| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | TNF receptor-associated factor 6, E3 ubiquitin protein ligase|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 7189) |
| External Link | https://ncbi.nlm.nih.gov/gene/7189 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the TRAF6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.0201373 |
| KRT14 | keratin 14, type I | 0.0183607 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0160504 |
| MT1X | metallothionein 1X | 0.0155387 |
| DEFB1 | defensin, beta 1 | 0.0147736 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0143629 |
| ANXA1 | annexin A1 | 0.0143055 |
| G0S2 | G0/G1 switch 2 | 0.0134272 |
| KRT5 | keratin 5, type II | 0.0133492 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0132123 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.0130128 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.0125087 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0123987 |
| NRIP3 | nuclear receptor interacting protein 3 | 0.0116202 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.011523 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0113592 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.0112268 |
| MYO1C | myosin IC | 0.0111758 |
| NEFH | neurofilament, heavy polypeptide | 0.0108516 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0106971 |
| KRT15 | keratin 15, type I | 0.0105537 |
| SRPX | sushi-repeat containing protein, X-linked | 0.0101935 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0101064 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00991127 |
| MMP7 | matrix metallopeptidase 7 | 0.00989863 |
| TRIM22 | tripartite motif containing 22 | 0.00988148 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00986321 |
| RBM34 | RNA binding motif protein 34 | 0.00985648 |
| PRAME | preferentially expressed antigen in melanoma | 0.00983638 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00970528 |
| AREG | amphiregulin | 0.0097005 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00969944 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00967647 |
| LAMC2 | laminin, gamma 2 | 0.00961147 |
| MT1G | metallothionein 1G | 0.00960691 |
| CHEK2 | checkpoint kinase 2 | 0.00958768 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00950766 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00943446 |
| KLK10 | kallikrein-related peptidase 10 | 0.00941216 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.00934639 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00930939 |
| GLOD4 | glyoxalase domain containing 4 | 0.00926482 |
| MT1F | metallothionein 1F | 0.00926154 |
| C6ORF48 | chromosome 6 open reading frame 48 | 0.00916955 |
| CSTA | cystatin A (stefin A) | 0.00913944 |
| KRT17 | keratin 17, type I | 0.00902556 |
| CES1 | carboxylesterase 1 | 0.00898745 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00893957 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00888875 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.0088526 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00871003 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.0086228 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00862196 |
| THBS2 | thrombospondin 2 | 0.00860138 |
| CFB | complement factor B | 0.00859734 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00853058 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00850505 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00844405 |
| SYNGR3 | synaptogyrin 3 | 0.00837979 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00836016 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00833781 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0083241 |
| KDSR | 3-ketodihydrosphingosine reductase | 0.00830066 |
| VNN1 | vanin 1 | 0.00827399 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00825164 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00824113 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00822768 |
| MT1H | metallothionein 1H | 0.00822 |
| IQCG | IQ motif containing G | 0.00821925 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00811833 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | 0.00810893 |
| NXT2 | nuclear transport factor 2-like export factor 2 | 0.00797542 |
| S100A7 | S100 calcium binding protein A7 | 0.00791063 |
| ECM1 | extracellular matrix protein 1 | 0.00789676 |
| IL1B | interleukin 1, beta | 0.00785453 |
| PTHLH | parathyroid hormone-like hormone | 0.00785212 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | 0.00785184 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00781305 |
| CPM | carboxypeptidase M | 0.0077592 |
| KRT6A | keratin 6A, type II | 0.00774421 |
| LBH | limb bud and heart development | 0.00774369 |
| SSR4 | signal sequence receptor, delta | 0.00772403 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00771678 |
| SPRR3 | small proline-rich protein 3 | 0.00770186 |
| RPS27L | ribosomal protein S27-like | 0.00765023 |
| MT1E | metallothionein 1E | 0.00764582 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00763421 |
| OXTR | oxytocin receptor | 0.00762503 |
| SP140L | SP140 nuclear body protein-like | 0.00761345 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.00756538 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.00755577 |
| PITX3 | paired-like homeodomain 3 | 0.00753776 |
| ZIC1 | Zic family member 1 | 0.00746681 |
| LTF | lactotransferrin | 0.00744803 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00739224 |
| NPC2 | Niemann-Pick disease, type C2 | 0.00737096 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0073601 |
