TRAF6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TNF receptor-associated factor 6, E3 ubiquitin protein ligase|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 7189)
External Link http://www.ncbi.nlm.nih.gov/gene/7189
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599 interacting proteins for TRAF6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAT2 acetyl-CoA acetyltransferase 2
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAM17 ADAM metallopeptidase domain 17
ADCK3 aarF domain containing kinase 3
AHCY adenosylhomocysteinase
AHCYL2 adenosylhomocysteinase-like 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AJUBA ajuba LIM protein
AK2 adenylate kinase 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBRA1 autophagy/beclin-1 regulator 1
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
APP amyloid beta (A4) precursor protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APRT adenine phosphoribosyltransferase
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASXL2 additional sex combs like transcriptional regulator 2
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATXN3 ataxin 3
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAG6 BCL2-associated athanogene 6
BCL10 B-cell CLL/lymphoma 10
BECN1 beclin 1, autophagy related
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMPR1B bone morphogenetic protein receptor, type IB
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
BRI3BP BRI3 binding protein
BTF3 basic transcription factor 3
BUB3 BUB3 mitotic checkpoint protein
C14ORF166 chromosome 14 open reading frame 166
C19ORF40 chromosome 19 open reading frame 40
CACYBP calcyclin binding protein
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CAMLG calcium modulating ligand
CANX calnexin
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CARD11 caspase recruitment domain family, member 11
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR1 carbonyl reductase 1
CCDC59 coiled-coil domain containing 59
CCL20 chemokine (C-C motif) ligand 20
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD14 CD14 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD81 CD81 molecule
CDC37 cell division cycle 37
CDC40 cell division cycle 40
CDC42 cell division cycle 42
CEP55 centrosomal protein 55kDa
CHUK conserved helix-loop-helix ubiquitous kinase
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPG1 coatomer protein complex, subunit gamma 1
CS citrate synthase
CSDE1 cold shock domain containing E1, RNA-binding
CSNK1G1 casein kinase 1, gamma 1
CTAGE5 CTAGE family, member 5
CTPS1 CTP synthase 1
CUL1 cullin 1
CYB5A cytochrome b5 type A (microsomal)
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCXR dicarbonyl/L-xylulose reductase
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DIABLO diablo, IAP-binding mitochondrial protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECSIT ECSIT signalling integrator
EDA2R ectodysplasin A2 receptor
EDAR ectodysplasin A receptor
EDARADD EDAR-associated death domain
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4E eukaryotic translation initiation factor 4E
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPPK1 epiplakin 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERH enhancer of rudimentary homolog (Drosophila)
ERLIN1 ER lipid raft associated 1
ERN1 endoplasmic reticulum to nucleus signaling 1
ESD esterase D
ESR1 estrogen receptor 1
ETF1 eukaryotic translation termination factor 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCD2 Fanconi anemia, complementation group D2
FASTKD2 FAST kinase domains 2
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FOXG1 forkhead box G1
FSCN1 fascin actin-bundling protein 1
FUS FUS RNA binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GANAB glucosidase, alpha; neutral AB
GARS glycyl-tRNA synthetase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GDI2 GDP dissociation inhibitor 2
GLUD1 glutamate dehydrogenase 1
GMFB glia maturation factor, beta
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GOLGA2 golgin A2
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO1 glutathione S-transferase omega 1
GTF2I general transcription factor IIi
GXYLT1 glucoside xylosyltransferase 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HARS histidyl-tRNA synthetase
HEATR3 HEAT repeat containing 3
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB2 high mobility group box 2
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPL heterogeneous nuclear ribonucleoprotein L
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB2 heat shock 27kDa protein 2
HSPE1 heat shock 10kDa protein 1
HTT huntingtin
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IER3IP1 immediate early response 3 interacting protein 1
IFT54 intraflagellar transport 54
IGF2R insulin-like growth factor 2 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL33R interleukin 33 receptor
IPO7 importin 7
IQCB1 IQ motif containing B1
IQSEC1 IQ motif and Sec7 domain 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
ITCH itchy E3 ubiquitin protein ligase
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
JAK2 Janus kinase 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD9 potassium channel tetramerization domain containing 9
KHSRP KH-type splicing regulatory protein
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KPNB1 karyopherin (importin) beta 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LGMN legumain
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC59 leucine rich repeat containing 59
LY96 lymphocyte antigen 96
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MALT1 MALT1 paracaspase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPT microtubule-associated protein tau
MARCH5 membrane-associated ring finger (C3HC4) 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MARS methionyl-tRNA synthetase
MAST2 microtubule associated serine/threonine kinase 2
MAT2A methionine adenosyltransferase II, alpha
MAVS mitochondrial antiviral signaling protein
MBP myelin basic protein
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MEDAG mesenteric estrogen-dependent adipogenesis
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLEC malectin
MOB1A MOB kinase activator 1A
MRPL13 mitochondrial ribosomal protein L13
MRPS27 mitochondrial ribosomal protein S27
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSN moesin
MSR1 macrophage scavenger receptor 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTPN myotrophin
MYB v-myb avian myeloblastosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYDGF myeloid-derived growth factor
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NAP1L1 nucleosome assembly protein 1-like 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NCSTN nicastrin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NHP2 NHP2 ribonucleoprotein
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NLRC3 NLR family, CARD domain containing 3
