TRAF4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description TNF receptor-associated factor 4|This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9618)
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Genes

321 genes differentially expressed following the TRAF4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LIPK lipase, family member K 2.50551
SLC26A5 solute carrier family 26 (anion exchanger), member 5 2.50551
ANKRD22 ankyrin repeat domain 22 2.50551
DNASE1L2 deoxyribonuclease I-like 2 2.50551
FOXA2 forkhead box A2 2.50551
GLYAT glycine-N-acyltransferase 2.50551
SKOR2 SKI family transcriptional corepressor 2 2.50551
GJB3 gap junction protein, beta 3, 31kDa 2.50551
PAX3 paired box 3 2.50551
SYCP3 synaptonemal complex protein 3 2.50551
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.50551
VTA1 vesicle (multivesicular body) trafficking 1 2.50551
FAM180A family with sequence similarity 180, member A 2.50551
LIPC lipase, hepatic 2.50551
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.50551
ATR ATR serine/threonine kinase 2.50551
SIX3 SIX homeobox 3 2.50551
TMPRSS11F transmembrane protease, serine 11F 2.50551
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.50551
ZACN zinc activated ligand-gated ion channel 2.50551
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.50551
LRRD1 leucine-rich repeats and death domain containing 1 2.50551
TUBB8 tubulin, beta 8 class VIII 2.50551
TLX2 T-cell leukemia homeobox 2 2.50551
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.50551
PRDM12 PR domain containing 12 2.50551
BMP3 bone morphogenetic protein 3 2.50551
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.50551
MYO1A myosin IA 2.50551
VCX variable charge, X-linked 2.50551
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 2.50551
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.50551
LHX6 LIM homeobox 6 2.50551
MMP20 matrix metallopeptidase 20 2.50551
GIMD1 GIMAP family P-loop NTPase domain containing 1 2.50551
COPZ2 coatomer protein complex, subunit zeta 2 2.50551
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.50551
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.50551
GUCY2F guanylate cyclase 2F, retinal 2.50551
FSCN2 fascin actin-bundling protein 2, retinal 2.50551
UBA7 ubiquitin-like modifier activating enzyme 7 2.50551
RGPD4 RANBP2-like and GRIP domain containing 4 2.50551
UMODL1 uromodulin-like 1 2.50551
TTLL8 tubulin tyrosine ligase-like family member 8 2.50551
PRSS36 protease, serine, 36 2.50551
FAM161B family with sequence similarity 161, member B 2.50551
ACTL10 actin-like 10 2.50551
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.50551
DNAI7 dynein axonemal intermediate chain 7 2.50551
LOC112694756 uncharaterized LOC112694756 2.50551
STING1 stimulator of interferon response cGAMP interactor 1 2.50551
HAO2 hydroxyacid oxidase 2 (long chain) 2.50551
ALDOB aldolase B, fructose-bisphosphate 2.50551
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2.50551
RHCE Rh blood group, CcEe antigens 2.50551
FRG2C FSHD region gene 2 family, member C 2.50551
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.50551
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.50551
ELOA2 elongin A2 2.50551
CBY2 chibby family member 2 2.50551
SPMAP2L sperm microtubule associated protein 2 like 2.50551
SPATA31H1 SPATA31 subfamily H member 1 2.50551
LINC02268 long intergenic non-protein coding RNA 2268 2.50551
CPNE8-AS1 CPNE8 antisense RNA 1 2.50551
REELD1 reeler domain containing 1 2.50551
H2BK1 H2B.K variant histone 1 2.50551
MUCL3 mucin like 3 2.50551
ARMH2 armadillo like helical domain containing 2 2.50551
CFAP107 cilia and flagella associated protein 107 2.50551
WDR64 WD repeat domain 64 2.50551
DOK2 docking protein 2, 56kDa 2.50551
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.50551
SIM2 single-minded family bHLH transcription factor 2 2.50551
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.50551