| TRIM29 | tripartite motif containing 29 | 0.00735841 |
| RAB13 | RAB13, member RAS oncogene family | 0.00734464 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0073214 |
| RCAN1 | regulator of calcineurin 1 | 0.00730943 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.00725545 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00724835 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00722693 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0072136 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00719823 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00718805 |
| GPX7 | glutathione peroxidase 7 | 0.00715495 |
| CRYAB | crystallin, alpha B | 0.00714019 |
| LUM | lumican | 0.007125 |
| MME | membrane metallo-endopeptidase | 0.00710915 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.00706419 |
| RND3 | Rho family GTPase 3 | 0.00706019 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0070149 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00701267 |
| MMP1 | matrix metallopeptidase 1 | 0.00701008 |
| SP110 | SP110 nuclear body protein | 0.00700046 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00698598 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00697672 |
| MICB | MHC class I polypeptide-related sequence B | 0.00696039 |
| RGS4 | regulator of G-protein signaling 4 | 0.00695453 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00691838 |
| MYOF | myoferlin | 0.00690123 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00688059 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.00687301 |
| IER3 | immediate early response 3 | 0.00686891 |
| TRIM8 | tripartite motif containing 8 | 0.00685342 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.00683414 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.00682124 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00681901 |
| TSPAN31 | tetraspanin 31 | 0.00680043 |
| NKX3-1 | NK3 homeobox 1 | 0.00679808 |
| IL1RN | interleukin 1 receptor antagonist | 0.00677937 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | 0.0067529 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00674593 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00673729 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00673336 |
| RGS10 | regulator of G-protein signaling 10 | 0.00673319 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00672424 |
| MT2A | metallothionein 2A | 0.00671258 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 0.0067125 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00668445 |
| S100A10 | S100 calcium binding protein A10 | 0.00666779 |
| ADM | adrenomedullin | 0.00665263 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.00662513 |
| TSPAN3 | tetraspanin 3 | 0.00662057 |
| GDF15 | growth differentiation factor 15 | 0.0066035 |
| C9 | complement component 9 | 0.00659145 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0065872 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00657493 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00657478 |
| MX1 | MX dynamin-like GTPase 1 | 0.00656815 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00654663 |
| COX5B | cytochrome c oxidase subunit Vb | 0.00652709 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00652481 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00650976 |
| HIST3H2A | histone cluster 3, H2a | 0.0065073 |
| LY96 | lymphocyte antigen 96 | 0.00649807 |
| MT1M | metallothionein 1M | 0.0064936 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.00649277 |
| RUNX1 | runt-related transcription factor 1 | 0.00648394 |
| CAV2 | caveolin 2 | 0.00644835 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00643684 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 0.00642998 |
| DNMBP | dynamin binding protein | 0.00641774 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00641444 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00640827 |
| C1S | complement component 1, s subcomponent | 0.00637479 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00636956 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.00636827 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00634747 |
| LRRC17 | leucine rich repeat containing 17 | 0.00633619 |
| TXNIP | thioredoxin interacting protein | 0.00631635 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00630401 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.00628566 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00626449 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00625912 |
| ATF3 | activating transcription factor 3 | 0.00625096 |
| ARPC3 | actin related protein 2/3 complex, subunit 3, 21kDa | 0.00624728 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00623487 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00623266 |
| KRT18 | keratin 18, type I | 0.00620617 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00620305 |
| UTP11 | UTP11 small subunit processome component | 0.0061977 |
| SPRR2B | small proline-rich protein 2B | 0.00619285 |
| SCPEP1 | serine carboxypeptidase 1 | 0.00618399 |
| KRT6B | keratin 6B, type II | 0.00614913 |
| HOXC10 | homeobox C10 | 0.00613468 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00613355 |
| LAMB3 | laminin, beta 3 | 0.00613202 |
| POSTN | periostin, osteoblast specific factor | 0.00612234 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00610016 |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent | 0.00609202 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.00608763 |
| ERGIC2 | ERGIC and golgi 2 | 0.00608239 |
| SP100 | SP100 nuclear antigen | 0.00607789 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00607788 |