NLRX1 NLR family member X1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPEPPS aminopeptidase puromycin sensitive
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5
NUMBL numb homolog (Drosophila)-like
NUP155 nucleoporin 155kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OAT ornithine aminotransferase
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OTUD7A OTU deubiquitinase 7A
OTUD7B OTU deubiquitinase 7B
PA2G4 proliferation-associated 2G4, 38kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCBP1 poly(rC) binding protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPK1 3-phosphoinositide dependent protein kinase 1
PDS5A PDS5 cohesin associated factor A
PEBP1 phosphatidylethanolamine binding protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PELI3 pellino E3 ubiquitin protein ligase family member 3
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PGRMC1 progesterone receptor membrane component 1
PHB2 prohibitin 2
PHPT1 phosphohistidine phosphatase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINK1 PTEN induced putative kinase 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP4C protein phosphatase 4, catalytic subunit
PREP prolyl endopeptidase
PRKCSH protein kinase C substrate 80K-H
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB10 RAB10, member RAS oncogene family
RAB11A RAB11A, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RANBP1 RAN binding protein 1
RANBP9 RAN binding protein 9
RANGAP1 Ran GTPase activating protein 1
RAP1A RAP1A, member of RAS oncogene family
RBBP7 retinoblastoma binding protein 7
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCAN1 regulator of calcineurin 1
RCC1 regulator of chromosome condensation 1
RCC2 regulator of chromosome condensation 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REXO2 RNA exonuclease 2
RHOC ras homolog family member C
RHPN2 rhophilin, Rho GTPase binding protein 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF114 ring finger protein 114
RNF126 ring finger protein 126
RNF31 ring finger protein 31
RPA3 replication protein A3, 14kDa
RPL18A ribosomal protein L18a
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL35 ribosomal protein L35
RPL35A ribosomal protein L35a
RPL36 ribosomal protein L36
RPL38 ribosomal protein L38
RPS10 ribosomal protein S10
RPS11 ribosomal protein S11
RPS27A ribosomal protein S27a
RPS3A ribosomal protein S3A
RPS9 ribosomal protein S9
RPTOR regulatory associated protein of MTOR, complex 1
RRAGC Ras-related GTP binding C
RTN4 reticulon 4
RUNX1 runt-related transcription factor 1
RUSC1 RUN and SH3 domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100A11 S100 calcium binding protein A11
SAE1 SUMO1 activating enzyme subunit 1
SAR1A secretion associated, Ras related GTPase 1A
SARM1 sterile alpha and TIR motif containing 1
SDCBP syndecan binding protein (syntenin)
SDCCAG8 serologically defined colon cancer antigen 8
SEC11A SEC11 homolog A (S. cerevisiae)
SEPT11 septin 11
SEPT9 septin 9
SESTD1 SEC14 and spectrin domains 1
SET SET nuclear proto-oncogene
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SOCS3 suppressor of cytokine signaling 3
SPHK1 sphingosine kinase 1
SPOP speckle-type POZ protein
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSB Sjogren syndrome antigen B (autoantigen La)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
STRADB STE20-related kinase adaptor beta
STRAP serine/threonine kinase receptor associated protein
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAGLN2 transgelin 2
TALDO1 transaldolase 1
TANK TRAF family member-associated NFKB activator
TARDBP TAR DNA binding protein
TARS threonyl-tRNA synthetase
TARSL2 threonyl-tRNA synthetase-like 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBCA tubulin folding cofactor A
TBK1 TANK-binding kinase 1
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCP1 t-complex 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TFG TRK-fused gene
TFRC transferrin receptor
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRAP3 thyroid hormone receptor associated protein 3
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIFA TRAF-interacting protein with forkhead-associated domain
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TJP2 tight junction protein 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM109 transmembrane protein 109
TMEM173 transmembrane protein 173
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIK TRAF2 and NCK interacting kinase
TOLLIP toll interacting protein
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TPR translocated promoter region, nuclear basket protein
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TRAIP TRAF interacting protein
TRAM1 translocation associated membrane protein 1
TRIM17 tripartite motif containing 17
TRIM25 tripartite motif containing 25
TRIM28 tripartite motif containing 28
TRIM37 tripartite motif containing 37
TRIM38 tripartite motif containing 38
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TSGA10 testis specific, 10
TSN translin
TSSC1 tumor suppressing subtransferable candidate 1
TUBA1A tubulin, alpha 1a
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB4A tubulin, beta 4A class IVa
TUBB6 tubulin, beta 6 class V
TUFM Tu translation elongation factor, mitochondrial
TXN thioredoxin
UBA1 ubiquitin-like modifier activating enzyme 1
UBA2 ubiquitin-like modifier activating enzyme 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2I ubiquitin-conjugating enzyme E2I
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2M ubiquitin-conjugating enzyme E2M
UBE2N ubiquitin-conjugating enzyme E2N
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBE2O ubiquitin-conjugating enzyme E2O
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE4A ubiquitination factor E4A
UBOX5 U-box domain containing 5
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UEVLD UEV and lactate/malate dehyrogenase domains
ULK1 unc-51 like autophagy activating kinase 1
USP1 ubiquitin specific peptidase 1
USP15 ubiquitin specific peptidase 15
USP2 ubiquitin specific peptidase 2
USP21 ubiquitin specific peptidase 21
USP25 ubiquitin specific peptidase 25
USP39 ubiquitin specific peptidase 39
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
VARS valyl-tRNA synthetase
VAT1 vesicle amine transport 1
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VTA1 vesicle (multivesicular body) trafficking 1
WDFY3 WD repeat and FYVE domain containing 3
WDR1 WD repeat domain 1
WDR34 WD repeat domain 34
WDR5 WD repeat domain 5
WDR61 WD repeat domain 61
WDR82 WD repeat domain 82
WRNIP1 Werner helicase interacting protein 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO5 exportin 5
YARS tyrosyl-tRNA synthetase
YBX1 Y box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12C zinc finger CCCH-type containing 12C
ZFAND5 zinc finger, AN1-type domain 5
ZMYND11 zinc finger, MYND-type containing 11
ZNF675 zinc finger protein 675
ZRANB1 zinc finger, RAN-binding domain containing 1