C3ORF80 chromosome 3 open reading frame 80 2.50551
MAL mal, T-cell differentiation protein 2.50551
CLEC3B C-type lectin domain family 3, member B 2.50551
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.50551
CLDN5 claudin 5 2.50551
PCDHB12 protocadherin beta 12 2.50551
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.50551
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.50551
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.50551
LY6H lymphocyte antigen 6 complex, locus H 2.50551
F5 coagulation factor V (proaccelerin, labile factor) 2.50551
SYT15 synaptotagmin XV 2.50551
LTK leukocyte receptor tyrosine kinase 2.50551
DLK1 delta-like 1 homolog (Drosophila) 2.50551
PRG4 proteoglycan 4 2.50551
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.50551
BEST3 bestrophin 3 2.50551
SAA2 serum amyloid A2 2.50551
KLHL33 kelch-like family member 33 2.50551
FAM81B family with sequence similarity 81, member B 2.50551
CABP2 calcium binding protein 2 2.50551
LCN1 lipocalin 1 2.50551
FAM163A family with sequence similarity 163, member A 2.50551
SCT secretin 2.50551
TMEM207 transmembrane protein 207 2.50551
NPFFR1 neuropeptide FF receptor 1 2.50551
PSKH2 protein serine kinase H2 2.50551
FIBIN fin bud initiation factor homolog (zebrafish) 2.50551
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.50551
C17ORF99 chromosome 17 open reading frame 99 2.50551
CLRN2 clarin 2 2.50551
CRYBB3 crystallin, beta B3 2.50551
PCDHGB4 protocadherin gamma subfamily B, 4 2.50551
PCDHGB2 protocadherin gamma subfamily B, 2 2.50551
LRRC46 leucine rich repeat containing 46 2.50551
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.50551
GAB3 GRB2-associated binding protein 3 2.50551
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.50551
RGS13 regulator of G-protein signaling 13 2.50551
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.50551
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.50551
KLK15 kallikrein-related peptidase 15 2.50551
PRDM9 PR domain containing 9 2.50551
ASTL astacin-like metallo-endopeptidase (M12 family) 2.50551
SPRYD3 SPRY domain containing 3 2.50551
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.50551
PLA2G2C phospholipase A2, group IIC 2.50551
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.50551
ESPNL espin-like 2.50551
OTP orthopedia homeobox 2.50551
CASQ2 calsequestrin 2 (cardiac muscle) 2.50551
LAMB4 laminin, beta 4 2.50551
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.50551
FAIM2 Fas apoptotic inhibitory molecule 2 2.50551
C1ORF105 chromosome 1 open reading frame 105 2.50551
CALR3 calreticulin 3 2.50551
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.50551
LGALS12 lectin, galactoside-binding, soluble, 12 2.50551
MORN5 MORN repeat containing 5 2.50551
SIGLEC14 sialic acid binding Ig-like lectin 14 2.50551
GSTA2 glutathione S-transferase alpha 2 2.50551
TP63 tumor protein p63 2.50551
TAGAP T-cell activation RhoGTPase activating protein 2.50551
CTSE cathepsin E 2.50551
ART1 ADP-ribosyltransferase 1 2.50551
PRR15L proline rich 15-like 2.50551
STOML3 stomatin (EPB72)-like 3 2.50551
ZNF404 zinc finger protein 404 2.50551
TGM6 transglutaminase 6 2.50551
ALOX15B arachidonate 15-lipoxygenase, type B 2.50551
STMND1 stathmin domain containing 1 2.50551
IFNK interferon, kappa 2.50551
NUTM2A NUT family member 2A 2.50551
EPX eosinophil peroxidase 2.50551
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.50551
ALLC allantoicase 2.50551
GH2 growth hormone 2 2.50551
NNMT nicotinamide N-methyltransferase 2.50551
PATE1 prostate and testis expressed 1 2.50551
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.50551
ASCL2 achaete-scute family bHLH transcription factor 2 2.50551
DBX2 developing brain homeobox 2 2.50551
MORC1 MORC family CW-type zinc finger 1 2.50551
PMP2 peripheral myelin protein 2 2.50551
TMEM184A transmembrane protein 184A 2.50551
CPZ carboxypeptidase Z 2.50551
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.50551