| RBKS | ribokinase | 0.00606791 |
| ERP44 | endoplasmic reticulum protein 44 | 0.00606476 |
| SERINC3 | serine incorporator 3 | 0.00605646 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00605359 |
| MSMB | microseminoprotein, beta- | 0.0060502 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00604181 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00603519 |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 | 0.00602102 |
| PLSCR1 | phospholipid scramblase 1 | 0.00601463 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00600635 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00600213 |
| PLSCR3 | phospholipid scramblase 3 | 0.00600176 |
| IRS1 | insulin receptor substrate 1 | 0.00599033 |
| GSTK1 | glutathione S-transferase kappa 1 | 0.00596931 |
| MVP | major vault protein | 0.00596679 |
| ARHGAP6 | Rho GTPase activating protein 6 | 0.00596434 |
| FOXD1 | forkhead box D1 | 0.00596053 |
| KRT16 | keratin 16, type I | 0.00595159 |
| YAF2 | YY1 associated factor 2 | 0.00594258 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.00593953 |
| ADIRF | adipogenesis regulatory factor | 0.00593478 |
| GRN | granulin | 0.00591247 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.00589209 |
| TUFT1 | tuftelin 1 | 0.00588499 |
| S100A11 | S100 calcium binding protein A11 | 0.00584935 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00583804 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.00583577 |
| ANXA10 | annexin A10 | 0.00582729 |
| TRIM38 | tripartite motif containing 38 | 0.00580905 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00579021 |
| MAGEA3 | melanoma antigen family A3 | 0.00576782 |
| EFNA1 | ephrin-A1 | 0.00575769 |
| COL1A1 | collagen, type I, alpha 1 | 0.00575141 |
| KRT13 | keratin 13, type I | 0.00575075 |
| CTBS | chitobiase, di-N-acetyl- | 0.00573239 |
| NEFM | neurofilament, medium polypeptide | 0.00572763 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.0057052 |
| NAV3 | neuron navigator 3 | 0.00570269 |
| KYNU | kynureninase | 0.00570052 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0056925 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.00568693 |
| CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 0.00568398 |
| DIO1 | deiodinase, iodothyronine, type I | 0.00567585 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0056732 |
| WBP1L | WW domain binding protein 1-like | 0.00565267 |
| IFI35 | interferon-induced protein 35 | 0.00565207 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 0.00564745 |
| NGRN | neugrin, neurite outgrowth associated | 0.00563921 |
| CDC37L1 | cell division cycle 37-like 1 | 0.00563826 |
| HECA | headcase homolog (Drosophila) | 0.00562211 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00559025 |
| F8 | coagulation factor VIII, procoagulant component | 0.00557973 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00557651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.0145237 |
| EPHB2 | EPH receptor B2 | -0.0141995 |
| MAP7 | microtubule-associated protein 7 | -0.0134369 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.011853 |
| CD200 | CD200 molecule | -0.0110888 |
| CPE | carboxypeptidase E | -0.0110268 |
| FRZB | frizzled-related protein | -0.0106919 |
| TOX3 | TOX high mobility group box family member 3 | -0.0106361 |
| CLC | Charcot-Leyden crystal galectin | -0.0105153 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | -0.0105078 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0104893 |
| MBD1 | methyl-CpG binding domain protein 1 | -0.0102996 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.0102891 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0100334 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00996535 |
| CLCA1 | chloride channel accessory 1 | -0.00992294 |
| CCNB1 | cyclin B1 | -0.00988846 |
| PMP22 | peripheral myelin protein 22 | -0.0097111 |
| DACH1 | dachshund family transcription factor 1 | -0.00963552 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00960082 |
| IFRD2 | interferon-related developmental regulator 2 | -0.00957385 |
| SDC2 | syndecan 2 | -0.00955839 |
| PRDX2 | peroxiredoxin 2 | -0.00939634 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00925073 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00924442 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00894141 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.0088852 |
| RXRA | retinoid X receptor, alpha | -0.00881885 |
| FGL2 | fibrinogen-like 2 | -0.008752 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00859345 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | -0.00856042 |
| INSM1 | insulinoma-associated 1 | -0.00854356 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00843363 |
| SNX7 | sorting nexin 7 | -0.00843229 |
| GLS | glutaminase | -0.00834536 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00832639 |
| SEPTIN10 | septin 10 | -0.00823256 |
| CCND2 | cyclin D2 | -0.00819148 |
| COL4A6 | collagen, type IV, alpha 6 | -0.00813379 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00810248 |
| ITGA6 | integrin, alpha 6 | -0.00809486 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00808791 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | -0.00797998 |
| AURKB | aurora kinase B | -0.00789056 |
| PAX6 | paired box 6 | -0.00786614 |
| PTK2 | protein tyrosine kinase 2 | -0.00783353 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.0078245 |
| PON3 | paraoxonase 3 | -0.0078119 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0078117 |
| REG3A | regenerating islet-derived 3 alpha | -0.00781034 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00780473 |
