protein 205
ZNF646 zinc finger protein 646