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.50551
FCAR Fc fragment of IgA receptor 2.50551
RHOJ ras homolog family member J 2.50551
SMYD1 SET and MYND domain containing 1 2.50551
PDCD1 programmed cell death 1 2.50551
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.50551
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.50551
BMX BMX non-receptor tyrosine kinase 2.50551
SLC71A1 solute carrier family 71 member 1 2.45055
TBX22 T-box 22 2.43122
PARD6A par-6 family cell polarity regulator alpha 2.41887
WIPF2 WAS/WASL interacting protein family, member 2 2.40064
PRSS3 protease, serine, 3 2.39549
IMMT inner membrane protein, mitochondrial 2.3711
ATP5F1B ATP synthase F1 subunit beta 2.34293
PYDC1 PYD (pyrin domain) containing 1 2.33944
SLC25A44 solute carrier family 25, member 44 2.33944
RPS14 ribosomal protein S14 2.33063
GFM2 G elongation factor, mitochondrial 2 2.3147
C18ORF32 chromosome 18 open reading frame 32 2.31122
CGRRF1 cell growth regulator with ring finger domain 1 2.29286
FGF11 fibroblast growth factor 11 2.25188
SAMD13 sterile alpha motif domain containing 13 2.25065
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 2.24624
KCTD16 potassium channel tetramerization domain containing 16 2.23185
ZSCAN9 zinc finger and SCAN domain containing 9 2.23185
CPTP ceramide-1-phosphate transfer protein 2.2128
CCDC86 coiled-coil domain containing 86 2.2128
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.2041
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.20035
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.19915
OSBPL9 oxysterol binding protein-like 9 2.1928
GRAMD2A GRAM domain containing 2A 2.18504
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.18504
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.16131
TMEM230 transmembrane protein 230 2.15279
ANXA5 annexin A5 2.15279
NUTF2 nuclear transport factor 2 2.14145
BTF3L4 basic transcription factor 3-like 4 2.11327
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.0958
PXN paxillin 2.0958
ZNF358 zinc finger protein 358 2.08293
TMED1 transmembrane emp24 protein transport domain containing 1 2.07517
NAT10 N-acetyltransferase 10 (GCN5-related) 2.07094
ZNF177 zinc finger protein 177 2.05308
ZNF324 zinc finger protein 324 2.02181
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.01453
ZNF107 zinc finger protein 107 2.01453
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.00989
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.00989
YBX1 Y box binding protein 1 2.00297

decreased expression

Symbol Name Standardized Value
TXN2 thioredoxin 2 -2.50551
SH3RF2 SH3 domain containing ring finger 2 -2.50551
TM2D3 TM2 domain containing 3 -2.50551
NRIP3 nuclear receptor interacting protein 3 -2.50551
CLC Charcot-Leyden crystal galectin -2.50551
FAM90A1 family with sequence similarity 90, member A1 -2.50551
ACP2 acid phosphatase 2, lysosomal -2.50551
ZSWIM1 zinc finger, SWIM-type containing 1 -2.50551
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.50551
CD82 CD82 molecule -2.50551
PROKR2 prokineticin receptor 2 -2.50551
REEP1 receptor accessory protein 1 -2.50551
KIAA1614 KIAA1614 -2.50551
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.50551
FES FES proto-oncogene, tyrosine kinase -2.50551
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.50551
SLC35F2 solute carrier family 35, member F2 -2.50551
NOTCH2NLA notch 2 N-terminal like A -2.50551
NLE1 notchless homolog 1 (Drosophila) -2.50551
STX19 syntaxin 19 -2.50344
CPXM2 carboxypeptidase X (M14 family), member 2 -2.49242
SPRING1 SREBF pathway regulator in golgi 1 -2.40064
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.34157
GRN granulin -2.34157
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.33944
DLX4 distal-less homeobox 4 -2.33944
OPRL1 opiate receptor-like 1 -2.33944
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.33944
THSD1 thrombospondin, type I, domain containing 1 -2.33944