| DAPK1 | death-associated protein kinase 1 | -0.00770056 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00762043 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00759597 |
| TYMS | thymidylate synthetase | -0.00743982 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00740695 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00740265 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00738137 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00737681 |
| CAMP | cathelicidin antimicrobial peptide | -0.00734212 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00728257 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -0.00722103 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | -0.00717288 |
| CHKB | choline kinase beta | -0.00711468 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00704589 |
| FCGBP | Fc fragment of IgG binding protein | -0.00703894 |
| CHN1 | chimerin 1 | -0.00701725 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0070055 |
| IL17RB | interleukin 17 receptor B | -0.00693075 |
| FASN | fatty acid synthase | -0.00689645 |
| RAPSN | receptor-associated protein of the synapse | -0.00689242 |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | -0.00681644 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -0.00672623 |
| IPO9 | importin 9 | -0.00670915 |
| CBX1 | chromobox homolog 1 | -0.00670656 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00670055 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00666887 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00664258 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00662579 |
| FABP1 | fatty acid binding protein 1, liver | -0.00662384 |
| RAP2A | RAP2A, member of RAS oncogene family | -0.00658683 |
| AFP | alpha-fetoprotein | -0.00655304 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.00653551 |
| FZD5 | frizzled class receptor 5 | -0.00652401 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | -0.00651256 |
| INSIG1 | insulin induced gene 1 | -0.00649668 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00649486 |
| TNIK | TRAF2 and NCK interacting kinase | -0.00648465 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | -0.00646719 |
| CA9 | carbonic anhydrase IX | -0.00644197 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00642649 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00639972 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00639893 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.00638854 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00638681 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00635054 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00634735 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.00633984 |
| TCF4 | transcription factor 4 | -0.00632678 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00630207 |
| KLHDC3 | kelch domain containing 3 | -0.00629321 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00627807 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00626568 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0062588 |
| KRT81 | keratin 81, type II | -0.006248 |
| EPHB6 | EPH receptor B6 | -0.00622165 |
| FOXG1 | forkhead box G1 | -0.00622046 |
| GPC3 | glypican 3 | -0.00622037 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00621159 |
| ACTN4 | actinin, alpha 4 | -0.00620995 |
| COL21A1 | collagen, type XXI, alpha 1 | -0.00619366 |
| CALD1 | caldesmon 1 | -0.00617783 |
| TRAF5 | TNF receptor-associated factor 5 | -0.00614682 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00613666 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00613635 |
| ELN | elastin | -0.00613543 |
| CAPN15 | calpain 15 | -0.00612343 |
| AUTS2 | autism susceptibility candidate 2 | -0.0061212 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | -0.00612087 |
| KRT20 | keratin 20, type I | -0.00610093 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00608486 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00605947 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00605845 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -0.00605789 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | -0.00604461 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.00604115 |
| MYO1D | myosin ID | -0.00603309 |
| CDC20 | cell division cycle 20 | -0.00602355 |
| CA2 | carbonic anhydrase II | -0.00601661 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00601325 |
| HPCAL1 | hippocalcin-like 1 | -0.0059961 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00593601 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00593171 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00592291 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | -0.00592032 |
| RHOB | ras homolog family member B | -0.00591693 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00590802 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00590393 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | -0.00589414 |
| H2AX | H2A.X variant histone | -0.00588865 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00588785 |
| ACTN1 | actinin, alpha 1 | -0.00588714 |
| FBN2 | fibrillin 2 | -0.00588487 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00588483 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.005879 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00587713 |
| CADM1 | cell adhesion molecule 1 | -0.00584273 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.005842 |
| MYO5C | myosin VC | -0.00583761 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.00583437 |
| PCP4 | Purkinje cell protein 4 | -0.00581942 |
