TRAF3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TNF receptor-associated factor 3|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 7187)
External Link http://www.ncbi.nlm.nih.gov/gene/7187
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Genes

162 interacting proteins for TRAF3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AGTR1 angiotensin II receptor, type 1
ALPL alkaline phosphatase, liver/bone/kidney
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARRB2 arrestin, beta 2
AZI2 5-azacytidine induced 2
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALCOCO2 calcium binding and coiled-coil domain 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD14 CD14 molecule
CD27 CD27 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDC40 cell division cycle 40
CFLAR CASP8 and FADD-like apoptosis regulator
CLGN calmegin
COG5 component of oligomeric golgi complex 5
COG7 component of oligomeric golgi complex 7
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
DAXX death-domain associated protein
DCAF7 DDB1 and CUL4 associated factor 7
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIABLO diablo, IAP-binding mitochondrial protein
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDA2R ectodysplasin A2 receptor
EDAR ectodysplasin A receptor
ETV6 ets variant 6
EWSR1 EWS RNA-binding protein 1
FAS Fas cell surface death receptor
GALC galactosylceramidase
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HCFC1 host cell factor C1
IFT54 intraflagellar transport 54
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15 interleukin 15
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
KDM1A lysine (K)-specific demethylase 1A
KEAP1 kelch-like ECH-associated protein 1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY96 lymphocyte antigen 96
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAVS mitochondrial antiviral signaling protein
MIB1 mindbomb E3 ubiquitin protein ligase 1
MTPAP mitochondrial poly(A) polymerase
MYD88 myeloid differentiation primary response 88
MYT1 myelin transcription factor 1
N4BP1 NEDD4 binding protein 1
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NLRX1 NLR family member X1
NMRAL1 NmrA-like family domain containing 1
NUP62 nucleoporin 62kDa
OPTN optineurin
ORC3 origin recognition complex, subunit 3
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OTUD5 OTU deubiquitinase 5
PALD1 phosphatase domain containing, paladin 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PLXDC2 plexin domain containing 2
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBM14 RNA binding motif protein 14
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF216 ring finger protein 216
RNF31 ring finger protein 31
RPS27A ribosomal protein S27a
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAR1A secretion associated, Ras related GTPase 1A
SARM1 sterile alpha and TIR motif containing 1
SEC16A SEC16 homolog A (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SNAP29 synaptosomal-associated protein, 29kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK11IP serine/threonine kinase 11 interacting protein
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SYK spleen tyrosine kinase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TANK TRAF family member-associated NFKB activator
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TFG TRK-fused gene
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMEM173 transmembrane protein 173
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNIP1 TNFAIP3 interacting protein 1
TOLLIP toll interacting protein
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TRAF3IP3 TRAF3 interacting protein 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRIM37 tripartite motif containing 37
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TROAP trophinin associated protein
TXLNA taxilin alpha
UBA1 ubiquitin-like modifier activating enzyme 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2O ubiquitin-conjugating enzyme E2O
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USO1 USO1 vesicle transport factor
USP15 ubiquitin specific peptidase 15
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WDR1 WD repeat domain 1
WDR5 WD repeat domain 5
WDR61 WD repeat domain 61
WDR82 WD repeat domain 82
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBP1 Z-DNA binding protein 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF516 zinc finger protein 516