OVCH1 ovochymase 1 -2.33944
XCL1 chemokine (C motif) ligand 1 -2.33944
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -2.33944
CCDC196 coiled-coil domain containing 196 -2.33944
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 -2.33944
BNC1 basonuclin 1 -2.33944
IL1R1 interleukin 1 receptor, type I -2.33944
FAM186A family with sequence similarity 186, member A -2.33944
NPNT nephronectin -2.33944
S100B S100 calcium binding protein B -2.33944
SP140 SP140 nuclear body protein -2.33944
PRB2 proline-rich protein BstNI subfamily 2 -2.33944
TMEM229A transmembrane protein 229A -2.33944
SPMIP8 sperm microtubule inner protein 8 -2.33944
BTBD18 BTB (POZ) domain containing 18 -2.33944
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -2.33944
TNS2 tensin 2 -2.33944
ADIRF adipogenesis regulatory factor -2.33944
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -2.33944
LDB3 LIM domain binding 3 -2.33944
PSD2 pleckstrin and Sec7 domain containing 2 -2.33944
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.33944
TMPPE transmembrane protein with metallophosphoesterase domain -2.33944
KLHL10 kelch-like family member 10 -2.33944
UPP2 uridine phosphorylase 2 -2.33944
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.33944
NKD2 naked cuticle homolog 2 (Drosophila) -2.33944
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.33944
H4C11 H4 clustered histone 11 -2.33806
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.33806
CCDC13 coiled-coil domain containing 13 -2.33806
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.33806
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.33806
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.33806
ARL6 ADP-ribosylation factor-like 6 -2.32366
MRI1 methylthioribose-1-phosphate isomerase 1 -2.31023
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -2.30078
LIMD1 LIM domains containing 1 -2.29537
USP6 ubiquitin specific peptidase 6 -2.2871
TCP11L2 t-complex 11, testis-specific-like 2 -2.2871
PDE8A phosphodiesterase 8A -2.28699
ZNF213 zinc finger protein 213 -2.28699
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.27277
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.26685
PNMA6A paraneoplastic Ma antigen family member 6A -2.25785
DPYSL3 dihydropyrimidinase-like 3 -2.25065
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.24624
APOL2 apolipoprotein L, 2 -2.23185
SLC35G1 solute carrier family 35, member G1 -2.23185
H2BC17 H2B clustered histone 17 -2.22434
CLDN20 claudin 20 -2.22083
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -2.21349
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.2128
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.18747
GPNMB glycoprotein (transmembrane) nmb -2.18747
DISP3 dispatched RND transporter family member 3 -2.18747
MCTP2 multiple C2 domains, transmembrane 2 -2.18504
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.17274
DNHD1 dynein heavy chain domain 1 -2.1725
TTN titin -2.15453
FERMT3 fermitin family member 3 -2.15168
SPTB spectrin, beta, erythrocytic -2.14169
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.13215
BBS5 Bardet-Biedl syndrome 5 -2.11742
SNX15 sorting nexin 15 -2.10032
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -2.09314
JAK2 Janus kinase 2 -2.08614
TRIM66 tripartite motif containing 66 -2.0843
TRIM3 tripartite motif containing 3 -2.07759
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.07602
TAOK2 TAO kinase 2 -2.06549
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -2.04772
AIRIM AFG2 interacting ribosome maturation factor -2.03403
LRRC8D leucine rich repeat containing 8 family, member D -2.02279
PHC2 polyhomeotic homolog 2 (Drosophila) -2.01635
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -2.01453
SLC16A9 solute carrier family 16, member 9 -2.00989
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.00814
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.00297
PYGM phosphorylase, glycogen, muscle -2.00297