| IL2RB | interleukin 2 receptor, beta | -0.00581226 |
| ELANE | elastase, neutrophil expressed | -0.00580961 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00580413 |
| MPO | myeloperoxidase | -0.00580073 |
| DCK | deoxycytidine kinase | -0.00576791 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.00575876 |
| DSE | dermatan sulfate epimerase | -0.00575111 |
| SMAD7 | SMAD family member 7 | -0.00574794 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | -0.00574729 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00574038 |
| CEP350 | centrosomal protein 350kDa | -0.0057395 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00573186 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00572469 |
| ENO1 | enolase 1, (alpha) | -0.00569581 |
| CDHR1 | cadherin-related family member 1 | -0.00569535 |
| MLXIP | MLX interacting protein | -0.00569009 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.00568999 |
| BPI | bactericidal/permeability-increasing protein | -0.00568917 |
| SNCAIP | synuclein, alpha interacting protein | -0.00568401 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00567613 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | -0.00565726 |
| PFKL | phosphofructokinase, liver | -0.00565663 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.00563721 |
| FANCL | Fanconi anemia, complementation group L | -0.00562877 |
| SNX5 | sorting nexin 5 | -0.00562522 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00558802 |
| ADCY2 | adenylate cyclase 2 (brain) | -0.00557465 |
| NFASC | neurofascin | -0.00556783 |
| FOXM1 | forkhead box M1 | -0.00555551 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00555292 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00554689 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00554451 |
| ZG16 | zymogen granule protein 16 | -0.00553848 |
| HMGB2 | high mobility group box 2 | -0.00552826 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00552388 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.00551489 |
| FBN1 | fibrillin 1 | -0.00551456 |
| PGLYRP1 | peptidoglycan recognition protein 1 | -0.00550926 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00550312 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.0054921 |
| PLXNC1 | plexin C1 | -0.00548523 |
| FPR3 | formyl peptide receptor 3 | -0.00548142 |
| MDFIC | MyoD family inhibitor domain containing | -0.00546312 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0054609 |
| COLEC12 | collectin sub-family member 12 | -0.00545028 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.00544678 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.0054355 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -0.0054343 |
| L1TD1 | LINE-1 type transposase domain containing 1 | -0.00539491 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00538179 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.00535826 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00535318 |
| FOXF1 | forkhead box F1 | -0.00534629 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | -0.00534543 |
| ELP1 | elongator acetyltransferase complex subunit 1 | -0.0053342 |
| UTP18 | UTP18 small subunit (SSU) processome component homolog (yeast) | -0.00533319 |
| KIF1B | kinesin family member 1B | -0.00531456 |
| SON | SON DNA binding protein | -0.00531285 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00530334 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | -0.00530239 |
| COMP | cartilage oligomeric matrix protein | -0.00530233 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | -0.00527706 |
| CENPF | centromere protein F, 350/400kDa | -0.00527651 |
| ATXN7 | ataxin 7 | -0.0052691 |
| H2AZ1 | H2A.Z variant histone 1 | -0.00525928 |
| DGKZ | diacylglycerol kinase, zeta | -0.00525857 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.00525475 |
| OLFM4 | olfactomedin 4 | -0.00524501 |
| SELENBP1 | selenium binding protein 1 | -0.0052431 |
| CD34 | CD34 molecule | -0.00522712 |
| PDGFD | platelet derived growth factor D | -0.00522465 |
| NELL2 | NEL-like 2 (chicken) | -0.00521768 |
| DEFA4 | defensin, alpha 4, corticostatin | -0.00521576 |
| MECOM | MDS1 and EVI1 complex locus | -0.00520039 |
| CHGB | chromogranin B | -0.00519811 |
| ZNF331 | zinc finger protein 331 | -0.00519428 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0051913 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | -0.00518325 |
| CENPM | centromere protein M | -0.00518087 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00517281 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | -0.00516671 |
| REG1A | regenerating islet-derived 1 alpha | -0.00516581 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00515599 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -0.00515588 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | -0.00515577 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00515395 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | -0.00513208 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | -0.00512965 |
| CST7 | cystatin F (leukocystatin) | -0.00512922 |
| NAV2 | neuron navigator 2 | -0.00512914 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.00511164 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0051063 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00510258 |
| ACTL6A | actin-like 6A | -0.00509816 |
| QKI | QKI, KH domain containing, RNA binding | -0.00509667 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00509641 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00509142 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00506578 |
