TRAF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TNF receptor-associated factor 4|This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9618)
External Link http://www.ncbi.nlm.nih.gov/gene/9618
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Genes

66 interacting proteins for TRAF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTN1 actinin, alpha 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BCKDK branched chain ketoacid dehydrogenase kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BYSL bystin-like
CALCOCO2 calcium binding and coiled-coil domain 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCHCR1 coiled-coil alpha-helical rod protein 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CENPE centromere protein E, 312kDa
CHUK conserved helix-loop-helix ubiquitous kinase
DTX3 deltex 3, E3 ubiquitin ligase
FAM214B family with sequence similarity 214, member B
FAM90A1 family with sequence similarity 90, member A1
FTH1 ferritin, heavy polypeptide 1
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP6 glycoprotein VI (platelet)
GPRASP1 G protein-coupled receptor associated sorting protein 1
IRAK1 interleukin-1 receptor-associated kinase 1
KDM1A lysine (K)-specific demethylase 1A
KIF11 kinesin family member 11
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAGED1 melanoma antigen family D1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K7 mitogen-activated protein kinase kinase kinase 7
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MYH9 myosin, heavy chain 9, non-muscle
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPAS2 neuronal PAS domain protein 2
PDE4DIP phosphodiesterase 4D interacting protein
PLSCR1 phospholipid scramblase 1
PRMT5 protein arginine methyltransferase 5
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTK2B protein tyrosine kinase 2 beta
RIPK2 receptor-interacting serine-threonine kinase 2
RNF114 ring finger protein 114
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORBS2 sorbin and SH3 domain containing 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TARBP2 TAR (HIV-1) RNA binding protein 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM37 tripartite motif containing 37
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2O ubiquitin-conjugating enzyme E2O
USP15 ubiquitin specific peptidase 15
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZNF512B zinc finger protein 512B